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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
IGFBP3 is not prognostic in Testicular Germ Cell Tumor (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
68.6
Number of samples
133
Samples
Sample
Description
TPM
TCGA-2G-AAGV-01A
0 years, male, white, stage:'--, alive, 4527 days
1176.3
TCGA-2G-AAGI-01A
0 years, male, white, stage:Stage IS, alive, 3137 days
497.8
TCGA-XE-AAOJ-01A
0 years, male, white, stage:Stage IS, alive, 1550 days
374.5
TCGA-2G-AAGX-01A
0 years, male, white, stage:Stage IA, alive, 5514 days
291.6
TCGA-X3-A8G4-01A
0 years, male, white, stage:Stage IS, alive, 856 days
282.4
TCGA-2G-AAFJ-01A
0 years, male, asian, stage:'--, alive, 792 days
267.9
TCGA-2G-AAH4-01A
0 years, male, white, stage:Stage II, alive, 6210 days
257.0
TCGA-2G-AAGP-01A
0 years, male, white, stage:Stage IIA, alive, 4018 days
256.9
TCGA-2G-AAG6-01A
0 years, male, white, stage:Stage IS, alive, 2231 days
244.9
TCGA-2G-AAG5-01A
0 years, male, white, stage:Stage IS, alive, 2299 days
209.8
TCGA-YU-AA61-01A
0 years, male, white, stage:Stage IS, alive, 864 days
203.5
TCGA-2G-AAH2-01A
0 years, male, white, stage:Stage IS, alive, 6060 days
201.6
TCGA-2G-AAFZ-01A
0 years, male, white, stage:Stage III, alive, 1353 days
193.7
TCGA-2G-AAGG-01A
0 years, male, white, stage:Stage IIIC, alive, 2611 days
171.8
TCGA-2G-AAFV-01A
0 years, male, white, stage:Stage IS, alive, 1389 days
154.1
TCGA-SN-A84W-01A
0 years, male, white, stage:Stage IS, alive, 293 days
153.6
TCGA-YU-A94I-01A
0 years, male, stage:Stage IA, alive, 536 days
149.2
TCGA-W4-A7U3-01A
0 years, male, white, stage:'--, alive, 149 days
142.1
TCGA-2G-AAGM-01A
0 years, male, white, stage:Stage IS, alive, 3891 days
133.2
TCGA-SN-A84X-01A
0 years, male, white, stage:Stage IS, alive, 312 days
129.5
TCGA-XE-AANI-01A
0 years, male, white, stage:Stage IS, alive, 1041 days
115.7
TCGA-2G-AAGS-01A
0 years, male, white, stage:Stage IIIB, alive, 4816 days
114.5
TCGA-2G-AAGY-01A
0 years, male, white, stage:Stage IS, alive, 5329 days
113.5
TCGA-2G-AAKD-01A
0 years, male, white, stage:Stage III, alive, 6340 days
107.7
TCGA-YU-A90Y-01A
0 years, male, black or african american, stage:Stage IIIC, dead, 17 days
94.0
TCGA-2G-AAG3-01A
0 years, male, white, stage:Stage IS, alive, 1593 days
84.5
TCGA-XE-AAOC-01A
0 years, male, white, stage:Stage IA, alive, 270 days
83.4
TCGA-2G-AAGT-01A
0 years, male, white, stage:Stage IS, alive, 4406 days
83.4
TCGA-2G-AAFI-01A
0 years, male, white, stage:Stage IB, alive, 675 days
81.1
TCGA-2G-AAFY-01A
0 years, male, white, stage:Stage IIA, alive, 1099 days
80.0
TCGA-4K-AAAL-01A
0 years, male, white, stage:Stage IS, alive, 483 days
