Single cell type - SLCO2B1 - The Human Protein Atlas

SLCO2B1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLCO2B1
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier organic anion transporter family member 2B1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Microglial cells, Hepatocytes, Kupffer cells, Hofbauer cells, Macrophages, Lymphatic endothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.75
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Central nervous system macrophage, Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Microglial cells, Hepatocytes, Kupffer cells, Hofbauer cells, Macrophages, Lymphatic endothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Central nervous system macrophage, Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLCO2B1 is part of cluster 58 Macrophages - Innate immune response with confidenceⁱ 1
420 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MS4A4A	Membrane spanning 4-domains A4A	0.8150	58
SIGLEC1	Sialic acid binding Ig like lectin 1	0.8123	58
MRC1	Mannose receptor C-type 1	0.7998	58
C1QA	Complement C1q A chain	0.7977	58
C1QB	Complement C1q B chain	0.7937	58
VSIG4	V-set and immunoglobulin domain containing 4	0.7803	58
C1QC	Complement C1q C chain	0.7499	58
LYVE1	Lymphatic vessel endothelial hyaluronan receptor 1	0.7339	58
LILRB5	Leukocyte immunoglobulin like receptor B5	0.7152	58
GPR34	G protein-coupled receptor 34	0.7021	58
GSDMA	Gasdermin A	0.7011	58
CD163	CD163 molecule	0.7009	58
MSR1	Macrophage scavenger receptor 1	0.6984	58
HFE	Homeostatic iron regulator	0.6907	58
FOLR2	Folate receptor beta	0.6830	58

Adipocytes	4.9 nTPM
Breast	6.2 nTPM
Adipose tissue	3.6 nTPM

Alveolar cells type 1	2.1 nTPM
Lung	2.1 nTPM

Alveolar cells type 2	1.6 nTPM
Lung	1.6 nTPM

Astrocytes	1.2 nTPM
Brain	1.2 nTPM

B-cells	1.8 nTPM
Liver	14.5 nTPM
Lung	5.4 nTPM
Skin	1.7 nTPM
Salivary gland	0.8 nTPM
Thymus	0.7 nTPM
Lymph node	0.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	2.8 nTPM
Lung	9.3 nTPM
Fallopian tube	1.7 nTPM
Endometrium	0.1 nTPM
Bronchus	0.0 nTPM

Club cells	4.0 nTPM
Lung	11.4 nTPM
Prostate	0.5 nTPM
Bronchus	0.0 nTPM

Endothelial cells	24.8 nTPM
Ovary	96.9 nTPM
Breast	66.8 nTPM
Testis	64.4 nTPM
Liver	54.2 nTPM
Fallopian tube	28.8 nTPM
Esophagus	22.1 nTPM
Skeletal muscle	21.0 nTPM
Lung	20.6 nTPM
Skin	16.8 nTPM
Salivary gland	14.9 nTPM
Tongue	12.6 nTPM
Vascular	7.8 nTPM
Heart muscle	5.2 nTPM
Placenta	5.1 nTPM
Prostate	4.3 nTPM
Endometrium	2.7 nTPM
Thymus	2.7 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	9.1 nTPM
Small intestine	17.2 nTPM
Colon	8.6 nTPM
Rectum	1.7 nTPM

Fibroblasts	2.5 nTPM
Vascular	9.1 nTPM
Skin	5.8 nTPM
Skeletal muscle	4.5 nTPM
Salivary gland	4.5 nTPM
Lung	4.4 nTPM
Placenta	1.5 nTPM
Stomach	1.4 nTPM
Heart muscle	1.3 nTPM
Prostate	1.3 nTPM
Liver	1.2 nTPM
Thymus	1.2 nTPM
Esophagus	1.0 nTPM
Breast	0.8 nTPM
Fallopian tube	0.7 nTPM
Adipose tissue	0.3 nTPM
Pancreas	0.2 nTPM

Granulocytes	16.2 nTPM
Lung	31.8 nTPM
Fallopian tube	16.9 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	3.5 nTPM
Small intestine	6.3 nTPM
Rectum	2.3 nTPM
Colon	2.0 nTPM

Lymphatic endothelial cells	69.3 nTPM
Fallopian tube	89.4 nTPM
Ovary	49.1 nTPM

Macrophages	104.1 nTPM
Vascular	253.6 nTPM
Lung	219.4 nTPM
Prostate	199.2 nTPM
Thymus	177.3 nTPM
Salivary gland	153.1 nTPM
Esophagus	118.2 nTPM
Fallopian tube	115.9 nTPM
Breast	112.3 nTPM
Pancreas	96.6 nTPM
Tongue	89.1 nTPM
Adipose tissue	88.9 nTPM
Testis	88.7 nTPM
Skin	82.5 nTPM
Skeletal muscle	43.3 nTPM
Stomach	33.4 nTPM
Endometrium	29.5 nTPM
Bone marrow	28.4 nTPM
Spleen	26.1 nTPM
Kidney	23.0 nTPM

