Single cell type - DGKQ - The Human Protein Atlas

DGKQ

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DGKQ
Gene descriptionⁱ Full gene name according to HGNC.	Diacylglycerol kinase theta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal goblet cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Distal enterocytes, Proximal enterocytes, Intestinal goblet cells, Paneth cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.57
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Proximal enterocytes, Intestinal goblet cells, Paneth cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DGKQ is part of cluster 16 Intestinal goblet cells - Mucin production with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ANO9	Anoctamin 9	0.6079	16
CAPN15	Calpain 15	0.5883	33
MAMDC4	MAM domain containing 4	0.5600	16
CAPN5	Calpain 5	0.5599	16
SLC10A5	Solute carrier family 10 member 5	0.5556	16
DISP2	Dispatched RND transporter family member 2	0.5487	16
IL17RE	Interleukin 17 receptor E	0.5359	16
FAM83E	Family with sequence similarity 83 member E	0.5207	16
MIGA2	Mitoguardin 2	0.5195	57
GPR153	G protein-coupled receptor 153	0.5192	16
TBX10	T-box transcription factor 10	0.5151	16
OSBPL7	Oxysterol binding protein like 7	0.5144	46
HEPH	Hephaestin	0.5137	16
B3GALT5	Beta-1,3-galactosyltransferase 5	0.5133	16
MUC13	Mucin 13, cell surface associated	0.5118	16

IMMUNE CELLS

DGKQ is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.99
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AP4E1	Adaptor related protein complex 4 subunit epsilon 1	1.0000	33
ENSG00000285253	Novel protein	0.9762	33
ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	0.9762	33
LZTR1	Leucine zipper like transcription regulator 1	0.9762	33
TCAF1	TRPM8 channel associated factor 1	0.9762	33
HSPH1	Heat shock protein family H (Hsp110) member 1	0.9762	33
IDUA	Alpha-L-iduronidase	0.9762	33
SMC2	Structural maintenance of chromosomes 2	0.9762	33
ZNF71	Zinc finger protein 71	0.9762	33
WDCP	WD repeat and coiled coil containing	0.9762	33
NME7	NME/NM23 family member 7	0.9762	33
NUP54	Nucleoporin 54	0.9524	33
GBP4	Guanylate binding protein 4	0.9524	33
FUBP1	Far upstream element binding protein 1	0.9524	33
PPP2R5E	Protein phosphatase 2 regulatory subunit B'epsilon	0.9524	33

Adipocytes	4.3 nTPM
Adipose tissue	5.3 nTPM
Breast	3.3 nTPM

Alveolar cells type 1	3.7 nTPM
Lung	3.7 nTPM

Alveolar cells type 2	3.8 nTPM
Lung	3.8 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	2.9 nTPM
Thymus	8.4 nTPM
Salivary gland	7.1 nTPM
Adipose tissue	6.6 nTPM
Lung	5.4 nTPM
Lymph node	3.0 nTPM
Spleen	2.2 nTPM
Skin	1.7 nTPM
Stomach	1.7 nTPM
Bone marrow	1.4 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	3.6 nTPM
Lung	4.9 nTPM
Bronchus	4.7 nTPM
Fallopian tube	2.9 nTPM
Endometrium	2.0 nTPM

Club cells	5.3 nTPM
Prostate	7.2 nTPM
Bronchus	4.9 nTPM
Lung	3.9 nTPM

Endothelial cells	3.0 nTPM
Thymus	5.1 nTPM
Tongue	4.6 nTPM
Vascular	4.6 nTPM
Endometrium	4.5 nTPM
Lung	4.5 nTPM
Liver	3.8 nTPM
Prostate	3.6 nTPM
Salivary gland	3.6 nTPM
Breast	3.5 nTPM
Placenta	2.8 nTPM
Ovary	2.7 nTPM
Esophagus	2.6 nTPM
Fallopian tube	2.6 nTPM
Testis	2.1 nTPM
Heart muscle	1.3 nTPM
Skin	1.2 nTPM
Skeletal muscle	0.9 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	9.7 nTPM
Colon	13.7 nTPM
Small intestine	10.3 nTPM
Rectum	5.0 nTPM

