Transcription factor landscape - Cell line - Myeloma

34 different cell lines are representing myeloma in the atlas, different ages and collection site are represented, find more details about the different cell lines here. For each of the myeloma related cell line, up- and downregulated cancer-related pathways can be explored based on the transcriptomics data.

The mean value of the different cell lines are used as representation, when classifying gene expression based on specificity in the different cancer types represented by cell lines. To explore the expression profile in the indivudial cell lines- click the bar in the bar chart and you will reach the overivew of the different cell lines.

Here we provide the expression overview of all 33 transcription factors that show elevated expression levels in myeloma compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

DUX4

Cancer enriched (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGKJ4	Immunoglobulin kappa joining 4	0.8362	51
IGKV2D-40	Immunoglobulin kappa variable 2D-40	0.8318	51
PRSS51	Serine protease 51	0.8265	51

MAF

Cancer enriched (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SYCP3	Synaptonemal complex protein 3	0.8977	51
CRYBB1	Crystallin beta B1	0.8567	51
IGLV2-14	Immunoglobulin lambda variable 2-14	0.8418	51

BATF2

Cancer enriched (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR13C2	Olfactory receptor family 13 subfamily C member 2	0.9275	51
IGHD	Immunoglobulin heavy constant delta	0.8539	51
OR13C5	Olfactory receptor family 13 subfamily C member 5	0.8344	51

BHLHA15

Cancer enriched (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TXNDC11	Thioredoxin domain containing 11	0.7566	51
MZB1	Marginal zone B and B1 cell specific protein	0.6851	51
IGLC1	Immunoglobulin lambda constant 1	0.6832	51

PRDM1

Cancer enriched (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IRF4	Interferon regulatory factor 4	0.7675	51
PIM2	Pim-2 proto-oncogene, serine/threonine kinase	0.6943	51
ITGB7	Integrin subunit beta 7	0.6932	51

Enriched transcription factors

Gene

Expression

Expression clustering

IKZF1

Group enriched (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAX5	Paired box 5	0.5982	6
PTGDR	Prostaglandin D2 receptor	0.5858	6
ARHGAP25	Rho GTPase activating protein 25	0.5830	55

IRF4

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRDM1	PR/SET domain 1	0.7675	51
LIMD1	LIM domain containing 1	0.5869	51
SLAMF7	SLAM family member 7	0.5684	51

IKZF3

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	0.6740	46
POU2F2	POU class 2 homeobox 2	0.6577	55
RASGRP3	RAS guanyl releasing protein 3	0.6421	46

ARID5A

Group enriched (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF8	TNF receptor superfamily member 8	0.7390	21
PROB1	Proline rich basic protein 1	0.7166	21
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.6991	21

BHLHE22

Group enriched (Bone cancer, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TENM1	Teneurin transmembrane protein 1	0.6642	12
KRTAP10-10	Keratin associated protein 10-10	0.6621	10
KRTAP10-11	Keratin associated protein 10-11	0.6373	10

SP140

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLEC17A	C-type lectin domain containing 17A	0.7667	55
FGD2	FYVE, RhoGEF and PH domain containing 2	0.7606	55
TNFRSF13B	TNF receptor superfamily member 13B	0.7590	55

POU2F2

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD37	CD37 molecule	0.8430	55
SPIB	Spi-B transcription factor	0.8354	55
TLR9	Toll like receptor 9	0.8220	55

RHOXF2

Group enriched (Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RHOXF2B	Rhox homeobox family member 2B	0.9077	51
NAA11	N-alpha-acetyltransferase 11, NatA catalytic subunit	0.6889	51
GAGE12H	G antigen 12H	0.6865	51

RHOXF2B

Group enriched (Gastric cancer, Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RHOXF2	Rhox homeobox family member 2	0.9077	51
EPX	Eosinophil peroxidase	0.6403	51
NAA11	N-alpha-acetyltransferase 11, NatA catalytic subunit	0.5515	51

ZBTB32

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CCL4	C-C motif chemokine ligand 4	0.9293	55
EBI3	Epstein-Barr virus induced 3	0.9260	55
CCL22	C-C motif chemokine ligand 22	0.9223	55

Enriched transcription factors

Gene

Expression

Expression clustering

DNAJC1

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COMMD3	COMM domain containing 3	0.7895	51
IGLV3-16	Immunoglobulin lambda variable 3-16	0.7432	51
IGLV3-25	Immunoglobulin lambda variable 3-25	0.7283	51

