Single cell type - ZSCAN2 - The Human Protein Atlas

ZSCAN2

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZSCAN2
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger and SCAN domain containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Proximal tubular cells - Transmembrane transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids, Proximal tubular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.58
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids, Proximal tubular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZSCAN2 is part of cluster 38 Proximal tubular cells - Transmembrane transport with confidenceⁱ 1
131 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADM2	Adrenomedullin 2	0.5625	38
RPL26L1	Ribosomal protein L26 like 1	0.5596	39
PDZK1IP1	PDZK1 interacting protein 1	0.5341	38
ENSG00000276256		0.5324	38
UGT3A1	UDP glycosyltransferase family 3 member A1	0.5227	38
DIO1	Iodothyronine deiodinase 1	0.5153	56
CYP27B1	Cytochrome P450 family 27 subfamily B member 1	0.5144	38
SMIM32	Small integral membrane protein 32	0.5142	56
SLC5A10	Solute carrier family 5 member 10	0.5138	56
HOGA1	4-hydroxy-2-oxoglutarate aldolase 1	0.5129	38
BHMT	Betaine--homocysteine S-methyltransferase	0.5112	56
WDR72	WD repeat domain 72	0.5051	38
KIF12	Kinesin family member 12	0.5007	38
DPYS	Dihydropyrimidinase	0.5002	56
BHMT2	Betaine--homocysteine S-methyltransferase 2	0.4909	56

IMMUNE CELLS

ZSCAN2 is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.99
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SP2	Sp2 transcription factor	1.0000	42
SGPP1	Sphingosine-1-phosphate phosphatase 1	1.0000	42
TBC1D23	TBC1 domain family member 23	1.0000	42
MTMR12	Myotubularin related protein 12	1.0000	42
ISG20L2	Interferon stimulated exonuclease gene 20 like 2	0.9762	42
SPATA33	Spermatogenesis associated 33	0.9762	42
CCNDBP1	Cyclin D1 binding protein 1	0.9762	42
VPS39	VPS39 subunit of HOPS complex	0.9762	42
PIGA	Phosphatidylinositol glycan anchor biosynthesis class A	0.9762	42
IER5	Immediate early response 5	0.9762	42
CENPU	Centromere protein U	0.9762	42
SNX12	Sorting nexin 12	0.9762	42
ACVR1B	Activin A receptor type 1B	0.9762	42
GNL3L	G protein nucleolar 3 like	0.9762	42
NAPB	NSF attachment protein beta	0.9762	42

Adipocytes	7.9 nTPM
Breast	8.1 nTPM
Adipose tissue	7.7 nTPM

Alveolar cells type 1	1.5 nTPM
Lung	1.5 nTPM

Alveolar cells type 2	1.2 nTPM
Lung	1.2 nTPM

Astrocytes	1.5 nTPM
Brain	1.5 nTPM

B-cells	4.2 nTPM
Esophagus	11.8 nTPM
Bone marrow	9.1 nTPM
Kidney	5.2 nTPM
PBMC	4.6 nTPM
Lung	4.0 nTPM
Skin	3.4 nTPM
Lymph node	3.4 nTPM
Spleen	3.4 nTPM
Adipose tissue	2.9 nTPM
Thymus	2.8 nTPM
Salivary gland	2.4 nTPM
Stomach	1.7 nTPM
Liver	0.0 nTPM

Ciliated cells	1.8 nTPM
Endometrium	5.1 nTPM
Bronchus	0.9 nTPM
Fallopian tube	0.7 nTPM
Lung	0.5 nTPM

Club cells	2.4 nTPM
Bronchus	3.2 nTPM
Prostate	2.4 nTPM
Lung	1.5 nTPM

Endothelial cells	2.7 nTPM
Pancreas	5.2 nTPM
Skin	4.9 nTPM
Breast	4.4 nTPM
Endometrium	3.7 nTPM
Skeletal muscle	3.4 nTPM
Vascular	3.3 nTPM
Esophagus	3.0 nTPM
Testis	2.7 nTPM
Thymus	2.7 nTPM
Tongue	2.4 nTPM
Salivary gland	2.2 nTPM
Ovary	2.2 nTPM
Placenta	1.7 nTPM
Fallopian tube	1.6 nTPM
Liver	1.3 nTPM
Lung	1.2 nTPM
Prostate	1.2 nTPM
Heart muscle	0.9 nTPM

