Single cell type - PIGQ - The Human Protein Atlas

PIGQ

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIGQ
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol glycan anchor biosynthesis class Q
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PIGQ is part of cluster 1 Erythroid cells - Oxygen transport with confidenceⁱ 1
138 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC25A39	Solute carrier family 25 member 39	0.6663	1
FOXH1	Forkhead box H1	0.5989	1
NARF	Nuclear prelamin A recognition factor	0.5907	1
ERMAP	Erythroblast membrane associated protein (Scianna blood group)	0.5893	1
ADD2	Adducin 2	0.5817	1
CA1	Carbonic anhydrase 1	0.5620	1
UBAC1	UBA domain containing 1	0.5373	1
HBZ	Hemoglobin subunit zeta	0.5311	1
SLC25A21	Solute carrier family 25 member 21	0.5289	1
RNF123	Ring finger protein 123	0.5226	1
UROS	Uroporphyrinogen III synthase	0.5177	1
MINPP1	Multiple inositol-polyphosphate phosphatase 1	0.5106	1
PPOX	Protoporphyrinogen oxidase	0.5038	1
HBE1	Hemoglobin subunit epsilon 1	0.5031	1
HBG2	Hemoglobin subunit gamma 2	0.5028	1

IMMUNE CELLS

PIGQ is part of cluster 13 Non-specific - Mitochondria with confidenceⁱ 0.62
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AARSD1	Alanyl-tRNA synthetase domain containing 1	0.9762	13
USP40	Ubiquitin specific peptidase 40	0.9762	13
UTP6	UTP6 small subunit processome component	0.9762	13
RASGEF1B	RasGEF domain family member 1B	0.9524	8
ATF6B	Activating transcription factor 6 beta	0.9524	13
FAM156B	Family with sequence similarity 156 member B	0.9524	13
WARS2	Tryptophanyl tRNA synthetase 2, mitochondrial	0.9524	13
NOMO1	NODAL modulator 1	0.9524	13
MRI1	Methylthioribose-1-phosphate isomerase 1	0.9524	13
WDR77	WD repeat domain 77	0.9286	13
CYP51A1	Cytochrome P450 family 51 subfamily A member 1	0.9286	13
FEM1A	Fem-1 homolog A	0.9286	13
AOPEP	Aminopeptidase O (putative)	0.9286	30
SLX4IP	SLX4 interacting protein	0.9286	30
MYO1E	Myosin IE	0.9286	13

Adipocytes	9.9 nTPM
Adipose tissue	10.9 nTPM
Breast	9.0 nTPM

Alveolar cells type 1	23.5 nTPM
Lung	23.5 nTPM

Alveolar cells type 2	21.2 nTPM
Lung	21.2 nTPM

Astrocytes	13.3 nTPM
Brain	13.3 nTPM

B-cells	5.4 nTPM
Stomach	11.4 nTPM
Adipose tissue	7.8 nTPM
Lung	6.7 nTPM
Lymph node	6.1 nTPM
Esophagus	5.9 nTPM
Spleen	5.7 nTPM
Bone marrow	5.5 nTPM
Salivary gland	5.3 nTPM
Kidney	5.2 nTPM
Thymus	3.9 nTPM
Skin	3.4 nTPM
PBMC	3.1 nTPM
Liver	0.0 nTPM

Ciliated cells	24.3 nTPM
Lung	31.1 nTPM
Bronchus	26.3 nTPM
Endometrium	20.2 nTPM
Fallopian tube	19.4 nTPM

Club cells	11.9 nTPM
Bronchus	12.8 nTPM
Prostate	12.8 nTPM
Lung	10.2 nTPM

Endothelial cells	10.1 nTPM
Pancreas	20.7 nTPM
Breast	20.2 nTPM
Placenta	16.5 nTPM
Lung	11.4 nTPM
Endometrium	11.0 nTPM
Heart muscle	10.3 nTPM
Ovary	9.6 nTPM
Tongue	8.8 nTPM
Fallopian tube	8.5 nTPM
Esophagus	8.2 nTPM
Vascular	8.2 nTPM
Salivary gland	8.1 nTPM
Thymus	8.1 nTPM
Skeletal muscle	6.7 nTPM
Liver	6.3 nTPM
Prostate	6.3 nTPM
Skin	6.2 nTPM
Testis	6.1 nTPM

Enteroendocrine cells	11.4 nTPM
Rectum	15.1 nTPM
Colon	12.1 nTPM
Small intestine	6.9 nTPM

