GENERAL INFORMATIONi
Gene namei LYN
Synonyms JTK8
Gene descriptioni LYN proto-oncogene, Src family tyrosine kinase
Protein classi Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 8
Cytoband q12.1
Chromosome location (bp) 55879835 - 56014169
Number of transcriptsi 3
Ensembl ENSG00000254087 (version 109)
Entrez gene 4067
HGNC HGNC:6735
UniProt P07948 (UniProt - Evidence at protein level)
neXtProt NX_P07948
GeneCards LYN
Antibodypedia LYN antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration 1. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 2. show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Adaptive immunity, Host-virus interaction, Immunity, Inflammatory response, Innate immunity
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
LYN-202
ENSP00000428924
ENST00000519728
P07948
[Direct mapping] Tyrosine-protein kinase Lyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001782 [B cell homeostasis]
GO:0001817 [regulation of cytokine production]
GO:0001932 [regulation of protein phosphorylation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002431 [Fc receptor mediated stimulatory signaling pathway]
GO:0002513 [tolerance induction to self antigen]
GO:0002553 [histamine secretion by mast cell]
GO:0002576 [platelet degranulation]
GO:0002762 [negative regulation of myeloid leukocyte differentiation]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002774 [Fc receptor mediated inhibitory signaling pathway]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005758 [mitochondrial intermembrane space]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006991 [response to sterol depletion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0009636 [response to toxic substance]
GO:0009725 [response to hormone]
GO:0009743 [response to carbohydrate]
GO:0010976 [positive regulation of neuron projection development]
GO:0014003 [oligodendrocyte development]
GO:0014069 [postsynaptic density]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030061 [mitochondrial crista]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030666 [endocytic vesicle membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0031966 [mitochondrial membrane]
GO:0032868 [response to insulin]
GO:0032991 [protein-containing complex]
GO:0033003 [regulation of mast cell activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038159 [C-X-C chemokine receptor CXCR4 signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0043015 [gamma-tubulin binding]
GO:0043200 [response to amino acid]
GO:0043208 [glycosphingolipid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043304 [regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043434 [response to peptide hormone]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044325 [transmembrane transporter binding]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045646 [regulation of erythrocyte differentiation]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048678 [response to axon injury]
GO:0050727 [regulation of inflammatory response]
GO:0050777 [negative regulation of immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0050855 [regulation of B cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051219 [phosphoprotein binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0060369 [positive regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0060397 [growth hormone receptor signaling pathway via JAK-STAT]
GO:0070062 [extracellular exosome]
GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070447 [positive regulation of oligodendrocyte progenitor proliferation]
GO:0070667 [negative regulation of mast cell proliferation]
GO:0070668 [positive regulation of mast cell proliferation]
GO:0071300 [cellular response to retinoic acid]
GO:0090025 [regulation of monocyte chemotaxis]
GO:0090330 [regulation of platelet aggregation]
GO:0097028 [dendritic cell differentiation]
GO:0097110 [scaffold protein binding]
GO:0098978 [glutamatergic synapse]
GO:0099091 [postsynaptic specialization, intracellular component]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1902532 [negative regulation of intracellular signal transduction]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:2000670 [positive regulation of dendritic cell apoptotic process]
Show all
 512 aa
58.6 kDa 		No 0
LYN-203
ENSP00000428313
ENST00000520050
E5RJ37
[Direct mapping] Tyrosine-protein kinase Lyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 150 aa
17.1 kDa 		No 0
LYN-204
ENSP00000428424
ENST00000520220
P07948
[Direct mapping] Tyrosine-protein kinase Lyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001782 [B cell homeostasis]
GO:0001817 [regulation of cytokine production]
GO:0001932 [regulation of protein phosphorylation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002431 [Fc receptor mediated stimulatory signaling pathway]
GO:0002513 [tolerance induction to self antigen]
GO:0002576 [platelet degranulation]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002774 [Fc receptor mediated inhibitory signaling pathway]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009725 [response to hormone]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030666 [endocytic vesicle membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0033003 [regulation of mast cell activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038159 [C-X-C chemokine receptor CXCR4 signaling pathway]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043304 [regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045646 [regulation of erythrocyte differentiation]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050777 [negative regulation of immune response]
GO:0050855 [regulation of B cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060397 [growth hormone receptor signaling pathway via JAK-STAT]
GO:0070062 [extracellular exosome]
GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070667 [negative regulation of mast cell proliferation]
GO:0070668 [positive regulation of mast cell proliferation]
GO:0071300 [cellular response to retinoic acid]
GO:0090025 [regulation of monocyte chemotaxis]
GO:0090330 [regulation of platelet aggregation]
GO:0097028 [dendritic cell differentiation]
GO:0097110 [scaffold protein binding]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1902532 [negative regulation of intracellular signal transduction]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:2000670 [positive regulation of dendritic cell apoptotic process]
Show all
 491 aa
56 kDa 		No 0

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