Single cell type - ITGB2 - The Human Protein Atlas

ITGB2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITGB2
Gene descriptionⁱ Full gene name according to HGNC.	Integrin subunit beta 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	CD markers Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	16

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Hofbauer cells, NK-cells, Kupffer cells, Monocytes, Macrophages, Langerhans cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.73
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Leukocyte, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Hofbauer cells, NK-cells, Kupffer cells, Monocytes, Macrophages, Langerhans cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Leukocyte, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ITGB2 is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 1
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SNX20	Sorting nexin 20	0.8249	29
CD300A	CD300a molecule	0.7850	29
FGR	FGR proto-oncogene, Src family tyrosine kinase	0.7764	29
MYO1F	Myosin IF	0.7588	19
FCGR3A	Fc gamma receptor IIIa	0.7544	29
TYROBP	Transmembrane immune signaling adaptor TYROBP	0.7451	29
ARHGAP30	Rho GTPase activating protein 30	0.7217	19
CASP1	Caspase 1	0.7165	29
CX3CR1	C-X3-C motif chemokine receptor 1	0.7158	19
ABI3	ABI family member 3	0.7112	19
ADCY7	Adenylate cyclase 7	0.7081	29
SIGLEC7	Sialic acid binding Ig like lectin 7	0.7057	29
AOAH	Acyloxyacyl hydrolase	0.6961	19
CD300C	CD300c molecule	0.6931	29
PPM1M	Protein phosphatase, Mg2+/Mn2+ dependent 1M	0.6787	29

IMMUNE CELLS

ITGB2 is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 0.98
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SIRPB2	Signal regulatory protein beta 2	1.0000	38
GAA	Alpha glucosidase	1.0000	38
YIPF1	Yip1 domain family member 1	1.0000	38
AOAH	Acyloxyacyl hydrolase	1.0000	38
QSOX1	Quiescin sulfhydryl oxidase 1	1.0000	38
TYROBP	Transmembrane immune signaling adaptor TYROBP	1.0000	38
TNFSF13B	TNF superfamily member 13b	1.0000	38
TSPO	Translocator protein	0.9762	38
CTSD	Cathepsin D	0.9762	38
BST1	Bone marrow stromal cell antigen 1	0.9762	38
FCGRT	Fc gamma receptor and transporter	0.9762	38
RAB11A	RAB11A, member RAS oncogene family	0.9762	38
DTX2	Deltex E3 ubiquitin ligase 2	0.9762	38
SPG21	SPG21 abhydrolase domain containing, maspardin	0.9762	38
SCARF1	Scavenger receptor class F member 1	0.9762	38

Adipocytes	4.6 nTPM
Breast	7.2 nTPM
Adipose tissue	2.0 nTPM

Alveolar cells type 1	2.1 nTPM
Lung	2.1 nTPM

Alveolar cells type 2	2.6 nTPM
Lung	2.6 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	92.8 nTPM
Skin	218.5 nTPM
PBMC	147.8 nTPM
Lung	127.4 nTPM
Thymus	100.8 nTPM
Kidney	93.6 nTPM
Spleen	83.1 nTPM
Bone marrow	78.7 nTPM
Stomach	76.3 nTPM
Salivary gland	75.4 nTPM
Lymph node	65.7 nTPM
Liver	58.0 nTPM
Adipose tissue	57.2 nTPM
Esophagus	23.6 nTPM

Ciliated cells	8.9 nTPM
Lung	27.7 nTPM
Fallopian tube	4.6 nTPM
Bronchus	2.6 nTPM
Endometrium	0.4 nTPM

