Single cell type - GAS2L1 - The Human Protein Atlas

GAS2L1

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GAS2L1
Gene descriptionⁱ Full gene name according to HGNC.	Growth arrest specific 2 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Platelets - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.46
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GAS2L1 is part of cluster 57 Platelets - Hemostasis with confidenceⁱ 1
173 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SPDYC	Speedy/RINGO cell cycle regulator family member C	0.6563	57
ITGB3	Integrin subunit beta 3	0.6557	57
MINDY1	MINDY lysine 48 deubiquitinase 1	0.6440	57
MAP3K7CL	MAP3K7 C-terminal like	0.6417	57
TRAPPC3L	Trafficking protein particle complex subunit 3L	0.6404	57
RUFY1	RUN and FYVE domain containing 1	0.6385	57
LY6G6F	Lymphocyte antigen 6 family member G6F	0.6342	57
TUBB1	Tubulin beta 1 class VI	0.6339	57
GP9	Glycoprotein IX platelet	0.6339	57
ITGA2B	Integrin subunit alpha 2b	0.6337	57
PPBP	Pro-platelet basic protein	0.6325	57
PF4	Platelet factor 4	0.6324	57
INKA1	Inka box actin regulator 1	0.6290	57
GNG11	G protein subunit gamma 11	0.6274	57
MARCHF2	Membrane associated ring-CH-type finger 2	0.6274	57

IMMUNE CELLS

GAS2L1 is part of cluster 45 Eosinophils - Unknown function with confidenceⁱ 1
257 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MOB3C	MOB kinase activator 3C	1.0000	45
ZDHHC13	Zinc finger DHHC-type palmitoyltransferase 13	1.0000	45
SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	1.0000	45
CLTB	Clathrin light chain B	1.0000	45
SERF1A	Small EDRK-rich factor 1A	1.0000	45
RNF187	Ring finger protein 187	1.0000	45
TMUB1	Transmembrane and ubiquitin like domain containing 1	1.0000	45
UBALD1	UBA like domain containing 1	1.0000	45
PPP1R18	Protein phosphatase 1 regulatory subunit 18	1.0000	45
ENSA	Endosulfine alpha	1.0000	45
ZNF263	Zinc finger protein 263	1.0000	45
CAMK1	Calcium/calmodulin dependent protein kinase I	1.0000	45
MKRN1	Makorin ring finger protein 1	1.0000	45
ARPP19	CAMP regulated phosphoprotein 19	1.0000	45
MAP2K2	Mitogen-activated protein kinase kinase 2	1.0000	45

Adipocytes	32.4 nTPM
Adipose tissue	40.3 nTPM
Breast	24.5 nTPM

Alveolar cells type 1	11.3 nTPM
Lung	11.3 nTPM

Alveolar cells type 2	4.9 nTPM
Lung	4.9 nTPM

Astrocytes	26.6 nTPM
Brain	26.6 nTPM

B-cells	1.6 nTPM
Skin	16.9 nTPM
Lung	1.3 nTPM
Thymus	1.2 nTPM
Salivary gland	0.8 nTPM
Spleen	0.3 nTPM
Lymph node	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	14.7 nTPM
Endometrium	20.9 nTPM
Lung	16.7 nTPM
Fallopian tube	14.6 nTPM
Bronchus	6.6 nTPM

Club cells	8.0 nTPM
Lung	10.7 nTPM
Prostate	7.2 nTPM
Bronchus	6.0 nTPM

Endothelial cells	27.7 nTPM
Liver	59.2 nTPM
Skeletal muscle	56.2 nTPM
Breast	36.9 nTPM
Tongue	32.8 nTPM
Thymus	32.7 nTPM
Ovary	29.7 nTPM
Testis	29.3 nTPM
Esophagus	26.3 nTPM
Lung	24.0 nTPM
Prostate	23.6 nTPM
Salivary gland	23.6 nTPM
Fallopian tube	22.7 nTPM
Skin	22.4 nTPM
Vascular	22.1 nTPM
Endometrium	19.3 nTPM
Placenta	14.2 nTPM
Heart muscle	13.1 nTPM
Pancreas	10.3 nTPM

Enteroendocrine cells	5.5 nTPM
Colon	13.0 nTPM
Small intestine	3.4 nTPM
Rectum	0.0 nTPM

