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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
MT-ND4L is not prognostic in Testicular Germ Cell Tumor (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
6097.5
Number of samples
133
Samples
Sample
Description
TPM
TCGA-XE-AAOL-01A
0 years, male, black or african american, stage:Stage I, alive, 13 days
52657.6
TCGA-ZM-AA05-01A
0 years, male, white, stage:Stage IIC, alive, 1126 days
34194.6
TCGA-ZM-AA06-01A
0 years, male, white, stage:Stage IB, alive, 1498 days
32074.6
TCGA-ZM-AA0E-01A
0 years, male, white, stage:Stage IA, alive, 811 days
27439.1
TCGA-ZM-AA0N-01A
0 years, male, white, stage:Stage IB, alive, 634 days
25995.6
TCGA-XE-AAO6-01A
0 years, male, white, stage:Stage IA, alive, 240 days
20594.9
TCGA-ZM-AA0F-01A
0 years, male, white, stage:Stage IA, alive, 681 days
20565.1
TCGA-ZM-AA0B-01A
0 years, male, white, stage:Stage IA, alive, 838 days
19971.6
TCGA-ZM-AA0H-01A
0 years, male, white, stage:Stage IS, alive, 1736 days
16148.7
TCGA-2G-AAG6-01A
0 years, male, white, stage:Stage IS, alive, 2231 days
11669.6
TCGA-XE-AAO4-01A
0 years, male, white, stage:Stage IA, alive, 367 days
11101.7
TCGA-S6-A8JX-01A
0 years, male, white, stage:Stage IB, alive, 552 days
9384.4
TCGA-YU-A90P-01A
0 years, male, white, stage:Stage IA, alive, 2069 days
9099.3
TCGA-WZ-A8D5-01A
0 years, male, white, stage:'--, alive, 774 days
8897.9
TCGA-YU-A90Y-01A
0 years, male, black or african american, stage:Stage IIIC, dead, 17 days
8862.1
TCGA-ZM-AA0D-01A
0 years, male, white, stage:Stage IA, alive, 848 days
8459.1
TCGA-XE-A8H1-01A
0 years, male, white, stage:Stage IS, alive, 209 days
8411.5
TCGA-2G-AAHG-01A
0 years, male, white, stage:Stage I, alive, 1819 days
8223.7
TCGA-4K-AA1I-01A
0 years, male, white, stage:Stage IA, alive, 3 days
7990.9
TCGA-XE-A8H5-01A
0 years, male, stage:Stage IS, alive, 1217 days
7959.5
TCGA-2G-AAFE-01A
0 years, male, white, stage:Stage IIA, alive, 4702 days
7957.4
TCGA-WZ-A7V4-01A
0 years, male, white, stage:Stage I, alive, 894 days
7945.3
TCGA-2G-AAG7-01A
0 years, male, white, stage:Stage IS, alive, 2475 days
7940.2
TCGA-SN-A84W-01A
0 years, male, white, stage:Stage IS, alive, 293 days
7742.4
TCGA-2G-AAGG-01A
0 years, male, white, stage:Stage IIIC, alive, 2611 days
7703.8
TCGA-YU-A94I-01A
0 years, male, stage:Stage IA, alive, 536 days
7465.4
TCGA-YU-A90S-01A
0 years, male, white, stage:Stage IA, alive, 971 days
7422.0
TCGA-2G-AAFJ-01A
0 years, male, asian, stage:'--, alive, 792 days
7235.3
TCGA-S6-A8JY-01A
0 years, male, white, stage:Stage IS, alive, 278 days
7083.3
TCGA-2G-AAGY-01A
0 years, male, white, stage:Stage IS, alive, 5329 days
6971.8
TCGA-XE-AAOC-01A
0 years, male, white, stage:Stage IA, alive, 270 days