Paneth cells	18.2 nTPM
Small intestine	27.6 nTPM
Rectum	23.3 nTPM
Colon	3.6 nTPM

Basal prostatic cells	1.9 nTPM
Prostate	1.9 nTPM

Basal squamous epithelial cells	0.9 nTPM
Esophagus	0.9 nTPM

Plasma cells	3.5 nTPM
Liver	20.0 nTPM
Esophagus	5.2 nTPM
Salivary gland	1.8 nTPM
Thymus	0.6 nTPM
Stomach	0.4 nTPM
Fallopian tube	0.3 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	1.0 nTPM
Vascular	3.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.2 nTPM
Salivary gland	4.4 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.7 nTPM
Lung	12.9 nTPM
Liver	3.8 nTPM
Vascular	3.7 nTPM
Skeletal muscle	3.6 nTPM
Salivary gland	3.2 nTPM
Prostate	3.0 nTPM
Tongue	3.0 nTPM
Esophagus	2.4 nTPM
Skin	1.6 nTPM
Thymus	1.6 nTPM
Breast	1.4 nTPM
Placenta	1.2 nTPM
Fallopian tube	0.9 nTPM
Ovary	0.9 nTPM
Adipose tissue	0.2 nTPM
Endometrium	0.0 nTPM

T-cells	1.2 nTPM
Lung	6.6 nTPM
Colon	4.9 nTPM
Vascular	4.0 nTPM
Tongue	2.3 nTPM
Skin	1.8 nTPM
Skeletal muscle	1.1 nTPM
Prostate	1.0 nTPM
Liver	0.8 nTPM
Salivary gland	0.6 nTPM
Thymus	0.5 nTPM
Fallopian tube	0.4 nTPM
Stomach	0.3 nTPM
Breast	0.3 nTPM
Adipose tissue	0.1 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	8.9 nTPM
Small intestine	20.8 nTPM
Rectum	4.1 nTPM
Colon	1.8 nTPM

Amygdala excitatory	4.5 nTPM
Hypothalamus	5.0 nTPM
Hippocampus	4.7 nTPM
Cerebral cortex	4.5 nTPM
Thalamus	4.5 nTPM
Amygdala	4.2 nTPM
Basal ganglia	3.9 nTPM

Astrocyte	2.0 nTPM
Spinal cord	3.7 nTPM
Basal ganglia	2.4 nTPM
Hippocampus	2.3 nTPM
Pons	2.2 nTPM
Midbrain	2.1 nTPM
Cerebellum	2.0 nTPM
Amygdala	1.9 nTPM
Medulla oblongata	1.6 nTPM
Cerebral cortex	1.3 nTPM
Hypothalamus	1.1 nTPM
Thalamus	0.9 nTPM

Bergmann glia	1.1 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	1.3 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	847.1 nTPM
Amygdala	1104.8 nTPM
Hippocampus	958.6 nTPM
Cerebral cortex	947.0 nTPM
Midbrain	880.3 nTPM
Thalamus	867.1 nTPM
Hypothalamus	834.9 nTPM
Cerebellum	814.0 nTPM
Basal ganglia	784.0 nTPM
Pons	781.9 nTPM
Medulla oblongata	688.9 nTPM
Spinal cord	656.5 nTPM

Cerebellar inhibitory	1.1 nTPM
Midbrain	1.9 nTPM
Cerebellum	1.8 nTPM
Medulla oblongata	1.1 nTPM
Pons	0.8 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	2.3 nTPM
Hypothalamus	2.7 nTPM
Amygdala	2.6 nTPM
Midbrain	2.6 nTPM
Basal ganglia	2.4 nTPM
Thalamus	2.3 nTPM
Hippocampus	2.0 nTPM
Cerebral cortex	1.8 nTPM

Choroid plexus epithelial cell	1.1 nTPM
Basal ganglia	2.9 nTPM
Medulla oblongata	1.6 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	5.1 nTPM
Basal ganglia	15.9 nTPM
Hippocampus	10.1 nTPM
Spinal cord	7.4 nTPM
Midbrain	5.9 nTPM
Cerebral cortex	5.7 nTPM
Amygdala	3.4 nTPM
Cerebellum	3.2 nTPM
Thalamus	3.2 nTPM
Hypothalamus	1.4 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Deep-layer corticothalamic and 6b	5.6 nTPM
Hypothalamus	10.3 nTPM
Amygdala	6.1 nTPM
Cerebral cortex	5.9 nTPM
Hippocampus	5.6 nTPM
Basal ganglia	4.5 nTPM
Midbrain	1.1 nTPM

Deep-layer intratelencephalic	6.0 nTPM
Amygdala	10.2 nTPM
Hypothalamus	6.7 nTPM
Basal ganglia	5.5 nTPM
Cerebral cortex	4.3 nTPM
Hippocampus	3.2 nTPM

Deep-layer near-projecting	1.9 nTPM
Hippocampus	2.3 nTPM
Amygdala	2.1 nTPM
Hypothalamus	1.9 nTPM
Cerebral cortex	1.6 nTPM
Basal ganglia	1.5 nTPM

Eccentric medium spiny neuron	3.4 nTPM
Cerebral cortex	4.2 nTPM
Basal ganglia	3.9 nTPM
Thalamus	3.9 nTPM
Amygdala	3.8 nTPM
Hypothalamus	2.7 nTPM
Hippocampus	1.7 nTPM

Endothelial cell	577.9 nTPM
Cerebellum	687.6 nTPM
Midbrain	672.9 nTPM
Amygdala	653.9 nTPM
Thalamus	593.6 nTPM
Hippocampus	573.5 nTPM
Hypothalamus	570.7 nTPM
Basal ganglia	565.8 nTPM
Pons	559.2 nTPM
Spinal cord	548.9 nTPM
Cerebral cortex	525.5 nTPM
Medulla oblongata	405.1 nTPM

Ependymal cell	1.7 nTPM
Amygdala	6.3 nTPM
Hippocampus	3.4 nTPM
Spinal cord	1.9 nTPM
Medulla oblongata	1.8 nTPM
Basal ganglia	1.5 nTPM
Pons	0.4 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM
Thalamus	0.0 nTPM