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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q28
Chromosome location (bp)
154541199 - 154565046
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor 1,2,3,4. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways 5,6,7,8,9,10,11. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin 12,13,14,15,16,17. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 18. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination 19....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, Host-virus interaction, Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
D3DWY0 [Direct mapping] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b; NF-kappa-B essential modulator
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000922[spindle pole] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008385[IkappaB kinase complex] GO:0009615[response to virus] GO:0016239[positive regulation of macroautophagy] GO:0019904[protein domain specific binding] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043276[anoikis] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051650[establishment of vesicle localization] GO:0065003[protein-containing complex assembly] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:0072686[mitotic spindle] GO:1901215[negative regulation of neuron death] GO:1990450[linear polyubiquitin binding] GO:1990459[transferrin receptor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Show all
GO:0005737[cytoplasm] GO:0046872[metal ion binding] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Congenital malformations of skin Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency
Show all
GO:0005737[cytoplasm] GO:0046872[metal ion binding] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding]
The Human Protein Atlas project is funded