6929.8
TCGA-YU-A90W-01A
0 years, male, white, stage:Stage IA, alive, 1113 days
6844.3
TCGA-2G-AAG5-01A
0 years, male, white, stage:Stage IS, alive, 2299 days
6707.6
TCGA-YU-A90Q-01A
0 years, male, stage:Stage IB, alive, 1964 days
6668.7
TCGA-2G-AAG3-01A
0 years, male, white, stage:Stage IS, alive, 1593 days
6595.0
TCGA-2G-AAF8-01A
0 years, male, white, stage:Stage IA, alive, 3911 days
6564.7
TCGA-XE-A8H4-01A
0 years, male, white, stage:Stage IA, alive, 559 days
6563.0
TCGA-2G-AAGV-01A
0 years, male, white, stage:'--, alive, 4527 days
6540.3
TCGA-S6-A8JW-01A
0 years, male, white, stage:Stage IS, alive, 698 days
6405.9
TCGA-2G-AAFY-01A
0 years, male, white, stage:Stage IIA, alive, 1099 days
6355.3
TCGA-YU-A94D-01A
0 years, male, stage:Stage IIIB, alive, 2167 days
6197.3
TCGA-2G-AAFH-01A
0 years, male, white, stage:Stage IIB, alive, 1375 days
6133.8
TCGA-2G-AAH2-01A
0 years, male, white, stage:Stage IS, alive, 6060 days
6119.1
TCGA-XE-AAOJ-01A
0 years, male, white, stage:Stage IS, alive, 1550 days
6102.3
TCGA-W4-A7U4-01A
0 years, male, white, stage:'--, alive, 738 days
6021.0
TCGA-2G-AAHA-01A
0 years, male, white, stage:Stage IB, alive, 3349 days
5871.7
TCGA-2G-AAGI-01A
0 years, male, white, stage:Stage IS, alive, 3137 days
5841.4
TCGA-2X-A9D6-01A
0 years, male, white, stage:Stage I, alive, 607 days
5590.4
TCGA-2G-AAH0-01A
0 years, male, white, stage:Stage IS, alive, 5477 days
5525.6
TCGA-2G-AAG0-01A
0 years, male, white, stage:Stage IS, alive, 1529 days
5500.6
TCGA-VF-A8A9-01A
0 years, male, white, stage:Stage IA, alive, 1119 days
5492.8
TCGA-XE-AANJ-01A
0 years, male, white, stage:Stage IS, alive, 2007 days
5492.7
TCGA-2G-AAKM-01A
0 years, male, white, stage:Stage II, dead, 6972 days
5490.7
TCGA-2X-A9D5-01A
0 years, male, white, stage:Stage I, alive, 435 days
5490.1
TCGA-2G-AAG9-01A
0 years, male, white, stage:Stage IIIB, alive, 2234 days
5403.7
TCGA-2G-AAF4-01A
0 years, male, white, stage:Stage I, alive, 2315 days
5310.2
TCGA-2G-AAKD-01A
0 years, male, white, stage:Stage III, alive, 6340 days
5144.8
TCGA-2G-AAGP-01A
0 years, male, white, stage:Stage IIA, alive, 4018 days
5144.5
TCGA-2G-AAKL-01A
0 years, male, white, stage:Stage II, alive, 7023 days
5143.1
TCGA-2G-AAFZ-01A
0 years, male, white, stage:Stage III, alive, 1353 days
5026.9
TCGA-VF-A8AB-01A
0 years, male, black or african american, stage:Stage IA, alive, 760 days
4960.6
TCGA-2G-AAH8-01A
0 years, male, white, stage:Stage IIIC, alive, 2248 days
4903.8
TCGA-W4-A7U2-01A
0 years, male, white, stage:'--, alive, 1263 days
4894.0
TCGA-2G-AAGS-01A
0 years, male, white, stage:Stage IIIB, alive, 4816 days
4727.1
TCGA-2G-AAGE-01A
0 years, male, white, stage:Stage IS, alive, 2478 days
4595.3
TCGA-4K-AA1H-01A