Fibroblasts	19.2 nTPM
Liver	94.9 nTPM
Pancreas	33.4 nTPM
Skin	23.4 nTPM
Thymus	19.9 nTPM
Skeletal muscle	18.7 nTPM
Adipose tissue	16.7 nTPM
Stomach	15.9 nTPM
Prostate	14.5 nTPM
Fallopian tube	12.6 nTPM
Vascular	11.8 nTPM
Lung	9.9 nTPM
Breast	9.7 nTPM
Placenta	9.6 nTPM
Salivary gland	7.4 nTPM
Esophagus	6.5 nTPM
Heart muscle	3.0 nTPM

Granulocytes	7.3 nTPM
Fallopian tube	10.6 nTPM
Tongue	9.7 nTPM
Lung	1.5 nTPM

Intestinal goblet cells	5.4 nTPM
Colon	6.6 nTPM
Rectum	5.0 nTPM
Small intestine	4.6 nTPM

Lymphatic endothelial cells	35.8 nTPM
Fallopian tube	38.8 nTPM
Ovary	32.7 nTPM

Macrophages	12.1 nTPM
Lung	22.6 nTPM
Adipose tissue	21.3 nTPM
Tongue	19.4 nTPM
Skin	18.9 nTPM
Pancreas	16.4 nTPM
Stomach	15.4 nTPM
Skeletal muscle	13.4 nTPM
Testis	10.5 nTPM
Thymus	10.1 nTPM
Spleen	10.0 nTPM
Breast	9.9 nTPM
Salivary gland	9.6 nTPM
Vascular	9.5 nTPM
Prostate	9.1 nTPM
Fallopian tube	8.6 nTPM
Endometrium	7.4 nTPM
Esophagus	6.4 nTPM
Kidney	6.2 nTPM
Bone marrow	5.1 nTPM

Paneth cells	6.4 nTPM
Small intestine	10.4 nTPM
Rectum	8.7 nTPM
Colon	0.0 nTPM

Basal keratinocytes	30.7 nTPM
Tongue	33.3 nTPM
Skin	28.1 nTPM

Basal prostatic cells	33.8 nTPM
Prostate	33.8 nTPM

Basal respiratory cells	11.1 nTPM
Bronchus	11.1 nTPM

Basal squamous epithelial cells	20.2 nTPM
Esophagus	20.2 nTPM

Plasma cells	1.0 nTPM
Salivary gland	2.7 nTPM
Liver	2.5 nTPM
Fallopian tube	1.6 nTPM
Thymus	1.1 nTPM
Spleen	0.2 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	7.1 nTPM
Vascular	17.8 nTPM
Adipose tissue	3.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	16.9 nTPM
Salivary gland	20.5 nTPM
Tongue	13.3 nTPM

Smooth muscle cells	18.6 nTPM
Liver	70.5 nTPM
Thymus	22.3 nTPM
Skeletal muscle	20.9 nTPM
Prostate	20.1 nTPM
Lung	20.0 nTPM
Vascular	16.6 nTPM
Tongue	15.3 nTPM
Skin	15.0 nTPM
Salivary gland	14.9 nTPM
Adipose tissue	14.5 nTPM
Esophagus	13.2 nTPM
Fallopian tube	12.3 nTPM
Breast	11.6 nTPM
Endometrium	11.2 nTPM
Ovary	10.4 nTPM
Placenta	9.5 nTPM

Suprabasal keratinocytes	32.5 nTPM
Skin	35.7 nTPM
Tongue	29.2 nTPM

T-cells	2.6 nTPM
Skin	11.6 nTPM
Tongue	10.7 nTPM
Prostate	10.0 nTPM
Endometrium	3.3 nTPM
Colon	2.9 nTPM
Fallopian tube	2.9 nTPM
Breast	2.7 nTPM
Skeletal muscle	2.6 nTPM
Adipose tissue	1.7 nTPM
Stomach	1.7 nTPM
Vascular	1.2 nTPM
Kidney	0.9 nTPM
PBMC	0.9 nTPM
Liver	0.8 nTPM
Spleen	0.6 nTPM
Lung	0.5 nTPM
Salivary gland	0.4 nTPM
Thymus	0.2 nTPM
Bone marrow	0.1 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM

Undifferentiated cells	10.8 nTPM
Small intestine	14.9 nTPM
Colon	10.5 nTPM
Rectum	7.0 nTPM

Amygdala excitatory	15.9 nTPM
Hippocampus	19.6 nTPM
Basal ganglia	18.4 nTPM
Cerebral cortex	16.9 nTPM
Amygdala	15.1 nTPM
Hypothalamus	13.7 nTPM
Thalamus	11.8 nTPM

Astrocyte	40.1 nTPM
Cerebellum	63.5 nTPM
Cerebral cortex	49.7 nTPM
Pons	44.0 nTPM
Hippocampus	41.5 nTPM
Medulla oblongata	41.5 nTPM
Midbrain	40.2 nTPM
Thalamus	39.6 nTPM
Basal ganglia	35.1 nTPM
Spinal cord	33.9 nTPM
Amygdala	27.9 nTPM
Hypothalamus	24.5 nTPM

Bergmann glia	38.9 nTPM
Cerebellum	43.1 nTPM
Pons	37.4 nTPM
Medulla oblongata	36.2 nTPM

Central nervous system macrophage	7.1 nTPM
Cerebral cortex	9.3 nTPM
Hippocampus	8.4 nTPM
Cerebellum	8.2 nTPM
Medulla oblongata	8.2 nTPM
Spinal cord	7.4 nTPM
Thalamus	7.4 nTPM
Pons	6.4 nTPM
Basal ganglia	6.1 nTPM
Midbrain	5.9 nTPM
Hypothalamus	5.5 nTPM
Amygdala	4.9 nTPM

Cerebellar inhibitory	4.7 nTPM
Pons	8.7 nTPM
Cerebellum	5.9 nTPM
Medulla oblongata	4.8 nTPM
Midbrain	4.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	11.2 nTPM
Cerebral cortex	13.3 nTPM
Hippocampus	12.7 nTPM
Midbrain	11.4 nTPM
Thalamus	11.4 nTPM
Basal ganglia	10.1 nTPM
Hypothalamus	10.0 nTPM
Amygdala	9.2 nTPM

Choroid plexus epithelial cell	26.3 nTPM
Thalamus	32.9 nTPM
Hippocampus	30.5 nTPM
Medulla oblongata	22.2 nTPM
Basal ganglia	19.5 nTPM

Committed oligodendrocyte precursor	8.6 nTPM
Medulla oblongata	16.8 nTPM
Pons	12.4 nTPM
Thalamus	10.1 nTPM
Basal ganglia	9.3 nTPM
Cerebral cortex	8.9 nTPM
Hippocampus	8.5 nTPM
Amygdala	6.8 nTPM
Hypothalamus	6.8 nTPM
Cerebellum	6.3 nTPM
Midbrain	5.0 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	17.9 nTPM
Midbrain	22.2 nTPM
Cerebral cortex	21.4 nTPM
Hippocampus	20.6 nTPM
Basal ganglia	15.5 nTPM
Amygdala	15.4 nTPM
Hypothalamus	12.4 nTPM

Deep-layer intratelencephalic	18.3 nTPM
Hippocampus	22.7 nTPM
Cerebral cortex	22.0 nTPM
Basal ganglia	17.7 nTPM
Amygdala	17.1 nTPM
Hypothalamus	11.9 nTPM

Deep-layer near-projecting	15.6 nTPM
Cerebral cortex	19.4 nTPM
Hippocampus	19.2 nTPM
Amygdala	15.3 nTPM
Basal ganglia	12.8 nTPM
Hypothalamus	11.1 nTPM

Eccentric medium spiny neuron	14.1 nTPM
Hippocampus	19.1 nTPM
Cerebral cortex	14.4 nTPM
Thalamus	14.3 nTPM
Basal ganglia	12.8 nTPM
Amygdala	12.3 nTPM
Hypothalamus	12.0 nTPM

Endothelial cell	25.7 nTPM
Cerebellum	37.9 nTPM
Pons	37.4 nTPM
Cerebral cortex	34.5 nTPM
Spinal cord	25.9 nTPM
Thalamus	25.4 nTPM
Hippocampus	25.3 nTPM
Midbrain	23.6 nTPM
Medulla oblongata	22.6 nTPM
Amygdala	17.9 nTPM
Basal ganglia	17.7 nTPM
Hypothalamus	14.9 nTPM