79.5
TCGA-YU-A94D-01A
0 years, male, stage:Stage IIIB, alive, 2167 days
76.8
TCGA-2G-AAGF-01A
0 years, male, white, stage:Stage IS, alive, 2734 days
75.8
TCGA-2G-AAKG-01A
0 years, male, white, stage:Stage I, alive, 6598 days
68.5
TCGA-2G-AAGE-01A
0 years, male, white, stage:Stage IS, alive, 2478 days
68.2
TCGA-YU-AA4L-01A
0 years, male, black or african american, stage:Stage IIIC, alive, 1573 days
66.0
TCGA-XE-AAOB-01A
0 years, male, white, stage:Stage IS, dead, 513 days
65.6
TCGA-2G-AAFM-01A
0 years, male, white, stage:Stage IIA, alive, 503 days
62.3
TCGA-W4-A7U4-01A
0 years, male, white, stage:'--, alive, 738 days
62.1
TCGA-YU-A90P-01A
0 years, male, white, stage:Stage IA, alive, 2069 days
60.9
TCGA-2G-AAGZ-01A
0 years, male, white, stage:Stage IIIA, alive, 5233 days
59.1
TCGA-2G-AAKL-01A
0 years, male, white, stage:Stage II, alive, 7023 days
54.6
TCGA-XE-A8H1-01A
0 years, male, white, stage:Stage IS, alive, 209 days
54.5
TCGA-2G-AAGK-01A
0 years, male, white, stage:Stage IS, alive, 3621 days
52.2
TCGA-2G-AAFO-01A
0 years, male, white, stage:Stage IIA, alive, 685 days
50.6
TCGA-SN-A84Y-01A
0 years, male, white, stage:Stage IS, alive, 524 days
49.6
TCGA-2G-AAL5-01A
0 years, male, white, stage:Stage I, alive, 7437 days
46.9
TCGA-2G-AALP-01A
0 years, male, white, stage:Stage IIIB, alive, 2645 days
45.9
TCGA-2G-AAG7-01A
0 years, male, white, stage:Stage IS, alive, 2475 days
45.5
TCGA-2G-AAGW-01A
0 years, male, white, stage:Stage IS, alive, 4899 days
44.9
TCGA-2G-AAF8-01A
0 years, male, white, stage:Stage IA, alive, 3911 days
43.7
TCGA-2G-AAGC-01A
0 years, male, white, stage:Stage IS, alive, 2585 days
43.6
TCGA-2G-AAKH-01A
0 years, male, white, stage:Stage II, alive, 6862 days
43.6
TCGA-2G-AAGA-01A
0 years, male, white, stage:Stage IIA, alive, 2439 days
42.5
TCGA-4K-AA1H-01A
0 years, male, white, stage:Stage IA, alive, 518 days
42.5
TCGA-2G-AAHP-01A
0 years, male, white, stage:Stage IS, alive, 5667 days
42.5
TCGA-2G-AAH3-01A
0 years, male, white, stage:Stage I, alive, 1822 days
39.6
TCGA-2G-AAGJ-01A
0 years, male, black or african american, stage:Stage IA, alive, 2938 days
39.2
TCGA-VF-A8AD-01A
0 years, male, white, stage:Stage IB, alive, 1006 days
38.6
TCGA-S6-A8JX-01A
0 years, male, white, stage:Stage IB, alive, 552 days
36.4
TCGA-2G-AAFN-01A
0 years, male, white, stage:Stage IIIB, alive, 773 days
35.2
TCGA-2G-AAFL-01A
0 years, male, white, stage:Stage IB, alive, 750 days
32.3
TCGA-VF-A8A8-01A
0 years, male, white, stage:Stage IA, alive, 1131 days
32.3
TCGA-2G-AAG0-01A
0 years, male, white, stage:Stage IS, alive, 1529 days
31.6
TCGA-XE-A9SE-01A
0 years, male, white, stage:Stage IA, alive, 708 days
31.4
TCGA-XE-AANR-01A
