Single cell type - MINPP1 - The Human Protein Atlas

MINPP1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MINPP1
Gene descriptionⁱ Full gene name according to HGNC.	Multiple inositol-polyphosphate phosphatase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Erythroid cells, Hepatocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.54
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Erythroid cells, Hepatocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MINPP1 is part of cluster 1 Erythroid cells - Oxygen transport with confidenceⁱ 1
138 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UROD	Uroporphyrinogen decarboxylase	0.9039	1
HMBS	Hydroxymethylbilane synthase	0.8941	1
CR1L	Complement C3b/C4b receptor 1 like	0.8934	1
GYPE	Glycophorin E (MNS blood group)	0.8894	1
FECH	Ferrochelatase	0.8879	1
EPB42	Erythrocyte membrane protein band 4.2	0.8839	1
GYPA	Glycophorin A (MNS blood group)	0.8820	1
SPTA1	Spectrin alpha, erythrocytic 1	0.8813	1
HBM	Hemoglobin subunit mu	0.8812	1
GYPB	Glycophorin B (MNS blood group)	0.8806	1
AHSP	Alpha hemoglobin stabilizing protein	0.8799	1
TSPO2	Translocator protein 2	0.8796	1
SLC4A1	Solute carrier family 4 member 1 (Diego blood group)	0.8782	1
KLF1	KLF transcription factor 1	0.8780	1
RHCE	Rh blood group CcEe antigens	0.8770	1

IMMUNE CELLS

MINPP1 is part of cluster 9 T-regs - Cell cycle regulation with confidenceⁱ 1
166 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MCM6	Minichromosome maintenance complex component 6	1.0000	9
CLUL1	Clusterin like 1	0.9762	9
TRIM16	Tripartite motif containing 16	0.9762	9
EOGT	EGF domain specific O-linked N-acetylglucosamine transferase	0.9762	9
INTS4	Integrator complex subunit 4	0.9762	9
RBMX	RNA binding motif protein X-linked	0.9762	9
PLK4	Polo like kinase 4	0.9762	9
LOXL1	Lysyl oxidase like 1	0.9762	9
SDC4	Syndecan 4	0.9762	9
MAD1L1	Mitotic arrest deficient 1 like 1	0.9524	9
RAD54L	RAD54 like	0.9524	9
RHOXF1	Rhox homeobox family member 1	0.9524	9
LMCD1	LIM and cysteine rich domains 1	0.9524	9
BCAS1	Brain enriched myelin associated protein 1	0.9524	9
LIMA1	LIM domain and actin binding 1	0.9524	9

Adipocytes	10.3 nTPM
Adipose tissue	11.7 nTPM
Breast	9.0 nTPM

Alveolar cells type 1	11.1 nTPM
Lung	11.1 nTPM

Alveolar cells type 2	10.3 nTPM
Lung	10.3 nTPM

Astrocytes	8.7 nTPM
Brain	8.7 nTPM

B-cells	8.0 nTPM
Liver	19.3 nTPM
Bone marrow	12.7 nTPM
Kidney	10.4 nTPM
Skin	10.2 nTPM
Lymph node	9.3 nTPM
Spleen	9.3 nTPM
Stomach	6.7 nTPM
Esophagus	5.9 nTPM
Thymus	5.5 nTPM
Salivary gland	4.5 nTPM
Lung	4.0 nTPM
Adipose tissue	3.7 nTPM
PBMC	3.1 nTPM

Ciliated cells	11.4 nTPM
Bronchus	17.7 nTPM
Lung	10.8 nTPM
Endometrium	8.5 nTPM
Fallopian tube	8.4 nTPM

Club cells	15.6 nTPM
Bronchus	27.7 nTPM
Prostate	10.7 nTPM
Lung	8.3 nTPM

Endothelial cells	10.8 nTPM
Liver	26.5 nTPM
Esophagus	17.7 nTPM
Placenta	17.0 nTPM
Endometrium	14.4 nTPM
Lung	12.4 nTPM
Thymus	11.9 nTPM
Pancreas	10.3 nTPM
Heart muscle	10.2 nTPM
Skeletal muscle	10.2 nTPM
Prostate	9.4 nTPM
Testis	7.9 nTPM
Breast	7.9 nTPM
Vascular	7.7 nTPM
Ovary	7.3 nTPM
Skin	6.8 nTPM
Fallopian tube	5.9 nTPM
Tongue	5.7 nTPM
Salivary gland	4.6 nTPM

