Single cell type - THAP6 - The Human Protein Atlas

THAP6

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	THAP6
Gene descriptionⁱ Full gene name according to HGNC.	THAP domain containing 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.47
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

THAP6 is part of cluster 21 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FAM209A	Family with sequence similarity 209 member A	0.6939	21
ZNF829	Zinc finger protein 829	0.6913	21
MS4A6E	Membrane spanning 4-domains A6E	0.6892	21
WFDC11	WAP four-disulfide core domain 11	0.6871	21
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.6864	21
OR2H2	Olfactory receptor family 2 subfamily H member 2	0.6802	21
SOX30	SRY-box transcription factor 30	0.6785	21
CCDC185	Coiled-coil domain containing 185	0.6719	21
CCIN	Calicin	0.6684	21
JRKL	JRK like	0.6672	21
ZSCAN29	Zinc finger and SCAN domain containing 29	0.6640	21
ASB17	Ankyrin repeat and SOCS box containing 17	0.6634	21
LRRC72	Leucine rich repeat containing 72	0.6611	21
CCDC168	Coiled-coil domain containing 168	0.6606	21
SPDYE10	Speedy/RINGO cell cycle regulator family member E10	0.6591	21

IMMUNE CELLS

THAP6 is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 1
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL16	Interleukin 16	1.0000	35
TAGAP	T cell activation RhoGTPase activating protein	1.0000	35
GTF2B	General transcription factor IIB	0.9762	35
CASTOR2	Cytosolic arginine sensor for mTORC1 subunit 2	0.9762	35
YOD1	YOD1 deubiquitinase	0.9762	35
EMSY	EMSY transcriptional repressor, BRCA2 interacting	0.9762	35
MFSD14A	Major facilitator superfamily domain containing 14A	0.9762	35
HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	0.9762	35
HTATIP2	HIV-1 Tat interactive protein 2	0.9762	35
MED31	Mediator complex subunit 31	0.9762	35
VRK3	VRK serine/threonine kinase 3	0.9762	35
KLF2	KLF transcription factor 2	0.9524	35
CD46	CD46 molecule	0.9524	35
CHMP3	Charged multivesicular body protein 3	0.9524	35
BRD8	Bromodomain containing 8	0.9524	35

Adipocytes	10.3 nTPM
Breast	11.9 nTPM
Adipose tissue	8.7 nTPM

Alveolar cells type 1	9.2 nTPM
Lung	9.2 nTPM

Alveolar cells type 2	10.1 nTPM
Lung	10.1 nTPM

Astrocytes	20.7 nTPM
Brain	20.7 nTPM

B-cells	17.8 nTPM
Kidney	36.4 nTPM
Bone marrow	28.3 nTPM
Stomach	27.8 nTPM
Esophagus	23.6 nTPM
Lymph node	18.9 nTPM
Spleen	17.2 nTPM
Salivary gland	16.4 nTPM
Thymus	15.7 nTPM
PBMC	15.4 nTPM
Adipose tissue	12.8 nTPM
Lung	10.7 nTPM
Liver	4.8 nTPM
Skin	3.4 nTPM

Ciliated cells	14.6 nTPM
Fallopian tube	16.4 nTPM
Lung	14.3 nTPM
Bronchus	13.9 nTPM
Endometrium	13.8 nTPM

Club cells	11.3 nTPM
Bronchus	13.1 nTPM
Prostate	11.8 nTPM
Lung	9.0 nTPM

Endothelial cells	8.2 nTPM
Heart muscle	14.1 nTPM
Prostate	13.3 nTPM
Ovary	12.5 nTPM
Breast	10.5 nTPM
Skeletal muscle	9.7 nTPM
Salivary gland	8.7 nTPM
Esophagus	8.6 nTPM
Vascular	8.6 nTPM
Pancreas	7.8 nTPM
Placenta	7.4 nTPM
Tongue	7.2 nTPM
Testis	7.0 nTPM
Endometrium	6.8 nTPM
Fallopian tube	5.9 nTPM
Thymus	5.3 nTPM
Liver	5.0 nTPM
Lung	4.9 nTPM
Skin	4.3 nTPM

Enteroendocrine cells	8.2 nTPM
Rectum	10.1 nTPM
Colon	7.7 nTPM
Small intestine	6.9 nTPM

