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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
RAMP2 is not prognostic in Skin Cuteneous Melanoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
3-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
3-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
45.2
Number of samples
99
Samples
Sample
Description
TPM
TCGA-ER-A194-01A
0 years, male, white, stage:'--, dead, 1354 days
242.2
TCGA-BF-AAP7-01A
0 years, female, white, stage:Stage IIC, alive, 318 days
202.5
TCGA-EB-A3HV-01A
0 years, male, white, stage:Stage IIC, alive, 39 days
147.7
TCGA-EB-A553-01A
0 years, male, white, stage:Stage IIC, alive, 226 days
145.7
TCGA-EB-A4OY-01A
0 years, female, white, stage:Stage IIIB, alive, 977 days
123.4
TCGA-EB-A97M-01A
0 years, male, white, stage:Stage IIC, alive, 414 days
115.4
TCGA-EB-A5UM-01A
0 years, female, white, stage:Stage IIC, alive, 779 days
115.1
TCGA-BF-A5EO-01A
0 years, male, white, stage:Stage IIC, alive, 703 days
103.8
TCGA-BF-A3DJ-01A
0 years, female, white, stage:Stage IIIB, alive, 464 days
93.0
TCGA-BF-AAP6-01A
0 years, male, white, stage:Stage III, alive, 325 days
91.0
TCGA-FW-A5DX-01A
0 years, male, white, stage:Stage IIIC, alive, 640 days
89.9
TCGA-EB-A3XE-01A
0 years, female, white, stage:Stage IIA, alive, 180 days
86.1
TCGA-XV-A9W5-01A
0 years, male, white, stage:Not Reported, alive, 392 days
84.6
TCGA-EB-A5VU-01A
0 years, male, asian, stage:Stage IIIB, dead, 321 days
83.7
TCGA-YG-AA3N-01A
0 years, male, stage:Stage IIC, alive, 306 days
78.5
TCGA-EB-A5SE-01A
0 years, male, white, stage:Stage IIB, dead, 401 days
77.3
TCGA-D9-A3Z4-01A
0 years, male, white, stage:Stage IIIC, dead, 519 days
74.0
TCGA-EB-A4P0-01A
0 years, male, white, stage:Stage IIC, dead, 326 days
73.0
TCGA-EB-A3XD-01A
0 years, female, white, stage:Stage IIC, alive, 1160 days
71.9
TCGA-GF-A769-01A
0 years, male, white, stage:Stage IIC, dead, 1070 days
69.7
TCGA-BF-A3DN-01A
0 years, female, white, stage:Stage IIIC, alive, 717 days
67.4
TCGA-EB-A5SF-01A
0 years, female, white, stage:Stage IIC, dead, 369 days
60.5
TCGA-D9-A4Z2-01A
0 years, male, white, stage:Stage IIIC, dead, 190 days
59.1
TCGA-BF-A1PX-01A
0 years, male, white, stage:Stage IIIB, dead, 282 days
58.4
TCGA-EB-A3Y6-01A
0 years, female, white, stage:Stage IIC, alive, 126 days
57.2
TCGA-BF-AAP1-01A
0 years, male, white, stage:Stage IIC, alive, 409 days
56.5
TCGA-BF-A3DM-01A
0 years, male, white, stage:Stage IIA, alive, 601 days
56.1
TCGA-EB-A57M-01A
0 years, male, asian, stage:Stage IIIB, dead, 472 days
55.3
TCGA-EB-A24C-01A
0 years, male, white, stage:'--, alive, 632 days
55.2
TCGA-GN-A8LN-01A
0 years, male, white, stage:Stage IIC, alive, 772 days
54.9
TCGA-EB-A85J-01A
0 years, female, white, stage:Stage IIB, alive, 360 days
54.7
TCGA-EB-A3XF-01A
0 years, male, white, stage:Stage IIC, alive, 278 days
52.9
TCGA-EB-A4OZ-01A
0 years, female, white, stage:Stage IIIC, alive, 620 days
52.1
TCGA-BF-A5EP-01A
0 years, female, white, stage:Stage IIIC, alive, 335 days
51.2
TCGA-ER-A42H-01A
0 years, male, white, stage:'--, dead, 426 days
47.9
TCGA-XV-AAZY-01A
0 years, female, white, stage:Stage IIIC, alive, 405 days
46.7
TCGA-BF-AAP2-01A
0 years, male, white, stage:Stage IIB, alive, 405 days
46.5
TCGA-EB-A4IQ-01A
0 years, female, asian, stage:Stage IIIB, dead, 636 days
46.0
TCGA-BF-A1PZ-01A
0 years, female, white, stage:Stage IIB, alive, 853 days
45.9
TCGA-IH-A3EA-01A
0 years, male, white, stage:Stage IIC, alive, 524 days
44.3
TCGA-GN-A263-01A
0 years, male, white, stage:Stage IV, dead, 467 days
44.0
TCGA-BF-A1PU-01A
0 years, female, white, stage:Stage IIC, alive, 387 days
43.6
TCGA-GF-A2C7-01A
0 years, male, white, stage:Stage IIC, alive, 21 days
42.0
TCGA-ER-A19T-01A
0 years, male, white, stage:Stage IV, dead, 270 days
41.0
TCGA-EB-A42Z-01A
0 years, male, asian, stage:Stage IIIC, alive, 441 days
40.5
TCGA-EB-A6QZ-01A
0 years, female, white, stage:Stage IIA, dead, 352 days
37.9
TCGA-FR-A2OS-01A
0 years, female, white, stage:Stage IIC, dead, 368 days
37.8
TCGA-XV-AAZV-01A
0 years, female, white, stage:Stage II, alive, 412 days