Fibroblasts	8.5 nTPM
Pancreas	16.4 nTPM
Adipose tissue	13.0 nTPM
Lung	10.5 nTPM
Breast	9.6 nTPM
Placenta	9.3 nTPM
Prostate	9.2 nTPM
Vascular	9.0 nTPM
Skin	8.6 nTPM
Esophagus	8.6 nTPM
Skeletal muscle	8.2 nTPM
Thymus	7.3 nTPM
Liver	7.1 nTPM
Fallopian tube	6.9 nTPM
Stomach	5.8 nTPM
Salivary gland	5.6 nTPM
Heart muscle	0.3 nTPM

Granulocytes	5.9 nTPM
Fallopian tube	7.9 nTPM
Lung	5.0 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	15.1 nTPM
Small intestine	24.4 nTPM
Colon	11.3 nTPM
Rectum	9.5 nTPM

Lymphatic endothelial cells	16.6 nTPM
Ovary	21.8 nTPM
Fallopian tube	11.5 nTPM

Macrophages	7.5 nTPM
Pancreas	16.4 nTPM
Esophagus	11.6 nTPM
Kidney	11.5 nTPM
Adipose tissue	9.2 nTPM
Lung	9.2 nTPM
Spleen	9.0 nTPM
Vascular	8.8 nTPM
Stomach	7.7 nTPM
Testis	7.4 nTPM
Skeletal muscle	7.2 nTPM
Breast	7.1 nTPM
Fallopian tube	6.5 nTPM
Skin	5.6 nTPM
Thymus	5.1 nTPM
Tongue	5.1 nTPM
Salivary gland	4.9 nTPM
Endometrium	4.3 nTPM
Prostate	4.3 nTPM
Bone marrow	2.0 nTPM

Paneth cells	11.5 nTPM
Small intestine	13.8 nTPM
Colon	10.9 nTPM
Rectum	9.7 nTPM

Basal squamous epithelial cells	4.4 nTPM
Esophagus	4.4 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Collecting duct cells	21.4 nTPM
Kidney	21.4 nTPM

Early spermatids	35.2 nTPM
Testis	35.2 nTPM

Plasma cells	6.8 nTPM
Spleen	9.4 nTPM
Stomach	9.2 nTPM
Fallopian tube	7.7 nTPM
Thymus	7.1 nTPM
Liver	7.0 nTPM
Esophagus	5.2 nTPM
Bone marrow	4.5 nTPM
Salivary gland	4.5 nTPM

Schwann cells	11.1 nTPM
Esophagus	12.0 nTPM
Vascular	11.5 nTPM
Adipose tissue	9.8 nTPM

Serous glandular cells	4.3 nTPM
Salivary gland	8.5 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	7.7 nTPM
Lung	14.1 nTPM
Breast	9.9 nTPM
Placenta	9.8 nTPM
Fallopian tube	9.2 nTPM
Endometrium	8.3 nTPM
Skin	7.8 nTPM
Tongue	7.8 nTPM
Vascular	7.5 nTPM
Thymus	7.4 nTPM
Ovary	7.4 nTPM
Salivary gland	7.1 nTPM
Adipose tissue	6.0 nTPM
Esophagus	6.0 nTPM
Skeletal muscle	5.7 nTPM
Liver	5.5 nTPM
Prostate	3.6 nTPM

T-cells	6.3 nTPM
Esophagus	14.6 nTPM
Lymph node	10.4 nTPM
Stomach	9.1 nTPM
Colon	8.8 nTPM
Breast	7.8 nTPM
Bone marrow	6.9 nTPM
Spleen	6.6 nTPM
Fallopian tube	6.6 nTPM
Adipose tissue	6.0 nTPM
PBMC	5.7 nTPM
Lung	5.7 nTPM
Endometrium	5.4 nTPM
Kidney	5.3 nTPM
Liver	4.9 nTPM
Tongue	4.8 nTPM
Thymus	4.6 nTPM
Skeletal muscle	4.5 nTPM
Prostate	4.1 nTPM
Skin	3.5 nTPM
Vascular	3.2 nTPM
Salivary gland	2.9 nTPM

Undifferentiated cells	11.0 nTPM
Colon	11.7 nTPM
Rectum	11.7 nTPM
Small intestine	9.4 nTPM

Amygdala excitatory	35.1 nTPM
Hypothalamus	41.2 nTPM
Basal ganglia	36.5 nTPM
Cerebral cortex	36.3 nTPM
Amygdala	34.4 nTPM
Hippocampus	34.3 nTPM
Thalamus	27.7 nTPM

