Single cell type - EVI5L - The Human Protein Atlas

EVI5L

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EVI5L
Gene descriptionⁱ Full gene name according to HGNC.	Ecotropic viral integration site 5 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Horizontal cells, Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.61
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (non-classical monocyte)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Horizontal cells, Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (non-classical monocyte)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

EVI5L is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.5480	76
SCD5	Stearoyl-CoA desaturase 5	0.5306	76
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.5155	51
NCKAP5	NCK associated protein 5	0.5118	51
VSTM2B	V-set and transmembrane domain containing 2B	0.4980	51
EPN2	Epsin 2	0.4917	76
TANC1	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	0.4651	76
ATG10	Autophagy related 10	0.4651	4
CADM1	Cell adhesion molecule 1	0.4591	47
KCNH8	Potassium voltage-gated channel subfamily H member 8	0.4559	51
APBB2	Amyloid beta precursor protein binding family B member 2	0.4513	51
TRIM62	Tripartite motif containing 62	0.4498	76
CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5	0.4493	71
CSPG5	Chondroitin sulfate proteoglycan 5	0.4481	76
EDIL3	EGF like repeats and discoidin domains 3	0.4475	51

Adipocytes	3.5 nTPM
Breast	4.3 nTPM
Adipose tissue	2.8 nTPM

Alveolar cells type 1	8.7 nTPM
Lung	8.7 nTPM

Alveolar cells type 2	5.9 nTPM
Lung	5.9 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	2.4 nTPM
Esophagus	5.9 nTPM
Lung	5.4 nTPM
Kidney	5.2 nTPM
Thymus	4.0 nTPM
Bone marrow	3.5 nTPM
Salivary gland	2.9 nTPM
PBMC	1.5 nTPM
Lymph node	0.9 nTPM
Adipose tissue	0.8 nTPM
Spleen	0.4 nTPM
Stomach	0.4 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM

Ciliated cells	3.0 nTPM
Bronchus	4.2 nTPM
Lung	3.1 nTPM
Endometrium	2.6 nTPM
Fallopian tube	2.2 nTPM

Club cells	4.6 nTPM
Lung	5.6 nTPM
Bronchus	4.2 nTPM
Prostate	4.0 nTPM

Endothelial cells	3.7 nTPM
Tongue	6.7 nTPM
Liver	6.3 nTPM
Lung	5.9 nTPM
Testis	5.8 nTPM
Placenta	5.7 nTPM
Ovary	4.8 nTPM
Thymus	4.5 nTPM
Vascular	4.3 nTPM
Esophagus	3.9 nTPM
Endometrium	3.6 nTPM
Fallopian tube	3.1 nTPM
Skeletal muscle	2.8 nTPM
Skin	2.7 nTPM
Prostate	2.4 nTPM
Salivary gland	2.2 nTPM
Breast	0.9 nTPM
Heart muscle	0.1 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	6.7 nTPM
Rectum	10.1 nTPM
Small intestine	6.9 nTPM
Colon	3.3 nTPM

Fibroblasts	2.7 nTPM
Liver	5.9 nTPM
Thymus	4.4 nTPM
Breast	3.9 nTPM
Pancreas	3.8 nTPM
Vascular	3.1 nTPM
Fallopian tube	3.0 nTPM
Placenta	2.8 nTPM
Salivary gland	2.7 nTPM
Lung	2.6 nTPM
Prostate	2.6 nTPM
Skin	2.5 nTPM
Skeletal muscle	2.1 nTPM
Adipose tissue	2.1 nTPM
Esophagus	1.7 nTPM
Heart muscle	0.7 nTPM
Stomach	0.0 nTPM

Granulocytes	2.2 nTPM
Lung	4.0 nTPM
Fallopian tube	2.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	4.4 nTPM
Small intestine	6.2 nTPM
Colon	3.4 nTPM
Rectum	3.4 nTPM