Club cells	20.8 nTPM
Lung	46.3 nTPM
Bronchus	15.4 nTPM
Prostate	0.8 nTPM

Dendritic cells	118.6 nTPM
PBMC	143.9 nTPM
Adipose tissue	93.3 nTPM

Endothelial cells	6.8 nTPM
Liver	56.7 nTPM
Heart muscle	11.9 nTPM
Tongue	9.9 nTPM
Placenta	9.7 nTPM
Lung	5.8 nTPM
Vascular	5.5 nTPM
Skin	5.3 nTPM
Salivary gland	5.0 nTPM
Thymus	4.5 nTPM
Esophagus	1.8 nTPM
Prostate	1.4 nTPM
Fallopian tube	1.3 nTPM
Endometrium	1.0 nTPM
Testis	0.9 nTPM
Breast	0.9 nTPM
Skeletal muscle	0.8 nTPM
Ovary	0.2 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	3.4 nTPM
Lung	17.5 nTPM
Liver	5.9 nTPM
Salivary gland	5.8 nTPM
Vascular	5.8 nTPM
Thymus	4.4 nTPM
Breast	2.9 nTPM
Skin	2.8 nTPM
Placenta	2.5 nTPM
Stomach	1.4 nTPM
Prostate	1.3 nTPM
Fallopian tube	1.3 nTPM
Heart muscle	0.8 nTPM
Skeletal muscle	0.8 nTPM
Esophagus	0.5 nTPM
Pancreas	0.4 nTPM
Adipose tissue	0.3 nTPM

Granulocytes	26.2 nTPM
Lung	43.4 nTPM
Tongue	24.3 nTPM
Fallopian tube	11.0 nTPM

Intestinal goblet cells	0.4 nTPM
Colon	1.0 nTPM
Small intestine	0.1 nTPM
Rectum	0.1 nTPM

Lymphatic endothelial cells	0.5 nTPM
Fallopian tube	1.0 nTPM
Ovary	0.0 nTPM

Macrophages	491.9 nTPM
Pancreas	1025.7 nTPM
Testis	796.6 nTPM
Kidney	701.8 nTPM
Stomach	661.0 nTPM
Lung	655.5 nTPM
Adipose tissue	531.9 nTPM
Fallopian tube	527.2 nTPM
Skeletal muscle	519.0 nTPM
Bone marrow	500.7 nTPM
Thymus	478.2 nTPM
Breast	452.2 nTPM
Vascular	383.5 nTPM
Prostate	365.5 nTPM
Spleen	355.9 nTPM
Salivary gland	346.8 nTPM
Endometrium	344.4 nTPM
Tongue	307.0 nTPM
Esophagus	281.3 nTPM
Skin	112.5 nTPM

Basal respiratory cells	9.3 nTPM
Bronchus	9.3 nTPM

Bipolar cells	3.2 nTPM
Eye	3.2 nTPM

Cholangiocytes	13.4 nTPM
Liver	13.4 nTPM

Early spermatids	1.5 nTPM
Testis	1.5 nTPM

Paneth cells	0.2 nTPM
Rectum	0.5 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	28.0 nTPM
Thymus	51.9 nTPM
Liver	49.6 nTPM
Stomach	35.2 nTPM
Bone marrow	27.2 nTPM
Spleen	21.7 nTPM
Salivary gland	17.5 nTPM
Esophagus	15.6 nTPM
Fallopian tube	5.5 nTPM

Schwann cells	183.4 nTPM
Adipose tissue	544.6 nTPM
Vascular	5.7 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	19.8 nTPM
Salivary gland	22.0 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	3.7 nTPM
Breast	9.4 nTPM
Thymus	7.3 nTPM
Liver	7.2 nTPM
Lung	7.1 nTPM
Placenta	5.1 nTPM
Salivary gland	5.0 nTPM
Skin	3.9 nTPM
Vascular	3.6 nTPM
Esophagus	2.4 nTPM
Prostate	1.8 nTPM
Fallopian tube	1.6 nTPM
Tongue	1.5 nTPM
Ovary	1.4 nTPM
Adipose tissue	0.9 nTPM
Skeletal muscle	0.8 nTPM
Endometrium	0.6 nTPM

