Single cell type - HTATSF1 - The Human Protein Atlas

HTATSF1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HTATSF1
Gene descriptionⁱ Full gene name according to HGNC.	HIV-1 Tat specific factor 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cardiomyocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.37
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

HTATSF1 is part of cluster 68 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
262 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TIMM21	Translocase of inner mitochondrial membrane 21	0.5326	68
SLC27A6	Solute carrier family 27 member 6	0.5188	24
ENSG00000262660	Novel protein	0.4996	68
MT-ATP8	Mitochondrially encoded ATP synthase membrane subunit 8	0.4963	68
MYOZ2	Myozenin 2	0.4958	68
KLHL31	Kelch like family member 31	0.4958	68
ITGB1BP2	Integrin subunit beta 1 binding protein 2	0.4948	68
ZNF106	Zinc finger protein 106	0.4938	68
BAZ1B	Bromodomain adjacent to zinc finger domain 1B	0.4935	39
SNURF	SNRPN upstream open reading frame	0.4912	68
SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	0.4860	6
MT-ND6	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	0.4849	68
NMRK2	Nicotinamide riboside kinase 2	0.4827	68
TNNT2	Troponin T2, cardiac type	0.4826	68
MYL7	Myosin light chain 7	0.4810	68

IMMUNE CELLS

HTATSF1 is part of cluster 3 Non-specific - Nuclear processes with confidenceⁱ 0.64
471 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARL4C	ADP ribosylation factor like GTPase 4C	0.9762	3
CKAP5	Cytoskeleton associated protein 5	0.9762	3
UBE2V2	Ubiquitin conjugating enzyme E2 V2	0.9762	1
TMEM35B	Transmembrane protein 35B	0.9524	5
CREM	CAMP responsive element modulator	0.9524	3
TRIM35	Tripartite motif containing 35	0.9524	5
RNF8	Ring finger protein 8	0.9524	3
UCHL5	Ubiquitin C-terminal hydrolase L5	0.9524	3
ACTR6	Actin related protein 6	0.9524	3
POLR2K	RNA polymerase II, I and III subunit K	0.9524	3
PTPN22	Protein tyrosine phosphatase non-receptor type 22	0.9524	5
PTPN7	Protein tyrosine phosphatase non-receptor type 7	0.9524	5
SBDS	SBDS ribosome maturation factor	0.9286	3
ACP1	Acid phosphatase 1	0.9286	5
THUMPD3	THUMP domain containing 3	0.9286	5

Adipocytes	26.2 nTPM
Breast	30.5 nTPM
Adipose tissue	21.9 nTPM

Alveolar cells type 1	39.4 nTPM
Lung	39.4 nTPM

Alveolar cells type 2	36.6 nTPM
Lung	36.6 nTPM

Astrocytes	10.8 nTPM
Brain	10.8 nTPM

B-cells	35.8 nTPM
Stomach	51.9 nTPM
Lymph node	48.9 nTPM
Spleen	46.9 nTPM
Salivary gland	45.3 nTPM
Liver	38.6 nTPM
Bone marrow	37.0 nTPM
Lung	34.9 nTPM
Thymus	34.5 nTPM
PBMC	32.3 nTPM
Adipose tissue	30.9 nTPM
Esophagus	23.6 nTPM
Kidney	20.8 nTPM
Skin	20.3 nTPM

Ciliated cells	36.4 nTPM
Endometrium	47.2 nTPM
Fallopian tube	40.3 nTPM
Lung	35.3 nTPM
Bronchus	22.8 nTPM

Club cells	37.7 nTPM
Prostate	45.1 nTPM
Lung	39.5 nTPM
Bronchus	28.3 nTPM

Dendritic cells	26.8 nTPM
Adipose tissue	35.7 nTPM
PBMC	18.0 nTPM

Endothelial cells	30.3 nTPM
Heart muscle	75.6 nTPM
Lung	37.6 nTPM
Thymus	35.1 nTPM
Fallopian tube	33.7 nTPM
Vascular	32.1 nTPM
Salivary gland	30.7 nTPM
Liver	29.0 nTPM
Skeletal muscle	28.6 nTPM
Endometrium	28.3 nTPM
Tongue	28.2 nTPM
Esophagus	27.5 nTPM
Prostate	25.5 nTPM
Placenta	25.0 nTPM
Breast	23.7 nTPM
Ovary	23.4 nTPM
Testis	21.7 nTPM
Pancreas	20.7 nTPM
Skin	19.3 nTPM

