Transcription factor landscape - Cell line - Esophageal cancer

27 different cell lines are representing esophageal cancer in the atlas, different ages, collection site and cancer subtypes are represented, find more details about the different cell lines here. The expression profile of the different cell lines can be explored in comparison to the bulk RNAseq transcriptomics data from TCGA's Esophageal Carcinoma (ESCA), defining the cell lines most similar to the tumour expression profile.

The mean value of the different cell lines are used as representation, when classifying gene expression based on specificity in the different cancer types represented by cell lines. To explore the expression profile in the indivudial cell lines- click the bar in the bar chart and you will reach the overivew of the different cell lines.

Here we provide the expression overview of all 5 transcription factors that show elevated expression levels in esophageal cancer compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors
Gene Expression Expression clustering
FOXN1
Group enriched (Cervical cancer, Esophageal cancer, Head and neck cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
GJB6 Gap junction protein beta 6 0.8621 53
KRT84 Keratin 84 0.8558 53
USH1G USH1 protein network component sans 0.8493 53

Enriched transcription factors
Gene Expression Expression clustering
DMRT2
Cancer enhanced (Esophageal cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
TAS2R38 Taste 2 receptor member 38 0.5837 24
TAS2R42 Taste 2 receptor member 42 0.5732 24
IL1RAPL2 Interleukin 1 receptor accessory protein like 2 0.5699 33
IRX4
Cancer enhanced (Cervical cancer, Esophageal cancer, Head and neck cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
KHDC1L KH domain containing 1 like 0.7072 53
IL1F10 Interleukin 1 family member 10 0.6364 53
SOX15 SRY-box transcription factor 15 0.6229 53
SOX15
Cancer enhanced (Cervical cancer, Esophageal cancer, Head and neck cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CFAP251 Cilia and flagella associated protein 251 0.7942 53
SFN Stratifin 0.7574 53
ENSG00000289700 Novel protein 0.7498 53
TP63
Cancer enhanced (Esophageal cancer, Gallbladder cancer, Head and neck cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
GBP6 Guanylate binding protein family member 6 0.8877 53
SERPINB13 Serpin family B member 13 0.8377 53
DSC3 Desmocollin 3 0.8369 53