Single cell type - U2SURP - The Human Protein Atlas

U2SURP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	U2SURP
Gene descriptionⁱ Full gene name according to HGNC.	U2 snRNP associated SURP domain containing
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.21
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

U2SURP is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SON	SON DNA and RNA binding protein	0.6665	55
PPIG	Peptidylprolyl isomerase G	0.6468	55
PPIL4	Peptidylprolyl isomerase like 4	0.5910	55
ZRANB2	Zinc finger RANBP2-type containing 2	0.5579	55
TAF7	TATA-box binding protein associated factor 7	0.5540	6
THOC2	THO complex subunit 2	0.5458	55
ESF1	ESF1 nucleolar pre-rRNA processing protein homolog	0.5376	6
SMC3	Structural maintenance of chromosomes 3	0.5373	79
CASP8AP2	Caspase 8 associated protein 2	0.5339	55
NIPBL	NIPBL cohesin loading factor	0.5313	55
DDX46	DEAD-box helicase 46	0.5299	39
RBM28	RNA binding motif protein 28	0.5295	39
CWC22	CWC22 spliceosome associated protein homolog	0.5157	55
NOL8	Nucleolar protein 8	0.5153	55
ZNF181	Zinc finger protein 181	0.5055	55

IMMUNE CELLS

U2SURP is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 1
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF614	Zinc finger protein 614	1.0000	5
HLTF	Helicase like transcription factor	0.9762	5
CENPQ	Centromere protein Q	0.9762	5
GDPGP1	GDP-D-glucose phosphorylase 1	0.9524	5
RAD50	RAD50 double strand break repair protein	0.9524	5
ENSG00000283201	Zinc finger protein 724	0.9286	5
ZNF578	Zinc finger protein 578	0.9286	5
SENP1	SUMO specific peptidase 1	0.9286	5
SMYD3	SET and MYND domain containing 3	0.9286	5
ZNF12	Zinc finger protein 12	0.9286	5
RGP1	RGP1 homolog, RAB6A GEF complex partner 1	0.9286	32
GAR1	GAR1 ribonucleoprotein	0.9048	24
ZNF827	Zinc finger protein 827	0.9048	5
GOLPH3L	Golgi phosphoprotein 3 like	0.9048	5
SERPINE1	Serpin family E member 1	0.9048	14

Adipocytes	118.8 nTPM
Adipose tissue	138.2 nTPM
Breast	99.4 nTPM

Alveolar cells type 1	86.5 nTPM
Lung	86.5 nTPM

Alveolar cells type 2	76.9 nTPM
Lung	76.9 nTPM

Astrocytes	110.2 nTPM
Brain	110.2 nTPM

B-cells	95.5 nTPM
Liver	144.9 nTPM
Salivary gland	144.9 nTPM
Adipose tissue	128.8 nTPM
Lung	108.7 nTPM
Stomach	105.9 nTPM
Thymus	99.5 nTPM
Bone marrow	98.9 nTPM
Lymph node	97.4 nTPM
PBMC	87.7 nTPM
Spleen	80.6 nTPM
Kidney	67.6 nTPM
Skin	40.7 nTPM
Esophagus	35.4 nTPM

Ciliated cells	81.5 nTPM
Endometrium	90.8 nTPM
Fallopian tube	90.6 nTPM
Bronchus	72.5 nTPM
Lung	72.2 nTPM

Club cells	82.5 nTPM
Bronchus	101.8 nTPM
Prostate	79.4 nTPM
Lung	66.3 nTPM

Dendritic cells	108.5 nTPM
Adipose tissue	137.9 nTPM
PBMC	79.1 nTPM

Endothelial cells	99.7 nTPM
Heart muscle	230.8 nTPM
Skeletal muscle	158.5 nTPM
Fallopian tube	143.9 nTPM
Ovary	117.6 nTPM
Breast	113.4 nTPM
Endometrium	106.8 nTPM
Vascular	91.6 nTPM
Thymus	91.5 nTPM
Salivary gland	89.7 nTPM
Esophagus	88.6 nTPM
Lung	85.4 nTPM
Testis	78.7 nTPM
Prostate	77.1 nTPM
Placenta	76.6 nTPM
Pancreas	69.8 nTPM
Skin	64.4 nTPM
Tongue	55.7 nTPM
Liver	54.2 nTPM

Enteroendocrine cells	59.9 nTPM
Colon	71.4 nTPM
Rectum	63.7 nTPM
Small intestine	44.6 nTPM

Erythroid cells	116.4 nTPM
Bone marrow	128.0 nTPM
Liver	104.9 nTPM

Fibroblasts	97.5 nTPM
Heart muscle	237.2 nTPM
Fallopian tube	140.2 nTPM
Adipose tissue	138.4 nTPM
Skeletal muscle	124.3 nTPM
Breast	108.4 nTPM
Pancreas	86.8 nTPM
Vascular	81.4 nTPM
Salivary gland	80.2 nTPM
Thymus	77.9 nTPM
Lung	75.6 nTPM
Prostate	73.9 nTPM
Esophagus	72.1 nTPM
Stomach	69.2 nTPM
Skin	66.1 nTPM
Liver	65.2 nTPM
Placenta	63.4 nTPM

Granulocytes	101.3 nTPM
Fallopian tube	147.4 nTPM
Lung	98.3 nTPM
Tongue	58.2 nTPM

Intestinal goblet cells	65.9 nTPM
Colon	70.4 nTPM
Rectum	64.8 nTPM
Small intestine	62.4 nTPM

Lymphatic endothelial cells	111.1 nTPM
Fallopian tube	134.9 nTPM
Ovary	87.3 nTPM

Basal keratinocytes	73.4 nTPM
Tongue	75.9 nTPM
Skin	70.8 nTPM

Basal respiratory cells	139.0 nTPM
Bronchus	139.0 nTPM

Basal squamous epithelial cells	70.2 nTPM
Esophagus	70.2 nTPM

Bipolar cells	99.2 nTPM
Eye	99.2 nTPM

Macrophages	82.1 nTPM
Testis	106.0 nTPM
Adipose tissue	105.8 nTPM
Fallopian tube	99.1 nTPM
Skeletal muscle	96.6 nTPM
Stomach	92.6 nTPM
Spleen	91.2 nTPM
Breast	86.2 nTPM
Salivary gland	84.7 nTPM
Vascular	83.2 nTPM
Bone marrow	83.1 nTPM
Lung	82.6 nTPM
Endometrium	82.4 nTPM
Prostate	77.7 nTPM
Thymus	74.5 nTPM
Kidney	69.0 nTPM
Tongue	64.6 nTPM
Pancreas	61.7 nTPM
Esophagus	61.7 nTPM
Skin	57.9 nTPM

Paneth cells	55.2 nTPM
Small intestine	65.6 nTPM
Rectum	63.9 nTPM
Colon	36.2 nTPM

Plasma cells	112.3 nTPM
Fallopian tube	150.5 nTPM
Thymus	143.6 nTPM
Spleen	122.9 nTPM
Stomach	107.6 nTPM
Bone marrow	107.2 nTPM
Liver	105.6 nTPM
Salivary gland	87.7 nTPM
Esophagus	72.8 nTPM

Schwann cells	88.5 nTPM
Vascular	112.8 nTPM
Adipose tissue	92.9 nTPM
Esophagus	59.9 nTPM

Serous glandular cells	83.5 nTPM
Salivary gland	96.2 nTPM
Tongue	70.7 nTPM

Smooth muscle cells	94.9 nTPM
Skeletal muscle	141.7 nTPM
Adipose tissue	131.4 nTPM
Fallopian tube	123.7 nTPM
Ovary	113.2 nTPM
Endometrium	109.6 nTPM
Breast	96.7 nTPM
Salivary gland	92.7 nTPM
Esophagus	92.5 nTPM
Lung	87.0 nTPM
Vascular	86.7 nTPM
Placenta	84.6 nTPM
Thymus	78.5 nTPM
Liver	73.4 nTPM
Prostate	72.4 nTPM
Skin	68.6 nTPM
Tongue	65.3 nTPM

Suprabasal keratinocytes	75.7 nTPM
Tongue	85.9 nTPM
Skin	65.4 nTPM

T-cells	106.2 nTPM
Salivary gland	149.8 nTPM
Fallopian tube	147.8 nTPM
Prostate	135.8 nTPM
Adipose tissue	132.4 nTPM
Endometrium	130.4 nTPM
PBMC	114.2 nTPM
Vascular	113.8 nTPM
Skeletal muscle	112.7 nTPM
Liver	109.4 nTPM
Thymus	106.8 nTPM
Bone marrow	106.6 nTPM
Stomach	101.5 nTPM
Lymph node	99.4 nTPM
Breast	98.9 nTPM
Lung	95.9 nTPM
Kidney	95.8 nTPM
Spleen	95.4 nTPM
Colon	82.9 nTPM
Esophagus	82.7 nTPM
Tongue	70.2 nTPM
Skin	48.0 nTPM

Undifferentiated cells	85.0 nTPM
Colon	102.7 nTPM
Small intestine	77.1 nTPM
Rectum	75.1 nTPM

Amygdala excitatory	122.9 nTPM
Thalamus	131.1 nTPM
Hippocampus	130.8 nTPM
Basal ganglia	127.2 nTPM
Amygdala	118.9 nTPM
Hypothalamus	118.7 nTPM
Cerebral cortex	111.0 nTPM

Astrocyte	185.3 nTPM
Amygdala	232.4 nTPM
Cerebral cortex	222.3 nTPM
Hippocampus	209.8 nTPM
Basal ganglia	196.6 nTPM
Thalamus	193.8 nTPM
Midbrain	191.1 nTPM
Pons	180.0 nTPM
Cerebellum	174.8 nTPM
Medulla oblongata	156.6 nTPM
Hypothalamus	154.3 nTPM
Spinal cord	126.5 nTPM

Bergmann glia	170.2 nTPM
Cerebellum	206.7 nTPM
Pons	169.7 nTPM
Medulla oblongata	134.3 nTPM

Central nervous system macrophage	172.1 nTPM
Amygdala	211.8 nTPM
Cerebellum	180.1 nTPM
Cerebral cortex	177.0 nTPM
Spinal cord	174.0 nTPM
Hippocampus	172.8 nTPM
Midbrain	170.8 nTPM
Basal ganglia	169.8 nTPM
Thalamus	166.8 nTPM
Pons	160.4 nTPM
Hypothalamus	158.7 nTPM
Medulla oblongata	150.9 nTPM

Cerebellar inhibitory	128.8 nTPM
Midbrain	140.9 nTPM
Spinal cord	140.2 nTPM
Cerebellum	131.3 nTPM
Pons	118.1 nTPM
Medulla oblongata	113.4 nTPM

Cge interneuron	125.4 nTPM
Basal ganglia	137.2 nTPM
Amygdala	131.1 nTPM
Thalamus	130.2 nTPM
Midbrain	125.0 nTPM
Cerebral cortex	123.3 nTPM
Hippocampus	118.7 nTPM
Hypothalamus	112.2 nTPM

Choroid plexus epithelial cell	120.9 nTPM
Hippocampus	133.1 nTPM
Basal ganglia	126.8 nTPM
Thalamus	112.4 nTPM
Medulla oblongata	111.3 nTPM

Committed oligodendrocyte precursor	146.5 nTPM
Amygdala	174.8 nTPM
Cerebral cortex	172.9 nTPM
Hippocampus	158.8 nTPM
Thalamus	157.8 nTPM
Basal ganglia	152.8 nTPM
Hypothalamus	151.6 nTPM
Midbrain	151.2 nTPM
Cerebellum	147.5 nTPM
Pons	139.9 nTPM
Spinal cord	106.7 nTPM
Medulla oblongata	98.1 nTPM

Deep-layer corticothalamic and 6b	111.7 nTPM
Midbrain	127.6 nTPM
Basal ganglia	113.9 nTPM
Amygdala	111.5 nTPM
Cerebral cortex	111.2 nTPM
Hippocampus	106.3 nTPM
Hypothalamus	99.9 nTPM

Deep-layer intratelencephalic	104.0 nTPM
Amygdala	112.8 nTPM
Basal ganglia	109.2 nTPM
Hippocampus	104.9 nTPM
Cerebral cortex	103.4 nTPM
Hypothalamus	90.0 nTPM

Deep-layer near-projecting	111.2 nTPM
Basal ganglia	120.4 nTPM
Cerebral cortex	116.3 nTPM
Amygdala	111.2 nTPM
Hypothalamus	104.9 nTPM
Hippocampus	103.1 nTPM