Single cell type - SQOR - The Human Protein Atlas

SQOR

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SQOR
Gene descriptionⁱ Full gene name according to HGNC.	Sulfide quinone oxidoreductase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Enterocytes - Absorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Distal enterocytes, Basal respiratory cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.51
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Central nervous system macrophage, Leukocyte, Endothelial cell, Vascular associated smooth muscle cell, Fibroblast, Pericyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Basal respiratory cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Central nervous system macrophage, Leukocyte, Endothelial cell, Vascular associated smooth muscle cell, Fibroblast, Pericyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SQOR is part of cluster 5 Enterocytes - Absorption with confidenceⁱ 1
330 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LGALS3	Galectin 3	0.7024	5
ETHE1	ETHE1 persulfide dioxygenase	0.6634	5
C15orf48	Chromosome 15 open reading frame 48	0.6560	45
SIRT6	Sirtuin 6	0.6519	5
ENSG00000284797	Novel protein	0.6433	5
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.6358	5
CASP7	Caspase 7	0.6331	5
MUC12	Mucin 12, cell surface associated	0.6306	5
TMEM171	Transmembrane protein 171	0.6212	5
CLDN7	Claudin 7	0.6204	5
GPR15LG	G protein-coupled receptor 15 ligand	0.6186	5
SULT1A4	Sulfotransferase family 1A member 4	0.6177	5
ST14	ST14 transmembrane serine protease matriptase	0.6137	5
TMEM54	Transmembrane protein 54	0.6083	5
LGALS4	Galectin 4	0.6006	5

IMMUNE CELLS

SQOR is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 1
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CARD16	Caspase recruitment domain family member 16	1.0000	38
TLR5	Toll like receptor 5	1.0000	38
LTA4H	Leukotriene A4 hydrolase	0.9762	38
NUP58	Nucleoporin 58	0.9762	38
HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.9762	38
PRAM1	PML-RARA regulated adaptor molecule 1	0.9762	38
RIN2	Ras and Rab interactor 2	0.9762	38
CFP	Complement factor properdin	0.9762	38
USP4	Ubiquitin specific peptidase 4	0.9762	38
PRLR	Prolactin receptor	0.9762	38
MVP	Major vault protein	0.9762	38
HIPK3	Homeodomain interacting protein kinase 3	0.9762	38
THOC5	THO complex subunit 5	0.9762	38
TOM1	Target of myb1 membrane trafficking protein	0.9762	38
PSEN1	Presenilin 1	0.9762	38

Adipocytes	23.0 nTPM
Breast	25.4 nTPM
Adipose tissue	20.6 nTPM

Alveolar cells type 1	75.9 nTPM
Lung	75.9 nTPM

Alveolar cells type 2	107.8 nTPM
Lung	107.8 nTPM

Astrocytes	2.2 nTPM
Brain	2.2 nTPM

B-cells	19.7 nTPM
PBMC	36.9 nTPM
Skin	30.5 nTPM
Lung	29.5 nTPM
Liver	29.0 nTPM
Kidney	20.8 nTPM
Bone marrow	20.6 nTPM
Spleen	18.5 nTPM
Stomach	15.6 nTPM
Adipose tissue	14.8 nTPM
Salivary gland	13.0 nTPM
Lymph node	11.9 nTPM
Thymus	9.7 nTPM
Esophagus	5.9 nTPM

Ciliated cells	38.8 nTPM
Bronchus	82.9 nTPM
Lung	31.9 nTPM
Fallopian tube	23.5 nTPM
Endometrium	16.7 nTPM

Club cells	69.3 nTPM
Bronchus	133.6 nTPM
Lung	45.6 nTPM
Prostate	28.8 nTPM

Dendritic cells	17.3 nTPM
PBMC	21.6 nTPM
Adipose tissue	13.0 nTPM

Endothelial cells	30.0 nTPM
Pancreas	69.8 nTPM
Breast	48.3 nTPM
Tongue	44.9 nTPM
Lung	39.0 nTPM
Skeletal muscle	38.8 nTPM
Testis	36.0 nTPM
Skin	33.9 nTPM
Salivary gland	29.7 nTPM
Fallopian tube	27.1 nTPM
Prostate	24.3 nTPM
Ovary	23.0 nTPM
Vascular	22.4 nTPM
Heart muscle	20.8 nTPM
Thymus	18.8 nTPM
Placenta	18.2 nTPM
Liver	17.6 nTPM
Esophagus	15.6 nTPM
Endometrium	12.6 nTPM

