Single cell type - MRC2 - The Human Protein Atlas

MRC2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRC2
Gene descriptionⁱ Full gene name according to HGNC.	Mannose receptor C type 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	CD markers
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Fibroblasts, Peritubular cells, Late spermatids, Leydig cells, Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.65
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Fibroblast, Pericyte, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Fibroblasts, Peritubular cells, Late spermatids, Leydig cells, Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Fibroblast, Pericyte, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MRC2 is part of cluster 53 Fibroblasts - ECM organization with confidenceⁱ 1
305 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FNDC1	Fibronectin type III domain containing 1	0.8115	53
PDGFRL	Platelet derived growth factor receptor like	0.8046	53
FBLN2	Fibulin 2	0.8036	53
ANGPTL2	Angiopoietin like 2	0.8020	53
HTRA3	HtrA serine peptidase 3	0.7957	53
BOC	BOC cell adhesion associated, oncogene regulated	0.7903	53
CILP	Cartilage intermediate layer protein	0.7868	53
GAS1	Growth arrest specific 1	0.7815	53
FBN1	Fibrillin 1	0.7808	53
PI16	Peptidase inhibitor 16	0.7740	53
DCN	Decorin	0.7644	53
FGF16	Fibroblast growth factor 16	0.7614	53
TNXB	Tenascin XB	0.7593	53
FSTL1	Follistatin like 1	0.7588	53
CCN5	Cellular communication network factor 5	0.7509	53

Adipocytes	3.2 nTPM
Adipose tissue	4.0 nTPM
Breast	2.3 nTPM

Alveolar cells type 1	4.0 nTPM
Lung	4.0 nTPM

Alveolar cells type 2	46.7 nTPM
Lung	46.7 nTPM

Astrocytes	5.6 nTPM
Brain	5.6 nTPM

B-cells	1.9 nTPM
Skin	11.9 nTPM
Esophagus	5.9 nTPM
Lung	2.7 nTPM
Thymus	2.2 nTPM
Adipose tissue	0.8 nTPM
Stomach	0.8 nTPM
Salivary gland	0.8 nTPM
Spleen	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	9.1 nTPM
Endometrium	20.4 nTPM
Fallopian tube	12.2 nTPM
Bronchus	2.0 nTPM
Lung	1.6 nTPM

Club cells	1.9 nTPM
Bronchus	3.0 nTPM
Lung	1.5 nTPM
Prostate	1.2 nTPM

Endothelial cells	3.4 nTPM
Tongue	10.4 nTPM
Heart muscle	6.1 nTPM
Ovary	5.8 nTPM
Skeletal muscle	5.5 nTPM
Pancreas	5.2 nTPM
Vascular	4.3 nTPM
Thymus	3.7 nTPM
Lung	3.4 nTPM
Endometrium	3.0 nTPM
Skin	2.7 nTPM
Esophagus	2.6 nTPM
Prostate	2.2 nTPM
Salivary gland	2.0 nTPM
Fallopian tube	1.4 nTPM
Liver	1.3 nTPM
Testis	1.2 nTPM
Placenta	0.6 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	122.9 nTPM
Adipose tissue	405.9 nTPM
Skeletal muscle	302.3 nTPM
Breast	163.5 nTPM
Vascular	122.1 nTPM
Fallopian tube	116.1 nTPM
Stomach	112.4 nTPM
Skin	103.5 nTPM
Pancreas	93.5 nTPM
Esophagus	91.2 nTPM
Salivary gland	87.4 nTPM
Heart muscle	85.8 nTPM
Thymus	84.4 nTPM
Lung	75.0 nTPM
Prostate	63.4 nTPM
Placenta	60.0 nTPM
Liver	0.0 nTPM

Granulocytes	6.6 nTPM
Tongue	14.6 nTPM
Fallopian tube	5.2 nTPM
Lung	0.0 nTPM

Intestinal goblet cells	0.1 nTPM
Rectum	0.3 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	9.5 nTPM
Ovary	16.4 nTPM
Fallopian tube	2.7 nTPM

Macrophages	7.9 nTPM
Breast	35.2 nTPM
Prostate	17.9 nTPM
Endometrium	16.6 nTPM
Skin	15.6 nTPM
Tongue	11.0 nTPM
Salivary gland	9.3 nTPM
Skeletal muscle	8.3 nTPM
Pancreas	8.2 nTPM
Fallopian tube	8.1 nTPM
Esophagus	5.1 nTPM
Vascular	4.2 nTPM
Bone marrow	2.0 nTPM
Testis	1.9 nTPM
Lung	1.6 nTPM
Thymus	1.6 nTPM
Adipose tissue	1.1 nTPM
Spleen	1.0 nTPM
Kidney	0.9 nTPM
Stomach	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal keratinocytes	32.3 nTPM
Tongue	53.2 nTPM
Skin	11.4 nTPM

Basal respiratory cells	19.0 nTPM
Bronchus	19.0 nTPM

Basal squamous epithelial cells	30.6 nTPM
Esophagus	30.6 nTPM

Bipolar cells	9.8 nTPM
Eye	9.8 nTPM

Plasma cells	1.2 nTPM
Fallopian tube	5.5 nTPM
Thymus	2.1 nTPM
Salivary gland	1.3 nTPM
Stomach	0.8 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	11.0 nTPM
Adipose tissue	32.0 nTPM
Vascular	1.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	14.3 nTPM
Tongue	17.7 nTPM
Salivary gland	10.9 nTPM

