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                                          • SUMMARY

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                                          • SSR1
                                          CANCER OVARIAN CANCER Show tissue menu
                                          BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA
                                          MELANOMA OVARIAN CANCER PANCREATIC CANCER PROSTATE CANCER RENAL CANCER SKIN CANCER STOMACH CANCER TESTIS CANCER THYROID CANCER UROTHELIAL CANCER
                                          OV TCGA OV VALIDATION PROTEIN OV CPTAC PROTEIN EXPRESSION
                                          ANTIBODIES
                                          AND
                                          VALIDATION
                                          Dictionary
                                          Ovarian cancer
                                          Human cancer
                                          Ovary serous cystadenocarcinoma
                                          Cancer methods
                                          OVARY SEROUS CYSTADENOCARCINOMA (TCGA) - Interactive survival scatter ploti

                                          The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

                                          The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

                                          Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

                                          Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

                                          & Survival analysisi

                                          Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.

                                          SSR1 is not prognostic in Ovary Serous Cystadenocarcinoma (TCGA)


                                          Stage:

                                          0 2 4 6 8101214Time after diagnosis (years)0.020406080100120140160180200220240260280Expression level (pTPM)Dead (n=217)Alive (n=132)75Density dead85Density alive3.4Density dead under cut off2.9Density dead over cut off0.20.40.60.8P score0.60.50.40.30.2Medain separation0.1P scoreDead median separationCut off
                                          0.00.10.20.30.40.50.60.70.80.91.0Survival probability 0 1 2 3 4 5 6 7 8 9101112131415Time (years)Low expression (n=70)High expression (n=279)
                                          Survival analysis
                                          Current cut offi

                                          Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.

                                          :
                                          Best expression cut offi

                                          Based on the pTPM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (pTPM) was examined. The best expression cut-off refers the pTPM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.

                                          : 52.11
                                          Median expressioni

                                          Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.

                                          : 79.24
                                          Median follow up timei

                                          Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.

                                          : 2.67
                                          P scorei

                                          Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.

                                          0.031
                                          5-year survival highi

                                          5-year survival for patients with higher expression than the expression cutoff.

                                          For melanoma and glioma, 3-year survival is shown.

                                          35%
                                          5-year survival lowi

                                          5-year survival for patients with lower expression than the expression cutoff.

                                          For melanoma and glioma, 3-year survival is shown.

                                          18%
                                          TCGA RNA samplesi

                                          RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .

                                          Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.

