Single cell type - NOS1 - The Human Protein Atlas

NOS1

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NOS1
Gene descriptionⁱ Full gene name according to HGNC.	Nitric oxide synthase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Enzymes FDA approved drug targets Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Salivary duct cells, Skeletal myocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.88
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Splatter, LAMP5-LHX6 and Chandelier, Cerebellar inhibitory)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Salivary duct cells, Skeletal myocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Splatter, LAMP5-LHX6 and Chandelier, Cerebellar inhibitory)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NOS1 is part of cluster 65 Neurons - Synaptic function with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTPRM	Protein tyrosine phosphatase receptor type M	0.6337	65
DPP6	Dipeptidyl peptidase like 6	0.6297	65
ALK	ALK receptor tyrosine kinase	0.6207	65
NXPH1	Neurexophilin 1	0.6160	8
TACR1	Tachykinin receptor 1	0.6127	65
TIAM1	TIAM Rac1 associated GEF 1	0.6086	65
ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif 20	0.5700	65
GRIK1	Glutamate ionotropic receptor kainate type subunit 1	0.5695	65
MYO16	Myosin XVI	0.5659	65
CDH13	Cadherin 13	0.5581	65
TOX2	TOX high mobility group box family member 2	0.5558	65
TMEM132C	Transmembrane protein 132C	0.5479	76
KIF26B	Kinesin family member 26B	0.5438	8
KCNIP1	Potassium voltage-gated channel interacting protein 1	0.5406	65
SP9	Sp9 transcription factor	0.5317	65

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

Astrocytes	1.2 nTPM
Brain	1.2 nTPM

B-cells	0.2 nTPM
Skin	1.7 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	1.4 nTPM
Endometrium	4.7 nTPM
Fallopian tube	0.6 nTPM
Bronchus	0.1 nTPM
Lung	0.0 nTPM

Club cells	0.9 nTPM
Prostate	2.2 nTPM
Lung	0.3 nTPM
Bronchus	0.1 nTPM

Endothelial cells	1.8 nTPM
Lung	17.1 nTPM
Liver	7.6 nTPM
Thymus	1.5 nTPM
Vascular	1.2 nTPM
Ovary	1.2 nTPM
Salivary gland	1.0 nTPM
Tongue	0.9 nTPM
Fallopian tube	0.6 nTPM
Esophagus	0.5 nTPM
Skin	0.4 nTPM
Testis	0.3 nTPM
Endometrium	0.2 nTPM
Skeletal muscle	0.2 nTPM
Prostate	0.2 nTPM
Heart muscle	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.1 nTPM
Thymus	1.1 nTPM
Salivary gland	0.4 nTPM
Vascular	0.3 nTPM
Skin	0.2 nTPM
Skeletal muscle	0.2 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.1 nTPM
Tongue	1.2 nTPM
Salivary gland	0.6 nTPM
Breast	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal keratinocytes	4.9 nTPM
Skin	5.4 nTPM
Tongue	4.5 nTPM

Basal respiratory cells	2.1 nTPM
Bronchus	2.1 nTPM

Distal tubular cells	3.1 nTPM
Kidney	3.1 nTPM

Early spermatids	2.4 nTPM
Testis	2.4 nTPM

Plasma cells	0.1 nTPM
Salivary gland	0.9 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.2 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.4 nTPM
Salivary gland	0.9 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.1 nTPM
Liver	31.0 nTPM
Skin	1.8 nTPM
Skeletal muscle	0.4 nTPM
Salivary gland	0.4 nTPM
Tongue	0.3 nTPM
Endometrium	0.2 nTPM
Placenta	0.1 nTPM
Vascular	0.1 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

T-cells	0.1 nTPM
Tongue	0.9 nTPM
Endometrium	0.5 nTPM
Skin	0.4 nTPM
Skeletal muscle	0.4 nTPM
Salivary gland	0.4 nTPM
Thymus	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	55.8 nTPM
Hypothalamus	98.1 nTPM
Thalamus	95.7 nTPM
Hippocampus	44.2 nTPM
Basal ganglia	43.1 nTPM
Amygdala	30.2 nTPM
Cerebral cortex	23.5 nTPM

