Single cell type - ADRA1B - The Human Protein Atlas

ADRA1B

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADRA1B
Gene descriptionⁱ Full gene name according to HGNC.	Adrenoceptor alpha 1B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes FDA approved drug targets G-protein coupled receptors Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Hepatocytes, Mesothelial cells, Horizontal cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.90
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (CGE interneuron, Hippocampal dentate gyrus)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Hepatocytes, Mesothelial cells, Horizontal cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (CGE interneuron, Hippocampal dentate gyrus)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ADRA1B is part of cluster 34 Neurons - Neuronal signaling with confidenceⁱ 1
518 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CACNA1E	Calcium voltage-gated channel subunit alpha1 E	0.8436	34
LRFN2	Leucine rich repeat and fibronectin type III domain containing 2	0.8172	34
CHRM3	Cholinergic receptor muscarinic 3	0.7986	34
LINGO2	Leucine rich repeat and Ig domain containing 2	0.7904	34
CREG2	Cellular repressor of E1A stimulated genes 2	0.7556	34
GRM1	Glutamate metabotropic receptor 1	0.7544	34
CACNA2D3	Calcium voltage-gated channel auxiliary subunit alpha2delta 3	0.7532	34
SLC8A2	Solute carrier family 8 member A2	0.7518	34
RGS6	Regulator of G protein signaling 6	0.7492	34
ST8SIA3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.7396	34
C2orf80	Chromosome 2 open reading frame 80	0.7314	34
UNC5A	Unc-5 netrin receptor A	0.7281	34
RNF103-CHMP3	RNF103-CHMP3 readthrough	0.7238	34
FAT3	FAT atypical cadherin 3	0.7221	34
SLITRK4	SLIT and NTRK like family member 4	0.7167	69

Adipocytes	0.4 nTPM
Breast	0.9 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.5 nTPM
Lung	0.5 nTPM

Alveolar cells type 2	0.6 nTPM
Lung	0.6 nTPM

Astrocytes	5.0 nTPM
Brain	5.0 nTPM

B-cells	0.1 nTPM
Adipose tissue	0.8 nTPM
Spleen	0.1 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	0.5 nTPM
Lung	0.9 nTPM
Fallopian tube	0.6 nTPM
Endometrium	0.3 nTPM
Bronchus	0.3 nTPM

Club cells	0.4 nTPM
Lung	1.2 nTPM
Bronchus	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.2 nTPM
Liver	1.3 nTPM
Ovary	0.7 nTPM
Vascular	0.4 nTPM
Thymus	0.3 nTPM
Tongue	0.3 nTPM
Fallopian tube	0.3 nTPM
Endometrium	0.2 nTPM
Skeletal muscle	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	6.2 nTPM
Adipose tissue	26.4 nTPM
Placenta	22.3 nTPM
Skeletal muscle	12.2 nTPM
Lung	10.5 nTPM
Breast	6.7 nTPM
Esophagus	4.6 nTPM
Thymus	3.9 nTPM
Salivary gland	3.2 nTPM
Vascular	2.6 nTPM
Liver	2.4 nTPM
Stomach	1.4 nTPM
Prostate	1.3 nTPM
Fallopian tube	0.6 nTPM
Pancreas	0.4 nTPM
Skin	0.3 nTPM
Heart muscle	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	0.2 nTPM
Kidney	0.9 nTPM
Skeletal muscle	0.9 nTPM
Thymus	0.4 nTPM
Vascular	0.2 nTPM
Breast	0.2 nTPM
Adipose tissue	0.1 nTPM
Salivary gland	0.1 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM

Paneth cells	0.2 nTPM
Rectum	0.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Bipolar cells	5.5 nTPM
Eye	5.5 nTPM

Excitatory neurons	40.1 nTPM
Brain	40.1 nTPM

Plasma cells	0.1 nTPM
Liver	0.5 nTPM
Fallopian tube	0.3 nTPM
Thymus	0.2 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	0.1 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.2 nTPM
Salivary gland	0.5 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	3.1 nTPM
Thymus	11.8 nTPM
Adipose tissue	10.0 nTPM
Vascular	8.2 nTPM
Fallopian tube	5.3 nTPM
Liver	2.5 nTPM
Breast	2.2 nTPM
Skeletal muscle	2.0 nTPM
Tongue	1.8 nTPM
Ovary	1.4 nTPM
Lung	1.2 nTPM
Endometrium	0.8 nTPM
Prostate	0.6 nTPM
Salivary gland	0.5 nTPM
Placenta	0.3 nTPM
Skin	0.2 nTPM
Esophagus	0.0 nTPM