Smooth muscle cells	19.0 nTPM
Placenta	80.7 nTPM
Tongue	41.9 nTPM
Endometrium	41.8 nTPM
Adipose tissue	30.5 nTPM
Vascular	29.9 nTPM
Lung	16.5 nTPM
Fallopian tube	15.1 nTPM
Skeletal muscle	9.1 nTPM
Ovary	7.8 nTPM
Breast	7.0 nTPM
Skin	6.6 nTPM
Liver	5.1 nTPM
Thymus	5.0 nTPM
Salivary gland	2.6 nTPM
Esophagus	2.4 nTPM
Prostate	1.8 nTPM

Suprabasal keratinocytes	16.1 nTPM
Tongue	24.8 nTPM
Skin	7.3 nTPM

T-cells	2.0 nTPM
Skin	11.6 nTPM
Tongue	7.3 nTPM
Endometrium	5.4 nTPM
Salivary gland	3.4 nTPM
Vascular	2.8 nTPM
Skeletal muscle	2.6 nTPM
Lung	1.1 nTPM
Colon	1.0 nTPM
Liver	1.0 nTPM
Breast	0.9 nTPM
Fallopian tube	0.9 nTPM
Thymus	0.8 nTPM
Prostate	0.7 nTPM
PBMC	0.6 nTPM
Adipose tissue	0.6 nTPM
Lymph node	0.6 nTPM
Spleen	0.6 nTPM
Stomach	0.6 nTPM
Bone marrow	0.2 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	0.3 nTPM
Colon	0.8 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	2.9 nTPM
Thalamus	5.0 nTPM
Amygdala	2.8 nTPM
Basal ganglia	2.6 nTPM
Cerebral cortex	2.5 nTPM
Hippocampus	2.3 nTPM
Hypothalamus	2.3 nTPM

Astrocyte	22.4 nTPM
Spinal cord	66.5 nTPM
Medulla oblongata	36.3 nTPM
Basal ganglia	28.2 nTPM
Pons	21.7 nTPM
Cerebellum	19.8 nTPM
Midbrain	16.9 nTPM
Amygdala	14.4 nTPM
Hypothalamus	13.8 nTPM
Hippocampus	13.0 nTPM
Thalamus	8.4 nTPM
Cerebral cortex	7.3 nTPM

Bergmann glia	1.7 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	1.4 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	192.1 nTPM
Midbrain	207.3 nTPM
Medulla oblongata	206.4 nTPM
Pons	205.5 nTPM
Cerebellum	198.4 nTPM
Hippocampus	195.7 nTPM
Thalamus	194.9 nTPM
Basal ganglia	185.5 nTPM
Amygdala	183.9 nTPM
Hypothalamus	183.5 nTPM
Cerebral cortex	182.8 nTPM
Spinal cord	169.6 nTPM

Cerebellar inhibitory	1.8 nTPM
Spinal cord	2.7 nTPM
Medulla oblongata	2.4 nTPM
Midbrain	1.6 nTPM
Pons	1.3 nTPM
Cerebellum	1.1 nTPM

Cge interneuron	1.4 nTPM
Hypothalamus	1.7 nTPM
Basal ganglia	1.6 nTPM
Amygdala	1.5 nTPM
Hippocampus	1.4 nTPM
Midbrain	1.3 nTPM
Cerebral cortex	1.2 nTPM
Thalamus	1.2 nTPM

Choroid plexus epithelial cell	47.0 nTPM
Basal ganglia	79.6 nTPM
Hippocampus	52.7 nTPM
Medulla oblongata	36.4 nTPM
Thalamus	19.2 nTPM

Committed oligodendrocyte precursor	3.5 nTPM
Pons	6.2 nTPM
Medulla oblongata	5.2 nTPM
Cerebellum	4.8 nTPM
Cerebral cortex	4.4 nTPM
Spinal cord	3.7 nTPM
Amygdala	3.4 nTPM
Hippocampus	3.4 nTPM
Basal ganglia	3.3 nTPM
Hypothalamus	2.7 nTPM
Thalamus	2.0 nTPM
Midbrain	0.0 nTPM

Deep-layer corticothalamic and 6b	9.2 nTPM
Cerebral cortex	14.1 nTPM
Basal ganglia	10.0 nTPM
Midbrain	8.9 nTPM
Hypothalamus	8.6 nTPM
Amygdala	7.4 nTPM
Hippocampus	6.0 nTPM

Deep-layer intratelencephalic	3.5 nTPM
Amygdala	4.0 nTPM
Hypothalamus	3.8 nTPM
Basal ganglia	3.2 nTPM
Cerebral cortex	3.2 nTPM
Hippocampus	3.2 nTPM

Deep-layer near-projecting	1.6 nTPM
Hypothalamus	2.1 nTPM
Hippocampus	2.0 nTPM
Basal ganglia	1.4 nTPM
Cerebral cortex	1.2 nTPM
Amygdala	1.1 nTPM

Eccentric medium spiny neuron	2.3 nTPM
Thalamus	3.2 nTPM
Basal ganglia	3.1 nTPM
Hippocampus	2.1 nTPM
Cerebral cortex	2.0 nTPM
Amygdala	1.9 nTPM
Hypothalamus	1.9 nTPM

Endothelial cell	7.8 nTPM
Basal ganglia	15.8 nTPM
Medulla oblongata	14.4 nTPM
Hypothalamus	11.2 nTPM
Cerebral cortex	7.7 nTPM
Spinal cord	6.9 nTPM
Amygdala	6.7 nTPM
Midbrain	6.6 nTPM
Hippocampus	4.5 nTPM
Thalamus	4.5 nTPM
Cerebellum	3.9 nTPM
Pons	3.7 nTPM