Lymphatic endothelial cells	3.8 nTPM
Ovary	5.5 nTPM
Fallopian tube	2.2 nTPM

Macrophages	3.1 nTPM
Thymus	5.1 nTPM
Tongue	4.7 nTPM
Kidney	4.4 nTPM
Bone marrow	4.1 nTPM
Esophagus	3.9 nTPM
Lung	3.9 nTPM
Breast	3.5 nTPM
Skin	3.3 nTPM
Skeletal muscle	3.2 nTPM
Fallopian tube	3.1 nTPM
Adipose tissue	3.0 nTPM
Spleen	3.0 nTPM
Prostate	2.9 nTPM
Salivary gland	2.8 nTPM
Vascular	2.8 nTPM
Pancreas	2.1 nTPM
Endometrium	1.8 nTPM
Testis	1.2 nTPM
Stomach	0.0 nTPM

Paneth cells	3.3 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM
Rectum	2.9 nTPM

Basal squamous epithelial cells	1.6 nTPM
Esophagus	1.6 nTPM

Bipolar cells	26.1 nTPM
Eye	26.1 nTPM

Collecting duct cells	9.7 nTPM
Kidney	9.7 nTPM

Cone photoreceptor cells	17.0 nTPM
Eye	17.0 nTPM

Plasma cells	3.1 nTPM
Thymus	7.1 nTPM
Esophagus	5.2 nTPM
Salivary gland	4.9 nTPM
Liver	3.0 nTPM
Fallopian tube	1.9 nTPM
Spleen	1.4 nTPM
Stomach	1.3 nTPM
Bone marrow	0.0 nTPM

Schwann cells	1.5 nTPM
Adipose tissue	2.3 nTPM
Vascular	2.1 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.7 nTPM
Salivary gland	3.3 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	4.4 nTPM
Thymus	8.3 nTPM
Skeletal muscle	6.1 nTPM
Lung	5.9 nTPM
Vascular	5.4 nTPM
Placenta	5.3 nTPM
Adipose tissue	5.3 nTPM
Skin	4.6 nTPM
Endometrium	4.5 nTPM
Breast	4.3 nTPM
Fallopian tube	4.1 nTPM
Prostate	3.6 nTPM
Tongue	3.6 nTPM
Salivary gland	3.5 nTPM
Ovary	3.2 nTPM
Liver	2.1 nTPM
Esophagus	0.0 nTPM

T-cells	2.5 nTPM
Thymus	5.0 nTPM
Skeletal muscle	4.5 nTPM
Breast	4.3 nTPM
Vascular	3.6 nTPM
Tongue	3.5 nTPM
Lung	3.2 nTPM
Endometrium	3.1 nTPM
PBMC	3.1 nTPM
Kidney	2.7 nTPM
Adipose tissue	2.5 nTPM
Fallopian tube	2.3 nTPM
Bone marrow	2.2 nTPM
Liver	2.1 nTPM
Prostate	2.0 nTPM
Skin	1.8 nTPM
Salivary gland	1.7 nTPM
Stomach	1.4 nTPM
Lymph node	1.3 nTPM
Colon	1.0 nTPM
Spleen	0.8 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	2.6 nTPM
Rectum	2.9 nTPM
Colon	2.7 nTPM
Small intestine	2.2 nTPM

Amygdala excitatory	28.8 nTPM
Hypothalamus	42.2 nTPM
Basal ganglia	28.6 nTPM
Thalamus	27.2 nTPM
Amygdala	26.1 nTPM
Hippocampus	25.9 nTPM
Cerebral cortex	22.8 nTPM

Astrocyte	20.8 nTPM
Cerebellum	26.9 nTPM
Pons	23.1 nTPM
Hippocampus	22.6 nTPM
Amygdala	22.3 nTPM
Thalamus	22.3 nTPM
Midbrain	22.2 nTPM
Cerebral cortex	21.9 nTPM
Medulla oblongata	17.7 nTPM
Spinal cord	17.2 nTPM
Basal ganglia	16.4 nTPM
Hypothalamus	15.8 nTPM

