Single cell type - RECQL5 - The Human Protein Atlas

RECQL5

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RECQL5
Gene descriptionⁱ Full gene name according to HGNC.	RecQ like helicase 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Glandular & Luminal cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Gastric mucus-secreting cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.46
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Gastric mucus-secreting cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RECQL5 is part of cluster 37 Glandular & Luminal cells - Unknown function with confidenceⁱ 1
334 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SMIM5	Small integral membrane protein 5	0.6363	59
ZNF888	Zinc finger protein 888	0.5561	37
RIPK4	Receptor interacting serine/threonine kinase 4	0.4960	37
LIMS4	LIM zinc finger domain containing 4	0.4930	37
POU5F1	POU class 5 homeobox 1	0.4901	37
PSORS1C2	Psoriasis susceptibility 1 candidate 2	0.4895	37
ENSG00000284976	Novel RING finger protein	0.4861	59
SHROOM3	Shroom family member 3	0.4837	37
TMEM184A	Transmembrane protein 184A	0.4812	59
CDSN	Corneodesmosin	0.4694	37
ZMYND8	Zinc finger MYND-type containing 8	0.4689	37
PAEP	Progestagen associated endometrial protein	0.4566	37
NUAK2	NUAK family kinase 2	0.4553	59
RAB11FIP1	RAB11 family interacting protein 1	0.4547	37
C2CD4A	C2 calcium dependent domain containing 4A	0.4521	37

IMMUNE CELLS

RECQL5 is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 1
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CEP68	Centrosomal protein 68	1.0000	30
ENSG00000268750	Novel protein	1.0000	30
C7orf31	Chromosome 7 open reading frame 31	1.0000	30
GAREM1	GRB2 associated regulator of MAPK1 subtype 1	1.0000	30
UBFD1	Ubiquitin family domain containing 1	1.0000	30
MCAT	Malonyl-CoA-acyl carrier protein transacylase	1.0000	30
ST7L	Suppression of tumorigenicity 7 like	1.0000	30
MROH8	Maestro heat like repeat family member 8	0.9762	30
ADNP2	ADNP homeobox 2	0.9762	30
ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase	0.9762	30
FZD3	Frizzled class receptor 3	0.9762	30
TENT4A	Terminal nucleotidyltransferase 4A	0.9762	30
USP34	Ubiquitin specific peptidase 34	0.9762	30
OSCP1	Organic solute carrier partner 1	0.9762	30
KRI1	KRI1 homolog	0.9762	30

Adipocytes	4.9 nTPM
Breast	5.1 nTPM
Adipose tissue	4.7 nTPM

Alveolar cells type 1	6.1 nTPM
Lung	6.1 nTPM

Alveolar cells type 2	6.3 nTPM
Lung	6.3 nTPM

Astrocytes	8.7 nTPM
Brain	8.7 nTPM

B-cells	6.5 nTPM
Bone marrow	13.1 nTPM
PBMC	10.8 nTPM
Thymus	10.5 nTPM
Kidney	10.4 nTPM
Stomach	8.0 nTPM
Lung	8.0 nTPM
Spleen	7.7 nTPM
Salivary gland	6.0 nTPM
Lymph node	5.2 nTPM
Adipose tissue	4.1 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	10.7 nTPM
Endometrium	13.0 nTPM
Bronchus	12.8 nTPM
Lung	10.6 nTPM
Fallopian tube	6.2 nTPM

Club cells	11.4 nTPM
Prostate	17.9 nTPM
Bronchus	10.6 nTPM
Lung	5.7 nTPM

Endothelial cells	4.4 nTPM
Liver	10.1 nTPM
Prostate	6.7 nTPM
Esophagus	6.5 nTPM
Endometrium	6.1 nTPM
Ovary	5.7 nTPM
Vascular	5.4 nTPM
Pancreas	5.2 nTPM
Thymus	5.1 nTPM
Tongue	4.2 nTPM
Skeletal muscle	3.7 nTPM
Lung	3.6 nTPM
Salivary gland	3.6 nTPM
Testis	3.4 nTPM
Heart muscle	3.1 nTPM
Fallopian tube	2.7 nTPM
Placenta	2.3 nTPM
Breast	1.8 nTPM
Skin	1.2 nTPM