T-cells	0.1 nTPM
Vascular	0.8 nTPM
Skeletal muscle	0.4 nTPM
Fallopian tube	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Small intestine	0.1 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	25.1 nTPM
Hypothalamus	49.9 nTPM
Basal ganglia	40.2 nTPM
Cerebral cortex	21.6 nTPM
Hippocampus	15.0 nTPM
Thalamus	13.2 nTPM
Amygdala	10.8 nTPM

Astrocyte	10.6 nTPM
Cerebral cortex	25.0 nTPM
Amygdala	24.8 nTPM
Hippocampus	20.9 nTPM
Spinal cord	13.7 nTPM
Basal ganglia	9.3 nTPM
Hypothalamus	7.3 nTPM
Thalamus	6.9 nTPM
Medulla oblongata	5.2 nTPM
Pons	2.1 nTPM
Midbrain	1.1 nTPM
Cerebellum	0.5 nTPM

Bergmann glia	0.3 nTPM
Cerebellum	1.0 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	1.8 nTPM
Hypothalamus	3.6 nTPM
Amygdala	2.7 nTPM
Cerebral cortex	2.6 nTPM
Thalamus	2.3 nTPM
Pons	2.0 nTPM
Medulla oblongata	1.8 nTPM
Hippocampus	1.6 nTPM
Basal ganglia	0.9 nTPM
Cerebellum	0.9 nTPM
Spinal cord	0.9 nTPM
Midbrain	0.8 nTPM

Cerebellar inhibitory	44.9 nTPM
Cerebellum	59.8 nTPM
Midbrain	54.4 nTPM
Medulla oblongata	37.6 nTPM
Pons	37.2 nTPM
Spinal cord	35.7 nTPM

Cge interneuron	144.7 nTPM
Hypothalamus	248.1 nTPM
Amygdala	174.0 nTPM
Cerebral cortex	152.6 nTPM
Basal ganglia	148.0 nTPM
Midbrain	116.4 nTPM
Hippocampus	104.1 nTPM
Thalamus	69.6 nTPM

Choroid plexus epithelial cell	1.0 nTPM
Hippocampus	2.8 nTPM
Basal ganglia	0.6 nTPM
Medulla oblongata	0.4 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	3.3 nTPM
Thalamus	7.4 nTPM
Medulla oblongata	6.5 nTPM
Hypothalamus	6.1 nTPM
Amygdala	5.1 nTPM
Basal ganglia	3.3 nTPM
Hippocampus	2.6 nTPM
Midbrain	1.7 nTPM
Cerebellum	1.6 nTPM
Cerebral cortex	1.3 nTPM
Pons	0.9 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	46.6 nTPM
Hypothalamus	87.6 nTPM
Cerebral cortex	54.8 nTPM
Basal ganglia	49.5 nTPM
Amygdala	45.5 nTPM
Midbrain	25.5 nTPM
Hippocampus	16.9 nTPM

Deep-layer intratelencephalic	72.5 nTPM
Hypothalamus	107.0 nTPM
Amygdala	106.1 nTPM
Cerebral cortex	60.6 nTPM
Basal ganglia	54.9 nTPM
Hippocampus	33.7 nTPM

Deep-layer near-projecting	2.1 nTPM
Basal ganglia	4.3 nTPM
Hypothalamus	2.1 nTPM
Amygdala	1.6 nTPM
Hippocampus	1.3 nTPM
Cerebral cortex	1.1 nTPM

Eccentric medium spiny neuron	4.1 nTPM
Cerebral cortex	7.7 nTPM
Amygdala	6.2 nTPM
Hypothalamus	3.7 nTPM
Basal ganglia	2.6 nTPM
Hippocampus	2.5 nTPM
Thalamus	2.1 nTPM

Endothelial cell	0.9 nTPM
Cerebral cortex	3.2 nTPM
Hypothalamus	2.5 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	0.8 nTPM
Thalamus	0.6 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	0.9 nTPM
Spinal cord	1.9 nTPM
Hypothalamus	1.8 nTPM
Amygdala	1.1 nTPM
Hippocampus	1.0 nTPM
Basal ganglia	0.9 nTPM
Medulla oblongata	0.9 nTPM
Pons	0.8 nTPM
Midbrain	0.0 nTPM
Thalamus	0.0 nTPM