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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.2
Chromosome location (bp)
66546395 - 66563334
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Actin-binding
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0003779[actin binding] GO:0005178[integrin binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005829[cytosol] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005903[brush border] GO:0005925[focal adhesion] GO:0008307[structural constituent of muscle] GO:0014728[regulation of the force of skeletal muscle contraction] GO:0014732[skeletal muscle atrophy] GO:0014883[transition between fast and slow fiber] GO:0014894[response to denervation involved in regulation of muscle adaptation] GO:0015629[actin cytoskeleton] GO:0030017[sarcomere] GO:0030018[Z disc] GO:0030036[actin cytoskeleton organization] GO:0030054[cell junction] GO:0030864[cortical actin cytoskeleton] GO:0031143[pseudopodium] GO:0031448[positive regulation of fast-twitch skeletal muscle fiber contraction] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0042995[cell projection] GO:0044325[transmembrane transporter binding] GO:0045820[negative regulation of glycolytic process] GO:0046872[metal ion binding] GO:0048041[focal adhesion assembly] GO:0048633[positive regulation of skeletal muscle tissue growth] GO:0048743[positive regulation of skeletal muscle fiber development] GO:0051015[actin filament binding] GO:0055001[muscle cell development] GO:0060349[bone morphogenesis] GO:0070062[extracellular exosome] GO:0070885[negative regulation of calcineurin-NFAT signaling cascade] GO:0090257[regulation of muscle system process] GO:0090324[negative regulation of oxidative phosphorylation] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1900159[positive regulation of bone mineralization involved in bone maturation] GO:1901078[negative regulation of relaxation of muscle] GO:1903715[regulation of aerobic respiration] GO:1904025[positive regulation of glucose catabolic process to lactate via pyruvate]
The Human Protein Atlas project is funded
