Expression of NUDT1 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

NUDT1 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 48.55

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average TPM

72.8

Number of samples

169

Samples

Sample	Description	TPM
TCGA-GV-A40E-01A	0 years, male, white, stage:Stage II, dead, 261 days	225.0
TCGA-FD-A3N5-01A	0 years, male, black or african american, stage:Stage II, dead, 685 days	212.2
TCGA-XF-AAMX-01A	0 years, female, black or african american, stage:Stage III, dead, 206 days	187.8
TCGA-S5-A6DX-01A	0 years, male, white, stage:Stage IV, dead, 56 days	186.7
TCGA-XF-A9T2-01A	0 years, male, white, stage:Stage III, dead, 575 days	172.0
TCGA-DK-A3X2-01A	0 years, male, white, stage:Stage IV, dead, 547 days	169.9
TCGA-ZF-AA4T-01A	0 years, male, white, stage:Stage IV, dead, 599 days	157.9
TCGA-C4-A0EZ-01A	0 years, female, stage:Stage IV, dead, 273 days	147.8
TCGA-GC-A3I6-01A	0 years, male, white, stage:Stage III, dead, 630 days	146.4
TCGA-DK-AA6L-01A	0 years, male, white, stage:Stage IV, dead, 1163 days	140.1
TCGA-BT-A20V-01A	0 years, female, black or african american, stage:Stage IV, dead, 154 days	134.7
TCGA-ZF-A9RN-01A	0 years, female, white, stage:Stage III, dead, 615 days	132.3
TCGA-G2-AA3C-01A	0 years, male, white, stage:Stage IV, dead, 211 days	132.0
TCGA-FJ-A871-01A	0 years, male, white, stage:Stage III, dead, 272 days	131.4
TCGA-BT-A20N-01A	0 years, male, stage:Stage III, dead, 795 days	127.8
TCGA-DK-A2I2-01A	0 years, female, white, stage:Stage IV, dead, 237 days	127.7
TCGA-HQ-A5ND-01A	0 years, male, stage:Stage IV, dead, 274 days	122.1
TCGA-G2-A2EL-01A	0 years, male, white, stage:Stage II, dead, 819 days	120.6
TCGA-E7-A541-01A	0 years, male, white, stage:Stage II, dead, 778 days	120.4
TCGA-C4-A0F7-01A	0 years, male, stage:Stage IV, dead, 62 days	120.4
TCGA-ZF-AA4R-01A	0 years, male, white, stage:Stage IV, dead, 1036 days	119.9
TCGA-FD-A5BT-01A	0 years, male, white, stage:Stage III, dead, 328 days	118.6
TCGA-FD-A3B3-01A	0 years, female, white, stage:Stage III, dead, 974 days	115.6
TCGA-UY-A78N-01A	0 years, male, white, stage:Stage IV, dead, 2641 days	115.2
TCGA-GU-A42Q-01A	0 years, male, white, stage:Stage III, dead, 344 days	111.8
TCGA-FD-A3B6-01A	0 years, male, white, stage:Stage II, dead, 1005 days	109.7
TCGA-DK-AA75-01A	0 years, male, white, stage:Stage III, dead, 340 days	108.9
TCGA-4Z-AA80-01A	0 years, male, white, stage:Stage II, dead, 19 days	104.8
TCGA-DK-A3IM-01A	0 years, male, white, stage:Stage III, dead, 248 days	104.8
TCGA-FD-A62P-01A	0 years, male, white, stage:Stage II, dead, 191 days	104.4
TCGA-GU-A762-01A	0 years, male, white, stage:Stage IV, dead, 232 days	104.4
TCGA-XF-AAMT-01A	0 years, female, white, stage:Stage IV, dead, 90 days	103.7
TCGA-DK-A3IN-01A	0 years, male, white, stage:Stage III, dead, 250 days	103.7
TCGA-XF-A9SU-01A	0 years, female, white, stage:Stage IV, dead, 182 days	102.5
TCGA-ZF-AA52-01A	0 years, male, white, stage:Stage III, dead, 1077 days	99.8
TCGA-BT-A20O-01A	0 years, male, white, stage:Stage III, dead, 370 days	99.0
TCGA-2F-A9KW-01A	0 years, female, white, stage:Stage III, dead, 254 days	98.4
TCGA-DK-A3IL-01A	0 years, female, white, stage:Stage IV, dead, 413 days	96.0
TCGA-FD-A3B7-01A	0 years, male, black or african american, stage:Stage III, dead, 122 days	95.8
TCGA-DK-A2HX-01A	0 years, female, white, stage:Stage IV, dead, 1420 days	95.0