Enteroendocrine cells	35.7 nTPM
Rectum	58.7 nTPM
Colon	34.7 nTPM
Small intestine	13.7 nTPM

Fibroblasts	44.3 nTPM
Heart muscle	102.8 nTPM
Placenta	88.1 nTPM
Vascular	59.7 nTPM
Thymus	52.6 nTPM
Fallopian tube	47.8 nTPM
Prostate	44.9 nTPM
Lung	43.8 nTPM
Esophagus	43.6 nTPM
Skeletal muscle	39.8 nTPM
Pancreas	35.7 nTPM
Salivary gland	31.1 nTPM
Breast	30.7 nTPM
Stomach	30.3 nTPM
Skin	27.7 nTPM
Adipose tissue	21.4 nTPM
Liver	8.3 nTPM

Granulocytes	42.1 nTPM
Fallopian tube	60.0 nTPM
Lung	46.9 nTPM
Tongue	19.4 nTPM

Intestinal goblet cells	35.5 nTPM
Colon	41.8 nTPM
Rectum	40.6 nTPM
Small intestine	24.0 nTPM

Lymphatic endothelial cells	29.1 nTPM
Fallopian tube	41.8 nTPM
Ovary	16.4 nTPM

Macrophages	30.4 nTPM
Bone marrow	43.6 nTPM
Stomach	41.2 nTPM
Tongue	38.4 nTPM
Vascular	36.6 nTPM
Skeletal muscle	36.5 nTPM
Lung	35.5 nTPM
Fallopian tube	34.2 nTPM
Thymus	32.3 nTPM
Esophagus	32.1 nTPM
Endometrium	30.7 nTPM
Kidney	30.1 nTPM
Salivary gland	29.3 nTPM
Adipose tissue	27.6 nTPM
Testis	27.3 nTPM
Prostate	26.7 nTPM
Breast	24.6 nTPM
Spleen	20.1 nTPM
Pancreas	18.5 nTPM
Skin	13.4 nTPM

Basal prostatic cells	45.4 nTPM
Prostate	45.4 nTPM

Basal respiratory cells	26.5 nTPM
Bronchus	26.5 nTPM

Basal squamous epithelial cells	38.8 nTPM
Esophagus	38.8 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Paneth cells	25.1 nTPM
Rectum	32.8 nTPM
Colon	25.3 nTPM
Small intestine	17.3 nTPM

Plasma cells	53.8 nTPM
Bone marrow	80.0 nTPM
Spleen	77.9 nTPM
Thymus	71.7 nTPM
Stomach	54.0 nTPM
Liver	44.1 nTPM
Fallopian tube	38.9 nTPM
Salivary gland	37.6 nTPM
Esophagus	26.0 nTPM

Schwann cells	30.9 nTPM
Adipose tissue	44.1 nTPM
Vascular	36.6 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	29.6 nTPM
Salivary gland	41.5 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	37.8 nTPM
Fallopian tube	60.8 nTPM
Vascular	56.5 nTPM
Breast	45.0 nTPM
Thymus	43.2 nTPM
Prostate	41.4 nTPM
Endometrium	40.6 nTPM
Skeletal muscle	38.3 nTPM
Ovary	38.3 nTPM
Salivary gland	37.6 nTPM
Skin	34.8 nTPM
Esophagus	34.8 nTPM
Adipose tissue	34.7 nTPM
Placenta	33.0 nTPM
Tongue	30.8 nTPM
Lung	18.8 nTPM
Liver	16.6 nTPM

Suprabasal keratinocytes	42.6 nTPM
Tongue	58.7 nTPM
Skin	26.4 nTPM

T-cells	57.1 nTPM
Esophagus	102.2 nTPM
Tongue	76.7 nTPM
Fallopian tube	71.0 nTPM
Adipose tissue	68.7 nTPM
Stomach	68.6 nTPM
Skeletal muscle	66.5 nTPM
Vascular	65.1 nTPM
Bone marrow	55.7 nTPM
Skin	55.0 nTPM
Spleen	53.3 nTPM
Salivary gland	52.7 nTPM
Thymus	51.5 nTPM
Prostate	51.3 nTPM
Kidney	50.5 nTPM
PBMC	50.2 nTPM
Lymph node	49.4 nTPM
Lung	49.1 nTPM
Endometrium	46.6 nTPM
Breast	42.5 nTPM
Liver	41.3 nTPM
Colon	30.2 nTPM