36.2
TCGA-BF-A5ER-01A
0 years, male, white, stage:Stage IIC, alive, 327 days
34.0
TCGA-EB-A299-01A
0 years, male, white, stage:Stage IIA, alive, 378 days
33.7
TCGA-EB-A3XC-01A
0 years, male, white, stage:Stage IIC, alive, 650 days
32.9
TCGA-EB-A4IS-01A
0 years, male, white, stage:Stage IIB, alive, 774 days
31.3
TCGA-EB-A3Y7-01A
0 years, female, white, stage:Stage IIIB, dead, 326 days
30.6
TCGA-D3-A5GT-01A
0 years, male, white, stage:Stage IIIC, alive, 487 days
29.9
TCGA-XV-AAZW-01A
0 years, female, white, stage:Stage II, dead, 393 days
29.2
TCGA-XV-A9W2-01A
0 years, male, white, stage:Stage I, alive, 417 days
28.2
TCGA-EB-A44N-01A
0 years, male, white, stage:Stage IIC, dead, 205 days
25.1
TCGA-EB-A550-01A
0 years, female, white, stage:Stage IIC, dead, 264 days
24.7
TCGA-BF-AAP4-01A
0 years, male, white, stage:Stage IIC, alive, 335 days
24.4
TCGA-EB-A1NK-01A
0 years, male, white, stage:Stage IIC, alive, 1039 days
24.2
TCGA-EB-A5FP-01A
0 years, female, white, stage:Stage IV, dead, 454 days
23.9
TCGA-ER-A2NB-01A
0 years, male, white, stage:Stage IIIB, dead, 857 days
23.1
TCGA-BF-A3DL-01A
0 years, female, white, stage:Stage IIIB, alive, 769 days
20.8
TCGA-D9-A4Z5-01A
0 years, male, white, stage:Stage IIB, alive, 218 days
20.3
TCGA-FR-A3R1-01A
0 years, male, white, stage:Stage IIC, alive, 685 days
20.1
TCGA-BF-AAOU-01A
0 years, female, white, stage:Stage IIC, alive, 476 days
20.1
TCGA-BF-A5EQ-01A
0 years, male, white, stage:Stage IIC, alive, 323 days
19.8
TCGA-EB-A4XL-01A
0 years, female, white, stage:Stage IIC, alive, 777 days
19.7
TCGA-FS-A1ZN-01A
0 years, male, white, stage:Stage IIIA, dead, 730 days
19.1
TCGA-GN-A4U5-01A
0 years, female, white, stage:Stage IB, alive, 1156 days
19.0
TCGA-EB-A85I-01A
0 years, male, white, stage:Stage IIC, alive, 362 days
18.8
TCGA-ER-A19K-01A
0 years, female, white, stage:Stage IIC, dead, 469 days
16.7
TCGA-EB-A6QY-01A
0 years, male, white, stage:Stage IIC, alive, 382 days
16.4
TCGA-EB-A82C-01A
0 years, female, asian, stage:Stage IIC, alive, 17 days
15.8
TCGA-BF-AAP8-01A
0 years, male, white, stage:Stage IIC, alive, 447 days
15.6
TCGA-GN-A26C-01A
0 years, male, white, stage:Stage IIIC, dead, 821 days
15.0
TCGA-WE-A8K4-01A
0 years, male, white, stage:Stage IIB, alive, 614 days
14.1
TCGA-BF-A5ES-01A
0 years, female, white, stage:Stage IIC, alive, 490 days
13.5
TCGA-EB-A44P-01A
0 years, female, white, stage:Stage IIC, alive, 741 days
13.3
TCGA-ER-A196-01A
0 years, female, white, stage:Stage IIC, alive, 1785 days
13.0
TCGA-EB-A82B-01A
0 years, female, asian, stage:Stage III, alive, 390 days
12.2
TCGA-ER-A2NF-01A
0 years, male, white, stage:Stage IIIB, dead, 877 days
12.1
TCGA-BF-A1PV-01A
0 years, female, white, stage:Stage IIC, alive, 14 days
11.6
TCGA-DA-A960-01A
0 years, male, white, stage:Stage IIB, alive, 804 days
11.6
TCGA-FR-A728-01A
0 years, female, white, stage:Stage IIIB, alive, 583 days
11.4
TCGA-EB-A6R0-01A
0 years, female, white, stage:Stage IIC, dead, 608 days
11.3
TCGA-BF-AAOX-01A
0 years, male, white, stage:Stage IIC, alive, 444 days
10.5
TCGA-EB-A42Y-01A
0 years, female, asian, stage:Stage IIC, dead, 721 days
10.3
TCGA-EB-A3XB-01A
0 years, male, white, stage:Stage II, alive, 796 days
9.8
TCGA-EB-A44O-01A
0 years, male, white, stage:Stage IIB, alive, 81 days
9.5
TCGA-BF-A1Q0-01A
0 years, male, white, stage:Stage IIC, alive, 831 days
9.2
TCGA-BF-A9VF-01A
0 years, male, white, stage:Stage IIC, alive, 440 days
8.4
TCGA-EB-A551-01A
0 years, female, white, stage:Stage IIIC, alive, 590 days
6.7
TCGA-EB-A51B-01A
0 years, male, white, stage:Stage IIC, alive, 931 days
6.7
TCGA-EB-A431-01A
0 years, male, white, stage:Stage IIC, alive, 568 days
6.2
TCGA-EB-A24D-01A
0 years, male, white, stage:Stage IIIB, alive, 645 days
5.9
TCGA-EB-A41B-01A
0 years, female, white, stage:Stage IIC, alive, 291 days
5.0
TCGA-D9-A4Z3-01A
0 years, female, white, stage:Stage IIIC, alive, 505 days
4.3
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MELANOMA - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
The Human Protein Atlas project is funded