                                          Average pTPM 85.3
                                          Number of samples 349
                                          Samples
                                          Sample Description pTPM
                                          TCGA-29-1695-01A 62 years, female, white, stage:Stage IIIC, dead, 1229 days 295.4
                                          TCGA-61-1737-01A 42 years, female, white, stage:Stage IV, alive, 1364 days 254.1
                                          TCGA-24-1558-01A 73 years, female, white, stage:Stage IIIC, dead, 594 days 244.7
                                          TCGA-25-1627-01A 73 years, female, white, stage:Stage IIIC, dead, 394 days 222.4
                                          TCGA-24-1474-01A 57 years, female, black or african american, stage:Stage IIIC, dead, 676 days 218.3
                                          TCGA-36-1581-01A 63 years, female, white, stage:Stage IIC, alive, 751 days 202.7
                                          TCGA-36-1570-01A 49 years, female, white, stage:Stage IIIC, alive, 655 days 196.1
                                          TCGA-61-2003-01A 53 years, female, white, stage:Stage IIIC, alive, 122 days 187.3
                                          TCGA-31-1953-01A 52 years, female, asian, stage:Stage IIIC, alive, 204 days 185.1
                                          TCGA-29-1778-01A 77 years, female, white, stage:Stage IIIC, alive, 454 days 179.0
                                          TCGA-09-2051-01A 42 years, female, white, stage:Stage IIIC, alive, 1919 days 175.7
                                          TCGA-24-1417-01A 54 years, female, white, stage:Stage IV, alive, 238 days 172.9
                                          TCGA-36-1568-01A 52 years, female, stage:Stage IIIC, alive, 875 days 172.7
                                          TCGA-24-1423-01A 61 years, female, white, stage:Stage IIIC, alive, 190 days 171.2
                                          TCGA-59-A5PD-01A 55 years, female, black or african american, stage:Stage IC, dead, 624 days 170.9
                                          TCGA-24-1551-01A 53 years, female, white, stage:Stage IIIC, dead, 1579 days 164.8
                                          TCGA-24-2289-01A 68 years, female, white, stage:Stage IV, dead, 2049 days 163.5
                                          TCGA-09-2054-01A 58 years, female, black or african american, stage:Stage IIIC, dead, 637 days 162.5
                                          TCGA-23-2077-01A 45 years, female, white, stage:Stage IIIC, alive, 3525 days 162.1
                                          TCGA-29-A5NZ-01A 66 years, female, black or african american, stage:Stage IIIC, dead, 1088 days 159.1
                                          TCGA-57-1585-01A 57 years, female, white, stage:Stage IIIC, dead, 53 days 157.4
                                          TCGA-25-1313-01A 62 years, female, white, stage:Stage IV, dead, 820 days 157.4
                                          TCGA-24-1435-01A 57 years, female, white, stage:Stage IIIC, dead, 1324 days 157.3
                                          TCGA-24-2254-01A 66 years, female, white, stage:Stage IIIC, dead, 1736 days 156.5
                                          TCGA-57-1994-01A 63 years, female, white, stage:'--, alive, 761 days 152.2
                                          TCGA-29-2425-01A 60 years, female, white, stage:Stage IIIC, alive, 1977 days 151.2
                                          TCGA-04-1530-01A 68 years, female, white, stage:Stage IIIC, dead, 3622 days 151.1
                                          TCGA-61-2102-01A 74 years, female, white, stage:Stage IIIC, dead, 197 days 149.6
                                          TCGA-25-1326-01A 61 years, female, white, stage:Stage IIIC, dead, 1249 days 149.5
                                          TCGA-61-1919-01A 58 years, female, white, stage:Stage IIIC, dead, 1161 days 146.3
                                          TCGA-24-1563-01A 66 years, female, black or african american, stage:Stage IIIC, dead, 1451 days 145.9
                                          TCGA-25-1633-01A 64 years, female, white, stage:Stage IIIC, dead, 1891 days 145.6
                                          TCGA-24-1604-01A 66 years, female, white, stage:Stage IIIC, dead, 2688 days 142.7
                                          TCGA-24-1550-01A 49 years, female, white, stage:Stage IIIC, dead, 1249 days 142.6
                                          TCGA-23-1028-01A 43 years, female, white, stage:Stage IIIC, alive, 1503 days 142.0
                                          TCGA-61-1918-01A 45 years, female, white, stage:Stage IV, dead, 479 days 139.2
                                          TCGA-24-2293-01A 47 years, female, white, stage:'--, dead, 506 days 138.7
                                          TCGA-04-1362-01A 59 years, female, white, stage:Stage IIC, dead, 1348 days 137.6
                                          TCGA-29-1693-01A 72 years, female, white, stage:Stage IIIC, alive, 3096 days 136.8
                                          TCGA-24-1424-01A 67 years, female, white, stage:Stage IIIC, alive, 183 days 133.0
                                          TCGA-5X-AA5U-01A 61 years, female, black or african american, stage:Stage IIC, alive, 361 days 133.0
                                          TCGA-31-1946-01A 30 years, female, stage:Stage IIIC, alive, 918 days 131.7
                                          TCGA-24-2261-01A 76 years, female, white, stage:Stage IIIC, dead, 24 days 131.5
                                          TCGA-61-2104-01A 53 years, female, white, stage:Stage IIC, alive, 2338 days 131.5
                                          TCGA-29-1691-01A 51 years, female, white, stage:Stage IIIC, dead, 1470 days 130.8
                                          TCGA-13-1496-01A 65 years, female, white, stage:Stage IIIC, dead, 129 days 129.8
                                          TCGA-57-1993-01A 56 years, female, white, stage:Stage IIIC, alive, 763 days 129.7
                                          TCGA-31-1959-01A 49 years, female, white, stage:Stage IV, alive, 67 days 127.4
                                          TCGA-23-1120-01A 60 years, female, white, stage:Stage IIIC, alive, 130 days 126.6
                                          TCGA-24-0982-01A 77 years, female, white, stage:Stage IIIC, dead, 679 days 125.0
                                          TCGA-61-2111-01A 61 years, female, white, stage:Stage IV, alive, 3825 days 123.8
                                          TCGA-61-2098-01A 62 years, female, white, stage:Stage IIIC, alive, 1993 days 122.8
                                          TCGA-24-1469-01A 71 years, female, white, stage:Stage IIIC, alive, 277 days 122.4
                                          TCGA-09-1669-01A 54 years, female, white, stage:Stage IIIA, alive, 928 days 121.3
                                          TCGA-24-1422-01A 82 years, female, black or african american, stage:Stage IIIC, dead, 23 days 119.2
                                          TCGA-24-2026-01A 79 years, female, white, stage:Stage IIIC, dead, 1059 days 119.1
                                          TCGA-59-2348-01A 59 years, female, white, stage:Stage IIIC, alive, 5481 days 117.6
                                          TCGA-23-2084-01A 45 years, female, white, stage:Stage IV, dead, 1516 days 117.6
                                          TCGA-36-1574-01A 48 years, female, asian, stage:Stage IIIC, alive, 686 days 117.6
                                          TCGA-61-2113-01A 53 years, female, white, stage:Stage IIC, dead, 676 days 116.5
                                          TCGA-13-1497-01A 47 years, female, white, stage:Stage IIIC, alive, 3871 days 115.8
                                          TCGA-13-1511-01A 52 years, female, asian, stage:Stage IV, dead, 1650 days 115.6
                                          TCGA-OY-A56Q-01A 78 years, female, black or african american, stage:Stage IIA, alive, 576 days 115.1
                                          TCGA-24-1464-01A 70 years, female, white, stage:Stage IIIC, dead, 379 days 115.1
                                          TCGA-13-0906-01A 50 years, female, white, stage:Stage IIIC, alive, 3619 days 114.4
                                          TCGA-25-2404-01A 38 years, female, american indian or alaska native, stage:Stage IIIC, dead, 883 days 113.0
                                          TCGA-25-2398-01A 71 years, female, white, stage:Stage IIIC, dead, 1369 days 112.7
                                          TCGA-13-1488-01A 59 years, female, white, stage:Stage IV, dead, 2154 days 110.4
                                          TCGA-61-2097-01A 71 years, female, white, stage:Stage IIC, alive, 1844 days 110.2
                                          TCGA-24-1928-01A 77 years, female, white, stage:Stage IIIC, dead, 336 days 109.7
                                          TCGA-25-2392-01A 75 years, female, white, stage:Stage IV, dead, 31 days 109.2
                                          TCGA-36-1576-01A 76 years, female, stage:Stage IIIC, alive, 915 days 109.1
                                          TCGA-09-0364-01A 80 years, female, white, stage:Stage IIC, dead, 887 days 108.9
                                          TCGA-30-1860-01A 58 years, female, white, stage:Stage IIIC, dead, 1366 days 108.7
                                          TCGA-31-1950-01A 76 years, female, white, stage:Stage IIIC, alive, 571 days 107.7
                                          TCGA-13-1410-01A 57 years, female, white, stage:Stage IV, alive, 2464 days 107.5
                                          TCGA-23-1122-01A 53 years, female, white, stage:Stage IIIC, dead, 1189 days 106.5
                                          TCGA-61-2009-01A 65 years, female, white, stage:Stage IIIC, alive, 1212 days 106.2
                                          TCGA-24-1603-01A 53 years, female, white, stage:Stage IIIB, dead, 2742 days 105.7
                                          TCGA-59-2363-01A 40 years, female, asian, stage:Stage IIIA, alive, 165 days 105.7
                                          TCGA-61-1914-01A 65 years, female, stage:Stage IIIC, alive, 1722 days 105.6
                                          TCGA-24-1105-01A 36 years, female, white, stage:Stage IIIC, dead, 1442 days 105.6
                                          TCGA-61-1998-01A 48 years, female, white, stage:Stage IIIC, alive, 168 days 105.6
                                          TCGA-13-1512-01A 49 years, female, white, stage:Stage IIIC, alive, 442 days 105.4
                                          TCGA-13-0800-01A 52 years, female, white, stage:Stage IIIC, alive, 2661 days 104.8
                                          TCGA-25-2400-01A 76 years, female, white, stage:Stage IIIC, dead, 1278 days 104.8