E2F2

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BEST3	Bestrophin 3	0.6252	46
BACH2	BTB domain and CNC homolog 2	0.6088	46
CD38	CD38 molecule	0.5985	46

FLI1

Cancer enhanced (Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PECAM1	Platelet and endothelial cell adhesion molecule 1	0.7308	48
ERG	ETS transcription factor ERG	0.7061	6
ESAM	Endothelial cell adhesion molecule	0.6561	48

KLF2

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CEP295NL	CEP295 N-terminal like	0.6160	51
IGLC1	Immunoglobulin lambda constant 1	0.5605	51
IGLV2-11	Immunoglobulin lambda variable 2-11	0.5475	51

MEF2C

Cancer enhanced (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TEC	Tec protein tyrosine kinase	0.6806	6
PTK2B	Protein tyrosine kinase 2 beta	0.6641	55
PPP3CC	Protein phosphatase 3 catalytic subunit gamma	0.6570	6

MYCL

Cancer enhanced (Lung cancer, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRIT1	TRNA isopentenyltransferase 1	0.8868	10
RLF	RLF zinc finger	0.7524	37
PPIE	Peptidylprolyl isomerase E	0.7440	10

OLIG1

Cancer enhanced (Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRAM1	PML-RARA regulated adaptor molecule 1	0.7701	14
SIGLEC1	Sialic acid binding Ig like lectin 1	0.7451	14
FCAR	Fc alpha receptor	0.7427	14

PRDM9

Cancer enhanced (Myeloma, Thyroid cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR4C6	Olfactory receptor family 4 subfamily C member 6	0.5503	51
IGKV1-16	Immunoglobulin kappa variable 1-16	0.5163	51
FAM237B	Family with sequence similarity 237 member B	0.4625	53

RORA

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD28	CD28 molecule	0.6357	20
IL17A	Interleukin 17A	0.6259	20
OTUD5	OTU deubiquitinase 5	0.6230	20

RUNX2

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NFIL3	Nuclear factor, interleukin 3 regulated	0.5912	71
SUPT3H	SPT3 homolog, SAGA and STAGA complex component	0.5561	51
MYBPC2	Myosin binding protein C2	0.5516	71

RUNX3

Cancer enhanced (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RGS1	Regulator of G protein signaling 1	0.6707	55
TNFRSF14	TNF receptor superfamily member 14	0.6052	9
TRAF1	TNF receptor associated factor 1	0.5898	55

SOHLH1

Cancer enhanced (Breast cancer, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIR2DL1	Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	0.8055	70
GABRA1	Gamma-aminobutyric acid type A receptor subunit alpha1	0.7982	70
CACNA1S	Calcium voltage-gated channel subunit alpha1 S	0.7958	70

STAT4

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRGV4	T cell receptor gamma variable 4	0.6515	59
TRGV2	T cell receptor gamma variable 2	0.5892	59
TRGV1	T cell receptor gamma variable 1 (non-functional)	0.5500	59

TGIF2LX

Cancer enhanced (Myeloma, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPP4R3C	Protein phosphatase 4 regulatory subunit 3C	0.6637	51
ENSG00000275869		0.5986	51
TRPC7	Transient receptor potential cation channel subfamily C member 7	0.5771	10

TSC22D3

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR2K2	Olfactory receptor family 2 subfamily K member 2	0.5455	51
STBD1	Starch binding domain 1	0.5293	51
INHBC	Inhibin subunit beta C	0.4836	51

XBP1

Cancer enhanced (Breast cancer, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SRARP	Steroid receptor associated and regulated protein	0.6794	27
SLC9A3R1	SLC9A3 regulator 1	0.6732	27
NCBP2L	Nuclear cap binding protein subunit 2 like	0.6723	27

ZBTB38

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ITGB7	Integrin subunit beta 7	0.7014	51
TNFRSF17	TNF receptor superfamily member 17	0.6561	51
MORC1	MORC family CW-type zinc finger 1	0.6340	51

ZNF275

Cancer enhanced (Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGLV5-48	Immunoglobulin lambda variable 5-48 (non-functional)	0.6231	51
CCDC110	Coiled-coil domain containing 110	0.5935	51
IGLJ2	Immunoglobulin lambda joining 2	0.5726	51