TCGA-K4-A5RI-01A	0 years, female, white, stage:Stage III, dead, 356 days	94.3
TCGA-4Z-AA7R-01A	0 years, male, black or african american, stage:Stage IV, dead, 522 days	93.6
TCGA-DK-AA6Q-01A	0 years, female, white, stage:Stage IV, dead, 413 days	93.5
TCGA-FD-A3B4-01A	0 years, female, black or african american, stage:Stage III, dead, 510 days	92.4
TCGA-ZF-AA56-01A	0 years, female, white, stage:Stage III, dead, 259 days	91.4
TCGA-XF-A9SX-01A	0 years, female, white, stage:Stage IV, dead, 719 days	89.8
TCGA-G2-A2EO-01A	0 years, male, white, stage:Stage III, dead, 1804 days	89.4
TCGA-FD-A3SJ-01A	0 years, male, white, stage:Stage IV, dead, 739 days	89.1
TCGA-BT-A2LD-01A	0 years, female, white, stage:Stage IV, dead, 623 days	88.7
TCGA-BT-A20X-01A	0 years, male, white, stage:Stage IV, dead, 251 days	88.4
TCGA-XF-AAMJ-01A	0 years, male, asian, stage:Stage III, dead, 1670 days	88.2
TCGA-BT-A20U-01A	0 years, female, white, stage:Stage III, dead, 455 days	87.6
TCGA-UY-A78M-01A	0 years, female, asian, stage:Stage IV, dead, 690 days	86.9
TCGA-XF-A9SV-01A	0 years, male, white, stage:Stage IV, dead, 388 days	84.8
TCGA-BT-A20T-01A	0 years, male, white, stage:Stage IV, dead, 453 days	84.8
TCGA-FD-A6TF-01A	0 years, female, white, stage:Stage IV, dead, 69 days	84.1
TCGA-K4-A4AC-01A	0 years, male, white, stage:Stage II, dead, 278 days	82.9
TCGA-BT-A20P-01A	0 years, female, white, stage:Stage III, dead, 544 days	82.0
TCGA-DK-A1A5-01A	0 years, male, white, stage:Stage II, dead, 65 days	81.5
TCGA-CU-A72E-01A	0 years, male, white, stage:Stage IV, dead, 413 days	81.3
TCGA-DK-AA6W-01A	0 years, male, white, stage:Stage II, dead, 415 days	80.7
TCGA-XF-AAN7-01A	0 years, male, white, stage:Stage IV, dead, 565 days	77.8
TCGA-BT-A3PK-01A	0 years, male, white, stage:Stage II, dead, 303 days	77.4
TCGA-2F-A9KR-01A	0 years, female, stage:Stage III, dead, 3183 days	76.6
TCGA-FD-A3B5-01A	0 years, male, black or african american, stage:Stage IV, dead, 272 days	75.7
TCGA-FD-A3SS-01A	0 years, male, white, stage:Stage IV, dead, 391 days	75.4
TCGA-BT-A20W-01A	0 years, male, white, stage:Stage II, dead, 254 days	75.3
TCGA-FD-A6TD-01A	0 years, male, white, stage:Stage III, dead, 386 days	74.4
TCGA-XF-A8HF-01A	0 years, male, white, stage:Stage III, dead, 2954 days	73.9
TCGA-4Z-AA7Q-01A	0 years, male, white, stage:Stage III, dead, 510 days	73.9
TCGA-UY-A78K-01A	0 years, male, white, stage:Stage IV, dead, 536 days	72.9
TCGA-GU-A767-01A	0 years, male, white, stage:Stage IV, dead, 144 days	72.2
TCGA-4Z-AA82-01A	0 years, male, black or african american, stage:Stage IV, dead, 1556 days	71.7
TCGA-ZF-A9RD-01A	0 years, female, white, stage:Stage IV, dead, 408 days	71.3
TCGA-ZF-AA4N-01A	0 years, male, white, stage:Stage II, dead, 88 days	71.2
TCGA-XF-A9ST-01A	0 years, male, white, stage:Stage III, dead, 128 days	69.8
TCGA-GU-AATQ-01A	0 years, male, white, stage:Stage III, dead, 213 days	69.0
TCGA-G2-A3IE-01A	0 years, male, white, stage:Stage II, dead, 612 days	68.3
TCGA-BL-A3JM-01A	0 years, male, white, stage:Stage III, dead, 205 days	67.7
TCGA-XF-AAME-01A	0 years, female, white, stage:Stage II, dead, 2828 days	66.7
TCGA-BT-A2LB-01A	0 years, female, white, stage:Stage III, dead, 492 days	65.9
TCGA-YC-A9TC-01A	0 years, male, white, stage:Stage IV, dead, 20 days	65.6
TCGA-FD-A3SO-01A	0 years, male, white, stage:Stage IV, dead, 168 days	65.6