                                          TCGA-25-1318-01A 54 years, female, white, stage:Stage IIIC, dead, 1064 days 104.4
                                          TCGA-24-1842-01A 49 years, female, white, stage:Stage IIIC, alive, 253 days 104.3
                                          TCGA-13-2060-01A 51 years, female, white, stage:Stage IV, alive, 2369 days 102.8
                                          TCGA-20-1682-01A 56 years, female, white, stage:Stage IIIC, alive, 837 days 102.5
                                          TCGA-59-2352-01A 78 years, female, white, stage:Stage IIIC, dead, 286 days 102.1
                                          TCGA-61-1741-01A 76 years, female, white, stage:Stage IIIB, dead, 1024 days 101.4
                                          TCGA-36-1580-01A 82 years, female, stage:Stage IIIC, dead, 737 days 101.0
                                          TCGA-29-1710-01A 54 years, female, white, stage:Stage IIIC, dead, 951 days 100.8
                                          TCGA-59-2355-01A 58 years, female, white, stage:Stage IV, dead, 65 days 100.8
                                          TCGA-25-1626-01A 65 years, female, white, stage:Stage IIIC, dead, 518 days 100.3
                                          TCGA-WR-A838-01A 72 years, female, black or african american, stage:Stage IIIC, dead, 304 days 100.2
                                          TCGA-29-1774-01A 82 years, female, white, stage:Stage IIIC, alive, 527 days 99.3
                                          TCGA-09-1666-01A 57 years, female, white, stage:Stage IIIC, alive, 1752 days 98.8
                                          TCGA-30-1718-01A 44 years, female, white, stage:Stage IIIC, dead, 1579 days 98.5
                                          TCGA-25-1312-01A 69 years, female, white, stage:Stage IV, dead, 31 days 98.5
                                          TCGA-24-1567-01A 54 years, female, white, stage:Stage IIIB, dead, 524 days 98.0
                                          TCGA-23-2078-01A 66 years, female, white, stage:Stage IIIC, alive, 2661 days 97.0
                                          TCGA-13-0920-01A 65 years, female, white, stage:Stage IIIC, dead, 1484 days 96.9
                                          TCGA-29-1763-01A 43 years, female, black or african american, stage:Stage IIC, alive, 2032 days 96.5
                                          TCGA-09-1662-01A 58 years, female, white, stage:Stage IV, dead, 2717 days 96.5
                                          TCGA-29-1769-01A 40 years, female, white, stage:Stage IIIC, alive, 699 days 96.3
                                          TCGA-09-1673-01A 50 years, female, white, stage:Stage IV, alive, 92 days 95.7
                                          TCGA-24-1419-01A 62 years, female, white, stage:Stage IIIC, alive, 239 days 95.6
                                          TCGA-29-1701-01A 56 years, female, white, stage:Stage IIIC, dead, 515 days 94.9
                                          TCGA-23-1116-01A 83 years, female, white, stage:Stage IIIC, dead, 592 days 94.9
                                          TCGA-13-0916-01A 49 years, female, white, stage:Stage IIIC, alive, 1785 days 94.5
                                          TCGA-23-1030-01A 64 years, female, white, stage:Stage IIIC, alive, 886 days 93.5
                                          TCGA-25-1634-01A 75 years, female, white, stage:Stage IIIC, dead, 1091 days 92.9
                                          TCGA-25-2401-01A 64 years, female, white, stage:Stage IIIC, dead, 90 days 92.9
                                          TCGA-23-1809-01A 63 years, female, white, stage:Stage IIC, alive, 16 days 92.8
                                          TCGA-13-1510-01A 62 years, female, white, stage:Stage IIIC, dead, 1359 days 92.6
                                          TCGA-24-2297-01A 56 years, female, white, stage:Stage IIIC, dead, 1699 days 92.3
                                          TCGA-25-1877-01A 81 years, female, white, stage:Stage IIIC, dead, 730 days 92.3
                                          TCGA-29-1711-01A 45 years, female, black or african american, stage:Stage IIIC, alive, 1053 days 91.7
                                          TCGA-25-1870-01A 59 years, female, white, stage:Stage IIIC, dead, 455 days 91.4
                                          TCGA-20-0987-01A 61 years, female, white, stage:Stage IIIC, dead, 701 days 91.2
                                          TCGA-20-1683-01A 65 years, female, white, stage:Stage IIIC, alive, 772 days 90.8
                                          TCGA-61-2000-01A 67 years, female, white, stage:Stage IIIC, alive, 441 days 90.6
                                          TCGA-24-1930-01A 53 years, female, white, stage:Stage IIIC, dead, 2467 days 90.5
                                          TCGA-24-1843-01A 66 years, female, white, stage:Stage IIIC, alive, 106 days 90.5
                                          TCGA-57-1582-01A 50 years, female, white, stage:Stage IIIC, dead, 731 days 89.8
                                          TCGA-10-0937-01A 44 years, female, white, stage:Stage IIIC, dead, 608 days 89.6
                                          TCGA-25-1323-01A 72 years, female, white, stage:Stage IIIC, dead, 395 days 89.6
                                          TCGA-13-1403-01A 48 years, female, white, stage:Stage IIIC, dead, 2345 days 89.5
                                          TCGA-24-1413-01A 51 years, female, white, stage:Stage IIIC, alive, 192 days 89.4
                                          TCGA-13-1483-01A 61 years, female, white, stage:Stage IIIC, dead, 895 days 89.4
                                          TCGA-13-1411-01A 81 years, female, white, stage:Stage IIIC, dead, 531 days 89.2
                                          TCGA-29-1770-01A 54 years, female, white, stage:Stage IIIC, alive, 741 days 89.0
                                          TCGA-13-1404-01A 48 years, female, white, stage:Stage IIIC, alive, 2469 days 89.0
                                          TCGA-13-A5FT-01A 67 years, female, black or african american, stage:Stage IIIC, alive, 2143 days 88.9
                                          TCGA-13-0886-01A 67 years, female, white, stage:Stage IIIC, alive, 4665 days 88.6
                                          TCGA-24-1425-01A 45 years, female, white, stage:Stage IIIC, alive, 181 days 88.2
                                          TCGA-24-1418-01A 68 years, female, white, stage:Stage IIIC, alive, 243 days 88.1
                                          TCGA-25-1631-01A 73 years, female, white, stage:Stage IIIC, dead, 9 days 88.0
                                          TCGA-24-2290-01A 56 years, female, white, stage:Stage IIIC, dead, 1102 days 86.0
                                          TCGA-24-2288-01A 70 years, female, white, stage:Stage IIIC, dead, 25 days 85.7
                                          TCGA-04-1514-01A 45 years, female, white, stage:Stage IIIA, dead, 1720 days 85.5
                                          TCGA-24-1616-01A 56 years, female, white, stage:Stage IIIC, dead, 1163 days 85.4
                                          TCGA-25-1319-01A 73 years, female, white, stage:Stage IIIC, dead, 1977 days 85.3
                                          TCGA-24-2023-01A 54 years, female, white, stage:Stage IIIA, dead, 1364 days 85.3
                                          TCGA-30-1862-01A 65 years, female, white, stage:Stage IV, dead, 186 days 85.1
                                          TCGA-29-2427-01A 60 years, female, white, stage:Stage IIIC, alive, 1900 days 84.9
                                          TCGA-23-1118-01A 45 years, female, white, stage:Stage IIIC, alive, 2616 days 84.8
                                          TCGA-29-1768-01A 50 years, female, white, stage:Stage IV, dead, 952 days 84.8
                                          TCGA-09-0366-01A 55 years, female, white, stage:Stage IIIC, dead, 1757 days 84.6
                                          TCGA-59-2351-01A 51 years, female, white, stage:Stage IIIC, alive, 3532 days 84.2
                                          TCGA-25-1632-01A 68 years, female, white, stage:Stage IV, dead, 1799 days 84.2
                                          TCGA-57-1584-01A 47 years, female, white, stage:Stage IIIC, alive, 643 days 83.8
                                          TCGA-25-2042-01A 60 years, female, american indian or alaska native, stage:Stage IIIC, dead, 396 days 83.8
                                          TCGA-36-1569-01A 52 years, female, white, stage:Stage IIIC, alive, 885 days 83.4
                                          TCGA-04-1536-01A 60 years, female, black or african american, stage:Stage IV, dead, 885 days 83.3
                                          TCGA-24-1549-01A 58 years, female, white, stage:Stage IIIB, dead, 1721 days 83.2
                                          TCGA-25-2399-01A 80 years, female, white, stage:Stage IIIC, dead, 608 days 83.1
                                          TCGA-24-2267-01A 58 years, female, white, stage:Stage IIB, dead, 1446 days 82.9
                                          TCGA-04-1356-01A 62 years, female, white, stage:Stage IIC, dead, 1499 days 82.7
                                          TCGA-13-0924-01A 45 years, female, white, stage:Stage IV, alive, 2614 days 82.7
                                          TCGA-09-0369-01A 56 years, female, white, stage:Stage IIIC, dead, 1082 days 82.5
                                          TCGA-57-1586-01A 66 years, female, white, stage:Stage IIIC, alive, 679 days 82.3
                                          TCGA-24-1847-01A 45 years, female, white, stage:Stage IV, alive, 343 days 82.1
                                          TCGA-20-1686-01A 75 years, female, white, stage:Stage IIIC, alive, 89 days 81.9
                                          TCGA-30-1891-01A 61 years, female, white, stage:Stage IIIC, dead, 914 days 81.0
                                          TCGA-13-1498-01A 73 years, female, white, stage:Stage IIIC, dead, 2012 days 81.0
                                          TCGA-31-1944-01A 47 years, female, white, stage:Stage IIIC, alive, 1386 days 80.7
                                          TCGA-61-2101-01A 55 years, female, white, stage:Stage IIIC, dead, 1688 days 80.2
                                          TCGA-29-1783-01A 58 years, female, white, stage:Stage IIIC, alive, 220 days 80.1
                                          TCGA-24-1557-01A 49 years, female, white, stage:Stage IIIC, dead, 1213 days 79.6
                                          TCGA-61-2008-01A 40 years, female, asian, stage:Stage IIC, alive, 932 days 79.4
                                          TCGA-13-1507-01A 77 years, female, white, stage:Stage IIIC, dead, 1993 days 79.3
