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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q11.2
Chromosome location (bp)
23306833 - 23326175
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0006915[apoptotic process] GO:0007283[spermatogenesis] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016020[membrane] GO:0031966[mitochondrial membrane] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0046982[protein heterodimerization activity] GO:0097136[Bcl-2 family protein complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097718[disordered domain specific binding] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0006915[apoptotic process] GO:0007283[spermatogenesis] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016020[membrane] GO:0031966[mitochondrial membrane] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0046982[protein heterodimerization activity] GO:0097136[Bcl-2 family protein complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097718[disordered domain specific binding] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