0 years, male, white, stage:Stage IA, alive, 518 days
4466.3
TCGA-SN-A6IS-01A
0 years, male, white, stage:Stage IS, alive, 496 days
4383.2
TCGA-WZ-A7V5-01A
0 years, male, white, stage:Stage I, alive, 1061 days
4314.3
TCGA-2G-AAGC-01A
0 years, male, white, stage:Stage IS, alive, 2585 days
4310.6
TCGA-2G-AAFI-01A
0 years, male, white, stage:Stage IB, alive, 675 days
4306.2
TCGA-2G-AAHC-01A
0 years, male, white, stage:Stage IS, alive, 5539 days
4204.2
TCGA-YU-A912-01A
0 years, male, black or african american, stage:Stage IIIC, alive, 866 days
4192.2
TCGA-2G-AAFG-01A
0 years, male, white, stage:Stage IS, alive, 6183 days
4164.0
TCGA-2G-AAGO-01A
0 years, male, white, stage:Stage IS, alive, 4026 days
4077.7
TCGA-2G-AAKH-01A
0 years, male, white, stage:Stage II, alive, 6862 days
4073.4
TCGA-2G-AAHT-01A
0 years, male, white, stage:Stage IS, alive, 542 days
4027.5
TCGA-XE-AAOD-01A
0 years, male, white, stage:Stage IB, alive, 2058 days
4003.0
TCGA-XE-AAOF-01A
0 years, male, asian, stage:Stage IA, alive, 1268 days
3923.2
TCGA-XY-A89B-01A
0 years, male, white, stage:Stage IA, alive, 471 days
3903.6
TCGA-XE-AANI-01A
0 years, male, white, stage:Stage IS, alive, 1041 days
3851.1
TCGA-SO-A8JP-01A
0 years, male, white, stage:Stage I, alive, 540 days
3810.7
TCGA-XE-AANV-01A
0 years, male, stage:Stage IB, alive, 1701 days
3804.8
TCGA-YU-AA4L-01A
0 years, male, black or african american, stage:Stage IIIC, alive, 1573 days
3767.7
TCGA-2G-AAGM-01A
0 years, male, white, stage:Stage IS, alive, 3891 days
3719.6
TCGA-SB-A76C-01A
0 years, male, white, stage:'--, alive, 42 days
3712.8
TCGA-YU-AA61-01A
0 years, male, white, stage:Stage IS, alive, 864 days
3683.0
TCGA-XE-AAO3-01A
0 years, male, asian, stage:Stage I, alive, 2857 days
3680.4
TCGA-SB-A6J6-01A
0 years, male, white, stage:Stage IA, alive, 413 days
3384.3
TCGA-4K-AA1G-01A
0 years, male, white, stage:Stage IS, alive, 436 days
3182.7
TCGA-2G-AAGX-01A
0 years, male, white, stage:Stage IA, alive, 5514 days
3182.4
TCGA-2G-AAEX-01A
0 years, male, white, stage:Stage IS, alive, 1259 days
3159.7
TCGA-WZ-A7V3-01A
0 years, male, white, stage:Stage I, alive, 753 days
3143.6
TCGA-2G-AAEW-01A
0 years, male, white, stage:Stage IS, dead, 618 days
3096.4
TCGA-2G-AAH3-01A
0 years, male, white, stage:Stage I, alive, 1822 days
3046.0
TCGA-XY-A8S2-01A
0 years, male, white, stage:Stage I, alive, 672 days
3041.7
TCGA-SN-A84Y-01A
0 years, male, white, stage:Stage IS, alive, 524 days
2844.7
TCGA-VF-A8AD-01A
0 years, male, white, stage:Stage IB, alive, 1006 days
2806.0
TCGA-VF-A8AA-01A
0 years, male, white, stage:Stage I, alive, 1146 days
2769.0
TCGA-2G-AALP-01A
0 years, male, white, stage:Stage IIIB, alive, 2645 days
2768.2
TCGA-2G-AAGF-01A
0 years, male, white, stage:Stage IS, alive, 2734 days