                                          TCGA-24-1544-01A 71 years, female, black or african american, stage:Stage IIIC, dead, 820 days 79.2
                                          TCGA-13-0883-01A 61 years, female, white, stage:Stage IIIC, dead, 2097 days 79.2
                                          TCGA-29-1705-01A 47 years, female, white, stage:Stage IIIC, dead, 555 days 79.1
                                          TCGA-24-1434-01A 59 years, female, white, stage:Stage IIIC, dead, 568 days 78.4
                                          TCGA-24-2024-01A 72 years, female, black or african american, stage:Stage IIIC, dead, 1769 days 77.9
                                          TCGA-24-1430-01A 68 years, female, white, stage:Stage IIIC, dead, 863 days 77.8
                                          TCGA-13-0795-01A 66 years, female, white, stage:Stage IIIC, dead, 619 days 77.8
                                          TCGA-61-2012-01A 81 years, female, white, stage:Stage IIC, alive, 932 days 77.6
                                          TCGA-61-2109-01A 40 years, female, white, stage:Stage IIIC, dead, 629 days 77.4
                                          TCGA-36-1571-01A 53 years, female, white, stage:Stage IIIB, dead, 695 days 77.2
                                          TCGA-25-1320-01A 65 years, female, white, stage:Stage IIIC, dead, 1155 days 77.0
                                          TCGA-61-2088-01A 51 years, female, white, stage:Stage IIIC, alive, 145 days 76.8
                                          TCGA-25-1321-01A 65 years, female, white, stage:Stage IIIC, dead, 1033 days 76.2
                                          TCGA-29-1776-01A 63 years, female, black or african american, stage:Stage IIIC, alive, 360 days 75.9
                                          TCGA-61-2002-01A 46 years, female, white, stage:Stage IIIC, alive, 547 days 75.5
                                          TCGA-09-2045-01A 50 years, female, asian, stage:Stage IV, dead, 1069 days 75.3
                                          TCGA-24-0968-01A 59 years, female, white, stage:Stage IIIC, dead, 598 days 75.1
                                          TCGA-25-1623-01A 71 years, female, white, stage:Stage IV, dead, 565 days 75.1
                                          TCGA-25-1628-01A 67 years, female, white, stage:Stage IIIC, dead, 627 days 74.9
                                          TCGA-23-1027-01A 48 years, female, white, stage:Stage IIIC, dead, 976 days 74.0
                                          TCGA-61-1911-01A 55 years, female, white, stage:Stage IIA, alive, 1293 days 73.7
                                          TCGA-10-0933-01A 77 years, female, white, stage:Stage IIIC, dead, 446 days 73.3
                                          TCGA-04-1542-01A 52 years, female, white, stage:Stage IIIB, dead, 2561 days 73.2
                                          TCGA-61-2092-01A 57 years, female, white, stage:Stage IIIC, alive, 1573 days 73.1
                                          TCGA-30-1861-01A 74 years, female, white, stage:Stage IIIC, dead, 1058 days 72.9
                                          TCGA-29-1785-01A 55 years, female, white, stage:Stage IIIC, dead, 1104 days 72.8
                                          TCGA-24-1845-01A 42 years, female, white, stage:Stage IIIC, alive, 116 days 72.8
                                          TCGA-25-1315-01A 50 years, female, white, stage:Stage IIIC, dead, 1583 days 72.6
                                          TCGA-20-0991-01A 78 years, female, white, stage:Stage IIB, alive, 797 days 72.5
                                          TCGA-13-0923-01A 74 years, female, white, stage:Stage IIIC, alive, 2547 days 72.1
                                          TCGA-61-1910-01A 56 years, female, white, stage:Stage IIC, alive, 1127 days 71.4
                                          TCGA-25-1317-01A 66 years, female, white, stage:Stage IIIC, dead, 61 days 71.2
                                          TCGA-04-1361-01A 57 years, female, white, stage:Stage IIIB, alive, 989 days 70.9
                                          TCGA-24-2027-01A 51 years, female, white, stage:Stage IV, dead, 3337 days 70.6
                                          TCGA-61-1900-01A 51 years, female, black or african american, stage:Stage IIIB, alive, 176 days 70.3
                                          TCGA-VG-A8LO-01A 55 years, female, black or african american, stage:Stage IV, dead, 24 days 70.0
                                          TCGA-24-1846-01A 45 years, female, stage:Stage IIIC, alive, 133 days 70.0
                                          TCGA-29-1766-01A 74 years, female, white, stage:Stage IIIC, dead, 1199 days 69.8
                                          TCGA-23-1023-01A 65 years, female, white, stage:Stage IIIC, alive, 1233 days 69.7
                                          TCGA-31-1951-01A 58 years, female, white, stage:Stage IIIC, alive, 684 days 69.6
                                          TCGA-13-1487-01A 74 years, female, white, stage:Stage IV, dead, 681 days 69.3
                                          TCGA-13-0891-01A 73 years, female, white, stage:Stage IV, dead, 3128 days 69.1
                                          TCGA-10-0938-01A 80 years, female, white, stage:Stage IIIC, dead, 636 days 67.9
                                          TCGA-13-0724-01A 72 years, female, white, stage:Stage IV, dead, 83 days 67.5
                                          TCGA-24-1428-01A 50 years, female, white, stage:Stage IIIC, alive, 529 days 67.3
                                          TCGA-25-1630-01A 73 years, female, white, stage:Stage IIIC, dead, 1162 days 67.3
                                          TCGA-29-1762-01A 59 years, female, white, stage:Stage IV, dead, 2634 days 66.9
                                          TCGA-24-2020-01A 67 years, female, white, stage:Stage IIIC, dead, 4624 days 66.9
                                          TCGA-24-1562-01A 67 years, female, white, stage:Stage IIIC, dead, 1384 days 66.7
                                          TCGA-04-1365-01A 87 years, female, white, stage:Stage IIIB, alive, 947 days 66.3
                                          TCGA-59-2354-01A 63 years, female, white, stage:Stage IIIC, dead, 1046 days 66.0
                                          TCGA-24-2035-01A 65 years, female, white, stage:Stage IIIC, dead, 857 days 65.8
                                          TCGA-61-1724-01A 47 years, female, white, stage:Stage IIIC, dead, 637 days 65.8
                                          TCGA-04-1648-01A 57 years, female, white, stage:Stage IIIC, dead, 871 days 65.6
                                          TCGA-29-2414-01A 75 years, female, white, stage:Stage IIIC, dead, 2621 days 65.4
                                          TCGA-24-2033-01A 87 years, female, white, stage:Stage IIIC, dead, 562 days 65.4
                                          TCGA-04-1364-01A 61 years, female, white, stage:Stage IIIC, dead, 1024 days 65.1
                                          TCGA-25-2409-01A 71 years, female, white, stage:Stage IV, dead, 821 days 65.0
                                          TCGA-13-1489-01A 70 years, female, white, stage:Stage IIIC, dead, 2553 days 64.9
                                          TCGA-25-1328-01A 38 years, female, white, stage:Stage IIIC, dead, 2009 days 64.8
                                          TCGA-24-1467-01A 51 years, female, white, stage:Stage IIIC, dead, 3224 days 64.7
                                          TCGA-13-1492-01A 66 years, female, white, stage:Stage IIIC, dead, 3819 days 64.7
                                          TCGA-24-1427-01A 58 years, female, stage:Stage IIIC, alive, 147 days 64.0
                                          TCGA-24-1431-01A 67 years, female, white, stage:Stage IIIC, dead, 583 days 63.0
                                          TCGA-24-2036-01A 50 years, female, white, stage:Stage IIIA, dead, 1947 days 62.5
                                          TCGA-25-2396-01A 71 years, female, white, stage:Stage IIIC, dead, 92 days 62.4
                                          TCGA-24-1546-01A 46 years, female, white, stage:Stage IIIC, dead, 1955 days 61.8
                                          TCGA-61-1907-01A 63 years, female, white, stage:Stage IIIC, alive, 952 days 61.6
                                          TCGA-23-1022-01A 67 years, female, white, stage:Stage IIIC, dead, 1511 days 61.5
                                          TCGA-23-1109-01A 62 years, female, white, stage:Stage IIIC, dead, 1562 days 61.2
                                          TCGA-36-1577-01A 43 years, female, asian, stage:Stage IIC, alive, 783 days 60.7
                                          TCGA-23-1110-01A 42 years, female, white, stage:Stage IIIC, alive, 1658 days 60.6
                                          TCGA-24-1924-01A 65 years, female, white, stage:Stage IIIC, dead, 919 days 60.5
                                          TCGA-29-1696-01A 43 years, female, white, stage:Stage IIIC, dead, 1032 days 60.2
                                          TCGA-13-1408-01A 59 years, female, white, stage:Stage IIIC, dead, 1680 days 60.1
                                          TCGA-04-1338-01A 78 years, female, white, stage:Stage IIIC, alive, 1418 days 60.0
                                          TCGA-30-1714-01A 68 years, female, white, stage:Stage IV, dead, 1158 days 60.0
                                          TCGA-31-1956-01A 60 years, female, white, stage:Stage IIIB, alive, 1342 days 59.9
                                          TCGA-13-0885-01A 70 years, female, white, stage:Stage IIIC, alive, 3388 days 59.8
                                          TCGA-13-1477-01A 49 years, female, white, stage:Stage IV, dead, 1662 days 58.7
                                          TCGA-09-1670-01A 57 years, female, white, stage:Stage IIIA, alive, 547 days 58.5
                                          TCGA-13-0726-01A 55 years, female, white, stage:Stage IIIC, dead, 949 days 58.2
                                          TCGA-20-1687-01A 46 years, female, white, stage:Stage IV, alive, 81 days 58.0
                                          TCGA-13-0768-01A 73 years, female, white, stage:Stage IIIC, dead, 1784 days 57.4
                                          TCGA-23-1119-01A 64 years, female, white, stage:Stage IIIC, alive, 3953 days 57.4
                                          TCGA-13-0804-01A 73 years, female, white, stage:Stage IIIC, dead, 1073 days 57.2
                                          TCGA-29-1688-01A 39 years, female, white, stage:Stage IIIC, dead, 2400 days 57.2
                                          TCGA-13-0888-01A 78 years, female, white, stage:Stage IIIC, dead, 2811 days 56.5
                                          TCGA-24-1844-01A 64 years, female, white, stage:Stage IIIC, alive, 113 days 56.3