Fibroblasts	2.4 nTPM
Lung	4.4 nTPM
Adipose tissue	4.1 nTPM
Prostate	4.0 nTPM
Thymus	3.7 nTPM
Salivary gland	3.5 nTPM
Vascular	3.2 nTPM
Breast	2.9 nTPM
Skeletal muscle	2.7 nTPM
Fallopian tube	2.2 nTPM
Skin	2.0 nTPM
Pancreas	1.9 nTPM
Esophagus	1.6 nTPM
Liver	1.2 nTPM
Heart muscle	0.2 nTPM
Placenta	0.2 nTPM
Stomach	0.0 nTPM

Granulocytes	4.5 nTPM
Lung	7.1 nTPM
Tongue	4.9 nTPM
Fallopian tube	1.7 nTPM

Intestinal goblet cells	25.6 nTPM
Small intestine	45.9 nTPM
Colon	16.2 nTPM
Rectum	14.7 nTPM

Lymphatic endothelial cells	4.1 nTPM
Ovary	5.5 nTPM
Fallopian tube	2.8 nTPM

Macrophages	4.6 nTPM
Lung	10.4 nTPM
Stomach	7.7 nTPM
Salivary gland	7.7 nTPM
Spleen	7.0 nTPM
Breast	6.0 nTPM
Thymus	5.6 nTPM
Tongue	5.1 nTPM
Adipose tissue	5.0 nTPM
Skeletal muscle	4.9 nTPM
Vascular	4.8 nTPM
Testis	4.3 nTPM
Esophagus	3.9 nTPM
Endometrium	3.7 nTPM
Prostate	3.2 nTPM
Fallopian tube	2.9 nTPM
Skin	2.2 nTPM
Pancreas	2.1 nTPM
Bone marrow	1.0 nTPM
Kidney	0.9 nTPM

Paneth cells	24.0 nTPM
Small intestine	41.4 nTPM
Rectum	19.7 nTPM
Colon	10.9 nTPM

Basal prostatic cells	3.4 nTPM
Prostate	3.4 nTPM

Cytotrophoblasts	0.4 nTPM
Placenta	0.4 nTPM

Distal enterocytes	30.6 nTPM
Colon	38.5 nTPM
Rectum	22.7 nTPM

Early spermatids	0.6 nTPM
Testis	0.6 nTPM

Plasma cells	3.0 nTPM
Salivary gland	5.4 nTPM
Esophagus	5.2 nTPM
Thymus	3.5 nTPM
Liver	3.0 nTPM
Fallopian tube	2.6 nTPM
Stomach	1.7 nTPM
Bone marrow	1.5 nTPM
Spleen	1.0 nTPM

Schwann cells	2.2 nTPM
Adipose tissue	3.9 nTPM
Vascular	2.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.0 nTPM
Tongue	4.4 nTPM
Salivary gland	3.5 nTPM

Smooth muscle cells	2.7 nTPM
Tongue	4.5 nTPM
Thymus	3.6 nTPM
Placenta	3.5 nTPM
Salivary gland	3.5 nTPM
Breast	3.4 nTPM
Endometrium	3.3 nTPM
Vascular	3.3 nTPM
Liver	3.0 nTPM
Esophagus	2.4 nTPM
Lung	2.4 nTPM
Prostate	2.4 nTPM
Skeletal muscle	2.1 nTPM
Adipose tissue	1.8 nTPM
Ovary	1.4 nTPM
Skin	1.1 nTPM
Fallopian tube	1.0 nTPM

T-cells	6.9 nTPM
Breast	11.5 nTPM
Adipose tissue	11.4 nTPM
Thymus	10.2 nTPM
Salivary gland	10.1 nTPM
Vascular	9.6 nTPM
Lung	9.5 nTPM
Tongue	8.8 nTPM
Liver	8.4 nTPM
Skeletal muscle	8.3 nTPM
Kidney	7.1 nTPM
Endometrium	7.0 nTPM
Fallopian tube	6.0 nTPM
Spleen	5.7 nTPM
PBMC	5.6 nTPM
Bone marrow	5.2 nTPM
Colon	4.9 nTPM
Lymph node	4.5 nTPM
Prostate	4.1 nTPM
Skin	3.5 nTPM
Stomach	2.8 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	9.1 nTPM
Small intestine	11.4 nTPM
Rectum	8.7 nTPM
Colon	7.1 nTPM

Amygdala excitatory	24.4 nTPM
Hippocampus	26.6 nTPM
Thalamus	25.9 nTPM
Basal ganglia	24.4 nTPM
Amygdala	23.7 nTPM
Cerebral cortex	23.7 nTPM
Hypothalamus	21.9 nTPM