0 years, male, white, stage:Stage I, alive, 14 days
30.4
TCGA-2G-AAG8-01A
0 years, male, white, stage:Stage IB, alive, 2289 days
29.2
TCGA-2X-A9D6-01A
0 years, male, white, stage:Stage I, alive, 607 days
27.7
TCGA-XY-A8S2-01A
0 years, male, white, stage:Stage I, alive, 672 days
27.5
TCGA-XE-AAOD-01A
0 years, male, white, stage:Stage IB, alive, 2058 days
27.3
TCGA-2G-AAGN-01A
0 years, male, white, stage:Stage IIIB, alive, 3656 days
26.7
TCGA-WZ-A7V5-01A
0 years, male, white, stage:Stage I, alive, 1061 days
24.7
TCGA-ZM-AA0H-01A
0 years, male, white, stage:Stage IS, alive, 1736 days
23.8
TCGA-2G-AAH8-01A
0 years, male, white, stage:Stage IIIC, alive, 2248 days
23.5
TCGA-2G-AAKM-01A
0 years, male, white, stage:Stage II, dead, 6972 days
22.7
TCGA-ZM-AA0F-01A
0 years, male, white, stage:Stage IA, alive, 681 days
22.2
TCGA-XE-AAO3-01A
0 years, male, asian, stage:Stage I, alive, 2857 days
21.7
TCGA-W4-A7U2-01A
0 years, male, white, stage:'--, alive, 1263 days
21.5
TCGA-VF-A8AC-01A
0 years, male, white, stage:Stage IA, alive, 1083 days
19.9
TCGA-2G-AAGO-01A
0 years, male, white, stage:Stage IS, alive, 4026 days
19.5
TCGA-2G-AAFH-01A
0 years, male, white, stage:Stage IIB, alive, 1375 days
18.7
TCGA-4K-AA1I-01A
0 years, male, white, stage:Stage IA, alive, 3 days
18.5
TCGA-YU-A90Q-01A
0 years, male, stage:Stage IB, alive, 1964 days
17.8
TCGA-YU-A912-01A
0 years, male, black or african american, stage:Stage IIIC, alive, 866 days
17.4
TCGA-ZM-AA06-01A
0 years, male, white, stage:Stage IB, alive, 1498 days
17.2
TCGA-XE-AANJ-01A
0 years, male, white, stage:Stage IS, alive, 2007 days
16.6
TCGA-2G-AAG9-01A
0 years, male, white, stage:Stage IIIB, alive, 2234 days
15.8
TCGA-VF-A8A9-01A
0 years, male, white, stage:Stage IA, alive, 1119 days
15.5
TCGA-ZM-AA0D-01A
0 years, male, white, stage:Stage IA, alive, 848 days
15.3
TCGA-ZM-AA05-01A
0 years, male, white, stage:Stage IIC, alive, 1126 days
14.6
TCGA-XE-AAOF-01A
0 years, male, asian, stage:Stage IA, alive, 1268 days
14.4
TCGA-XE-AAO4-01A
0 years, male, white, stage:Stage IA, alive, 367 days
14.4
TCGA-WZ-A7V3-01A
0 years, male, white, stage:Stage I, alive, 753 days
13.9
TCGA-2G-AAHL-01A
0 years, male, white, stage:Stage I, alive, 7081 days
13.7
TCGA-VF-A8AE-01A
0 years, male, white, stage:Stage IA, alive, 727 days
12.7
TCGA-VF-A8AA-01A
0 years, male, white, stage:Stage I, alive, 1146 days
12.4
TCGA-2G-AAL7-01A
0 years, male, white, stage:Stage IS, alive, 3991 days
12.4
TCGA-SO-A8JP-01A
0 years, male, white, stage:Stage I, alive, 540 days
12.3
TCGA-2G-AAEX-01A
0 years, male, white, stage:Stage IS, alive, 1259 days
11.8
TCGA-ZM-AA0B-01A
0 years, male, white, stage:Stage IA, alive, 838 days
