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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p22
Chromosome location (bp)
17224966 - 17246878
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate 1,2,3. Its function seems to be partially redundant with that of CNOT8 4. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation 5,6,7. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation 8. Additional complex functions may be a consequence of its influence on mRNA expression 9,10. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity 11,12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000175[3'-5'-exoribonuclease activity] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000290[deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932[P-body] GO:0003676[nucleic acid binding] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004518[nuclease activity] GO:0004527[exonuclease activity] GO:0004532[exoribonuclease activity] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0006417[regulation of translation] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016604[nuclear body] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0031047[gene silencing by RNA] GO:0033962[P-body assembly] GO:0035195[miRNA-mediated gene silencing] GO:0042509[regulation of tyrosine phosphorylation of STAT protein] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0045070[positive regulation of viral genome replication] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051607[defense response to virus] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0061014[positive regulation of mRNA catabolic process] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:0140297[DNA-binding transcription factor binding] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000175[3'-5'-exoribonuclease activity] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0003676[nucleic acid binding] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004518[nuclease activity] GO:0004527[exonuclease activity] GO:0004532[exoribonuclease activity] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0006417[regulation of translation] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016604[nuclear body] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0031047[gene silencing by RNA] GO:0035195[miRNA-mediated gene silencing] GO:0042509[regulation of tyrosine phosphorylation of STAT protein] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0045070[positive regulation of viral genome replication] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0051607[defense response to virus] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0061014[positive regulation of mRNA catabolic process] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:0140297[DNA-binding transcription factor binding] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
The Human Protein Atlas project is funded
