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Fumarate Hydratase (FH) RNA is widely expressed across many human organs (including brain), with higher levels in the liver, heart and skeletal muscle tissue. In the mouse, a wide range of neurons exhibit somatic immunoreactivity, of various intensities, in many brain regions. It is particularly strong in the septum, nuclei of BNST, neocortical layers IV-V, thalamic and hypothalamic paraventricular nuclei, amygdala, hippocampal CA2-3 layers, hypothalamic arcuate nucleus and multiple brainstem nuclei. Occasional apical dendrites of neocortical neurons are also immunoreactive while choroid plexus cells are stained positive too.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
Soma and nucleus in neurons. Choroid plexus of ependymal cells.