Transcription factor landscape - Cell line - Adrenocortical cancer

One cell line is representing adrenocortical cancer in the atlas (called HCC1576), find more details about it here. Up- and downregulated cancer-related pathways can be explored based on the transcriptomics data.

Here we provide the expression overview of all 17 transcription factors that show elevated expression levels in adrenocortical cancer compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

ZNF534

Cancer enriched (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF732	Zinc finger protein 732	0.6471	4
ZNF98	Zinc finger protein 98	0.6458	4
ZNF729	Zinc finger protein 729	0.6401	4

KLF17

Cancer enriched (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR2T8	Olfactory receptor family 2 subfamily T member 8	0.5829	72
RTL3	Retrotransposon Gag like 3	0.5802	72
TENM2	Teneurin transmembrane protein 2	0.5787	72

ESX1

Cancer enriched (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDH5	Cadherin 5	0.5899	48
ENSG00000288625	Novel protein	0.5819	48
HTR1B	5-hydroxytryptamine receptor 1B	0.5568	48

Enriched transcription factors

Gene

Expression

Expression clustering

FOXE3

Group enriched (Adrenocortical cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KDM4E	Lysine demethylase 4E	0.6666	4
ARHGEF33	Rho guanine nucleotide exchange factor 33	0.6498	4
RIT2	Ras like without CAAX 2	0.6450	66

BATF3

Group enriched (Adrenocortical cancer, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GZMH	Granzyme H	0.7636	71
H2AB1	H2A.B variant histone 1	0.7482	50
IL1R2	Interleukin 1 receptor type 2	0.7405	71

Enriched transcription factors

Gene

Expression

Expression clustering

FOXE1

Cancer enhanced (Adrenocortical cancer, Cervical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXN1	Forkhead box N1	0.8046	53
KRT6C	Keratin 6C	0.7560	53
FETUB	Fetuin B	0.7531	53

GBX2

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM88	Transmembrane protein 88	0.6278	5
SEMA3D	Semaphorin 3D	0.5716	5
UTF1	Undifferentiated embryonic cell transcription factor 1	0.5544	5

MYBL1

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AXL	AXL receptor tyrosine kinase	0.4719	72
PXDNL	Peroxidasin like	0.4605	27
HLA-DOB	Major histocompatibility complex, class II, DO beta	0.4574	46

NFKB2

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAF1	TNF receptor associated factor 1	0.7691	55
EBI3	Epstein-Barr virus induced 3	0.7257	55
RGS1	Regulator of G protein signaling 1	0.7127	55

PBX4

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TVP23A	Trans-golgi network vesicle protein 23 homolog A	0.5110	55
SYNGR3	Synaptogyrin 3	0.4656	59
OR2V1	Olfactory receptor family 2 subfamily V member 1	0.4489	55

RELB

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NFKB2	Nuclear factor kappa B subunit 2	0.6345	55
CXCR5	C-X-C motif chemokine receptor 5	0.6160	55
CD83	CD83 molecule	0.6062	55

SP9

Cancer enhanced (Adrenocortical cancer, Rhabdoid)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MLNR	Motilin receptor	0.5695	4
SCN1A	Sodium voltage-gated channel alpha subunit 1	0.5219	10
BARX1	BARX homeobox 1	0.5073	10

TFAP2E

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OLIG1	Oligodendrocyte transcription factor 1	0.6864	14
RGL4	Ral guanine nucleotide dissociation stimulator like 4	0.6448	14
PARVG	Parvin gamma	0.6016	14

ZFY

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPS4Y1	Ribosomal protein S4 Y-linked 1	0.8461	25
UTY	Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	0.8360	47
DDX3Y	DEAD-box helicase 3 Y-linked	0.8061	47

ZNF469

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MN1	MN1 proto-oncogene, transcriptional regulator	0.6175	64
COL5A1	Collagen type V alpha 1 chain	0.6142	64
BGN	Biglycan	0.6079	64

ZNF560

Cancer enhanced (Adrenocortical cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF729	Zinc finger protein 729	0.7335	4
ZNF676	Zinc finger protein 676	0.7144	4
ZNF728	Zinc finger protein 728	0.7075	4

ZNF732

Cancer enhanced (Adrenocortical cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WDR87	WD repeat domain 87	0.7583	4
ZNF98	Zinc finger protein 98	0.7518	4
ZNF729	Zinc finger protein 729	0.7439	4