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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Major histocompatibility complex, class II, DO beta
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.32
Chromosome location (bp)
32812763 - 32820466
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P13765 [Direct mapping] HLA class II histocompatibility antigen, DO beta chain
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Q5QNS2 [Target identity:100%; Query identity:100%] HLA-DOB; MHC class II antigen; Major histocompatibility complex, class II, DO beta, isoform CRA_a
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) DeepTMHMM predicted membrane proteins
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GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002503[peptide antigen assembly with MHC class II protein complex] GO:0002504[antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0002587[negative regulation of antigen processing and presentation of peptide antigen via MHC class II] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0006955[immune response] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0019882[antigen processing and presentation] GO:0019886[antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026[MHC class II protein complex binding] GO:0032395[MHC class II receptor activity] GO:0042613[MHC class II protein complex] GO:0050870[positive regulation of T cell activation]
GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002503[peptide antigen assembly with MHC class II protein complex] GO:0002504[antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0002587[negative regulation of antigen processing and presentation of peptide antigen via MHC class II] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0006955[immune response] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0019882[antigen processing and presentation] GO:0019886[antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026[MHC class II protein complex binding] GO:0032395[MHC class II receptor activity] GO:0042613[MHC class II protein complex] GO:0050870[positive regulation of T cell activation]
The Human Protein Atlas project is funded
