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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q26.11
Chromosome location (bp)
119726042 - 119829147
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling 1. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms 2. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation 3. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus 4. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001921[positive regulation of receptor recycling] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005905[clathrin-coated pit] GO:0006661[phosphatidylinositol biosynthetic process] GO:0008344[adult locomotory behavior] GO:0008934[inositol monophosphate 1-phosphatase activity] GO:0014898[cardiac muscle hypertrophy in response to stress] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0030424[axon] GO:0030425[dendrite] GO:0031161[phosphatidylinositol catabolic process] GO:0031901[early endosome membrane] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034595[phosphatidylinositol phosphate 5-phosphatase activity] GO:0034596[phosphatidylinositol phosphate 4-phosphatase activity] GO:0042532[negative regulation of tyrosine phosphorylation of STAT protein] GO:0042803[protein homodimerization activity] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0043812[phosphatidylinositol-4-phosphate phosphatase activity] GO:0045334[clathrin-coated endocytic vesicle] GO:0046856[phosphatidylinositol dephosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048681[negative regulation of axon regeneration] GO:0051896[regulation of protein kinase B signaling] GO:0052832[inositol monophosphate 3-phosphatase activity] GO:0052833[inositol monophosphate 4-phosphatase activity] GO:0052834[inositol monophosphate phosphatase activity] GO:0055037[recycling endosome] GO:0072583[clathrin-dependent endocytosis] GO:2000145[regulation of cell motility] GO:2001135[regulation of endocytic recycling]
The Human Protein Atlas project is funded