Enteroendocrine cells	7.8 nTPM
Small intestine	13.7 nTPM
Rectum	8.4 nTPM
Colon	1.2 nTPM

Fibroblasts	2.2 nTPM
Pancreas	5.7 nTPM
Placenta	4.2 nTPM
Breast	3.4 nTPM
Stomach	2.9 nTPM
Prostate	2.6 nTPM
Lung	2.3 nTPM
Esophagus	1.8 nTPM
Salivary gland	1.7 nTPM
Heart muscle	1.5 nTPM
Skeletal muscle	1.5 nTPM
Skin	1.4 nTPM
Thymus	1.4 nTPM
Fallopian tube	1.4 nTPM
Liver	1.2 nTPM
Adipose tissue	1.2 nTPM
Vascular	1.2 nTPM

Granulocytes	2.7 nTPM
Lung	4.5 nTPM
Fallopian tube	3.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	3.1 nTPM
Rectum	4.0 nTPM
Small intestine	2.8 nTPM
Colon	2.5 nTPM

Lymphatic endothelial cells	3.3 nTPM
Ovary	5.5 nTPM
Fallopian tube	1.1 nTPM

Macrophages	2.9 nTPM
Kidney	8.0 nTPM
Endometrium	4.3 nTPM
Lung	4.3 nTPM
Pancreas	4.1 nTPM
Prostate	3.2 nTPM
Testis	3.1 nTPM
Breast	3.1 nTPM
Salivary gland	2.8 nTPM
Skeletal muscle	2.7 nTPM
Thymus	2.7 nTPM
Adipose tissue	2.6 nTPM
Esophagus	2.6 nTPM
Stomach	2.6 nTPM
Fallopian tube	2.2 nTPM
Tongue	2.1 nTPM
Bone marrow	2.0 nTPM
Vascular	1.1 nTPM
Spleen	1.0 nTPM
Skin	0.0 nTPM

Paneth cells	3.1 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM
Rectum	2.2 nTPM

Collecting duct cells	5.8 nTPM
Kidney	5.8 nTPM

Early spermatids	23.0 nTPM
Testis	23.0 nTPM

Plasma cells	9.0 nTPM
Esophagus	15.6 nTPM
Stomach	12.1 nTPM
Spleen	11.3 nTPM
Bone marrow	9.1 nTPM
Liver	6.5 nTPM
Salivary gland	6.3 nTPM
Thymus	5.9 nTPM
Fallopian tube	4.8 nTPM

Schwann cells	1.3 nTPM
Adipose tissue	2.3 nTPM
Vascular	1.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.3 nTPM
Salivary gland	4.7 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.1 nTPM
Endometrium	3.7 nTPM
Lung	3.5 nTPM
Liver	2.5 nTPM
Esophagus	2.4 nTPM
Fallopian tube	2.4 nTPM
Ovary	2.4 nTPM
Placenta	2.3 nTPM
Salivary gland	2.2 nTPM
Skeletal muscle	2.0 nTPM
Adipose tissue	2.0 nTPM
Breast	1.9 nTPM
Prostate	1.8 nTPM
Skin	1.6 nTPM
Vascular	1.6 nTPM
Thymus	1.1 nTPM
Tongue	0.9 nTPM

T-cells	3.0 nTPM
Esophagus	7.3 nTPM
Kidney	5.3 nTPM
PBMC	5.0 nTPM
Bone marrow	4.4 nTPM
Lung	4.4 nTPM
Breast	2.8 nTPM
Lymph node	2.7 nTPM
Stomach	2.7 nTPM
Prostate	2.7 nTPM
Skeletal muscle	2.6 nTPM
Endometrium	2.5 nTPM
Salivary gland	2.5 nTPM
Thymus	2.5 nTPM
Fallopian tube	2.4 nTPM
Liver	2.3 nTPM
Skin	2.1 nTPM
Spleen	2.1 nTPM
Vascular	2.0 nTPM
Colon	1.9 nTPM
Adipose tissue	1.8 nTPM
Tongue	1.3 nTPM

Undifferentiated cells	3.2 nTPM
Small intestine	3.6 nTPM
Rectum	3.5 nTPM
Colon	2.6 nTPM

Amygdala excitatory	5.6 nTPM
Thalamus	6.8 nTPM
Amygdala	5.9 nTPM
Hypothalamus	5.6 nTPM
Hippocampus	5.5 nTPM
Cerebral cortex	5.4 nTPM
Basal ganglia	4.2 nTPM

