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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p22.1
Chromosome location (bp)
30326479 - 30343729
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
[Isoform 1]: E3 ubiquitin-protein ligase 1. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 2,3. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 4. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Cell cycle, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0061630[ubiquitin protein ligase activity] GO:1902806[regulation of cell cycle G1/S phase transition] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2001235[positive regulation of apoptotic signaling pathway]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0061630[ubiquitin protein ligase activity] GO:1902806[regulation of cell cycle G1/S phase transition] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2001235[positive regulation of apoptotic signaling pathway]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0061630[ubiquitin protein ligase activity] GO:1902806[regulation of cell cycle G1/S phase transition] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2001235[positive regulation of apoptotic signaling pathway]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0061630[ubiquitin protein ligase activity] GO:1902806[regulation of cell cycle G1/S phase transition] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2001235[positive regulation of apoptotic signaling pathway]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0061630[ubiquitin protein ligase activity] GO:1902806[regulation of cell cycle G1/S phase transition] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2001235[positive regulation of apoptotic signaling pathway]
The Human Protein Atlas project is funded
