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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.32
Chromosome location (bp)
102106489 - 102120368
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables LIM domain binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and enzyme binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in chromatin. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q86U70 [Direct mapping] LIM domain-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000972[transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0019899[enzyme binding] GO:0030182[neuron differentiation] GO:0030274[LIM domain binding] GO:0030334[regulation of cell migration] GO:0031252[cell leading edge] GO:0032991[protein-containing complex] GO:0034243[regulation of transcription elongation by RNA polymerase II] GO:0042803[protein homodimerization activity] GO:0043549[regulation of kinase activity] GO:0043973[histone H3-K4 acetylation] GO:0045647[negative regulation of erythrocyte differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046985[positive regulation of hemoglobin biosynthetic process] GO:0051893[regulation of focal adhesion assembly] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0140297[DNA-binding transcription factor binding] GO:1990907[beta-catenin-TCF complex]
Q86U70 [Direct mapping] LIM domain-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000972[transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0001702[gastrulation with mouth forming second] GO:0001942[hair follicle development] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007155[cell adhesion] GO:0007399[nervous system development] GO:0009948[anterior/posterior axis specification] GO:0010669[epithelial structure maintenance] GO:0016055[Wnt signaling pathway] GO:0019899[enzyme binding] GO:0021549[cerebellum development] GO:0021702[cerebellar Purkinje cell differentiation] GO:0022607[cellular component assembly] GO:0030182[neuron differentiation] GO:0030274[LIM domain binding] GO:0030334[regulation of cell migration] GO:0031252[cell leading edge] GO:0032991[protein-containing complex] GO:0034243[regulation of transcription elongation by RNA polymerase II] GO:0035019[somatic stem cell population maintenance] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043549[regulation of kinase activity] GO:0043621[protein self-association] GO:0043973[histone H3-K4 acetylation] GO:0045647[negative regulation of erythrocyte differentiation] GO:0045785[positive regulation of cell adhesion] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046985[positive regulation of hemoglobin biosynthetic process] GO:0048382[mesendoderm development] GO:0051893[regulation of focal adhesion assembly] GO:0060322[head development] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140297[DNA-binding transcription factor binding] GO:1990907[beta-catenin-TCF complex]
The Human Protein Atlas project is funded