Astrocyte	5.4 nTPM
Hypothalamus	8.0 nTPM
Medulla oblongata	5.8 nTPM
Thalamus	5.8 nTPM
Amygdala	5.6 nTPM
Cerebral cortex	5.1 nTPM
Pons	5.1 nTPM
Cerebellum	5.0 nTPM
Spinal cord	4.9 nTPM
Hippocampus	4.7 nTPM
Midbrain	4.7 nTPM
Basal ganglia	4.4 nTPM

Bergmann glia	7.0 nTPM
Pons	10.1 nTPM
Medulla oblongata	6.4 nTPM
Cerebellum	4.7 nTPM

Central nervous system macrophage	7.6 nTPM
Hypothalamus	9.3 nTPM
Hippocampus	8.6 nTPM
Cerebral cortex	8.3 nTPM
Medulla oblongata	8.3 nTPM
Basal ganglia	8.1 nTPM
Cerebellum	8.0 nTPM
Thalamus	8.0 nTPM
Amygdala	7.8 nTPM
Midbrain	7.5 nTPM
Pons	6.6 nTPM
Spinal cord	3.5 nTPM

Cerebellar inhibitory	3.5 nTPM
Medulla oblongata	4.4 nTPM
Pons	3.8 nTPM
Cerebellum	3.7 nTPM
Midbrain	3.1 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	4.2 nTPM
Amygdala	4.8 nTPM
Hypothalamus	4.8 nTPM
Basal ganglia	4.5 nTPM
Hippocampus	4.4 nTPM
Cerebral cortex	4.3 nTPM
Midbrain	3.6 nTPM
Thalamus	3.1 nTPM

Choroid plexus epithelial cell	4.5 nTPM
Medulla oblongata	8.0 nTPM
Basal ganglia	7.2 nTPM
Hippocampus	2.8 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	5.0 nTPM
Cerebral cortex	7.0 nTPM
Cerebellum	6.3 nTPM
Amygdala	6.2 nTPM
Basal ganglia	6.0 nTPM
Thalamus	5.6 nTPM
Hypothalamus	5.5 nTPM
Pons	4.4 nTPM
Midbrain	4.2 nTPM
Spinal cord	3.7 nTPM
Hippocampus	3.4 nTPM
Medulla oblongata	2.6 nTPM

Deep-layer corticothalamic and 6b	3.3 nTPM
Hypothalamus	4.0 nTPM
Amygdala	3.3 nTPM
Cerebral cortex	3.3 nTPM
Hippocampus	3.3 nTPM
Midbrain	3.3 nTPM
Basal ganglia	2.4 nTPM

Deep-layer intratelencephalic	4.3 nTPM
Hypothalamus	5.2 nTPM
Basal ganglia	4.4 nTPM
Amygdala	4.3 nTPM
Cerebral cortex	3.9 nTPM
Hippocampus	3.6 nTPM

Deep-layer near-projecting	5.9 nTPM
Hypothalamus	10.1 nTPM
Amygdala	7.0 nTPM
Cerebral cortex	4.6 nTPM
Basal ganglia	4.2 nTPM
Hippocampus	3.9 nTPM

Eccentric medium spiny neuron	6.1 nTPM
Hypothalamus	7.8 nTPM
Cerebral cortex	6.9 nTPM
Amygdala	6.5 nTPM
Basal ganglia	6.5 nTPM
Thalamus	6.4 nTPM
Hippocampus	2.5 nTPM

Endothelial cell	3.7 nTPM
Spinal cord	6.9 nTPM
Pons	4.4 nTPM
Thalamus	4.0 nTPM
Cerebellum	3.9 nTPM
Cerebral cortex	3.8 nTPM
Basal ganglia	3.7 nTPM
Hippocampus	3.5 nTPM
Amygdala	3.4 nTPM
Midbrain	2.8 nTPM
Hypothalamus	2.5 nTPM
Medulla oblongata	2.1 nTPM

Ependymal cell	2.2 nTPM
Medulla oblongata	3.7 nTPM
Amygdala	2.8 nTPM
Midbrain	2.5 nTPM
Thalamus	2.4 nTPM
Basal ganglia	2.3 nTPM
Hippocampus	2.2 nTPM
Spinal cord	1.9 nTPM
Hypothalamus	0.9 nTPM
Pons	0.8 nTPM