2723.1
TCGA-VF-A8A8-01A
0 years, male, white, stage:Stage IA, alive, 1131 days
2666.8
TCGA-2G-AAGK-01A
0 years, male, white, stage:Stage IS, alive, 3621 days
2607.1
TCGA-2G-AAGA-01A
0 years, male, white, stage:Stage IIA, alive, 2439 days
2603.2
TCGA-2G-AAKG-01A
0 years, male, white, stage:Stage I, alive, 6598 days
2574.0
TCGA-2G-AAF1-01A
0 years, male, asian, stage:Stage IS, alive, 1403 days
2545.8
TCGA-2G-AAGN-01A
0 years, male, white, stage:Stage IIIB, alive, 3656 days
2534.9
TCGA-2G-AAF6-01A
0 years, male, white, stage:Stage IS, alive, 3491 days
2524.0
TCGA-4K-AAAL-01A
0 years, male, white, stage:Stage IS, alive, 483 days
2388.8
TCGA-XE-A9SE-01A
0 years, male, white, stage:Stage IA, alive, 708 days
2313.9
TCGA-2G-AAFV-01A
0 years, male, white, stage:Stage IS, alive, 1389 days
2241.4
TCGA-W4-A7U3-01A
0 years, male, white, stage:'--, alive, 149 days
2176.2
TCGA-XE-AAOB-01A
0 years, male, white, stage:Stage IS, dead, 513 days
2138.2
TCGA-XY-A9T9-01A
0 years, male, white, stage:Stage IS, alive, 281 days
2098.2
TCGA-X3-A8G4-01A
0 years, male, white, stage:Stage IS, alive, 856 days
2089.9
TCGA-VF-A8AE-01A
0 years, male, white, stage:Stage IA, alive, 727 days
1910.4
TCGA-2G-AAGJ-01A
0 years, male, black or african american, stage:Stage IA, alive, 2938 days
1860.1
TCGA-2G-AAGZ-01A
0 years, male, white, stage:Stage IIIA, alive, 5233 days
1717.6
TCGA-2G-AAL7-01A
0 years, male, white, stage:Stage IS, alive, 3991 days
1691.7
TCGA-2G-AAGT-01A
0 years, male, white, stage:Stage IS, alive, 4406 days
1522.9
TCGA-2G-AAH4-01A
0 years, male, white, stage:Stage II, alive, 6210 days
1494.6
TCGA-XE-AANR-01A
0 years, male, white, stage:Stage I, alive, 14 days
1445.2
TCGA-2G-AAG8-01A
0 years, male, white, stage:Stage IB, alive, 2289 days
1431.4
TCGA-VF-A8AC-01A
0 years, male, white, stage:Stage IA, alive, 1083 days
1280.7
TCGA-2G-AAL5-01A
0 years, male, white, stage:Stage I, alive, 7437 days
1142.9
TCGA-2G-AAGW-01A
0 years, male, white, stage:Stage IS, alive, 4899 days
1114.1
TCGA-2G-AAFO-01A
0 years, male, white, stage:Stage IIA, alive, 685 days
954.7
TCGA-2G-AAHN-01A
0 years, male, white, stage:Stage I, alive, 6445 days
900.7
TCGA-2G-AAFN-01A
0 years, male, white, stage:Stage IIIB, alive, 773 days
800.4
TCGA-2G-AAFL-01A
0 years, male, white, stage:Stage IB, alive, 750 days
799.2
TCGA-2G-AAHP-01A
0 years, male, white, stage:Stage IS, alive, 5667 days
772.7
TCGA-SN-A84X-01A
0 years, male, white, stage:Stage IS, alive, 312 days
640.0
TCGA-2G-AAHL-01A
0 years, male, white, stage:Stage I, alive, 7081 days
584.6
TCGA-2G-AAFM-01A
0 years, male, white, stage:Stage IIA, alive, 503 days
419.9
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TESTIS CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.