                                          TCGA-25-1329-01A 76 years, female, white, stage:Stage IIIC, dead, 457 days 56.1
                                          TCGA-13-0762-01A 65 years, female, white, stage:Stage IIIC, alive, 3400 days 56.1
                                          TCGA-13-0714-01A 55 years, female, white, stage:Stage IV, dead, 189 days 56.1
                                          TCGA-23-1111-01A 63 years, female, white, stage:Stage IIIC, alive, 98 days 56.1
                                          TCGA-25-1322-01A 62 years, female, white, stage:Stage IV, dead, 91 days 56.0
                                          TCGA-13-1499-01A 56 years, female, white, stage:Stage IIIC, alive, 3500 days 55.9
                                          TCGA-04-1651-01A 53 years, female, white, stage:Stage IIIC, dead, 1102 days 54.2
                                          TCGA-13-0797-01A 49 years, female, white, stage:Stage IIIC, alive, 2121 days 53.7
                                          TCGA-04-1332-01A 70 years, female, white, stage:Stage IIIC, dead, 1247 days 53.1
                                          TCGA-61-1738-01A 60 years, female, black or african american, stage:Stage IIIC, dead, 1089 days 52.9
                                          TCGA-61-1721-01A 38 years, female, white, stage:Stage IV, alive, 338 days 52.9
                                          TCGA-13-1405-01A 49 years, female, white, stage:Stage IV, dead, 868 days 52.7
                                          TCGA-13-1505-01A 63 years, female, white, stage:Stage IIIC, alive, 1998 days 52.7
                                          TCGA-29-1690-01A 66 years, female, white, stage:Stage IIIC, dead, 1448 days 52.5
                                          TCGA-23-1024-01A 52 years, female, white, stage:Stage IV, alive, 468 days 52.4
                                          TCGA-13-1495-01A 60 years, female, white, stage:Stage IIIC, dead, 2749 days 52.1
                                          TCGA-24-1553-01A 53 years, female, white, stage:Stage IIIB, dead, 1767 days 52.1
                                          TCGA-24-1850-01A 72 years, female, white, stage:Stage IIIC, alive, 168 days 51.8
                                          TCGA-09-0367-01A 67 years, female, native hawaiian or other pacific islander, stage:Stage IIIC, dead, 547 days 51.5
                                          TCGA-29-1784-01A 55 years, female, white, stage:Stage IIIC, alive, 163 days 51.4
                                          TCGA-10-0928-01A 71 years, female, white, stage:Stage IIIC, dead, 563 days 50.9
                                          TCGA-30-1857-01A 64 years, female, white, stage:Stage IV, dead, 8 days 50.3
                                          TCGA-13-1501-01A 50 years, female, white, stage:Stage IV, dead, 1314 days 49.7
                                          TCGA-24-1560-01A 51 years, female, white, stage:Stage IIIC, dead, 1341 days 49.4
                                          TCGA-13-1506-01A 45 years, female, white, stage:Stage IIIC, dead, 1039 days 49.4
                                          TCGA-13-1407-01A 51 years, female, white, stage:Stage IIIC, alive, 2534 days 49.3
                                          TCGA-13-1485-01A 48 years, female, white, stage:Stage IV, dead, 629 days 48.9
                                          TCGA-30-1892-01A 52 years, female, white, stage:Stage IIIC, dead, 1484 days 47.8
                                          TCGA-61-1725-01A 40 years, female, white, stage:Stage IIIC, alive, 956 days 47.7
                                          TCGA-23-1107-01A 59 years, female, white, stage:Stage IV, dead, 9 days 47.5
                                          TCGA-25-1635-01A 71 years, female, white, stage:Stage IIIC, dead, 1583 days 47.5
                                          TCGA-24-1103-01A 50 years, female, black or african american, stage:Stage IIIC, dead, 1646 days 47.4
                                          TCGA-13-0897-01A 54 years, female, white, stage:Stage IIIC, dead, 2182 days 47.0
                                          TCGA-59-2350-01A 44 years, female, stage:Stage IV, dead, 679 days 47.0
                                          TCGA-57-1583-01A 57 years, female, black or african american, stage:Stage IIIC, dead, 346 days 46.6
                                          TCGA-30-1866-01A 61 years, female, white, stage:Stage IV, dead, 1114 days 46.6
                                          TCGA-09-2048-01A 63 years, female, white, stage:Stage IIIC, dead, 138 days 46.0
                                          TCGA-61-1728-01A 59 years, female, white, stage:Stage IV, alive, 848 days 45.9
                                          TCGA-13-1409-01A 73 years, female, white, stage:Stage IIIC, dead, 1742 days 45.8
                                          TCGA-04-1347-01A 81 years, female, white, stage:Stage IV, alive, 1919 days 45.8
                                          TCGA-04-1341-01A 85 years, female, white, stage:'--, alive, 33 days 44.7
                                          TCGA-13-0730-01A 71 years, female, white, stage:Stage IIIC, dead, 542 days 44.3
                                          TCGA-13-0911-01A 55 years, female, white, stage:Stage IV, dead, 1355 days 44.1
                                          TCGA-24-2298-01A 55 years, female, white, stage:Stage IIIC, dead, 1620 days 44.0
                                          TCGA-23-1123-01A 59 years, female, white, stage:Stage IIIC, dead, 1018 days 43.7
                                          TCGA-29-1703-01A 56 years, female, black or african american, stage:Stage IIIC, dead, 1815 days 43.6
                                          TCGA-25-2393-01A 81 years, female, white, stage:Stage IIIC, dead, 1157 days 43.6
                                          TCGA-24-1471-01A 60 years, female, white, stage:Stage IIIC, alive, 36 days 42.6
                                          TCGA-24-0979-01A 53 years, female, white, stage:Stage IV, dead, 1264 days 42.0
                                          TCGA-24-1104-01A 56 years, female, white, stage:Stage IV, dead, 1933 days 41.9
                                          TCGA-24-1552-01A 77 years, female, white, stage:Stage IIIC, dead, 1259 days 41.8
                                          TCGA-61-1733-01A 71 years, female, white, stage:Stage IIIC, alive, 967 days 41.8
                                          TCGA-61-1995-01A 43 years, female, white, stage:Stage IIIC, alive, 61 days 41.7
                                          TCGA-10-0931-01A 44 years, female, white, stage:Stage IIIC, dead, 1000 days 41.3
                                          TCGA-24-2281-01A 68 years, female, white, stage:Stage IIA, alive, 1357 days 40.7
                                          TCGA-24-2280-01A 74 years, female, white, stage:Stage IIIC, alive, 2143 days 39.2
                                          TCGA-24-2038-01A 68 years, female, white, stage:Stage IIIA, dead, 1354 days 39.1
                                          TCGA-04-1343-01A 72 years, female, white, stage:Stage IV, dead, 361 days 38.9
                                          TCGA-29-1781-01A 69 years, female, white, stage:Stage IIIC, alive, 255 days 38.9
                                          TCGA-29-1697-01A 62 years, female, white, stage:Stage IIIC, dead, 949 days 38.7
                                          TCGA-24-1565-01A 74 years, female, white, stage:Stage IIIC, dead, 312 days 37.8
                                          TCGA-25-1316-01A 55 years, female, white, stage:Stage IIIC, dead, 1279 days 37.3
                                          TCGA-29-1694-01A 45 years, female, white, stage:Stage IIIC, dead, 1187 days 37.2
                                          TCGA-13-0766-01A 42 years, female, white, stage:Stage IIIC, dead, 1725 days 36.8
                                          TCGA-13-0727-01A 71 years, female, white, stage:Stage IIIC, dead, 462 days 36.0
                                          TCGA-24-2271-01A 55 years, female, asian, stage:Stage IIIC, dead, 962 days 35.8
                                          TCGA-13-0887-01A 42 years, female, white, stage:Stage IIIC, dead, 2028 days 35.3
                                          TCGA-29-1777-01A 47 years, female, white, stage:Stage IIIC, alive, 374 days 35.3
                                          TCGA-29-1761-01A 80 years, female, asian, stage:Stage IIIC, dead, 528 days 35.0
                                          TCGA-04-1331-01A 78 years, female, white, stage:Stage IIIC, dead, 1336 days 34.9
                                          TCGA-04-1519-01A 48 years, female, stage:Stage IIIC, alive, 24 days 34.7
                                          TCGA-04-1350-01A 46 years, female, white, stage:Stage IIIC, dead, 1946 days 34.5
                                          TCGA-13-0725-01A 44 years, female, white, stage:Stage IIIC, dead, 377 days 34.0
                                          TCGA-13-1509-01A 64 years, female, white, stage:Stage IV, alive, 2438 days 33.3
                                          TCGA-04-1655-01A 49 years, female, white, stage:Stage IIIB, dead, 1380 days 33.1
                                          TCGA-30-1853-01A 58 years, female, white, stage:Stage IIIC, dead, 1103 days 31.6
                                          TCGA-29-2428-01A 58 years, female, white, stage:Stage IIIC, alive, 1372 days 30.9
                                          TCGA-13-0720-01A 48 years, female, white, stage:Stage IIIC, dead, 1355 days 30.3
                                          TCGA-24-1416-01A 34 years, female, white, stage:Stage IV, alive, 194 days 27.5
                                          TCGA-24-1923-01A 51 years, female, white, stage:Stage IIIC, dead, 690 days 27.3
                                          TCGA-13-0765-01A 50 years, female, white, stage:Stage IIIC, dead, 1389 days 26.3
                                          TCGA-24-0966-01A 78 years, female, black or african american, stage:Stage IIIC, alive, 232 days 25.9
                                          TCGA-61-2110-01A 56 years, female, white, stage:Stage IIIC, dead, 1354 days 25.8
                                          TCGA-24-1426-01A 43 years, female, white, stage:Stage IIIC, alive, 163 days 25.4
                                          TCGA-10-0927-01A 65 years, female, stage:Stage IIIC, dead, 2490 days 24.6
                                          TCGA-23-1113-01A 48 years, female, white, stage:Stage IV, dead, 949 days 20.4
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                                          56.579.2104.320.4175.7020406080100120140160180200220240260280
                                          56.579.2104.320.4175.7020406080100120140160180200220240260280
                                          OVARY SEROUS CYSTADENOCARCINOMA (VALIDATION) - Interactive survival scatter ploti