TCGA-BT-A0S7-01A	0 years, male, white, stage:Stage III, dead, 200 days	64.7
TCGA-ZF-AA54-01A	0 years, male, white, stage:Stage III, dead, 590 days	64.5
TCGA-CU-A5W6-01A	0 years, male, white, stage:Stage III, dead, 56 days	63.4
TCGA-E5-A4TZ-01A	0 years, male, white, stage:Stage IV, dead, 467 days	62.1
TCGA-XF-A9SJ-01A	0 years, male, white, stage:Stage IV, dead, 98 days	61.6
TCGA-G2-A3IB-01A	0 years, male, black or african american, stage:Stage II, dead, 220 days	61.5
TCGA-FD-A5BV-01A	0 years, female, white, stage:Stage III, dead, 163 days	61.2
TCGA-BL-A13I-01A	0 years, female, white, stage:Stage III, dead, 223 days	61.1
TCGA-FD-A3SR-01A	0 years, male, white, stage:Stage IV, dead, 602 days	60.4
TCGA-CU-A0YR-01A	0 years, male, white, stage:Stage IV, dead, 460 days	60.3
TCGA-XF-AAMH-01A	0 years, male, white, stage:Stage IV, dead, 344 days	60.2
TCGA-HQ-A5NE-01A	0 years, male, stage:Stage III, dead, 370 days	60.1
TCGA-XF-A8HG-01A	0 years, male, white, stage:Stage III, dead, 467 days	59.1
TCGA-4Z-AA86-01A	0 years, male, black or african american, stage:Stage IV, dead, 311 days	56.5
TCGA-GU-A42P-01A	0 years, male, white, stage:Stage IV, dead, 332 days	56.4
TCGA-FD-A43Y-01A	0 years, male, white, stage:Stage III, dead, 474 days	56.4
TCGA-ZF-A9RE-01A	0 years, female, white, stage:Stage II, dead, 106 days	56.2
TCGA-FD-A6TG-01A	0 years, male, white, stage:Stage IV, dead, 93 days	56.0
TCGA-FD-A6TH-01A	0 years, male, white, stage:Stage IV, dead, 131 days	55.5
TCGA-XF-AAML-01A	0 years, male, white, stage:Stage II, dead, 232 days	53.6
TCGA-XF-A9SW-01A	0 years, male, white, stage:Stage IV, dead, 362 days	53.5
TCGA-FD-A5BX-01A	0 years, male, white, stage:Stage IV, dead, 173 days	53.0
TCGA-FD-A5C0-01A	0 years, male, white, stage:Stage IV, dead, 550 days	52.7
TCGA-5N-A9KI-01A	0 years, female, white, stage:Stage III, dead, 76 days	52.6
TCGA-DK-A1A3-01A	0 years, male, white, stage:Stage IV, dead, 665 days	52.5
TCGA-2F-A9KO-01A	0 years, male, white, stage:Stage IV, dead, 734 days	52.1
TCGA-BT-A3PH-01A	0 years, male, white, stage:Stage IV, dead, 142 days	50.5
TCGA-GC-A3BM-01A	0 years, male, white, stage:Stage II, dead, 651 days	50.1
TCGA-ZF-AA5N-01A	0 years, female, white, stage:Stage IV, dead, 168 days	50.1
TCGA-XF-AAN1-01A	0 years, female, stage:Stage III, dead, 941 days	49.6
TCGA-CF-A47T-01A	0 years, female, asian, stage:Stage II, dead, 385 days	49.2
TCGA-CU-A0YO-01A	0 years, male, white, stage:Stage IV, dead, 149 days	49.0
TCGA-ZF-A9R9-01A	0 years, male, white, stage:Stage IV, dead, 864 days	48.8
TCGA-XF-A8HC-01A	0 years, male, asian, stage:Stage IV, dead, 200 days	48.7
TCGA-XF-A9SP-01A	0 years, male, white, stage:Stage III, dead, 454 days	48.6
TCGA-XF-A9SZ-01A	0 years, male, white, stage:Stage IV, dead, 859 days	48.5
TCGA-CU-A0YN-01A	0 years, male, white, stage:Stage III, dead, 393 days	48.2
TCGA-E7-A97P-01A	0 years, male, asian, stage:Stage II, dead, 437 days	47.8
TCGA-XF-AAN2-01A	0 years, male, white, stage:Stage II, dead, 1869 days	47.8
TCGA-FD-A5BZ-01A	0 years, female, white, stage:Stage IV, dead, 835 days	47.7
TCGA-GU-AATO-01A	0 years, male, white, stage:Stage IV, dead, 324 days	46.4
TCGA-XF-AAN0-01A	0 years, male, white, stage:Stage IV, dead, 1718 days	46.1
TCGA-FD-A62S-01A	0 years, female, black or african american, stage:Stage III, dead, 406 days	45.8
TCGA-4Z-AA81-01A	0 years, male, white, stage:Stage II, dead, 1270 days	45.4