Enteroendocrine cells	9.8 nTPM
Rectum	11.7 nTPM
Colon	10.8 nTPM
Small intestine	6.9 nTPM

Erythroid cells	192.7 nTPM
Liver	202.8 nTPM
Bone marrow	182.6 nTPM

Fibroblasts	13.9 nTPM
Placenta	24.0 nTPM
Pancreas	22.6 nTPM
Liver	21.3 nTPM
Stomach	20.2 nTPM
Esophagus	16.8 nTPM
Adipose tissue	15.3 nTPM
Thymus	14.1 nTPM
Prostate	12.5 nTPM
Skeletal muscle	12.4 nTPM
Lung	11.4 nTPM
Breast	10.8 nTPM
Skin	10.7 nTPM
Vascular	9.9 nTPM
Fallopian tube	9.0 nTPM
Salivary gland	8.7 nTPM
Heart muscle	2.8 nTPM

Granulocytes	7.5 nTPM
Fallopian tube	11.3 nTPM
Lung	11.1 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	25.5 nTPM
Small intestine	34.2 nTPM
Rectum	25.3 nTPM
Colon	17.0 nTPM

Lymphatic endothelial cells	3.8 nTPM
Fallopian tube	7.7 nTPM
Ovary	0.0 nTPM

Macrophages	8.8 nTPM
Lung	15.5 nTPM
Bone marrow	15.2 nTPM
Kidney	13.3 nTPM
Vascular	12.8 nTPM
Pancreas	12.3 nTPM
Stomach	10.3 nTPM
Prostate	10.1 nTPM
Testis	9.9 nTPM
Thymus	9.7 nTPM
Esophagus	9.0 nTPM
Endometrium	7.4 nTPM
Spleen	7.0 nTPM
Salivary gland	6.9 nTPM
Fallopian tube	5.8 nTPM
Breast	5.4 nTPM
Skin	4.5 nTPM
Tongue	4.5 nTPM
Adipose tissue	3.6 nTPM
Skeletal muscle	3.2 nTPM

Basal prostatic cells	8.1 nTPM
Prostate	8.1 nTPM

Basal respiratory cells	24.4 nTPM
Bronchus	24.4 nTPM

Collecting duct cells	3.9 nTPM
Kidney	3.9 nTPM

Cytotrophoblasts	19.7 nTPM
Placenta	19.7 nTPM

Paneth cells	11.4 nTPM
Small intestine	24.2 nTPM
Rectum	10.0 nTPM
Colon	0.0 nTPM

Plasma cells	17.7 nTPM
Esophagus	31.2 nTPM
Stomach	18.8 nTPM
Bone marrow	18.1 nTPM
Fallopian tube	16.1 nTPM
Liver	16.0 nTPM
Thymus	16.0 nTPM
Spleen	15.4 nTPM
Salivary gland	10.3 nTPM

Schwann cells	2.6 nTPM
Vascular	5.7 nTPM
Adipose tissue	2.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.9 nTPM
Salivary gland	5.3 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	10.3 nTPM
Placenta	45.9 nTPM
Liver	13.2 nTPM
Lung	12.9 nTPM
Thymus	10.8 nTPM
Endometrium	9.4 nTPM
Adipose tissue	9.1 nTPM
Ovary	9.0 nTPM
Esophagus	8.4 nTPM
Tongue	7.5 nTPM
Salivary gland	6.9 nTPM
Prostate	6.7 nTPM
Vascular	6.1 nTPM
Skeletal muscle	5.3 nTPM
Skin	5.2 nTPM
Fallopian tube	4.4 nTPM
Breast	4.1 nTPM

T-cells	6.9 nTPM
Kidney	20.4 nTPM
Bone marrow	14.2 nTPM
Spleen	10.6 nTPM
Liver	10.1 nTPM
Stomach	8.8 nTPM
Prostate	8.2 nTPM
Lymph node	7.6 nTPM
Thymus	6.7 nTPM
PBMC	6.1 nTPM
Colon	5.8 nTPM
Breast	5.3 nTPM
Esophagus	4.9 nTPM
Salivary gland	4.8 nTPM
Lung	4.7 nTPM
Skin	4.6 nTPM
Tongue	4.5 nTPM
Vascular	4.4 nTPM
Endometrium	3.9 nTPM
Skeletal muscle	3.8 nTPM
Adipose tissue	2.8 nTPM
Fallopian tube	2.4 nTPM