                                          The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

                                          The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

                                          Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

                                          Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

                                          & Survival analysisi

                                          Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.

                                          SSR1 is not prognostic in Ovary Serous Cystadenocarcinoma (validation)


                                          Stage:
                                          0 2 4 6 810121416Time after diagnosis (years)0.020406080100120140160Expression level (pTPM)Dead (n=66)Alive (n=15)64Density dead47Density alive2.5Density dead under cut off1.8Density dead over cut off0.00.10.20.40.60.81.0P score0.30.00.20.40.60.81.51.0Medain separation0.5P scoreDead median separationCut off
                                          0.00.10.20.30.40.50.60.70.80.91.0Survival probability 0 1 2 3 4 5 6 7 8 910111213141516Time (years)Low expression (n=33)High expression (n=48)
                                          Survival analysis
                                          Current cut offi

                                          Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.

                                          :
                                          Best expression cut offi

                                          Based on the pTPM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (pTPM) was examined. The best expression cut-off refers the pTPM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.

                                          : 51.27
                                          Median expressioni

                                          Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.

                                          : 55.07
                                          Median follow up timei

                                          Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.

                                          : 2.2
                                          P scorei

                                          Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.

                                          0.013
                                          5-year survival highi

                                          5-year survival for patients with higher expression than the expression cutoff.

                                          For melanoma and glioma, 3-year survival is shown.

                                          16%
                                          5-year survival lowi

                                          5-year survival for patients with lower expression than the expression cutoff.

                                          For melanoma and glioma, 3-year survival is shown.

                                          37%
                                          TCGA RNA samplesi

                                          RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .

                                          Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.

