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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
MT-ND6 is not prognostic in Skin Cuteneous Melanoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
3-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
3-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
5609.1
Number of samples
99
Samples
Sample
Description
TPM
TCGA-DA-A960-01A
0 years, male, white, stage:Stage IIB, alive, 804 days
26770.0
TCGA-EB-A6QY-01A
0 years, male, white, stage:Stage IIC, alive, 382 days
13107.6
TCGA-YG-AA3N-01A
0 years, male, stage:Stage IIC, alive, 306 days
12405.6
TCGA-GN-A4U5-01A
0 years, female, white, stage:Stage IB, alive, 1156 days
11785.5
TCGA-EB-A85I-01A
0 years, male, white, stage:Stage IIC, alive, 362 days
11730.7
TCGA-EB-A4OZ-01A
0 years, female, white, stage:Stage IIIC, alive, 620 days
11666.5
TCGA-EB-A3XB-01A
0 years, male, white, stage:Stage II, alive, 796 days
11461.3
TCGA-EB-A4OY-01A
0 years, female, white, stage:Stage IIIB, alive, 977 days
11177.0
TCGA-EB-A24D-01A
0 years, male, white, stage:Stage IIIB, alive, 645 days
10846.5
TCGA-D3-A5GT-01A
0 years, male, white, stage:Stage IIIC, alive, 487 days
10442.6
TCGA-EB-A553-01A
0 years, male, white, stage:Stage IIC, alive, 226 days
10435.6
TCGA-EB-A42Z-01A
0 years, male, asian, stage:Stage IIIC, alive, 441 days
10232.9
TCGA-GN-A263-01A
0 years, male, white, stage:Stage IV, dead, 467 days
9853.8
TCGA-EB-A551-01A
0 years, female, white, stage:Stage IIIC, alive, 590 days
9812.9
TCGA-EB-A5UM-01A
0 years, female, white, stage:Stage IIC, alive, 779 days
9724.8
TCGA-BF-A1PX-01A
0 years, male, white, stage:Stage IIIB, dead, 282 days
9586.0
TCGA-ER-A194-01A
0 years, male, white, stage:'--, dead, 1354 days
8736.1
TCGA-BF-A5ER-01A
0 years, male, white, stage:Stage IIC, alive, 327 days
8533.8
TCGA-D9-A4Z5-01A
0 years, male, white, stage:Stage IIB, alive, 218 days
8477.0
TCGA-EB-A3XE-01A
0 years, female, white, stage:Stage IIA, alive, 180 days
8272.9
TCGA-BF-A3DL-01A
0 years, female, white, stage:Stage IIIB, alive, 769 days
8115.0
TCGA-EB-A6QZ-01A
0 years, female, white, stage:Stage IIA, dead, 352 days
8056.1
TCGA-FW-A5DX-01A
0 years, male, white, stage:Stage IIIC, alive, 640 days
8048.4
TCGA-XV-AAZW-01A
0 years, female, white, stage:Stage II, dead, 393 days
7972.1
TCGA-BF-AAP7-01A
0 years, female, white, stage:Stage IIC, alive, 318 days
7958.6
TCGA-FR-A728-01A
0 years, female, white, stage:Stage IIIB, alive, 583 days
7798.1
TCGA-XV-AAZY-01A
0 years, female, white, stage:Stage IIIC, alive, 405 days
7774.3
TCGA-BF-A5EQ-01A
0 years, male, white, stage:Stage IIC, alive, 323 days
7677.7
TCGA-EB-A4P0-01A
0 years, male, white, stage:Stage IIC, dead, 326 days
7529.9
TCGA-EB-A3XD-01A
0 years, female, white, stage:Stage IIC, alive, 1160 days
7294.6
TCGA-BF-A9VF-01A
0 years, male, white, stage:Stage IIC, alive, 440 days
7195.9
TCGA-XV-A9W5-01A
0 years, male, white, stage:Not Reported, alive, 392 days
7140.2
TCGA-EB-A44P-01A
0 years, female, white, stage:Stage IIC, alive, 741 days
6854.4
TCGA-BF-A5EO-01A
0 years, male, white, stage:Stage IIC, alive, 703 days
6675.2
TCGA-EB-A3Y6-01A
0 years, female, white, stage:Stage IIC, alive, 126 days
6424.5
TCGA-GF-A2C7-01A
0 years, male, white, stage:Stage IIC, alive, 21 days
6264.8
TCGA-BF-A5EP-01A
0 years, female, white, stage:Stage IIIC, alive, 335 days
6093.1
TCGA-EB-A299-01A
0 years, male, white, stage:Stage IIA, alive, 378 days
5994.3
TCGA-BF-A3DJ-01A
0 years, female, white, stage:Stage IIIB, alive, 464 days
5895.9
TCGA-D9-A4Z2-01A
0 years, male, white, stage:Stage IIIC, dead, 190 days
5659.8
TCGA-EB-A1NK-01A
0 years, male, white, stage:Stage IIC, alive, 1039 days
5524.2
TCGA-ER-A19K-01A
0 years, female, white, stage:Stage IIC, dead, 469 days
5458.0
TCGA-EB-A24C-01A
0 years, male, white, stage:'--, alive, 632 days
5439.8
TCGA-BF-AAOX-01A
0 years, male, white, stage:Stage IIC, alive, 444 days
5404.8
TCGA-XV-AAZV-01A
0 years, female, white, stage:Stage II, alive, 412 days
5361.6
TCGA-BF-A5ES-01A
