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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p13.3
Chromosome location (bp)
109668022 - 109709551
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Gene summary (Entrez)i
Useful information about the gene from Entrez
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004364[glutathione transferase activity] GO:0004602[glutathione peroxidase activity] GO:0005102[signaling receptor binding] GO:0005504[fatty acid binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006749[glutathione metabolic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014809[regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018916[nitrobenzene metabolic process] GO:0019899[enzyme binding] GO:0042178[xenobiotic catabolic process] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043295[glutathione binding] GO:0043651[linoleic acid metabolic process] GO:0045171[intercellular bridge] GO:0051122[hepoxilin biosynthetic process] GO:0055119[relaxation of cardiac muscle] GO:0060315[negative regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316[positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070062[extracellular exosome] GO:0070458[cellular detoxification of nitrogen compound] GO:0071313[cellular response to caffeine] GO:0098869[cellular oxidant detoxification]
P28161 [Direct mapping] Glutathione S-transferase Mu 2
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Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364[glutathione transferase activity] GO:0004602[glutathione peroxidase activity] GO:0005102[signaling receptor binding] GO:0005504[fatty acid binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006749[glutathione metabolic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014809[regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018916[nitrobenzene metabolic process] GO:0019899[enzyme binding] GO:0042178[xenobiotic catabolic process] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043295[glutathione binding] GO:0043651[linoleic acid metabolic process] GO:0045171[intercellular bridge] GO:0051122[hepoxilin biosynthetic process] GO:0055119[relaxation of cardiac muscle] GO:0060315[negative regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316[positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070062[extracellular exosome] GO:0070458[cellular detoxification of nitrogen compound] GO:0071313[cellular response to caffeine] GO:0098869[cellular oxidant detoxification]
P28161 [Direct mapping] Glutathione S-transferase Mu 2
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364[glutathione transferase activity] GO:0004602[glutathione peroxidase activity] GO:0005102[signaling receptor binding] GO:0005504[fatty acid binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006749[glutathione metabolic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014809[regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018916[nitrobenzene metabolic process] GO:0019899[enzyme binding] GO:0042178[xenobiotic catabolic process] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043295[glutathione binding] GO:0043651[linoleic acid metabolic process] GO:0045171[intercellular bridge] GO:0051122[hepoxilin biosynthetic process] GO:0055119[relaxation of cardiac muscle] GO:0060315[negative regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316[positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070062[extracellular exosome] GO:0070458[cellular detoxification of nitrogen compound] GO:0071313[cellular response to caffeine] GO:0098869[cellular oxidant detoxification]
The Human Protein Atlas project is funded