Bergmann glia	15.8 nTPM
Medulla oblongata	17.0 nTPM
Cerebellum	16.0 nTPM
Pons	14.4 nTPM

Central nervous system macrophage	12.0 nTPM
Hippocampus	15.7 nTPM
Cerebral cortex	15.4 nTPM
Cerebellum	12.9 nTPM
Midbrain	12.9 nTPM
Hypothalamus	12.4 nTPM
Thalamus	11.9 nTPM
Pons	11.6 nTPM
Amygdala	10.5 nTPM
Medulla oblongata	10.3 nTPM
Basal ganglia	9.2 nTPM
Spinal cord	9.1 nTPM

Cerebellar inhibitory	28.3 nTPM
Midbrain	35.1 nTPM
Cerebellum	30.9 nTPM
Pons	26.6 nTPM
Spinal cord	24.7 nTPM
Medulla oblongata	24.3 nTPM

Cge interneuron	29.4 nTPM
Hypothalamus	42.8 nTPM
Amygdala	30.6 nTPM
Cerebral cortex	29.5 nTPM
Hippocampus	28.5 nTPM
Basal ganglia	26.3 nTPM
Thalamus	24.3 nTPM
Midbrain	23.9 nTPM

Choroid plexus epithelial cell	22.3 nTPM
Thalamus	32.9 nTPM
Basal ganglia	21.8 nTPM
Hippocampus	19.4 nTPM
Medulla oblongata	14.9 nTPM

Committed oligodendrocyte precursor	83.6 nTPM
Amygdala	135.9 nTPM
Hypothalamus	121.5 nTPM
Thalamus	102.0 nTPM
Hippocampus	100.4 nTPM
Cerebellum	98.3 nTPM
Cerebral cortex	86.8 nTPM
Midbrain	67.2 nTPM
Basal ganglia	60.8 nTPM
Pons	60.2 nTPM
Spinal cord	47.8 nTPM
Medulla oblongata	38.7 nTPM

Deep-layer corticothalamic and 6b	29.3 nTPM
Hypothalamus	38.7 nTPM
Hippocampus	29.7 nTPM
Amygdala	29.5 nTPM
Cerebral cortex	28.6 nTPM
Basal ganglia	25.7 nTPM
Midbrain	23.3 nTPM

Deep-layer intratelencephalic	28.8 nTPM
Hypothalamus	44.7 nTPM
Hippocampus	26.4 nTPM
Amygdala	25.5 nTPM
Cerebral cortex	25.4 nTPM
Basal ganglia	22.0 nTPM

Deep-layer near-projecting	29.1 nTPM
Hypothalamus	36.4 nTPM
Amygdala	33.9 nTPM
Cerebral cortex	29.3 nTPM
Basal ganglia	24.7 nTPM
Hippocampus	21.1 nTPM

Eccentric medium spiny neuron	27.0 nTPM
Thalamus	30.8 nTPM
Hippocampus	28.6 nTPM
Cerebral cortex	26.3 nTPM
Hypothalamus	26.3 nTPM
Amygdala	25.0 nTPM
Basal ganglia	24.7 nTPM

Endothelial cell	9.7 nTPM
Midbrain	16.1 nTPM
Amygdala	13.4 nTPM
Thalamus	11.3 nTPM
Spinal cord	10.4 nTPM
Cerebral cortex	10.2 nTPM
Basal ganglia	9.3 nTPM
Hypothalamus	8.7 nTPM
Hippocampus	8.0 nTPM
Cerebellum	7.7 nTPM
Medulla oblongata	6.2 nTPM
Pons	5.6 nTPM

Ependymal cell	6.6 nTPM
Amygdala	14.2 nTPM
Basal ganglia	8.1 nTPM
Hippocampus	8.0 nTPM
Medulla oblongata	5.9 nTPM
Spinal cord	5.7 nTPM
Pons	4.7 nTPM
Thalamus	4.5 nTPM
Midbrain	4.4 nTPM
Hypothalamus	3.6 nTPM