Undifferentiated cells	11.8 nTPM
Small intestine	13.5 nTPM
Rectum	11.0 nTPM
Colon	10.9 nTPM

Amygdala excitatory	28.9 nTPM
Hypothalamus	31.0 nTPM
Cerebral cortex	30.4 nTPM
Amygdala	28.8 nTPM
Basal ganglia	28.3 nTPM
Hippocampus	28.3 nTPM
Thalamus	26.3 nTPM

Astrocyte	20.2 nTPM
Amygdala	28.6 nTPM
Basal ganglia	24.2 nTPM
Cerebral cortex	21.9 nTPM
Hippocampus	21.2 nTPM
Hypothalamus	21.0 nTPM
Midbrain	19.8 nTPM
Thalamus	19.2 nTPM
Pons	18.9 nTPM
Medulla oblongata	17.6 nTPM
Cerebellum	15.0 nTPM
Spinal cord	14.7 nTPM

Bergmann glia	29.8 nTPM
Medulla oblongata	34.1 nTPM
Pons	30.2 nTPM
Cerebellum	25.2 nTPM

Central nervous system macrophage	19.0 nTPM
Amygdala	24.6 nTPM
Pons	22.5 nTPM
Basal ganglia	20.1 nTPM
Thalamus	19.7 nTPM
Midbrain	19.0 nTPM
Hypothalamus	18.0 nTPM
Cerebral cortex	17.9 nTPM
Spinal cord	17.4 nTPM
Hippocampus	17.2 nTPM
Medulla oblongata	16.6 nTPM
Cerebellum	15.6 nTPM

Cerebellar inhibitory	22.1 nTPM
Spinal cord	27.5 nTPM
Pons	22.6 nTPM
Cerebellum	21.5 nTPM
Medulla oblongata	19.7 nTPM
Midbrain	19.3 nTPM

Cge interneuron	30.2 nTPM
Amygdala	32.8 nTPM
Hypothalamus	32.3 nTPM
Thalamus	31.5 nTPM
Basal ganglia	30.0 nTPM
Midbrain	29.5 nTPM
Cerebral cortex	27.9 nTPM
Hippocampus	27.6 nTPM

Choroid plexus epithelial cell	19.7 nTPM
Basal ganglia	27.2 nTPM
Hippocampus	19.4 nTPM
Thalamus	16.4 nTPM
Medulla oblongata	15.8 nTPM

Committed oligodendrocyte precursor	30.9 nTPM
Spinal cord	40.5 nTPM
Cerebellum	39.6 nTPM
Midbrain	36.1 nTPM
Hippocampus	33.6 nTPM
Pons	33.6 nTPM
Cerebral cortex	31.0 nTPM
Amygdala	26.5 nTPM
Basal ganglia	25.7 nTPM
Medulla oblongata	24.5 nTPM
Thalamus	24.5 nTPM
Hypothalamus	23.9 nTPM

Deep-layer corticothalamic and 6b	33.6 nTPM
Hypothalamus	38.3 nTPM
Hippocampus	36.6 nTPM
Amygdala	35.9 nTPM
Cerebral cortex	34.1 nTPM
Basal ganglia	31.4 nTPM
Midbrain	25.5 nTPM

Deep-layer intratelencephalic	27.9 nTPM
Hypothalamus	31.8 nTPM
Amygdala	28.8 nTPM
Hippocampus	28.5 nTPM
Cerebral cortex	26.2 nTPM
Basal ganglia	24.4 nTPM

Deep-layer near-projecting	33.6 nTPM
Hypothalamus	40.2 nTPM
Amygdala	36.6 nTPM
Basal ganglia	34.1 nTPM
Hippocampus	28.6 nTPM
Cerebral cortex	28.5 nTPM

Eccentric medium spiny neuron	28.7 nTPM
Amygdala	31.0 nTPM
Hippocampus	30.7 nTPM
Thalamus	29.8 nTPM
Hypothalamus	28.0 nTPM
Basal ganglia	26.4 nTPM
Cerebral cortex	26.3 nTPM

Endothelial cell	25.1 nTPM
Thalamus	31.1 nTPM
Basal ganglia	29.8 nTPM
Medulla oblongata	29.7 nTPM
Cerebral cortex	28.1 nTPM
Midbrain	27.4 nTPM
Hippocampus	27.2 nTPM
Amygdala	23.5 nTPM
Hypothalamus	21.1 nTPM
Cerebellum	20.9 nTPM
Spinal cord	20.7 nTPM
Pons	16.9 nTPM