Fibroblasts	14.4 nTPM
Heart muscle	32.0 nTPM
Stomach	23.1 nTPM
Adipose tissue	21.5 nTPM
Esophagus	20.6 nTPM
Breast	15.9 nTPM
Vascular	14.6 nTPM
Salivary gland	13.5 nTPM
Skeletal muscle	12.0 nTPM
Placenta	11.9 nTPM
Prostate	11.9 nTPM
Fallopian tube	11.2 nTPM
Thymus	10.1 nTPM
Liver	9.5 nTPM
Skin	9.5 nTPM
Pancreas	7.3 nTPM
Lung	6.7 nTPM

Granulocytes	12.6 nTPM
Fallopian tube	14.8 nTPM
Tongue	14.6 nTPM
Lung	8.6 nTPM

Intestinal goblet cells	15.9 nTPM
Small intestine	26.2 nTPM
Colon	13.3 nTPM
Rectum	8.2 nTPM

Lymphatic endothelial cells	10.2 nTPM
Ovary	10.9 nTPM
Fallopian tube	9.5 nTPM

Macrophages	9.8 nTPM
Kidney	15.0 nTPM
Breast	15.0 nTPM
Bone marrow	13.2 nTPM
Esophagus	12.8 nTPM
Prostate	12.6 nTPM
Salivary gland	12.5 nTPM
Vascular	12.1 nTPM
Spleen	12.0 nTPM
Testis	11.8 nTPM
Fallopian tube	9.2 nTPM
Lung	9.0 nTPM
Adipose tissue	8.9 nTPM
Endometrium	8.0 nTPM
Tongue	7.9 nTPM
Skeletal muscle	7.7 nTPM
Skin	6.7 nTPM
Pancreas	6.2 nTPM
Thymus	5.4 nTPM
Stomach	0.0 nTPM

Paneth cells	10.8 nTPM
Small intestine	20.7 nTPM
Rectum	8.0 nTPM
Colon	3.6 nTPM

Basal respiratory cells	12.2 nTPM
Bronchus	12.2 nTPM

Collecting duct cells	19.4 nTPM
Kidney	19.4 nTPM

Cone photoreceptor cells	23.8 nTPM
Eye	23.8 nTPM

Cytotrophoblasts	11.0 nTPM
Placenta	11.0 nTPM

Plasma cells	14.9 nTPM
Esophagus	31.2 nTPM
Stomach	16.3 nTPM
Bone marrow	15.1 nTPM
Spleen	14.9 nTPM
Salivary gland	12.5 nTPM
Fallopian tube	12.2 nTPM
Thymus	9.3 nTPM
Liver	7.5 nTPM

Schwann cells	14.3 nTPM
Esophagus	24.0 nTPM
Vascular	16.7 nTPM
Adipose tissue	2.3 nTPM

Serous glandular cells	9.9 nTPM
Salivary gland	10.9 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	13.9 nTPM
Esophagus	22.8 nTPM
Ovary	22.0 nTPM
Adipose tissue	19.2 nTPM
Vascular	16.1 nTPM
Breast	15.8 nTPM
Prostate	15.2 nTPM
Salivary gland	14.8 nTPM
Lung	12.9 nTPM
Skin	12.6 nTPM
Placenta	12.1 nTPM
Skeletal muscle	11.8 nTPM
Endometrium	11.2 nTPM
Thymus	10.2 nTPM
Fallopian tube	9.2 nTPM
Tongue	9.0 nTPM
Liver	8.1 nTPM

T-cells	18.3 nTPM
Bone marrow	29.9 nTPM
Kidney	29.3 nTPM
Lymph node	25.9 nTPM
Fallopian tube	24.7 nTPM
Stomach	24.0 nTPM
Spleen	22.7 nTPM
Prostate	22.5 nTPM
Breast	19.5 nTPM
PBMC	17.8 nTPM
Salivary gland	17.8 nTPM
Endometrium	17.5 nTPM
Thymus	16.2 nTPM
Adipose tissue	16.1 nTPM
Colon	14.6 nTPM
Esophagus	14.6 nTPM
Liver	13.6 nTPM
Tongue	13.3 nTPM
Skeletal muscle	12.5 nTPM
Vascular	12.5 nTPM
Lung	11.1 nTPM
Skin	8.4 nTPM

Undifferentiated cells	8.7 nTPM
Small intestine	10.3 nTPM
Colon	7.9 nTPM
Rectum	7.8 nTPM

Amygdala excitatory	17.2 nTPM
Thalamus	19.5 nTPM
Hypothalamus	18.2 nTPM
Amygdala	17.7 nTPM
Basal ganglia	16.1 nTPM
Hippocampus	16.1 nTPM
Cerebral cortex	15.9 nTPM