Astrocyte	3.5 nTPM
Cerebellum	6.0 nTPM
Pons	5.2 nTPM
Medulla oblongata	4.9 nTPM
Spinal cord	4.3 nTPM
Hypothalamus	3.3 nTPM
Midbrain	3.2 nTPM
Basal ganglia	2.8 nTPM
Amygdala	2.7 nTPM
Hippocampus	2.3 nTPM
Cerebral cortex	1.9 nTPM
Thalamus	1.6 nTPM

Bergmann glia	2.2 nTPM
Cerebellum	2.9 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	1.9 nTPM
Hypothalamus	2.8 nTPM
Spinal cord	2.6 nTPM
Basal ganglia	2.2 nTPM
Cerebellum	2.2 nTPM
Hippocampus	2.1 nTPM
Amygdala	1.8 nTPM
Cerebral cortex	1.8 nTPM
Medulla oblongata	1.8 nTPM
Midbrain	1.6 nTPM
Thalamus	1.4 nTPM
Pons	1.0 nTPM

Cerebellar inhibitory	194.9 nTPM
Cerebellum	276.1 nTPM
Midbrain	202.5 nTPM
Spinal cord	200.7 nTPM
Medulla oblongata	186.3 nTPM
Pons	109.0 nTPM

Cge interneuron	28.0 nTPM
Hypothalamus	39.0 nTPM
Thalamus	35.4 nTPM
Midbrain	34.7 nTPM
Amygdala	32.1 nTPM
Basal ganglia	23.0 nTPM
Hippocampus	18.3 nTPM
Cerebral cortex	13.4 nTPM

Choroid plexus epithelial cell	1.9 nTPM
Hippocampus	2.8 nTPM
Medulla oblongata	2.7 nTPM
Basal ganglia	2.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	86.3 nTPM
Cerebral cortex	131.7 nTPM
Cerebellum	128.4 nTPM
Amygdala	124.0 nTPM
Hippocampus	97.8 nTPM
Midbrain	94.1 nTPM
Basal ganglia	77.2 nTPM
Hypothalamus	72.4 nTPM
Medulla oblongata	71.0 nTPM
Spinal cord	62.5 nTPM
Pons	50.5 nTPM
Thalamus	39.4 nTPM

Deep-layer corticothalamic and 6b	6.4 nTPM
Hypothalamus	10.1 nTPM
Hippocampus	8.1 nTPM
Amygdala	6.1 nTPM
Cerebral cortex	5.9 nTPM
Basal ganglia	4.6 nTPM
Midbrain	3.3 nTPM

Deep-layer intratelencephalic	6.4 nTPM
Hypothalamus	9.4 nTPM
Amygdala	6.8 nTPM
Hippocampus	5.8 nTPM
Basal ganglia	5.2 nTPM
Cerebral cortex	4.7 nTPM

Deep-layer near-projecting	4.5 nTPM
Hypothalamus	6.4 nTPM
Basal ganglia	5.6 nTPM
Cerebral cortex	4.6 nTPM
Amygdala	4.1 nTPM
Hippocampus	1.6 nTPM

Eccentric medium spiny neuron	98.0 nTPM
Amygdala	112.4 nTPM
Hypothalamus	111.1 nTPM
Cerebral cortex	101.6 nTPM
Hippocampus	97.8 nTPM
Thalamus	88.1 nTPM
Basal ganglia	76.8 nTPM

Endothelial cell	41.6 nTPM
Hippocampus	74.1 nTPM
Basal ganglia	67.1 nTPM
Amygdala	58.1 nTPM
Hypothalamus	42.2 nTPM
Cerebral cortex	39.0 nTPM
Spinal cord	38.0 nTPM
Pons	36.2 nTPM
Midbrain	35.0 nTPM
Thalamus	24.3 nTPM
Cerebellum	21.7 nTPM
Medulla oblongata	21.5 nTPM

Ependymal cell	10.3 nTPM
Medulla oblongata	24.4 nTPM
Pons	22.0 nTPM
Midbrain	11.4 nTPM
Hypothalamus	9.8 nTPM
Amygdala	7.4 nTPM
Thalamus	6.5 nTPM
Hippocampus	4.7 nTPM
Basal ganglia	4.2 nTPM
Spinal cord	1.9 nTPM