Single cell type - KYAT1 - The Human Protein Atlas

KYAT1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KYAT1
Gene descriptionⁱ Full gene name according to HGNC.	Kynurenine aminotransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.58
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

KYAT1 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EIF1AY	Eukaryotic translation initiation factor 1A Y-linked	0.5328	1
RBM4	RNA binding motif protein 4	0.5250	49
BCDIN3D	BCDIN3 domain containing RNA methyltransferase	0.5016	55
TRAF3IP3	TRAF3 interacting protein 3	0.4997	19
OR2A25	Olfactory receptor family 2 subfamily A member 25	0.4886	19
ZNF586	Zinc finger protein 586	0.4670	55
OR4D1	Olfactory receptor family 4 subfamily D member 1	0.4655	19
ZNF346	Zinc finger protein 346	0.4585	55
RPS4Y1	Ribosomal protein S4 Y-linked 1	0.4553	64
ELMOD3	ELMO domain containing 3	0.4536	55
POLM	DNA polymerase mu	0.4485	55
ITFG2	Integrin alpha FG-GAP repeat containing 2	0.4452	55
BAZ2A	Bromodomain adjacent to zinc finger domain 2A	0.4360	55
ZNF550	Zinc finger protein 550	0.4338	55
ATF6B	Activating transcription factor 6 beta	0.4301	55

IMMUNE CELLS

KYAT1 is part of cluster 43 Non-specific - Transcription & Translation with confidenceⁱ 0.5
433 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MIF	Macrophage migration inhibitory factor	1.0000	43
SPATA24	Spermatogenesis associated 24	0.9762	3
OXT	Oxytocin/neurophysin I prepropeptide	0.9524	43
RPS2	Ribosomal protein S2	0.9524	3
TOMM7	Translocase of outer mitochondrial membrane 7	0.9524	43
METAP2	Methionyl aminopeptidase 2	0.9286	12
HDHD3	Haloacid dehalogenase like hydrolase domain containing 3	0.9286	43
SNRPD2	Small nuclear ribonucleoprotein D2 polypeptide	0.9286	3
ZNF675	Zinc finger protein 675	0.9286	43
NT5DC1	5'-nucleotidase domain containing 1	0.9286	43
ENSG00000284691	Novel zinc finger protein	0.9048	12
POLG2	DNA polymerase gamma 2, accessory subunit	0.9048	18
ATP6V1E2	ATPase H+ transporting V1 subunit E2	0.9048	43
TUBGCP6	Tubulin gamma complex associated protein 6	0.9048	3
C10orf95	Chromosome 10 open reading frame 95	0.9048	43

Adipocytes	1.0 nTPM
Breast	1.3 nTPM
Adipose tissue	0.8 nTPM

Alveolar cells type 1	1.0 nTPM
Lung	1.0 nTPM

Alveolar cells type 2	0.7 nTPM
Lung	0.7 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	1.3 nTPM
Kidney	5.2 nTPM
Bone marrow	2.8 nTPM
Lymph node	1.9 nTPM
PBMC	1.5 nTPM
Thymus	1.4 nTPM
Lung	1.3 nTPM
Spleen	1.1 nTPM
Salivary gland	0.9 nTPM
Adipose tissue	0.4 nTPM
Stomach	0.4 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	1.5 nTPM
Bronchus	3.4 nTPM
Fallopian tube	1.3 nTPM
Lung	0.7 nTPM
Endometrium	0.4 nTPM

Club cells	1.3 nTPM
Bronchus	2.5 nTPM
Prostate	0.9 nTPM
Lung	0.5 nTPM

Endothelial cells	1.3 nTPM
Pancreas	7.8 nTPM
Heart muscle	1.8 nTPM
Breast	1.8 nTPM
Ovary	1.7 nTPM
Skin	1.6 nTPM
Tongue	1.2 nTPM
Fallopian tube	1.1 nTPM
Esophagus	0.9 nTPM
Vascular	0.9 nTPM
Lung	0.7 nTPM
Prostate	0.7 nTPM
Testis	0.6 nTPM
Placenta	0.6 nTPM
Endometrium	0.6 nTPM
Thymus	0.5 nTPM
Skeletal muscle	0.4 nTPM
Salivary gland	0.4 nTPM
Liver	0.0 nTPM

Enteroendocrine cells	1.9 nTPM
Small intestine	3.4 nTPM
Rectum	1.7 nTPM
Colon	0.7 nTPM

Fibroblasts	1.0 nTPM
Pancreas	2.6 nTPM
Liver	2.4 nTPM
Placenta	2.1 nTPM
Heart muscle	1.7 nTPM
Esophagus	1.6 nTPM
Fallopian tube	1.4 nTPM
Skin	0.9 nTPM
Thymus	0.7 nTPM
Adipose tissue	0.6 nTPM
Vascular	0.6 nTPM
Breast	0.6 nTPM
Salivary gland	0.4 nTPM
Skeletal muscle	0.3 nTPM
Lung	0.3 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.3 nTPM
Lung	0.5 nTPM
Fallopian tube	0.4 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.6 nTPM
Small intestine	0.9 nTPM
Colon	0.7 nTPM
Rectum	0.2 nTPM

Lymphatic endothelial cells	0.8 nTPM
Fallopian tube	1.7 nTPM
Ovary	0.0 nTPM

Macrophages	0.5 nTPM
Kidney	1.8 nTPM
Prostate	1.4 nTPM
Salivary gland	1.2 nTPM
Bone marrow	1.0 nTPM
Spleen	1.0 nTPM
Adipose tissue	0.8 nTPM
Fallopian tube	0.8 nTPM
Lung	0.7 nTPM
Breast	0.4 nTPM
Skeletal muscle	0.3 nTPM
Vascular	0.3 nTPM
Thymus	0.2 nTPM
Tongue	0.2 nTPM
Testis	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal squamous epithelial cells	2.0 nTPM
Esophagus	2.0 nTPM

Bipolar cells	3.2 nTPM
Eye	3.2 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Cytotrophoblasts	2.9 nTPM
Placenta	2.9 nTPM

Plasma cells	2.0 nTPM
Bone marrow	4.5 nTPM
Spleen	2.9 nTPM
Liver	2.5 nTPM
Stomach	2.5 nTPM
Thymus	1.5 nTPM
Fallopian tube	1.3 nTPM
Salivary gland	0.4 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.3 nTPM
Vascular	3.7 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.6 nTPM
Salivary gland	1.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.5 nTPM
Esophagus	4.8 nTPM
Breast	2.4 nTPM
Placenta	2.2 nTPM
Prostate	1.8 nTPM
Fallopian tube	1.8 nTPM
Skin	1.6 nTPM
Liver	1.3 nTPM
Adipose tissue	1.3 nTPM
Lung	1.2 nTPM
Thymus	1.2 nTPM
Vascular	1.2 nTPM
Ovary	1.2 nTPM
Skeletal muscle	1.0 nTPM
Tongue	0.3 nTPM
Endometrium	0.0 nTPM
Salivary gland	0.0 nTPM

T-cells	1.5 nTPM
Kidney	7.1 nTPM
PBMC	3.7 nTPM
Bone marrow	3.2 nTPM
Colon	2.9 nTPM
Liver	2.4 nTPM
Lymph node	2.3 nTPM
Spleen	1.3 nTPM
Lung	1.3 nTPM
Endometrium	1.2 nTPM
Thymus	1.1 nTPM
Tongue	0.8 nTPM
Vascular	0.8 nTPM
Breast	0.8 nTPM
Skin	0.7 nTPM
Salivary gland	0.7 nTPM
Prostate	0.6 nTPM
Fallopian tube	0.6 nTPM
Adipose tissue	0.5 nTPM
Stomach	0.4 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	1.1 nTPM
Colon	1.3 nTPM
Rectum	1.1 nTPM
Small intestine	0.8 nTPM

Amygdala excitatory	55.9 nTPM
Hypothalamus	74.9 nTPM
Amygdala	59.5 nTPM
Basal ganglia	54.8 nTPM
Thalamus	50.8 nTPM
Cerebral cortex	49.9 nTPM
Hippocampus	45.4 nTPM