                                          Average pTPM 64.7
                                          Number of samples 81
                                          Samples
                                          Sample Description pTPM
                                          DO46568 66 years, female, NA, stage:III, dead, 320 days 177.0
                                          DO46588 74 years, female, NA, stage:III, dead, 438 days 172.4
                                          DO46378 59 years, female, NA, stage:III, alive, 843 days 147.7
                                          DO46346 54 years, female, NA, stage:III, dead, 1187 days 132.1
                                          DO46571 61 years, female, NA, stage:III, dead, 243 days 131.2
                                          DO46394 61 years, female, NA, stage:IV, dead, 1039 days 123.9
                                          DO46336 70 years, female, NA, stage:IV, dead, 664 days 121.9
                                          DO46354 73 years, female, NA, stage:III, dead, 843 days 120.6
                                          DO46458 67 years, female, NA, stage:IV, alive, 3787 days 111.7
                                          DO46560 45 years, female, NA, stage:IV, dead, 286 days 111.4
                                          DO46606 73 years, female, NA, stage:III, alive, 804 days 110.4
                                          DO46443 59 years, female, NA, stage:III, dead, 2464 days 107.6
                                          DO46400 70 years, female, NA, stage:III, dead, 719 days 104.1
                                          DO46362 61 years, female, NA, stage:III, dead, 1639 days 101.2
                                          DO46325 54 years, female, NA, stage:III, dead, 477 days 96.2
                                          DO46334 77 years, female, NA, stage:III, dead, 496 days 93.3
                                          DO46382 62 years, female, NA, stage:IV, dead, 311 days 93.2
                                          DO46340 62 years, female, NA, stage:III, dead, 616 days 88.3
                                          DO46386 49 years, female, NA, stage:III, dead, 1162 days 86.4
                                          DO46330 60 years, female, NA, stage:III, dead, 684 days 85.1
                                          DO46328 52 years, female, NA, stage:III, dead, 972 days 81.0
                                          DO46566 78 years, female, NA, stage:III, dead, 673 days 80.6
                                          DO46448 45 years, female, NA, stage:III, dead, 654 days 80.4
                                          DO46348 58 years, female, NA, stage:IV, dead, 287 days 79.6
                                          DO46388 74 years, female, NA, stage:III, dead, 413 days 79.4
                                          DO46508 50 years, female, NA, stage:III, dead, 2101 days 78.3
                                          DO46374 69 years, female, NA, stage:III, dead, 1409 days 77.3
                                          DO46327 54 years, female, NA, stage:III, dead, 184 days 76.5
                                          DO46332 56 years, female, NA, stage:III, dead, 689 days 74.4
                                          DO46432 56 years, female, NA, stage:III, alive, 2218 days 74.0
                                          DO46513 54 years, female, NA, stage:IV, dead, 1883 days 72.5
                                          DO46329 52 years, female, NA, stage:III, dead, 1699 days 72.3
                                          DO46368 57 years, female, NA, stage:III, dead, 2879 days 69.7
                                          DO46360 58 years, female, NA, stage:IV, dead, 1759 days 68.8
                                          DO46396 64 years, female, NA, stage:III, dead, 583 days 66.7
                                          DO46344 46 years, female, NA, stage:III, dead, 642 days 66.3
                                          DO46602 74 years, female, NA, stage:III, dead, 205 days 65.2
                                          DO46338 59 years, female, NA, stage:III, dead, 596 days 62.3
                                          DO46364 45 years, female, NA, stage:III, dead, 806 days 57.4
                                          DO46528 56 years, female, NA, stage:III, alive, 6139 days 55.1
                                          DO46390 65 years, female, NA, stage:III, dead, 374 days 55.1
                                          DO46326 51 years, female, NA, stage:III, dead, 701 days 55.0
                                          DO46597 60 years, female, NA, stage:III, dead, 393 days 54.8
                                          DO46358 60 years, female, NA, stage:III, dead, 423 days 54.7
                                          DO46402 77 years, female, NA, stage:III, dead, 511 days 53.9
                                          DO46561 52 years, female, NA, stage:III, dead, 195 days 53.7
                                          DO46404 55 years, female, NA, stage:III, dead, 690 days 52.7
                                          DO46551 58 years, female, NA, stage:III, dead, 1055 days 51.4
                                          DO46398 66 years, female, NA, stage:III, alive, 437 days 51.1
                                          DO46468 67 years, female, NA, stage:III, alive, 2776 days 50.9
                                          DO46392 48 years, female, NA, stage:III, dead, 628 days 48.8
                                          DO46370 54 years, female, NA, stage:III, dead, 1727 days 47.9
                                          DO46523 52 years, female, NA, stage:IV, alive, 1873 days 47.3
                                          DO46342 67 years, female, NA, stage:III, dead, 1398 days 46.6
                                          DO46533 46 years, female, NA, stage:III, alive, 3667 days 42.7
                                          DO46581 66 years, female, NA, stage:III, dead, 408 days 42.2
                                          DO46376 58 years, female, NA, stage:III, dead, 1430 days 40.4
                                          DO46350 66 years, female, NA, stage:III, dead, 886 days 39.8
                                          DO46586 55 years, female, NA, stage:III, dead, 1019 days 39.0
                                          DO46412 64 years, female, NA, stage:III, dead, 597 days 36.6
                                          DO46493 62 years, female, NA, stage:IV, alive, 839 days 36.0
                                          DO46408 56 years, female, NA, stage:III, dead, 489 days 34.8
                                          DO46352 60 years, female, NA, stage:III, dead, 677 days 33.1
                                          DO46438 55 years, female, NA, stage:IV, alive, 2227 days 32.7
                                          DO46372 39 years, female, NA, stage:III, dead, 1326 days 31.0
                                          DO46380 51 years, female, NA, stage:III, dead, 1423 days 28.9
                                          DO46611 52 years, female, NA, stage:III, dead, 734 days 28.8
                                          DO46576 75 years, female, NA, stage:III, alive, 133 days 27.9
                                          DO46436 58 years, female, NA, stage:III, alive, 3193 days 27.5
                                          DO46538 57 years, female, NA, stage:III, dead, 1527 days 27.0
                                          DO46384 55 years, female, NA, stage:III, dead, 614 days 25.0
                                          DO46463 49 years, female, NA, stage:III, dead, 2451 days 24.8
                                          DO46356 68 years, female, NA, stage:III, dead, 911 days 23.6
                                          DO46518 62 years, female, NA, stage:III, alive, 2960 days 22.8
                                          DO46366 65 years, female, NA, stage:III, dead, 2054 days 22.6
                                          DO46331 72 years, female, NA, stage:III, dead, 612 days 21.5
                                          DO46453 66 years, female, NA, stage:III, dead, 3294 days 21.0
                                          DO46591 58 years, female, NA, stage:III, dead, 195 days 18.2
                                          DO46333 58 years, female, NA, stage:III, dead, 359 days 16.0
                                          DO46428 59 years, female, NA, stage:IV, alive, 2644 days 13.4
                                          DO46546 73 years, female, NA, stage:III, dead, 1889 days 10.3
                                          Show allShow less
                                          36.055.181.010.3147.7020406080100120140160
                                          36.055.181.010.3147.7020406080100120140160
                                          OVARY SEROUS CYSTADENOCARCINOMA - Protein relative expression (CPTAC)
                                          Number of samples 108
                                          Samples
                                          Sample ID Sample type nRPX
                                          685ec3c2-e67a-40d3-9eb3-aa01c9_D1_D2 Normal 1.5
                                          0c87932d-b6fd-4eb5-b86a-a34d07_D2 Tumor 0.9
                                          a583d3ff-8165-43e9-b764-23b7ef_D1_D2 Normal 0.9
                                          3946a96c-e0ae-442f-83b4-a9350e_D2 Tumor 0.8
                                          3e746bea-ed68-40e6-b348-6ddf08_D2 Normal 0.8
                                          08296da7-70ea-44df-8646-09f2cc_D2 Tumor 0.8
                                          b22659b9-e12c-4725-a7db-a833de_D1_D2 Normal 0.6
                                          eb0a53df-7620-4024-8d2d-051142_D2 Tumor 0.5
                                          2f901c90-617e-46da-9fac-d68369_D2 Tumor 0.5
                                          6530147a-efe9-4df6-ac2f-03ece3_D2 Tumor 0.5
                                          6e209757-a7f4-45af-b5f3-2ebc02_D2 Normal 0.4
                                          a3a26070-fb84-406a-8280-d555e6_D2 Normal 0.4
                                          2563cb02-d58a-4286-8634-7502cd_D2 Tumor 0.3
                                          994f9b8e-46cb-413f-8ec8-2c2fed_D2 Normal 0.3
                                          fbb41c94-aabd-49cc-90b2-882c3e_D2 Tumor 0.3
                                          8d78194e-fbef-4819-a7b5-b73ae9_D2 Tumor 0.2