Enteroendocrine cells	124.7 nTPM
Colon	316.7 nTPM
Rectum	33.5 nTPM
Small intestine	24.0 nTPM

Fibroblasts	25.3 nTPM
Lung	50.5 nTPM
Stomach	38.9 nTPM
Esophagus	37.3 nTPM
Adipose tissue	36.1 nTPM
Liver	33.2 nTPM
Skeletal muscle	29.8 nTPM
Breast	28.7 nTPM
Pancreas	26.2 nTPM
Salivary gland	23.5 nTPM
Heart muscle	22.8 nTPM
Skin	21.3 nTPM
Vascular	18.4 nTPM
Fallopian tube	14.4 nTPM
Thymus	13.3 nTPM
Prostate	8.6 nTPM
Placenta	1.3 nTPM

Granulocytes	20.5 nTPM
Lung	25.2 nTPM
Tongue	24.3 nTPM
Fallopian tube	12.1 nTPM

Intestinal goblet cells	148.8 nTPM
Colon	189.2 nTPM
Rectum	162.1 nTPM
Small intestine	95.0 nTPM

Lymphatic endothelial cells	39.0 nTPM
Fallopian tube	61.7 nTPM
Ovary	16.4 nTPM

Macrophages	82.3 nTPM
Pancreas	392.6 nTPM
Lung	232.3 nTPM
Stomach	90.0 nTPM
Kidney	88.5 nTPM
Spleen	84.2 nTPM
Testis	73.8 nTPM
Skeletal muscle	68.2 nTPM
Adipose tissue	63.4 nTPM
Bone marrow	61.8 nTPM
Fallopian tube	61.2 nTPM
Tongue	48.9 nTPM
Prostate	44.1 nTPM
Breast	43.2 nTPM
Thymus	41.6 nTPM
Salivary gland	40.0 nTPM
Vascular	39.6 nTPM
Skin	37.9 nTPM
Endometrium	32.6 nTPM
Esophagus	20.6 nTPM

Bipolar cells	0.5 nTPM
Eye	0.5 nTPM

Cholangiocytes	36.2 nTPM
Liver	36.2 nTPM

Cone photoreceptor cells	0.0 nTPM
Eye	0.0 nTPM

Cytotrophoblasts	0.4 nTPM
Placenta	0.4 nTPM

Paneth cells	180.3 nTPM
Rectum	217.1 nTPM
Colon	209.9 nTPM
Small intestine	114.0 nTPM

Plasma cells	25.5 nTPM
Liver	36.1 nTPM
Salivary gland	31.8 nTPM
Fallopian tube	29.6 nTPM
Stomach	27.2 nTPM
Spleen	24.3 nTPM
Bone marrow	22.7 nTPM
Esophagus	20.8 nTPM
Thymus	11.5 nTPM

Schwann cells	19.9 nTPM
Adipose tissue	24.2 nTPM
Vascular	23.5 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	47.1 nTPM
Tongue	57.4 nTPM
Salivary gland	36.7 nTPM

Smooth muscle cells	22.6 nTPM
Lung	37.6 nTPM
Liver	36.1 nTPM
Breast	28.9 nTPM
Fallopian tube	28.6 nTPM
Prostate	26.8 nTPM
Skin	26.7 nTPM
Tongue	24.8 nTPM
Vascular	24.6 nTPM
Ovary	24.0 nTPM
Salivary gland	22.0 nTPM
Skeletal muscle	20.2 nTPM
Placenta	16.3 nTPM
Esophagus	14.4 nTPM
Adipose tissue	13.1 nTPM
Thymus	12.8 nTPM
Endometrium	5.2 nTPM

