Single cell type - RRAD - The Human Protein Atlas

RRAD

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RRAD
Gene descriptionⁱ Full gene name according to HGNC.	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal myocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Skeletal myocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.67
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Vascular associated smooth muscle cell, Pericyte, Choroid plexus epithelial cell, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Skeletal myocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Vascular associated smooth muscle cell, Pericyte, Choroid plexus epithelial cell, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RRAD is part of cluster 2 Skeletal myocytes - Muscle contraction with confidenceⁱ 1
133 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KLHL38	Kelch like family member 38	0.6040	2
KLHL30	Kelch like family member 30	0.5873	2
PCDHGA1	Protocadherin gamma subfamily A, 1	0.5811	2
TRIM7	Tripartite motif containing 7	0.5482	59
MYOZ1	Myozenin 1	0.5467	2
MYBPH	Myosin binding protein H	0.5349	2
TNNC2	Troponin C2, fast skeletal type	0.5271	2
DNAJB5	DnaJ heat shock protein family (Hsp40) member B5	0.5267	2
MYLK2	Myosin light chain kinase 2	0.5237	2
PPP1R27	Protein phosphatase 1 regulatory subunit 27	0.5171	2
CALML6	Calmodulin like 6	0.5139	2
NEB	Nebulin	0.5139	2
GDNF	Glial cell derived neurotrophic factor	0.5099	2
CACNG1	Calcium voltage-gated channel auxiliary subunit gamma 1	0.5096	2
ATP1B4	ATPase Na+/K+ transporting family member beta 4	0.5093	2

Adipocytes	16.6 nTPM
Breast	20.9 nTPM
Adipose tissue	12.3 nTPM

Alveolar cells type 1	28.8 nTPM
Lung	28.8 nTPM

Alveolar cells type 2	228.5 nTPM
Lung	228.5 nTPM

Astrocytes	3.1 nTPM
Brain	3.1 nTPM

B-cells	16.0 nTPM
Adipose tissue	112.8 nTPM
Lung	44.3 nTPM
Skin	33.9 nTPM
Kidney	10.4 nTPM
Thymus	2.1 nTPM
Lymph node	1.7 nTPM
Stomach	1.7 nTPM
Spleen	0.7 nTPM
Salivary gland	0.3 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	427.3 nTPM
Endometrium	529.5 nTPM
Lung	491.0 nTPM
Fallopian tube	398.4 nTPM
Bronchus	290.3 nTPM

Club cells	21.5 nTPM
Lung	44.8 nTPM
Bronchus	18.9 nTPM
Prostate	0.8 nTPM

Endothelial cells	19.4 nTPM
Tongue	122.6 nTPM
Prostate	36.7 nTPM
Fallopian tube	28.1 nTPM
Endometrium	25.2 nTPM
Ovary	18.2 nTPM
Heart muscle	17.9 nTPM
Lung	17.8 nTPM
Thymus	17.0 nTPM
Skin	15.6 nTPM
Skeletal muscle	13.2 nTPM
Esophagus	8.2 nTPM
Salivary gland	7.7 nTPM
Testis	7.6 nTPM
Vascular	6.8 nTPM
Pancreas	5.2 nTPM
Placenta	1.1 nTPM
Liver	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	2.4 nTPM
Colon	7.3 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	39.1 nTPM
Lung	172.2 nTPM
Fallopian tube	142.3 nTPM
Heart muscle	71.1 nTPM
Stomach	36.0 nTPM
Skeletal muscle	35.8 nTPM
Skin	33.1 nTPM
Thymus	31.9 nTPM
Vascular	25.8 nTPM
Pancreas	21.9 nTPM
Esophagus	15.2 nTPM
Salivary gland	14.6 nTPM
Adipose tissue	11.6 nTPM
Breast	6.6 nTPM
Placenta	4.8 nTPM
Prostate	1.3 nTPM
Liver	1.2 nTPM

Granulocytes	106.9 nTPM
Fallopian tube	175.1 nTPM
Tongue	140.7 nTPM
Lung	5.0 nTPM

Intestinal goblet cells	4.2 nTPM
Colon	10.6 nTPM
Rectum	1.4 nTPM
Small intestine	0.6 nTPM

Lymphatic endothelial cells	20.1 nTPM
Fallopian tube	34.6 nTPM
Ovary	5.5 nTPM

Macrophages	24.5 nTPM
Breast	104.6 nTPM
Endometrium	65.2 nTPM
Adipose tissue	63.0 nTPM
Fallopian tube	53.1 nTPM
Tongue	48.6 nTPM
Skeletal muscle	39.8 nTPM
Skin	27.9 nTPM
Spleen	17.0 nTPM
Stomach	10.3 nTPM
Vascular	8.3 nTPM
Thymus	6.4 nTPM
Salivary gland	5.6 nTPM
Esophagus	5.1 nTPM
Prostate	3.6 nTPM
Lung	2.5 nTPM
Pancreas	2.1 nTPM
Testis	1.9 nTPM
Kidney	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	0.5 nTPM
Rectum	1.5 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal keratinocytes	81.6 nTPM
Tongue	159.5 nTPM
Skin	3.7 nTPM

Basal prostatic cells	7.9 nTPM
Prostate	7.9 nTPM

Basal respiratory cells	10.5 nTPM
Bronchus	10.5 nTPM

Bipolar cells	21.0 nTPM
Eye	21.0 nTPM

Plasma cells	212.6 nTPM
Fallopian tube	1428.1 nTPM
Salivary gland	150.0 nTPM
Esophagus	104.0 nTPM
Stomach	16.8 nTPM
Thymus	1.8 nTPM
Liver	0.5 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	30.6 nTPM
Esophagus	83.9 nTPM
Adipose tissue	5.9 nTPM
Vascular	2.1 nTPM