11.2
TCGA-XE-A8H4-01A
0 years, male, white, stage:Stage IA, alive, 559 days
11.0
TCGA-4K-AA1G-01A
0 years, male, white, stage:Stage IS, alive, 436 days
10.9
TCGA-2X-A9D5-01A
0 years, male, white, stage:Stage I, alive, 435 days
10.8
TCGA-ZM-AA0E-01A
0 years, male, white, stage:Stage IA, alive, 811 days
10.7
TCGA-VF-A8AB-01A
0 years, male, black or african american, stage:Stage IA, alive, 760 days
10.4
TCGA-2G-AAFG-01A
0 years, male, white, stage:Stage IS, alive, 6183 days
9.9
TCGA-XE-AANV-01A
0 years, male, stage:Stage IB, alive, 1701 days
9.8
TCGA-ZM-AA0N-01A
0 years, male, white, stage:Stage IB, alive, 634 days
9.6
TCGA-2G-AAHN-01A
0 years, male, white, stage:Stage I, alive, 6445 days
9.5
TCGA-2G-AAFE-01A
0 years, male, white, stage:Stage IIA, alive, 4702 days
9.4
TCGA-2G-AAF1-01A
0 years, male, asian, stage:Stage IS, alive, 1403 days
9.4
TCGA-SN-A6IS-01A
0 years, male, white, stage:Stage IS, alive, 496 days
9.3
TCGA-YU-A90S-01A
0 years, male, white, stage:Stage IA, alive, 971 days
9.1
TCGA-S6-A8JW-01A
0 years, male, white, stage:Stage IS, alive, 698 days
8.9
TCGA-2G-AAHC-01A
0 years, male, white, stage:Stage IS, alive, 5539 days
8.9
TCGA-2G-AAH0-01A
0 years, male, white, stage:Stage IS, alive, 5477 days
8.8
TCGA-2G-AAHT-01A
0 years, male, white, stage:Stage IS, alive, 542 days
8.8
TCGA-2G-AAEW-01A
0 years, male, white, stage:Stage IS, dead, 618 days
8.8
TCGA-XE-AAOL-01A
0 years, male, black or african american, stage:Stage I, alive, 13 days
7.8
TCGA-XY-A89B-01A
0 years, male, white, stage:Stage IA, alive, 471 days
7.6
TCGA-YU-A90W-01A
0 years, male, white, stage:Stage IA, alive, 1113 days
7.3
TCGA-2G-AAHA-01A
0 years, male, white, stage:Stage IB, alive, 3349 days
7.2
TCGA-2G-AAF4-01A
0 years, male, white, stage:Stage I, alive, 2315 days
6.9
TCGA-WZ-A8D5-01A
0 years, male, white, stage:'--, alive, 774 days
6.9
TCGA-S6-A8JY-01A
0 years, male, white, stage:Stage IS, alive, 278 days
6.8
TCGA-2G-AAHG-01A
0 years, male, white, stage:Stage I, alive, 1819 days
5.6
TCGA-XE-AAO6-01A
0 years, male, white, stage:Stage IA, alive, 240 days
5.3
TCGA-WZ-A7V4-01A
0 years, male, white, stage:Stage I, alive, 894 days
5.1
TCGA-2G-AAF6-01A
0 years, male, white, stage:Stage IS, alive, 3491 days
4.4
TCGA-XE-A8H5-01A
0 years, male, stage:Stage IS, alive, 1217 days
4.4
TCGA-SB-A6J6-01A
0 years, male, white, stage:Stage IA, alive, 413 days
2.8
TCGA-XY-A9T9-01A
0 years, male, white, stage:Stage IS, alive, 281 days
1.9
TCGA-SB-A76C-01A
0 years, male, white, stage:'--, alive, 42 days
0.0
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TESTIS CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
The Human Protein Atlas project is funded
