Single cell type - TMC7 - The Human Protein Atlas

TMC7

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMC7
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane channel like 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Early spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids, Oligodendrocytes, Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.81
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Oligodendrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids, Oligodendrocytes, Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Oligodendrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TMC7 is part of cluster 18 Early spermatids - Unknown function with confidenceⁱ 1
283 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C4orf51	Chromosome 4 open reading frame 51	0.7406	18
OR14A2	Olfactory receptor family 14 subfamily A member 2	0.7367	18
EQTN	Equatorin	0.7365	18
SPACA1	Sperm acrosome associated 1	0.7270	18
TMEM262	Transmembrane protein 262	0.7205	18
FTMT	Ferritin mitochondrial	0.7181	18
TSSK4	Testis specific serine kinase 4	0.7150	18
C11orf94	Chromosome 11 open reading frame 94	0.7123	18
C17orf98	Chromosome 17 open reading frame 98	0.7122	18
ENSG00000284188	Novel protein	0.7101	18
CXorf66	Chromosome X open reading frame 66	0.6996	18
TSBP1	Testis expressed basic protein 1	0.6983	18
OR4M2B	Olfactory receptor family 4 subfamily M member 2B	0.6957	18
SPACA5	Sperm acrosome associated 5	0.6945	18
C1orf185	Chromosome 1 open reading frame 185	0.6921	18

Adipocytes	11.3 nTPM
Adipose tissue	12.9 nTPM
Breast	9.7 nTPM

Alveolar cells type 1	21.9 nTPM
Lung	21.9 nTPM

Alveolar cells type 2	7.1 nTPM
Lung	7.1 nTPM

Astrocytes	3.7 nTPM
Brain	3.7 nTPM

B-cells	0.2 nTPM
Skin	1.7 nTPM
Thymus	0.2 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	1.0 nTPM
Bronchus	1.6 nTPM
Endometrium	1.3 nTPM
Lung	0.9 nTPM
Fallopian tube	0.3 nTPM

Club cells	5.1 nTPM
Prostate	11.0 nTPM
Bronchus	2.6 nTPM
Lung	1.8 nTPM

Endothelial cells	4.3 nTPM
Skeletal muscle	8.8 nTPM
Thymus	6.8 nTPM
Esophagus	6.4 nTPM
Vascular	6.3 nTPM
Placenta	6.2 nTPM
Endometrium	5.7 nTPM
Salivary gland	5.5 nTPM
Testis	4.9 nTPM
Ovary	3.9 nTPM
Lung	3.8 nTPM
Prostate	3.6 nTPM
Tongue	3.2 nTPM
Pancreas	2.6 nTPM
Liver	2.5 nTPM
Skin	2.0 nTPM
Fallopian tube	1.9 nTPM
Heart muscle	1.8 nTPM
Breast	0.9 nTPM

Enteroendocrine cells	1.8 nTPM
Colon	3.8 nTPM
Rectum	1.7 nTPM
Small intestine	0.0 nTPM

Fibroblasts	0.5 nTPM
Stomach	2.9 nTPM
Lung	1.5 nTPM
Liver	1.2 nTPM
Placenta	0.4 nTPM
Pancreas	0.3 nTPM
Skin	0.3 nTPM
Thymus	0.3 nTPM
Skeletal muscle	0.2 nTPM
Salivary gland	0.1 nTPM
Vascular	0.1 nTPM
Heart muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.2 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	5.4 nTPM
Small intestine	8.5 nTPM
Rectum	5.1 nTPM
Colon	2.5 nTPM

Lymphatic endothelial cells	1.2 nTPM
Fallopian tube	2.5 nTPM
Ovary	0.0 nTPM

Macrophages	0.3 nTPM
Testis	1.9 nTPM
Kidney	0.9 nTPM
Endometrium	0.6 nTPM
Breast	0.6 nTPM
Skeletal muscle	0.5 nTPM
Prostate	0.3 nTPM
Salivary gland	0.3 nTPM
Fallopian tube	0.3 nTPM
Thymus	0.2 nTPM
Vascular	0.2 nTPM
Adipose tissue	0.1 nTPM
Lung	0.1 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Tongue	0.0 nTPM

Paneth cells	3.5 nTPM
Rectum	6.8 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	2.8 nTPM
Bronchus	2.8 nTPM

Distal enterocytes	7.2 nTPM
Rectum	9.5 nTPM
Colon	5.0 nTPM

Excitatory neurons	7.2 nTPM
Brain	7.2 nTPM

Plasma cells	0.1 nTPM
Liver	0.5 nTPM
Salivary gland	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	4.4 nTPM
Vascular	13.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.6 nTPM
Esophagus	3.6 nTPM
Breast	3.4 nTPM
Endometrium	2.7 nTPM
Skeletal muscle	2.5 nTPM
Fallopian tube	1.9 nTPM
Ovary	1.9 nTPM
Liver	1.7 nTPM
Adipose tissue	1.6 nTPM
Skin	1.3 nTPM
Lung	1.2 nTPM
Prostate	1.2 nTPM
Salivary gland	0.9 nTPM
Thymus	0.9 nTPM
Vascular	0.7 nTPM
Placenta	0.1 nTPM
Tongue	0.0 nTPM