Astrocyte	34.1 nTPM
Cerebellum	49.2 nTPM
Spinal cord	40.7 nTPM
Cerebral cortex	37.1 nTPM
Pons	36.8 nTPM
Midbrain	35.5 nTPM
Hippocampus	35.1 nTPM
Thalamus	32.7 nTPM
Medulla oblongata	30.7 nTPM
Basal ganglia	28.8 nTPM
Amygdala	24.4 nTPM
Hypothalamus	24.2 nTPM

Bergmann glia	24.5 nTPM
Cerebellum	29.2 nTPM
Pons	27.3 nTPM
Medulla oblongata	17.0 nTPM

Central nervous system macrophage	10.4 nTPM
Cerebral cortex	15.2 nTPM
Hippocampus	13.2 nTPM
Cerebellum	11.7 nTPM
Pons	11.7 nTPM
Spinal cord	10.0 nTPM
Midbrain	9.7 nTPM
Thalamus	9.6 nTPM
Basal ganglia	9.4 nTPM
Hypothalamus	8.5 nTPM
Amygdala	8.4 nTPM
Medulla oblongata	7.5 nTPM

Cerebellar inhibitory	36.3 nTPM
Spinal cord	44.0 nTPM
Cerebellum	40.5 nTPM
Midbrain	34.5 nTPM
Pons	32.6 nTPM
Medulla oblongata	29.8 nTPM

Cge interneuron	24.3 nTPM
Hypothalamus	29.7 nTPM
Cerebral cortex	25.5 nTPM
Hippocampus	24.6 nTPM
Amygdala	24.4 nTPM
Midbrain	23.9 nTPM
Basal ganglia	23.4 nTPM
Thalamus	18.7 nTPM

Choroid plexus epithelial cell	24.3 nTPM
Basal ganglia	30.7 nTPM
Thalamus	27.4 nTPM
Medulla oblongata	22.3 nTPM
Hippocampus	16.6 nTPM

Committed oligodendrocyte precursor	21.3 nTPM
Amygdala	26.5 nTPM
Pons	25.7 nTPM
Thalamus	25.0 nTPM
Hippocampus	24.8 nTPM
Cerebellum	22.2 nTPM
Hypothalamus	21.8 nTPM
Cerebral cortex	20.9 nTPM
Spinal cord	18.4 nTPM
Basal ganglia	18.1 nTPM
Medulla oblongata	18.1 nTPM
Midbrain	12.6 nTPM

Deep-layer corticothalamic and 6b	37.6 nTPM
Basal ganglia	41.8 nTPM
Hypothalamus	40.4 nTPM
Cerebral cortex	38.6 nTPM
Amygdala	38.3 nTPM
Midbrain	35.5 nTPM
Hippocampus	31.0 nTPM

Deep-layer intratelencephalic	39.0 nTPM
Hypothalamus	44.7 nTPM
Basal ganglia	40.1 nTPM
Amygdala	38.9 nTPM
Cerebral cortex	37.8 nTPM
Hippocampus	33.5 nTPM

Deep-layer near-projecting	25.9 nTPM
Hypothalamus	30.6 nTPM
Amygdala	27.3 nTPM
Basal ganglia	25.4 nTPM
Cerebral cortex	24.5 nTPM
Hippocampus	21.8 nTPM

Eccentric medium spiny neuron	29.3 nTPM
Hippocampus	30.7 nTPM
Basal ganglia	30.0 nTPM
Cerebral cortex	29.4 nTPM
Hypothalamus	29.4 nTPM
Thalamus	28.5 nTPM
Amygdala	28.0 nTPM

Endothelial cell	12.9 nTPM
Basal ganglia	20.5 nTPM
Midbrain	18.0 nTPM
Cerebellum	17.8 nTPM
Thalamus	14.7 nTPM
Cerebral cortex	12.1 nTPM
Spinal cord	12.1 nTPM
Amygdala	11.2 nTPM
Hippocampus	10.9 nTPM
Pons	10.0 nTPM
Hypothalamus	9.9 nTPM
Medulla oblongata	5.1 nTPM

Ependymal cell	49.9 nTPM
Spinal cord	59.4 nTPM
Basal ganglia	55.0 nTPM
Pons	51.5 nTPM
Amygdala	50.1 nTPM
Midbrain	48.9 nTPM
Hippocampus	48.5 nTPM
Hypothalamus	47.3 nTPM
Medulla oblongata	45.4 nTPM
Thalamus	43.3 nTPM