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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p23.1
Chromosome location (bp)
10764961 - 10839884
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables telomerase RNA binding activity and telomerase inhibitor activity. Involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005739[mitochondrion] GO:0005819[spindle] GO:0007004[telomere maintenance via telomerase] GO:0007080[mitotic metaphase plate congression] GO:0008285[negative regulation of cell population proliferation] GO:0010521[telomerase inhibitor activity] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0031397[negative regulation of protein ubiquitination] GO:0031647[regulation of protein stability] GO:0032211[negative regulation of telomere maintenance via telomerase] GO:0042274[ribosomal small subunit biogenesis] GO:0044877[protein-containing complex binding] GO:0051972[regulation of telomerase activity] GO:0051974[negative regulation of telomerase activity] GO:0070034[telomerase RNA binding] GO:0070198[protein localization to chromosome, telomeric region] GO:1902570[protein localization to nucleolus] GO:1904357[negative regulation of telomere maintenance via telomere lengthening] GO:1904744[positive regulation of telomeric DNA binding] GO:1904751[positive regulation of protein localization to nucleolus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228[nuclear chromosome] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005739[mitochondrion] GO:0005819[spindle] GO:0007004[telomere maintenance via telomerase] GO:0007080[mitotic metaphase plate congression] GO:0008285[negative regulation of cell population proliferation] GO:0010521[telomerase inhibitor activity] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0031397[negative regulation of protein ubiquitination] GO:0031647[regulation of protein stability] GO:0032211[negative regulation of telomere maintenance via telomerase] GO:0042274[ribosomal small subunit biogenesis] GO:0044877[protein-containing complex binding] GO:0051972[regulation of telomerase activity] GO:0051974[negative regulation of telomerase activity] GO:0070034[telomerase RNA binding] GO:0070198[protein localization to chromosome, telomeric region] GO:1902570[protein localization to nucleolus] GO:1904357[negative regulation of telomere maintenance via telomere lengthening] GO:1904744[positive regulation of telomeric DNA binding] GO:1904751[positive regulation of protein localization to nucleolus]