Astrocyte	62.1 nTPM
Amygdala	76.9 nTPM
Basal ganglia	67.7 nTPM
Cerebral cortex	66.4 nTPM
Hippocampus	65.4 nTPM
Thalamus	64.2 nTPM
Midbrain	62.2 nTPM
Pons	60.2 nTPM
Hypothalamus	58.6 nTPM
Cerebellum	54.0 nTPM
Medulla oblongata	53.8 nTPM
Spinal cord	53.5 nTPM

Bergmann glia	65.5 nTPM
Cerebellum	70.0 nTPM
Pons	69.1 nTPM
Medulla oblongata	57.5 nTPM

Central nervous system macrophage	33.1 nTPM
Amygdala	40.9 nTPM
Basal ganglia	36.6 nTPM
Midbrain	34.6 nTPM
Hypothalamus	34.1 nTPM
Thalamus	33.9 nTPM
Pons	32.8 nTPM
Medulla oblongata	32.6 nTPM
Spinal cord	30.3 nTPM
Hippocampus	30.2 nTPM
Cerebellum	28.9 nTPM
Cerebral cortex	28.9 nTPM

Cerebellar inhibitory	27.1 nTPM
Cerebellum	30.9 nTPM
Medulla oblongata	29.5 nTPM
Midbrain	27.7 nTPM
Pons	25.7 nTPM
Spinal cord	22.0 nTPM

Cge interneuron	31.9 nTPM
Thalamus	37.2 nTPM
Amygdala	34.2 nTPM
Midbrain	33.9 nTPM
Basal ganglia	30.7 nTPM
Cerebral cortex	29.6 nTPM
Hippocampus	29.0 nTPM
Hypothalamus	28.6 nTPM

Choroid plexus epithelial cell	42.1 nTPM
Basal ganglia	44.6 nTPM
Hippocampus	44.4 nTPM
Thalamus	41.1 nTPM
Medulla oblongata	38.4 nTPM

Committed oligodendrocyte precursor	48.8 nTPM
Midbrain	61.3 nTPM
Amygdala	60.3 nTPM
Cerebral cortex	57.0 nTPM
Spinal cord	55.2 nTPM
Pons	49.6 nTPM
Thalamus	46.4 nTPM
Hippocampus	46.0 nTPM
Basal ganglia	42.7 nTPM
Hypothalamus	41.7 nTPM
Cerebellum	41.2 nTPM
Medulla oblongata	34.9 nTPM

Deep-layer corticothalamic and 6b	19.0 nTPM
Midbrain	27.7 nTPM
Hypothalamus	18.9 nTPM
Cerebral cortex	17.3 nTPM
Hippocampus	17.0 nTPM
Amygdala	16.9 nTPM
Basal ganglia	16.0 nTPM

Deep-layer intratelencephalic	16.9 nTPM
Amygdala	18.7 nTPM
Basal ganglia	17.7 nTPM
Cerebral cortex	17.0 nTPM
Hippocampus	15.8 nTPM
Hypothalamus	15.6 nTPM

Deep-layer near-projecting	18.8 nTPM
Hypothalamus	21.2 nTPM
Cerebral cortex	21.0 nTPM
Hippocampus	18.5 nTPM
Basal ganglia	17.1 nTPM
Amygdala	16.4 nTPM

Eccentric medium spiny neuron	20.9 nTPM
Amygdala	22.9 nTPM
Basal ganglia	22.3 nTPM
Hypothalamus	21.2 nTPM
Cerebral cortex	21.1 nTPM
Thalamus	19.6 nTPM
Hippocampus	18.2 nTPM

Endothelial cell	19.2 nTPM
Spinal cord	29.3 nTPM
Thalamus	26.0 nTPM
Basal ganglia	24.2 nTPM
Hypothalamus	23.6 nTPM
Hippocampus	21.8 nTPM
Cerebellum	20.9 nTPM
Pons	16.9 nTPM
Cerebral cortex	13.4 nTPM
Midbrain	13.2 nTPM
Medulla oblongata	12.3 nTPM
Amygdala	10.1 nTPM

Ependymal cell	35.5 nTPM
Amygdala	43.2 nTPM
Spinal cord	40.2 nTPM
Hypothalamus	36.6 nTPM
Hippocampus	35.1 nTPM
Midbrain	34.9 nTPM
Thalamus	34.8 nTPM
Basal ganglia	34.4 nTPM
Medulla oblongata	33.6 nTPM
Pons	26.7 nTPM