Astrocyte	56.8 nTPM
Spinal cord	123.5 nTPM
Hypothalamus	72.8 nTPM
Medulla oblongata	58.7 nTPM
Cerebellum	56.4 nTPM
Thalamus	48.1 nTPM
Basal ganglia	46.9 nTPM
Midbrain	46.4 nTPM
Cerebral cortex	44.7 nTPM
Hippocampus	43.0 nTPM
Amygdala	42.9 nTPM
Pons	40.9 nTPM

Bergmann glia	63.5 nTPM
Medulla oblongata	68.2 nTPM
Cerebellum	63.4 nTPM
Pons	59.0 nTPM

Central nervous system macrophage	19.7 nTPM
Cerebral cortex	23.3 nTPM
Midbrain	20.2 nTPM
Thalamus	20.2 nTPM
Amygdala	20.1 nTPM
Spinal cord	20.0 nTPM
Cerebellum	19.6 nTPM
Hippocampus	19.6 nTPM
Basal ganglia	19.5 nTPM
Pons	18.9 nTPM
Hypothalamus	18.4 nTPM
Medulla oblongata	16.6 nTPM

Cerebellar inhibitory	34.6 nTPM
Spinal cord	38.5 nTPM
Cerebellum	37.1 nTPM
Medulla oblongata	36.5 nTPM
Pons	35.9 nTPM
Midbrain	25.2 nTPM

Cge interneuron	53.8 nTPM
Hypothalamus	76.8 nTPM
Amygdala	57.0 nTPM
Cerebral cortex	54.0 nTPM
Midbrain	48.8 nTPM
Hippocampus	48.1 nTPM
Basal ganglia	46.6 nTPM
Thalamus	45.7 nTPM

Choroid plexus epithelial cell	58.7 nTPM
Basal ganglia	99.5 nTPM
Hippocampus	55.5 nTPM
Medulla oblongata	49.8 nTPM
Thalamus	30.1 nTPM

Committed oligodendrocyte precursor	22.4 nTPM
Hypothalamus	34.8 nTPM
Thalamus	26.3 nTPM
Amygdala	25.9 nTPM
Medulla oblongata	23.2 nTPM
Pons	23.0 nTPM
Cerebellum	22.2 nTPM
Basal ganglia	21.4 nTPM
Hippocampus	20.7 nTPM
Midbrain	19.3 nTPM
Cerebral cortex	18.4 nTPM
Spinal cord	11.0 nTPM

Deep-layer corticothalamic and 6b	54.0 nTPM
Hypothalamus	75.4 nTPM
Cerebral cortex	55.9 nTPM
Midbrain	49.9 nTPM
Amygdala	48.6 nTPM
Basal ganglia	48.3 nTPM
Hippocampus	45.7 nTPM

Deep-layer intratelencephalic	50.1 nTPM
Hypothalamus	70.7 nTPM
Cerebral cortex	48.5 nTPM
Hippocampus	44.0 nTPM
Amygdala	43.8 nTPM
Basal ganglia	43.3 nTPM

Deep-layer near-projecting	56.5 nTPM
Hypothalamus	77.1 nTPM
Amygdala	61.2 nTPM
Cerebral cortex	51.8 nTPM
Hippocampus	48.8 nTPM
Basal ganglia	43.5 nTPM

Eccentric medium spiny neuron	61.8 nTPM
Hypothalamus	70.2 nTPM
Cerebral cortex	69.8 nTPM
Amygdala	64.9 nTPM
Basal ganglia	64.6 nTPM
Thalamus	58.1 nTPM
Hippocampus	43.1 nTPM

Endothelial cell	14.9 nTPM
Amygdala	23.5 nTPM
Midbrain	22.7 nTPM
Basal ganglia	20.5 nTPM
Hypothalamus	16.1 nTPM
Medulla oblongata	14.4 nTPM
Hippocampus	12.8 nTPM
Cerebellum	12.4 nTPM
Spinal cord	12.1 nTPM
Cerebral cortex	11.5 nTPM
Pons	10.0 nTPM
Thalamus	8.5 nTPM

Ependymal cell	24.1 nTPM
Basal ganglia	37.2 nTPM
Amygdala	29.0 nTPM
Hypothalamus	28.6 nTPM
Hippocampus	27.2 nTPM
Thalamus	26.3 nTPM
Midbrain	24.1 nTPM
Pons	17.7 nTPM
Medulla oblongata	17.1 nTPM
Spinal cord	9.6 nTPM