Undifferentiated cells	38.8 nTPM
Colon	49.4 nTPM
Rectum	34.9 nTPM
Small intestine	32.2 nTPM

Amygdala excitatory	12.5 nTPM
Thalamus	17.7 nTPM
Hypothalamus	13.8 nTPM
Hippocampus	12.1 nTPM
Cerebral cortex	10.8 nTPM
Basal ganglia	10.5 nTPM
Amygdala	10.1 nTPM

Astrocyte	17.0 nTPM
Cerebellum	20.8 nTPM
Thalamus	20.0 nTPM
Midbrain	18.9 nTPM
Pons	18.9 nTPM
Basal ganglia	17.4 nTPM
Medulla oblongata	17.1 nTPM
Amygdala	16.1 nTPM
Cerebral cortex	15.1 nTPM
Hypothalamus	14.9 nTPM
Hippocampus	14.1 nTPM
Spinal cord	14.1 nTPM

Bergmann glia	18.1 nTPM
Pons	30.2 nTPM
Cerebellum	13.5 nTPM
Medulla oblongata	10.7 nTPM

Central nervous system macrophage	13.5 nTPM
Thalamus	16.4 nTPM
Pons	15.7 nTPM
Amygdala	14.7 nTPM
Hypothalamus	14.2 nTPM
Spinal cord	13.5 nTPM
Midbrain	13.4 nTPM
Cerebral cortex	12.6 nTPM
Cerebellum	12.3 nTPM
Hippocampus	12.3 nTPM
Medulla oblongata	12.1 nTPM
Basal ganglia	10.9 nTPM

Cerebellar inhibitory	29.1 nTPM
Spinal cord	33.0 nTPM
Midbrain	29.2 nTPM
Pons	28.7 nTPM
Cerebellum	27.3 nTPM
Medulla oblongata	27.1 nTPM

Cge interneuron	28.1 nTPM
Thalamus	36.5 nTPM
Basal ganglia	31.4 nTPM
Midbrain	28.8 nTPM
Hippocampus	26.7 nTPM
Hypothalamus	25.3 nTPM
Cerebral cortex	25.1 nTPM
Amygdala	23.3 nTPM

Choroid plexus epithelial cell	11.2 nTPM
Hippocampus	13.9 nTPM
Thalamus	13.7 nTPM
Medulla oblongata	9.0 nTPM
Basal ganglia	8.0 nTPM

Committed oligodendrocyte precursor	16.1 nTPM
Medulla oblongata	21.9 nTPM
Midbrain	20.2 nTPM
Cerebral cortex	19.6 nTPM
Spinal cord	18.4 nTPM
Thalamus	18.2 nTPM
Basal ganglia	17.0 nTPM
Amygdala	15.8 nTPM
Hippocampus	14.0 nTPM
Hypothalamus	11.6 nTPM
Pons	10.6 nTPM
Cerebellum	9.5 nTPM

Deep-layer corticothalamic and 6b	12.3 nTPM
Hypothalamus	16.2 nTPM
Basal ganglia	14.7 nTPM
Cerebral cortex	12.3 nTPM
Amygdala	11.1 nTPM
Hippocampus	10.8 nTPM
Midbrain	8.9 nTPM

Deep-layer intratelencephalic	13.6 nTPM
Hypothalamus	16.6 nTPM
Cerebral cortex	14.7 nTPM
Basal ganglia	14.3 nTPM
Hippocampus	12.2 nTPM
Amygdala	10.3 nTPM

Deep-layer near-projecting	18.5 nTPM
Hippocampus	22.4 nTPM
Hypothalamus	20.3 nTPM
Basal ganglia	17.9 nTPM
Amygdala	16.1 nTPM
Cerebral cortex	15.9 nTPM

Eccentric medium spiny neuron	23.3 nTPM
Hippocampus	31.9 nTPM
Hypothalamus	26.1 nTPM
Thalamus	21.3 nTPM
Basal ganglia	21.0 nTPM
Amygdala	20.3 nTPM
Cerebral cortex	19.2 nTPM