T-cells	0.1 nTPM
Skin	0.7 nTPM
Endometrium	0.4 nTPM
Prostate	0.4 nTPM
Liver	0.3 nTPM
PBMC	0.3 nTPM
Lung	0.3 nTPM
Salivary gland	0.2 nTPM
Adipose tissue	0.1 nTPM
Thymus	0.1 nTPM
Tongue	0.1 nTPM
Fallopian tube	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	2.2 nTPM
Rectum	2.7 nTPM
Small intestine	2.2 nTPM
Colon	1.7 nTPM

Amygdala excitatory	13.0 nTPM
Hypothalamus	21.0 nTPM
Basal ganglia	14.1 nTPM
Thalamus	13.2 nTPM
Cerebral cortex	10.6 nTPM
Amygdala	10.3 nTPM
Hippocampus	8.6 nTPM

Astrocyte	6.2 nTPM
Amygdala	8.9 nTPM
Cerebral cortex	7.7 nTPM
Hypothalamus	7.0 nTPM
Midbrain	6.7 nTPM
Thalamus	6.7 nTPM
Hippocampus	6.1 nTPM
Pons	6.0 nTPM
Basal ganglia	5.5 nTPM
Cerebellum	5.1 nTPM
Spinal cord	4.8 nTPM
Medulla oblongata	4.1 nTPM

Bergmann glia	2.0 nTPM
Cerebellum	2.4 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	19.7 nTPM
Hippocampus	27.1 nTPM
Cerebral cortex	25.9 nTPM
Basal ganglia	24.1 nTPM
Midbrain	24.0 nTPM
Thalamus	21.9 nTPM
Amygdala	21.3 nTPM
Pons	18.3 nTPM
Cerebellum	17.9 nTPM
Hypothalamus	17.3 nTPM
Medulla oblongata	10.6 nTPM
Spinal cord	8.5 nTPM

Cerebellar inhibitory	8.1 nTPM
Pons	10.5 nTPM
Midbrain	10.0 nTPM
Spinal cord	8.2 nTPM
Medulla oblongata	7.5 nTPM
Cerebellum	4.4 nTPM

Cge interneuron	28.5 nTPM
Hypothalamus	38.7 nTPM
Cerebral cortex	31.5 nTPM
Amygdala	29.3 nTPM
Basal ganglia	28.9 nTPM
Hippocampus	27.6 nTPM
Midbrain	23.0 nTPM
Thalamus	20.8 nTPM

Choroid plexus epithelial cell	5.0 nTPM
Thalamus	11.0 nTPM
Medulla oblongata	3.3 nTPM
Basal ganglia	2.9 nTPM
Hippocampus	2.8 nTPM

Committed oligodendrocyte precursor	52.4 nTPM
Thalamus	142.5 nTPM
Hypothalamus	125.6 nTPM
Amygdala	93.0 nTPM
Basal ganglia	48.2 nTPM
Cerebral cortex	37.4 nTPM
Midbrain	31.9 nTPM
Hippocampus	31.0 nTPM
Pons	27.4 nTPM
Medulla oblongata	21.9 nTPM
Cerebellum	9.5 nTPM
Spinal cord	7.4 nTPM

Deep-layer corticothalamic and 6b	16.1 nTPM
Hypothalamus	26.1 nTPM
Amygdala	18.6 nTPM
Basal ganglia	15.2 nTPM
Hippocampus	13.2 nTPM
Cerebral cortex	12.2 nTPM
Midbrain	11.1 nTPM

Deep-layer intratelencephalic	16.0 nTPM
Hypothalamus	22.3 nTPM
Cerebral cortex	15.1 nTPM
Basal ganglia	14.4 nTPM
Hippocampus	14.2 nTPM
Amygdala	13.9 nTPM

Deep-layer near-projecting	12.7 nTPM
Hypothalamus	15.8 nTPM
Hippocampus	13.7 nTPM
Cerebral cortex	11.6 nTPM
Basal ganglia	11.3 nTPM
Amygdala	11.2 nTPM

Eccentric medium spiny neuron	10.2 nTPM
Thalamus	12.2 nTPM
Basal ganglia	10.7 nTPM
Cerebral cortex	10.6 nTPM
Amygdala	10.3 nTPM
Hippocampus	8.7 nTPM
Hypothalamus	8.7 nTPM

Endothelial cell	73.4 nTPM
Spinal cord	94.9 nTPM
Hypothalamus	88.1 nTPM
Amygdala	81.6 nTPM
Hippocampus	76.9 nTPM
Cerebral cortex	72.2 nTPM
Midbrain	71.8 nTPM
Thalamus	69.5 nTPM
Pons	68.7 nTPM
Cerebellum	68.1 nTPM
Basal ganglia	66.2 nTPM
Medulla oblongata	49.2 nTPM

Ependymal cell	11.2 nTPM
Thalamus	15.4 nTPM
Basal ganglia	13.9 nTPM
Hippocampus	12.8 nTPM
Midbrain	12.1 nTPM
Hypothalamus	11.6 nTPM
Pons	11.0 nTPM
Medulla oblongata	10.5 nTPM
Spinal cord	7.7 nTPM
Amygdala	5.7 nTPM