Suprabasal keratinocytes	95.1 nTPM
Tongue	153.9 nTPM
Skin	36.3 nTPM

T-cells	29.6 nTPM
Kidney	55.9 nTPM
Liver	55.9 nTPM
Skin	44.9 nTPM
Lung	38.9 nTPM
Tongue	37.2 nTPM
Breast	36.9 nTPM
Bone marrow	34.6 nTPM
PBMC	33.8 nTPM
Fallopian tube	33.4 nTPM
Adipose tissue	30.2 nTPM
Spleen	28.6 nTPM
Stomach	28.5 nTPM
Colon	25.3 nTPM
Skeletal muscle	21.5 nTPM
Esophagus	19.5 nTPM
Thymus	17.9 nTPM
Lymph node	17.4 nTPM
Prostate	17.3 nTPM
Endometrium	15.1 nTPM
Salivary gland	15.1 nTPM
Vascular	13.7 nTPM

Undifferentiated cells	158.1 nTPM
Colon	231.8 nTPM
Rectum	177.8 nTPM
Small intestine	64.7 nTPM

Amygdala excitatory	1.3 nTPM
Hypothalamus	1.9 nTPM
Amygdala	1.6 nTPM
Cerebral cortex	1.5 nTPM
Hippocampus	1.5 nTPM
Thalamus	0.9 nTPM
Basal ganglia	0.3 nTPM

Astrocyte	4.1 nTPM
Amygdala	7.6 nTPM
Thalamus	5.2 nTPM
Midbrain	5.1 nTPM
Basal ganglia	4.7 nTPM
Hippocampus	4.7 nTPM
Cerebral cortex	3.9 nTPM
Hypothalamus	3.6 nTPM
Spinal cord	2.6 nTPM
Medulla oblongata	2.5 nTPM
Pons	2.4 nTPM
Cerebellum	2.2 nTPM

Bergmann glia	2.3 nTPM
Cerebellum	4.9 nTPM
Medulla oblongata	2.1 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	53.3 nTPM
Cerebellum	63.9 nTPM
Amygdala	55.9 nTPM
Hypothalamus	55.9 nTPM
Midbrain	55.9 nTPM
Basal ganglia	55.4 nTPM
Medulla oblongata	53.7 nTPM
Thalamus	51.9 nTPM
Cerebral cortex	50.7 nTPM
Pons	50.3 nTPM
Hippocampus	48.2 nTPM
Spinal cord	44.2 nTPM

Cerebellar inhibitory	1.2 nTPM
Spinal cord	2.7 nTPM
Medulla oblongata	1.3 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.7 nTPM
Pons	0.4 nTPM

Cge interneuron	0.8 nTPM
Hypothalamus	1.0 nTPM
Midbrain	1.0 nTPM
Amygdala	0.8 nTPM
Hippocampus	0.8 nTPM
Basal ganglia	0.7 nTPM
Cerebral cortex	0.6 nTPM
Thalamus	0.6 nTPM

Choroid plexus epithelial cell	4.2 nTPM
Basal ganglia	7.9 nTPM
Medulla oblongata	6.2 nTPM
Thalamus	2.7 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	3.1 nTPM
Hippocampus	7.2 nTPM
Basal ganglia	5.5 nTPM
Cerebral cortex	5.1 nTPM
Thalamus	3.4 nTPM
Cerebellum	3.2 nTPM
Pons	2.7 nTPM
Medulla oblongata	2.6 nTPM
Amygdala	1.7 nTPM
Midbrain	1.7 nTPM
Hypothalamus	1.4 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.8 nTPM
Hypothalamus	1.3 nTPM
Hippocampus	1.0 nTPM
Amygdala	0.8 nTPM
Cerebral cortex	0.8 nTPM
Basal ganglia	0.5 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	1.5 nTPM
Hippocampus	1.9 nTPM
Hypothalamus	1.8 nTPM
Amygdala	1.5 nTPM
Basal ganglia	1.4 nTPM
Cerebral cortex	1.2 nTPM

Deep-layer near-projecting	0.5 nTPM
Hypothalamus	1.1 nTPM
Basal ganglia	0.6 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.0 nTPM

Eccentric medium spiny neuron	0.7 nTPM
Thalamus	1.0 nTPM
Amygdala	0.9 nTPM
Cerebral cortex	0.7 nTPM
Hypothalamus	0.6 nTPM
Basal ganglia	0.5 nTPM
Hippocampus	0.4 nTPM