                                          80873a0c-1f40-4d51-bab1-3f2071_D2 Tumor 0.2
                                          bd266bdd-12e4-42cb-9c49-911bfc_D2 Tumor 0.2
                                          1db5574d-aca7-403c-8100-6e705f_D2 Normal 0.2
                                          d38f40fb-dd78-43b2-8b7b-4b6977_D2 Tumor 0.1
                                          c17b0ff9-9057-4848-a0cc-abb25f_D2 Tumor 0.1
                                          3d3e1888-d67e-4c69-ba83-112d0f_D2 Tumor 0.0
                                          27f3ca2d-a86f-479d-8e7e-5307c7_D2 Tumor 0.0
                                          41d0619e-b299-42e2-ac32-29e784_D2 Tumor -0.1
                                          2115808b-6a0d-49bc-a8d7-b83bde_D2 Tumor -0.1
                                          2b73e01c-347a-4dae-a71d-752aeb_D2 Normal -0.1
                                          fe83e13f-9754-403b-8f74-d6caf8_D2 Tumor -0.1
                                          e3ebe010-cd31-4b5d-8fcb-b7103b_D2 Tumor -0.1
                                          e9d416e7-f661-400a-896e-388545_D2 Tumor -0.2
                                          6319b36b-533c-4e86-8e12-80552e_D3 Tumor -0.2
                                          1556af7e-c2ae-4fce-9aae-87c459_D1_D2 Normal -0.3
                                          f6c215ea-5381-4521-bb61-be8e97_D2 Tumor -0.3
                                          3490835c-c004-45ed-91f3-7c206f_D2 Tumor -0.3
                                          69d552be-7cb2-4bb4-b602-a27b3e_D2 Tumor -0.3
                                          1abbcb28-f221-4cd4-8c01-37b9bb_D1_D2 Normal -0.3
                                          2224c03f-b7b1-4368-887e-2b4cdf_D2 Tumor -0.4
                                          51a4ce2f-4166-4c6b-a7e0-942d0a_D2 Tumor -0.4
                                          a65d8e76-640f-4341-a561-afbb57_D2 Normal -0.5
                                          79b60f32-6cca-4cb6-9a1e-22a3ac_D2 Tumor -0.5
                                          927f0958-db5a-4bc5-92b7-2a3695_D2 Tumor -0.6
                                          2ed8beb2-bc63-4bad-b5fe-1916a0_D2 Tumor -0.6
                                          4ccb249a-6722-491e-97e9-e3b4e7_D2 Tumor -0.6
                                          340a3769-3031-41ae-bb08-a2f696_D2 Normal -0.6
                                          0cc794c3-5bf5-4621-b238-58a0f6_D2 Tumor -0.7
                                          8e17b45e-6a06-4e4e-913d-7b1edb_D2 Tumor -0.7
                                          a03d1103-b809-42c4-ad5c-5aff58_D2 Tumor -0.7
                                          9e0d47e0-f633-468b-b82b-4d752d_D2 Tumor -0.7
                                          28d0abdb-f682-4bd3-9425-a9c508_D2 Tumor -0.7
                                          d4791079-c826-4fc7-9d9b-ee20ba_D2 Tumor -0.8
                                          8234f8ea-bdbd-45b0-bd0b-16f1e7_D2 Tumor -0.8
                                          eb3f3494-7057-4afe-b212-e6e9a3_D2 Tumor -0.8
                                          e7b656bf-3c34-4ba1-bdf3-c7eefe_D2 Tumor -0.8
                                          b9c1f22e-61f7-45ed-b3b4-5094c7_D2 Normal -0.8
                                          50997c44-1c8b-4d34-b535-4a6cc2_D2 Tumor -0.8
                                          256ac9f5-1e19-44b4-92fb-fef3fc_D2 Tumor -0.8
                                          1a10c200-3895-4648-b951-94f99f_D2 Tumor -0.8
                                          05387aad-2a1f-42c2-8d6f-950598_D3 Tumor -0.8
                                          d109a3c0-350e-47f5-bda0-61899c_D2 Tumor -0.9
                                          1b2ab076-c72f-4bbe-b9f9-657d24_D2 Tumor -0.9
                                          7d953d1d-84b6-4ecd-b1d7-1ed865_D2 Tumor -0.9
                                          21efd60f-6a31-4b98-9477-16a905_D2 Normal -0.9
                                          3fbf076a-824b-4eac-b6dc-bf5e59_D2 Normal -0.9
                                          e6850782-fd2a-4c53-b682-1852fe_D2 Tumor -0.9
                                          62f5840e-6cd7-4200-b651-645e53_D2 Tumor -1.0
                                          2b4ce90c-8036-4207-ac3e-54a76f_D2 Tumor -1.0
                                          5ea22f5e-307b-491d-801f-8b7fa6_D2 Tumor -1.0
                                          52c064a7-78d9-4a1a-85b4-27c6d1_D2 Tumor -1.0
                                          9c8e78bf-b03e-4ba0-9909-5ff070_D2 Tumor -1.1
                                          cfd76f9a-ce60-4ec7-8e6b-a8fc31_D3 Tumor -1.1
                                          42d860a3-8a0c-4c44-a09a-9ad8cf_D2 Tumor -1.1
                                          af95e2c6-25c4-4ab8-bf06-3e15ff_D2 Tumor -1.1
                                          10c2d629-0287-4511-ac25-f29031_D2 Tumor -1.1
                                          9b90eb78-2f50-4aeb-b010-d642f9_D2 Tumor -1.2
                                          285fed94-1495-448e-879b-b55de9_D2 Tumor -1.2
                                          092af714-b97a-457c-b0e9-8c20e8_D2 Normal -1.2
                                          318d53c3-216b-4de1-a098-77d6dd_D2 Tumor -1.2
                                          31c15e30-21d4-4843-bd4a-9cd0d8_D2 Normal -1.3
                                          2433b136-fc7b-4cea-b958-bc6efb_D2 Tumor -1.3
                                          3a380577-c134-47ba-a1ce-988d7c_D2 Tumor -1.3
                                          a8853382-b726-4ce8-98d5-ca89df_D2 Tumor -1.4
                                          627e6e36-3dca-4ee5-9755-6f3510_D2 Tumor -1.4
                                          1c9145ad-1981-4871-aa7e-8b11de_D2 Tumor -1.5
                                          76e77c6b-c80e-4391-bdbb-e1dcea_D2 Tumor -1.5
                                          91b287fd-eadb-442d-abcd-20b741_D2 Tumor -1.5
                                          61f76fe6-a1c6-41b8-bdc2-2f9209_D2 Normal -1.6
                                          35a345a4-e954-4c81-ae3f-7797cd_D2 Tumor -1.6
                                          2dc28da8-7ff1-4b9b-b5bd-17cc25_D2 Tumor -1.7
                                          7069e990-4a4e-4984-a66d-4d835a_D2 Tumor -1.8
                                          74a45e5a-a35a-4c60-a4b4-f3f5ea_D2 Tumor -1.8
                                          558333b0-ea23-4303-9e3c-4932b1_D2 Tumor -1.9
                                          1772e913-f62e-446a-8cf3-720348_D2 Tumor -1.9
                                          15524912-685a-47ce-a824-567848_D2 Tumor -2.2
                                          49bd51fe-48a1-4828-b66e-b30c38_D2 Tumor -2.2
                                          e23eb014-69c1-460a-b9d4-9786c8_D2 Normal -2.3
                                          5c3971ee-87c7-4dff-b66e-f18892_D2 Tumor -2.3
                                          8ed739dd-ae0f-4881-971a-db3cf4_D1_D2 Normal -2.6
                                          0745488e-0bfb-4d1f-8228-dedf76_D1_D2 Normal -2.8
                                          1de8d3d8-fc0e-4be0-8aa7-127c7b_D2 Tumor -3.0
                                          347e379b-77c0-4dd3-aa25-18c9d1_D2 Tumor -3.0
                                          9a7a86d3-bbf2-4d36-941d-c75c03_D1_D2 Tumor N/A
                                          ce1e5dfc-2ef1-4633-af93-5ea4d9_D2 Tumor N/A
                                          efc971f8-54c5-4531-a792-705ecf_D2 Tumor N/A
                                          46c73531-f531-4ec3-97fe-b39d9d_D2 Tumor N/A
                                          3dcf8b3c-c0c5-4dfa-9543-5d30fb_D2 Tumor N/A
                                          51c1c79e-5a8e-4b0a-bf92-1c0cab_D2 Tumor N/A
                                          161317f3-1a39-438e-af45-cd2502_D2 Tumor N/A
                                          7edfd606-4bee-4529-9fec-1ca7f0_D2 Normal N/A
                                          7c7ce2d7-6c8a-424e-8e6c-d14ad1_D2 Tumor N/A
                                          Show allShow less
                                          -1.2-0.8-0.1-2.81.5-3.0-2.5-2.0-1.5-1.0-0.50.00.51.0
                                          -1.2-0.8-0.1-2.81.5-3.0-2.5-2.0-1.5-1.0-0.50.00.51.0
                                          OVARIAN CANCER - Protein expressioni

                                          A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

                                           

                                          Antibody stainingi

                                          Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

                                          Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

                                          Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

                                          Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts


                                          Antibody HPA011276

                                          Antibody HPA017062
                                           Staining
                                            High
                                            Medium
                                            Low
                                            Not detected
                                           Intensity
                                            Strong
                                            Moderate
                                            Weak
                                            Negative
                                           Quantity
                                            >75%
                                            75%-25%
                                            <25%
                                            None
                                           Location
                                            Nuclear
                                            Cytoplasmic/membranous
                                            Cytoplasmic/membranous,nuclear
                                            None
                                          Cystadenocarcinoma, serous, NOS
                                          Carcinoma, endometroid
                                          Cystadenocarcinoma, mucinous, NOS
                                          Carcinoma, NOS
                                          Cystadenocarcinoma, serous, NOS

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