Enteroendocrine cells	6.1 nTPM
Rectum	8.4 nTPM
Small intestine	6.9 nTPM
Colon	3.0 nTPM

Fibroblasts	3.9 nTPM
Placenta	7.2 nTPM
Liver	7.1 nTPM
Breast	5.8 nTPM
Esophagus	5.1 nTPM
Salivary gland	4.8 nTPM
Vascular	4.6 nTPM
Thymus	4.1 nTPM
Pancreas	3.8 nTPM
Prostate	3.3 nTPM
Adipose tissue	3.2 nTPM
Skeletal muscle	2.8 nTPM
Fallopian tube	2.7 nTPM
Skin	2.3 nTPM
Lung	2.0 nTPM
Heart muscle	1.8 nTPM
Stomach	1.4 nTPM

Granulocytes	2.9 nTPM
Lung	5.5 nTPM
Fallopian tube	3.1 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	11.3 nTPM
Small intestine	22.7 nTPM
Rectum	6.9 nTPM
Colon	4.4 nTPM

Lymphatic endothelial cells	9.9 nTPM
Ovary	16.4 nTPM
Fallopian tube	3.5 nTPM

Macrophages	5.3 nTPM
Bone marrow	9.1 nTPM
Spleen	8.0 nTPM
Kidney	7.1 nTPM
Endometrium	6.8 nTPM
Salivary gland	6.4 nTPM
Thymus	6.4 nTPM
Pancreas	6.2 nTPM
Tongue	5.9 nTPM
Breast	5.8 nTPM
Skin	5.6 nTPM
Lung	5.4 nTPM
Vascular	5.2 nTPM
Stomach	5.1 nTPM
Prostate	5.0 nTPM
Adipose tissue	4.0 nTPM
Fallopian tube	3.7 nTPM
Skeletal muscle	2.5 nTPM
Testis	1.9 nTPM
Esophagus	1.3 nTPM

Paneth cells	4.9 nTPM
Rectum	7.8 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM

Basal respiratory cells	4.3 nTPM
Bronchus	4.3 nTPM

Bipolar cells	8.2 nTPM
Eye	8.2 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Collecting duct cells	17.5 nTPM
Kidney	17.5 nTPM

Plasma cells	8.7 nTPM
Bone marrow	16.6 nTPM
Stomach	13.0 nTPM
Thymus	10.9 nTPM
Liver	7.5 nTPM
Spleen	7.0 nTPM
Salivary gland	5.8 nTPM
Esophagus	5.2 nTPM
Fallopian tube	3.9 nTPM

Schwann cells	2.8 nTPM
Vascular	6.8 nTPM
Adipose tissue	1.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.7 nTPM
Salivary gland	4.9 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	3.3 nTPM
Liver	5.5 nTPM
Placenta	4.6 nTPM
Breast	4.3 nTPM
Adipose tissue	4.2 nTPM
Thymus	3.9 nTPM
Tongue	3.9 nTPM
Vascular	3.8 nTPM
Endometrium	3.6 nTPM
Skeletal muscle	3.6 nTPM
Ovary	3.1 nTPM
Prostate	3.0 nTPM
Salivary gland	2.7 nTPM
Lung	2.4 nTPM
Fallopian tube	1.6 nTPM
Esophagus	1.2 nTPM
Skin	0.6 nTPM

Suprabasal keratinocytes	11.4 nTPM
Tongue	20.7 nTPM
Skin	2.2 nTPM

T-cells	4.4 nTPM
Thymus	6.6 nTPM
Tongue	6.6 nTPM
Bone marrow	6.4 nTPM
Lung	6.3 nTPM
Salivary gland	6.1 nTPM
Stomach	5.8 nTPM
PBMC	5.5 nTPM
Prostate	5.4 nTPM
Endometrium	5.2 nTPM
Spleen	5.1 nTPM
Vascular	4.8 nTPM
Kidney	4.4 nTPM
Lymph node	4.2 nTPM
Colon	3.9 nTPM
Liver	3.9 nTPM
Breast	2.8 nTPM
Fallopian tube	2.8 nTPM
Skin	2.1 nTPM
Skeletal muscle	1.9 nTPM
Adipose tissue	1.8 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	6.4 nTPM
Small intestine	7.9 nTPM
Rectum	6.1 nTPM
Colon	5.1 nTPM