TCGA-XF-AAMZ-01A	0 years, female, white, stage:Stage IV, dead, 1348 days	44.8
TCGA-FD-A3SL-01A	0 years, male, white, stage:Stage IV, dead, 712 days	44.0
TCGA-DK-A3IU-01A	0 years, male, white, stage:Stage II, dead, 706 days	43.1
TCGA-XF-AAMW-01A	0 years, female, white, stage:Stage IV, dead, 253 days	42.7
TCGA-5N-A9KM-01A	0 years, female, white, stage:Stage III, dead, 530 days	41.6
TCGA-ZF-AA4U-01A	0 years, male, white, stage:Stage III, dead, 262 days	41.3
TCGA-DK-A3IQ-01A	0 years, male, white, stage:Stage III, dead, 539 days	40.2
TCGA-E7-A3X6-01A	0 years, male, white, stage:Stage II, dead, 904 days	39.8
TCGA-XF-A9T8-01A	0 years, male, white, stage:Stage III, dead, 418 days	39.7
TCGA-2F-A9KP-01A	0 years, male, white, stage:Stage IV, dead, 364 days	39.5
TCGA-GV-A3QH-01A	0 years, male, white, stage:Stage II, dead, 258 days	39.4
TCGA-DK-A3IK-01A	0 years, male, white, stage:Stage IV, dead, 146 days	37.7
TCGA-DK-A1AB-01A	0 years, female, white, stage:Stage IV, dead, 508 days	37.6
TCGA-XF-A8HH-01A	0 years, female, white, stage:Stage IV, dead, 57 days	37.3
TCGA-BT-A20J-01A	0 years, male, white, stage:Stage II, dead, 579 days	37.1
TCGA-BT-A0YX-01A	0 years, female, white, stage:Stage III, dead, 400 days	37.0
TCGA-BL-A13J-01A	0 years, male, white, stage:Stage IV, dead, 81 days	36.6
TCGA-GV-A3QF-01A	0 years, male, white, stage:Stage IV, dead, 617 days	36.2
TCGA-FJ-A3Z9-01A	0 years, male, white, stage:'--, dead, 385 days	36.1
TCGA-GV-A3JV-01A	0 years, male, white, stage:Stage IV, dead, 434 days	35.4
TCGA-CF-A9FL-01A	0 years, male, asian, stage:Stage III, dead, 565 days	34.3
TCGA-XF-AAN8-01A	0 years, female, white, stage:Stage III, dead, 118 days	32.8
TCGA-FD-A62O-01A	0 years, male, white, stage:Stage IV, dead, 216 days	32.3
TCGA-4Z-AA7N-01A	0 years, male, white, stage:Stage III, dead, 1367 days	32.2
TCGA-ZF-A9R0-01A	0 years, male, white, stage:Stage III, dead, 680 days	32.0
TCGA-XF-A9SK-01A	0 years, male, white, stage:Stage IV, dead, 486 days	31.8
TCGA-GU-A42R-01A	0 years, male, white, stage:Stage IV, dead, 577 days	31.3
TCGA-SY-A9G0-01A	0 years, male, white, stage:Stage IV, dead, 1008 days	30.5
TCGA-4Z-AA7S-01A	0 years, male, black or african american, stage:Stage III, dead, 1064 days	30.2
TCGA-G2-A2ES-01A	0 years, male, white, stage:Stage II, dead, 1004 days	29.8
TCGA-FJ-A3ZE-01A	0 years, male, white, stage:Stage IV, dead, 324 days	29.5
TCGA-BT-A20Q-01A	0 years, male, white, stage:Stage IV, dead, 593 days	29.4
TCGA-FD-A3SQ-01A	0 years, male, white, stage:Stage IV, dead, 1423 days	29.0
TCGA-ZF-A9R3-01A	0 years, female, white, stage:Stage II, dead, 949 days	28.6
TCGA-G2-A2EC-01A	0 years, female, black or african american, stage:Stage II, dead, 696 days	28.0
TCGA-FD-A3SM-01A	0 years, male, white, stage:Stage IV, dead, 547 days	26.9
TCGA-E7-A4XJ-01A	0 years, male, asian, stage:Stage II, dead, 68 days	25.1
TCGA-XF-A9SH-01A	0 years, female, asian, stage:Stage II, dead, 1971 days	22.1
TCGA-XF-A9SL-01A	0 years, male, white, stage:Stage IV, dead, 2020 days	21.0
TCGA-XF-A8HI-01A	0 years, female, white, stage:Stage IV, dead, 544 days	20.2
TCGA-FD-A6TI-01A	0 years, male, white, stage:Stage IV, dead, 294 days	17.0
TCGA-XF-AAN4-01A	0 years, female, white, stage:Stage III, dead, 823 days	14.9
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA012636
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade
Urothelial carcinoma, NOS