Astrocyte	14.3 nTPM
Cerebellum	20.1 nTPM
Hippocampus	16.6 nTPM
Midbrain	15.7 nTPM
Spinal cord	15.7 nTPM
Pons	15.5 nTPM
Cerebral cortex	15.2 nTPM
Thalamus	15.2 nTPM
Medulla oblongata	12.2 nTPM
Basal ganglia	11.9 nTPM
Amygdala	10.2 nTPM
Hypothalamus	9.1 nTPM

Bergmann glia	9.7 nTPM
Medulla oblongata	12.8 nTPM
Cerebellum	9.1 nTPM
Pons	7.2 nTPM

Central nervous system macrophage	9.4 nTPM
Hippocampus	11.8 nTPM
Cerebellum	11.3 nTPM
Thalamus	10.5 nTPM
Midbrain	10.3 nTPM
Basal ganglia	9.8 nTPM
Cerebral cortex	9.7 nTPM
Amygdala	8.8 nTPM
Hypothalamus	8.3 nTPM
Medulla oblongata	8.0 nTPM
Pons	7.7 nTPM
Spinal cord	7.1 nTPM

Cerebellar inhibitory	8.8 nTPM
Midbrain	13.1 nTPM
Pons	10.4 nTPM
Cerebellum	9.3 nTPM
Medulla oblongata	8.5 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	14.1 nTPM
Hypothalamus	18.2 nTPM
Amygdala	15.4 nTPM
Basal ganglia	15.3 nTPM
Hippocampus	15.3 nTPM
Cerebral cortex	15.2 nTPM
Midbrain	9.6 nTPM
Thalamus	9.6 nTPM

Choroid plexus epithelial cell	8.1 nTPM
Thalamus	11.0 nTPM
Hippocampus	8.3 nTPM
Basal ganglia	6.8 nTPM
Medulla oblongata	6.5 nTPM

Committed oligodendrocyte precursor	11.7 nTPM
Spinal cord	18.4 nTPM
Hypothalamus	15.0 nTPM
Cerebral cortex	13.9 nTPM
Hippocampus	13.7 nTPM
Midbrain	12.6 nTPM
Thalamus	10.4 nTPM
Medulla oblongata	10.3 nTPM
Basal ganglia	9.9 nTPM
Pons	9.7 nTPM
Amygdala	8.5 nTPM
Cerebellum	6.3 nTPM

Deep-layer corticothalamic and 6b	20.3 nTPM
Hippocampus	22.2 nTPM
Amygdala	20.5 nTPM
Hypothalamus	20.0 nTPM
Midbrain	20.0 nTPM
Basal ganglia	19.8 nTPM
Cerebral cortex	19.2 nTPM

Deep-layer intratelencephalic	21.6 nTPM
Hippocampus	23.5 nTPM
Hypothalamus	22.5 nTPM
Amygdala	22.3 nTPM
Basal ganglia	20.8 nTPM
Cerebral cortex	18.8 nTPM

Deep-layer near-projecting	20.8 nTPM
Amygdala	27.8 nTPM
Hypothalamus	22.5 nTPM
Cerebral cortex	20.2 nTPM
Basal ganglia	17.6 nTPM
Hippocampus	15.9 nTPM

Eccentric medium spiny neuron	18.0 nTPM
Thalamus	19.2 nTPM
Amygdala	19.1 nTPM
Cerebral cortex	17.8 nTPM
Basal ganglia	17.6 nTPM
Hypothalamus	17.2 nTPM
Hippocampus	17.0 nTPM

Endothelial cell	7.3 nTPM
Spinal cord	12.1 nTPM
Hypothalamus	11.2 nTPM
Hippocampus	10.3 nTPM
Cerebellum	8.5 nTPM
Cerebral cortex	8.3 nTPM
Amygdala	5.6 nTPM
Basal ganglia	5.6 nTPM
Thalamus	5.1 nTPM
Pons	5.0 nTPM
Midbrain	4.7 nTPM
Medulla oblongata	4.1 nTPM

Ependymal cell	6.9 nTPM
Spinal cord	13.4 nTPM
Hippocampus	7.8 nTPM
Hypothalamus	7.1 nTPM
Amygdala	6.3 nTPM
Midbrain	6.3 nTPM
Pons	6.3 nTPM
Basal ganglia	5.7 nTPM
Thalamus	4.5 nTPM
Medulla oblongata	4.4 nTPM