T-cells	218.2 nTPM
Kidney	524.0 nTPM
Liver	398.6 nTPM
Lung	366.5 nTPM
Bone marrow	347.2 nTPM
Skeletal muscle	325.5 nTPM
PBMC	315.4 nTPM
Adipose tissue	278.0 nTPM
Breast	269.5 nTPM
Spleen	269.1 nTPM
Skin	225.0 nTPM
Thymus	214.3 nTPM
Lymph node	153.5 nTPM
Esophagus	150.9 nTPM
Vascular	126.2 nTPM
Salivary gland	117.3 nTPM
Fallopian tube	110.2 nTPM
Endometrium	110.1 nTPM
Stomach	106.9 nTPM
Tongue	99.1 nTPM
Colon	39.0 nTPM
Prostate	35.9 nTPM

Undifferentiated cells	0.1 nTPM
Rectum	0.3 nTPM
Small intestine	0.1 nTPM
Colon	0.0 nTPM

Amygdala excitatory	0.9 nTPM
Cerebral cortex	1.4 nTPM
Basal ganglia	1.1 nTPM
Hippocampus	0.9 nTPM
Hypothalamus	0.9 nTPM
Amygdala	0.8 nTPM
Thalamus	0.5 nTPM

Astrocyte	0.9 nTPM
Spinal cord	2.0 nTPM
Basal ganglia	1.4 nTPM
Cerebellum	1.4 nTPM
Midbrain	0.9 nTPM
Pons	0.8 nTPM
Hippocampus	0.7 nTPM
Cerebral cortex	0.6 nTPM
Thalamus	0.6 nTPM
Amygdala	0.4 nTPM
Hypothalamus	0.4 nTPM
Medulla oblongata	0.4 nTPM

Bergmann glia	0.1 nTPM
Cerebellum	0.4 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	126.3 nTPM
Spinal cord	166.3 nTPM
Cerebellum	150.1 nTPM
Midbrain	145.5 nTPM
Pons	137.1 nTPM
Cerebral cortex	129.4 nTPM
Medulla oblongata	128.2 nTPM
Basal ganglia	121.4 nTPM
Thalamus	114.7 nTPM
Hippocampus	114.0 nTPM
Hypothalamus	94.7 nTPM
Amygdala	88.0 nTPM

Cerebellar inhibitory	0.5 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.5 nTPM
Pons	0.5 nTPM
Medulla oblongata	0.4 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.4 nTPM
Hypothalamus	0.7 nTPM
Basal ganglia	0.6 nTPM
Amygdala	0.5 nTPM
Cerebral cortex	0.4 nTPM
Hippocampus	0.4 nTPM
Midbrain	0.2 nTPM
Thalamus	0.2 nTPM

Choroid plexus epithelial cell	1.0 nTPM
Thalamus	2.7 nTPM
Medulla oblongata	0.9 nTPM
Basal ganglia	0.5 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	1.2 nTPM
Basal ganglia	6.0 nTPM
Midbrain	2.5 nTPM
Hippocampus	1.8 nTPM
Cerebral cortex	1.3 nTPM
Hypothalamus	0.7 nTPM
Amygdala	0.6 nTPM
Thalamus	0.2 nTPM
Cerebellum	0.0 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.4 nTPM
Hypothalamus	0.8 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.4 nTPM
Cerebral cortex	0.4 nTPM
Hippocampus	0.4 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.6 nTPM
Amygdala	0.8 nTPM
Hypothalamus	0.6 nTPM
Basal ganglia	0.5 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.5 nTPM

Deep-layer near-projecting	0.4 nTPM
Hypothalamus	1.1 nTPM
Amygdala	0.4 nTPM
Cerebral cortex	0.3 nTPM
Basal ganglia	0.2 nTPM
Hippocampus	0.0 nTPM

Eccentric medium spiny neuron	1.6 nTPM
Basal ganglia	2.5 nTPM
Thalamus	2.3 nTPM
Hypothalamus	1.7 nTPM
Cerebral cortex	1.4 nTPM
Amygdala	0.9 nTPM
Hippocampus	0.8 nTPM

Endothelial cell	0.9 nTPM
Hypothalamus	2.5 nTPM
Medulla oblongata	2.1 nTPM
Basal ganglia	1.9 nTPM
Pons	1.9 nTPM
Cerebral cortex	0.6 nTPM
Thalamus	0.6 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Hippocampus	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM