Single cell type - INHBB - The Human Protein Atlas

INHBB

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	INHBB
Gene descriptionⁱ Full gene name according to HGNC.	Inhibin subunit beta B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Adipocytes & Endothelial cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Adipocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.78
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Ependymal cell, Fibroblast, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Adipocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Ependymal cell, Fibroblast, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

INHBB is part of cluster 41 Adipocytes & Endothelial cells - Mixed function with confidenceⁱ 1
325 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CYYR1	Cysteine and tyrosine rich 1	0.7760	41
ADGRL4	Adhesion G protein-coupled receptor L4	0.7682	41
CLEC14A	C-type lectin domain containing 14A	0.7547	41
SOX18	SRY-box transcription factor 18	0.7516	41
FAM110D	Family with sequence similarity 110 member D	0.7491	41
ADM5	Adrenomedullin 5 (putative)	0.7446	41
ARHGEF15	Rho guanine nucleotide exchange factor 15	0.7297	41
PLVAP	Plasmalemma vesicle associated protein	0.7127	41
SPRY1	Sprouty RTK signaling antagonist 1	0.7100	41
MMRN2	Multimerin 2	0.7054	41
ACKR1	Atypical chemokine receptor 1 (Duffy blood group)	0.7047	41
MEOX1	Mesenchyme homeobox 1	0.6979	41
SEMA3G	Semaphorin 3G	0.6950	41
CD34	CD34 molecule	0.6889	41
AQP1	Aquaporin 1 (Colton blood group)	0.6810	41

Adipocytes	199.2 nTPM
Adipose tissue	373.7 nTPM
Breast	24.6 nTPM

Alveolar cells type 1	20.5 nTPM
Lung	20.5 nTPM

Alveolar cells type 2	5.3 nTPM
Lung	5.3 nTPM

Astrocytes	7.7 nTPM
Brain	7.7 nTPM

B-cells	0.7 nTPM
Skin	6.8 nTPM
Thymus	1.3 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.2 nTPM
Lymph node	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	19.6 nTPM
Lung	43.4 nTPM
Bronchus	16.4 nTPM
Fallopian tube	9.6 nTPM
Endometrium	8.9 nTPM

Club cells	13.6 nTPM
Lung	26.1 nTPM
Bronchus	8.6 nTPM
Prostate	6.0 nTPM

Endothelial cells	46.5 nTPM
Salivary gland	161.1 nTPM
Thymus	142.8 nTPM
Vascular	118.5 nTPM
Fallopian tube	117.8 nTPM
Prostate	69.7 nTPM
Skeletal muscle	58.4 nTPM
Skin	38.1 nTPM
Tongue	29.9 nTPM
Lung	22.8 nTPM
Ovary	18.6 nTPM
Esophagus	15.9 nTPM
Placenta	13.1 nTPM
Liver	12.6 nTPM
Endometrium	8.1 nTPM
Breast	4.4 nTPM
Heart muscle	4.1 nTPM
Testis	1.2 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	13.4 nTPM
Adipose tissue	47.7 nTPM
Salivary gland	36.3 nTPM
Skin	35.9 nTPM
Liver	24.9 nTPM
Thymus	16.8 nTPM
Breast	11.6 nTPM
Stomach	7.2 nTPM
Placenta	6.7 nTPM
Fallopian tube	6.1 nTPM
Vascular	6.0 nTPM
Skeletal muscle	5.9 nTPM
Lung	5.0 nTPM
Heart muscle	2.5 nTPM
Prostate	2.0 nTPM
Esophagus	0.6 nTPM
Pancreas	0.0 nTPM

Granulocytes	0.1 nTPM
Fallopian tube	0.4 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	3.9 nTPM
Fallopian tube	7.8 nTPM
Ovary	0.0 nTPM

Macrophages	1.3 nTPM
Thymus	11.1 nTPM
Endometrium	3.1 nTPM
Skeletal muscle	3.0 nTPM
Salivary gland	2.3 nTPM
Vascular	1.1 nTPM
Breast	1.0 nTPM
Testis	0.6 nTPM
Adipose tissue	0.6 nTPM
Tongue	0.5 nTPM
Fallopian tube	0.4 nTPM
Lung	0.2 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal prostatic cells	1.4 nTPM
Prostate	1.4 nTPM

Basal respiratory cells	5.6 nTPM
Bronchus	5.6 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Collecting duct cells	1.9 nTPM
Kidney	1.9 nTPM