Serous glandular cells	26.8 nTPM
Tongue	53.0 nTPM
Salivary gland	0.7 nTPM

Smooth muscle cells	277.2 nTPM
Fallopian tube	694.3 nTPM
Lung	632.5 nTPM
Skin	513.8 nTPM
Ovary	427.8 nTPM
Breast	307.2 nTPM
Prostate	302.3 nTPM
Adipose tissue	269.0 nTPM
Esophagus	252.3 nTPM
Thymus	227.7 nTPM
Endometrium	211.5 nTPM
Tongue	167.4 nTPM
Vascular	152.0 nTPM
Skeletal muscle	143.7 nTPM
Salivary gland	95.0 nTPM
Placenta	37.2 nTPM
Liver	0.8 nTPM

Suprabasal keratinocytes	334.4 nTPM
Tongue	662.1 nTPM
Skin	6.7 nTPM

T-cells	9.0 nTPM
Endometrium	58.6 nTPM
Tongue	24.9 nTPM
Breast	24.8 nTPM
Fallopian tube	19.4 nTPM
Colon	10.7 nTPM
Vascular	9.6 nTPM
Skeletal muscle	9.5 nTPM
Skin	7.0 nTPM
Adipose tissue	5.8 nTPM
Esophagus	4.9 nTPM
Lung	4.5 nTPM
Prostate	2.0 nTPM
Kidney	1.8 nTPM
Salivary gland	1.3 nTPM
Thymus	1.3 nTPM
Spleen	1.2 nTPM
Lymph node	0.5 nTPM
Stomach	0.4 nTPM
Liver	0.2 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Undifferentiated cells	5.8 nTPM
Colon	11.4 nTPM
Small intestine	3.2 nTPM
Rectum	2.6 nTPM

Amygdala excitatory	1.5 nTPM
Hippocampus	2.1 nTPM
Amygdala	2.0 nTPM
Cerebral cortex	2.0 nTPM
Thalamus	1.4 nTPM
Hypothalamus	0.8 nTPM
Basal ganglia	0.7 nTPM

Astrocyte	21.6 nTPM
Spinal cord	55.1 nTPM
Cerebellum	35.6 nTPM
Pons	27.3 nTPM
Basal ganglia	25.2 nTPM
Midbrain	23.7 nTPM
Medulla oblongata	20.6 nTPM
Thalamus	19.7 nTPM
Hypothalamus	15.3 nTPM
Hippocampus	8.2 nTPM
Amygdala	3.8 nTPM
Cerebral cortex	3.5 nTPM

Bergmann glia	0.7 nTPM
Pons	1.4 nTPM
Cerebellum	0.6 nTPM
Medulla oblongata	0.0 nTPM

Central nervous system macrophage	0.7 nTPM
Basal ganglia	1.3 nTPM
Hypothalamus	1.2 nTPM
Spinal cord	1.2 nTPM
Cerebellum	0.7 nTPM
Medulla oblongata	0.7 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.5 nTPM
Thalamus	0.5 nTPM
Midbrain	0.4 nTPM
Amygdala	0.3 nTPM
Pons	0.2 nTPM

Cerebellar inhibitory	4.2 nTPM
Cerebellum	6.3 nTPM
Medulla oblongata	4.6 nTPM
Midbrain	3.7 nTPM
Pons	3.5 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	2.1 nTPM
Cerebral cortex	3.5 nTPM
Midbrain	2.6 nTPM
Basal ganglia	2.3 nTPM
Hippocampus	2.3 nTPM
Thalamus	1.6 nTPM
Hypothalamus	1.4 nTPM
Amygdala	1.1 nTPM

Choroid plexus epithelial cell	24.7 nTPM
Hippocampus	30.5 nTPM
Thalamus	27.4 nTPM
Medulla oblongata	23.5 nTPM
Basal ganglia	17.6 nTPM

Committed oligodendrocyte precursor	1.4 nTPM
Medulla oblongata	6.5 nTPM
Basal ganglia	4.9 nTPM
Thalamus	1.8 nTPM
Pons	0.9 nTPM
Hippocampus	0.8 nTPM
Midbrain	0.8 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.6 nTPM
Hippocampus	0.9 nTPM
Amygdala	0.7 nTPM
Cerebral cortex	0.7 nTPM
Hypothalamus	0.7 nTPM
Basal ganglia	0.6 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	1.0 nTPM
Amygdala	1.6 nTPM
Basal ganglia	1.2 nTPM
Cerebral cortex	0.9 nTPM
Hypothalamus	0.7 nTPM
Hippocampus	0.5 nTPM

Deep-layer near-projecting	0.7 nTPM
Hypothalamus	1.7 nTPM
Cerebral cortex	0.7 nTPM
Basal ganglia	0.5 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.2 nTPM

Eccentric medium spiny neuron	0.7 nTPM
Cerebral cortex	1.0 nTPM
Amygdala	0.9 nTPM
Thalamus	0.9 nTPM
Basal ganglia	0.6 nTPM
Hypothalamus	0.6 nTPM
Hippocampus	0.4 nTPM

Endothelial cell	7.3 nTPM
Medulla oblongata	23.6 nTPM
Cerebral cortex	21.7 nTPM
Midbrain	15.1 nTPM
Hypothalamus	11.2 nTPM
Pons	3.7 nTPM
Amygdala	1.1 nTPM
Thalamus	1.1 nTPM
Hippocampus	1.0 nTPM
Basal ganglia	0.9 nTPM
Cerebellum	0.8 nTPM
Spinal cord	0.0 nTPM