Amygdala excitatory	12.5 nTPM
Hypothalamus	14.5 nTPM
Amygdala	13.7 nTPM
Basal ganglia	13.1 nTPM
Cerebral cortex	12.5 nTPM
Hippocampus	11.6 nTPM
Thalamus	9.5 nTPM

Astrocyte	20.6 nTPM
Cerebellum	27.1 nTPM
Pons	23.4 nTPM
Spinal cord	23.1 nTPM
Thalamus	22.7 nTPM
Midbrain	21.3 nTPM
Medulla oblongata	19.2 nTPM
Hippocampus	19.1 nTPM
Cerebral cortex	18.7 nTPM
Amygdala	17.7 nTPM
Hypothalamus	17.5 nTPM
Basal ganglia	17.2 nTPM

Bergmann glia	13.5 nTPM
Pons	20.1 nTPM
Cerebellum	11.9 nTPM
Medulla oblongata	8.5 nTPM

Central nervous system macrophage	11.5 nTPM
Amygdala	14.7 nTPM
Hypothalamus	13.0 nTPM
Hippocampus	12.5 nTPM
Midbrain	11.9 nTPM
Cerebellum	11.7 nTPM
Thalamus	11.6 nTPM
Pons	10.8 nTPM
Cerebral cortex	10.7 nTPM
Basal ganglia	10.3 nTPM
Spinal cord	10.3 nTPM
Medulla oblongata	8.8 nTPM

Cerebellar inhibitory	9.7 nTPM
Medulla oblongata	11.8 nTPM
Cerebellum	11.3 nTPM
Pons	9.2 nTPM
Spinal cord	8.2 nTPM
Midbrain	8.1 nTPM

Cge interneuron	9.1 nTPM
Hypothalamus	12.3 nTPM
Amygdala	9.4 nTPM
Midbrain	9.4 nTPM
Cerebral cortex	8.8 nTPM
Hippocampus	8.7 nTPM
Basal ganglia	8.2 nTPM
Thalamus	6.5 nTPM

Choroid plexus epithelial cell	15.9 nTPM
Basal ganglia	23.7 nTPM
Medulla oblongata	20.4 nTPM
Hippocampus	11.1 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	16.6 nTPM
Hypothalamus	28.0 nTPM
Thalamus	24.3 nTPM
Midbrain	18.5 nTPM
Cerebral cortex	18.4 nTPM
Cerebellum	17.4 nTPM
Amygdala	16.9 nTPM
Hippocampus	14.7 nTPM
Pons	14.2 nTPM
Basal ganglia	13.1 nTPM
Medulla oblongata	12.9 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	11.9 nTPM
Hypothalamus	13.8 nTPM
Cerebral cortex	12.2 nTPM
Amygdala	12.1 nTPM
Hippocampus	11.8 nTPM
Basal ganglia	11.5 nTPM
Midbrain	10.0 nTPM

Deep-layer intratelencephalic	11.5 nTPM
Amygdala	12.5 nTPM
Hypothalamus	12.5 nTPM
Hippocampus	10.9 nTPM
Basal ganglia	10.7 nTPM
Cerebral cortex	10.7 nTPM

Deep-layer near-projecting	11.0 nTPM
Hypothalamus	13.7 nTPM
Amygdala	13.2 nTPM
Cerebral cortex	11.0 nTPM
Basal ganglia	9.8 nTPM
Hippocampus	7.5 nTPM

Eccentric medium spiny neuron	10.9 nTPM
Hippocampus	11.6 nTPM
Cerebral cortex	11.1 nTPM
Amygdala	10.8 nTPM
Thalamus	10.8 nTPM
Basal ganglia	10.6 nTPM
Hypothalamus	10.3 nTPM

Endothelial cell	9.0 nTPM
Basal ganglia	17.7 nTPM
Thalamus	11.9 nTPM
Cerebral cortex	11.5 nTPM
Cerebellum	10.1 nTPM
Spinal cord	8.6 nTPM
Midbrain	8.5 nTPM
Hippocampus	8.3 nTPM
Amygdala	7.8 nTPM
Pons	5.6 nTPM
Medulla oblongata	5.1 nTPM
Hypothalamus	3.7 nTPM