Plasma cells	0.9 nTPM
Salivary gland	4.5 nTPM
Thymus	1.3 nTPM
Liver	1.0 nTPM
Fallopian tube	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	0.2 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	9.9 nTPM
Salivary gland	15.5 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	5.2 nTPM
Tongue	17.4 nTPM
Liver	16.6 nTPM
Skeletal muscle	15.9 nTPM
Vascular	8.0 nTPM
Adipose tissue	5.8 nTPM
Salivary gland	3.5 nTPM
Thymus	3.1 nTPM
Endometrium	2.8 nTPM
Fallopian tube	2.7 nTPM
Breast	2.4 nTPM
Prostate	1.8 nTPM
Skin	1.4 nTPM
Placenta	1.0 nTPM
Ovary	0.4 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

T-cells	0.4 nTPM
Skin	2.5 nTPM
Vascular	1.6 nTPM
Skeletal muscle	0.8 nTPM
Breast	0.7 nTPM
Endometrium	0.6 nTPM
Salivary gland	0.6 nTPM
Prostate	0.4 nTPM
Liver	0.3 nTPM
Fallopian tube	0.3 nTPM
Adipose tissue	0.2 nTPM
Thymus	0.1 nTPM
Tongue	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	0.6 nTPM
Amygdala	0.9 nTPM
Hippocampus	0.8 nTPM
Cerebral cortex	0.7 nTPM
Hypothalamus	0.6 nTPM
Basal ganglia	0.4 nTPM
Thalamus	0.0 nTPM

Astrocyte	15.0 nTPM
Midbrain	21.4 nTPM
Cerebellum	19.2 nTPM
Cerebral cortex	18.3 nTPM
Pons	16.9 nTPM
Amygdala	16.3 nTPM
Thalamus	16.1 nTPM
Basal ganglia	16.0 nTPM
Hippocampus	13.5 nTPM
Hypothalamus	10.9 nTPM
Medulla oblongata	9.7 nTPM
Spinal cord	6.4 nTPM

Bergmann glia	3.3 nTPM
Medulla oblongata	6.4 nTPM
Cerebellum	2.1 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	0.3 nTPM
Thalamus	0.9 nTPM
Cerebellum	0.3 nTPM
Hippocampus	0.3 nTPM
Spinal cord	0.3 nTPM
Amygdala	0.2 nTPM
Cerebral cortex	0.2 nTPM
Hypothalamus	0.2 nTPM
Pons	0.2 nTPM
Basal ganglia	0.1 nTPM
Medulla oblongata	0.1 nTPM
Midbrain	0.1 nTPM

Cerebellar inhibitory	0.9 nTPM
Pons	2.3 nTPM
Cerebellum	0.9 nTPM
Medulla oblongata	0.7 nTPM
Midbrain	0.6 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.6 nTPM
Hypothalamus	1.5 nTPM
Amygdala	0.8 nTPM
Hippocampus	0.8 nTPM
Basal ganglia	0.5 nTPM
Midbrain	0.5 nTPM
Cerebral cortex	0.3 nTPM
Thalamus	0.1 nTPM

Choroid plexus epithelial cell	0.0 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	3.8 nTPM
Thalamus	6.8 nTPM
Hippocampus	5.4 nTPM
Pons	5.3 nTPM
Basal ganglia	4.9 nTPM
Cerebellum	4.8 nTPM
Amygdala	4.5 nTPM
Cerebral cortex	4.4 nTPM
Midbrain	2.5 nTPM
Hypothalamus	1.4 nTPM
Medulla oblongata	1.3 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.1 nTPM
Amygdala	0.3 nTPM
Hippocampus	0.2 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.9 nTPM
Hypothalamus	2.5 nTPM
Basal ganglia	0.6 nTPM
Amygdala	0.5 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.3 nTPM

Deep-layer near-projecting	0.1 nTPM
Hippocampus	0.3 nTPM
Hypothalamus	0.2 nTPM
Cerebral cortex	0.1 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM

Eccentric medium spiny neuron	0.1 nTPM
Hippocampus	0.4 nTPM
Amygdala	0.2 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.1 nTPM
Basal ganglia	0.0 nTPM
Thalamus	0.0 nTPM

Endothelial cell	4.6 nTPM
Basal ganglia	38.2 nTPM
Midbrain	3.8 nTPM
Medulla oblongata	2.1 nTPM
Thalamus	1.7 nTPM
Pons	1.2 nTPM
Amygdala	1.1 nTPM
Hippocampus	1.0 nTPM
Cerebellum	0.8 nTPM
Cerebral cortex	0.6 nTPM
Hypothalamus	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	21.6 nTPM
Spinal cord	40.2 nTPM
Basal ganglia	23.5 nTPM
Pons	22.4 nTPM
Hypothalamus	21.4 nTPM
Midbrain	19.7 nTPM
Thalamus	19.4 nTPM
Hippocampus	17.0 nTPM
Amygdala	16.5 nTPM
Medulla oblongata	14.5 nTPM