0 years, female, white, stage:Stage IIC, alive, 490 days
5162.0
TCGA-BF-AAOU-01A
0 years, female, white, stage:Stage IIC, alive, 476 days
5161.8
TCGA-EB-A5FP-01A
0 years, female, white, stage:Stage IV, dead, 454 days
5122.8
TCGA-BF-AAP8-01A
0 years, male, white, stage:Stage IIC, alive, 447 days
5077.1
TCGA-FS-A1ZN-01A
0 years, male, white, stage:Stage IIIA, dead, 730 days
5031.3
TCGA-EB-A3Y7-01A
0 years, female, white, stage:Stage IIIB, dead, 326 days
4786.5
TCGA-D9-A3Z4-01A
0 years, male, white, stage:Stage IIIC, dead, 519 days
4759.5
TCGA-EB-A4IS-01A
0 years, male, white, stage:Stage IIB, alive, 774 days
4530.4
TCGA-EB-A51B-01A
0 years, male, white, stage:Stage IIC, alive, 931 days
4428.1
TCGA-FR-A2OS-01A
0 years, female, white, stage:Stage IIC, dead, 368 days
4295.7
TCGA-BF-A1PZ-01A
0 years, female, white, stage:Stage IIB, alive, 853 days
4268.8
TCGA-GN-A8LN-01A
0 years, male, white, stage:Stage IIC, alive, 772 days
4189.2
TCGA-BF-AAP1-01A
0 years, male, white, stage:Stage IIC, alive, 409 days
4163.0
TCGA-WE-A8K4-01A
0 years, male, white, stage:Stage IIB, alive, 614 days
4012.1
TCGA-EB-A4IQ-01A
0 years, female, asian, stage:Stage IIIB, dead, 636 days
3915.7
TCGA-EB-A97M-01A
0 years, male, white, stage:Stage IIC, alive, 414 days
3827.9
TCGA-BF-AAP4-01A
0 years, male, white, stage:Stage IIC, alive, 335 days
3822.8
TCGA-EB-A3HV-01A
0 years, male, white, stage:Stage IIC, alive, 39 days
3724.1
TCGA-XV-A9W2-01A
0 years, male, white, stage:Stage I, alive, 417 days
3639.8
TCGA-EB-A3XF-01A
0 years, male, white, stage:Stage IIC, alive, 278 days
3560.7
TCGA-EB-A550-01A
0 years, female, white, stage:Stage IIC, dead, 264 days
3355.8
TCGA-EB-A57M-01A
0 years, male, asian, stage:Stage IIIB, dead, 472 days
3348.6
TCGA-BF-A3DN-01A
0 years, female, white, stage:Stage IIIC, alive, 717 days
3323.2
TCGA-EB-A4XL-01A
0 years, female, white, stage:Stage IIC, alive, 777 days
3289.7
TCGA-BF-AAP2-01A
0 years, male, white, stage:Stage IIB, alive, 405 days
3275.9
TCGA-EB-A431-01A
0 years, male, white, stage:Stage IIC, alive, 568 days
3220.2
TCGA-GF-A769-01A
0 years, male, white, stage:Stage IIC, dead, 1070 days
3170.1
TCGA-IH-A3EA-01A
0 years, male, white, stage:Stage IIC, alive, 524 days
2975.5
TCGA-EB-A5VU-01A
0 years, male, asian, stage:Stage IIIB, dead, 321 days
2940.6
TCGA-EB-A6R0-01A
0 years, female, white, stage:Stage IIC, dead, 608 days
2784.6
TCGA-BF-AAP6-01A
0 years, male, white, stage:Stage III, alive, 325 days
2774.3
TCGA-EB-A82C-01A
0 years, female, asian, stage:Stage IIC, alive, 17 days
2699.9
TCGA-EB-A44N-01A
0 years, male, white, stage:Stage IIC, dead, 205 days
2102.6
TCGA-EB-A5SF-01A
0 years, female, white, stage:Stage IIC, dead, 369 days
2056.7
TCGA-EB-A82B-01A
0 years, female, asian, stage:Stage III, alive, 390 days
2050.8
TCGA-EB-A44O-01A
0 years, male, white, stage:Stage IIB, alive, 81 days
2044.3
TCGA-EB-A85J-01A
0 years, female, white, stage:Stage IIB, alive, 360 days
2015.9
TCGA-BF-A1PU-01A
0 years, female, white, stage:Stage IIC, alive, 387 days
2000.8
TCGA-D9-A4Z3-01A
0 years, female, white, stage:Stage IIIC, alive, 505 days
1932.9
TCGA-ER-A2NB-01A
0 years, male, white, stage:Stage IIIB, dead, 857 days
1907.3
TCGA-FR-A3R1-01A
0 years, male, white, stage:Stage IIC, alive, 685 days
1878.7
TCGA-EB-A42Y-01A
0 years, female, asian, stage:Stage IIC, dead, 721 days
1802.3
TCGA-ER-A196-01A
0 years, female, white, stage:Stage IIC, alive, 1785 days
1604.3
TCGA-BF-A1PV-01A
0 years, female, white, stage:Stage IIC, alive, 14 days
1594.8
TCGA-BF-A1Q0-01A
0 years, male, white, stage:Stage IIC, alive, 831 days
1372.6
TCGA-ER-A2NF-01A
0 years, male, white, stage:Stage IIIB, dead, 877 days
1223.7
TCGA-EB-A3XC-01A
0 years, male, white, stage:Stage IIC, alive, 650 days
1041.3
TCGA-EB-A41B-01A
0 years, female, white, stage:Stage IIC, alive, 291 days
1006.0
TCGA-ER-A19T-01A
0 years, male, white, stage:Stage IV, dead, 270 days
775.1
TCGA-GN-A26C-01A
0 years, male, white, stage:Stage IIIC, dead, 821 days
715.0
TCGA-BF-A3DM-01A
0 years, male, white, stage:Stage IIA, alive, 601 days
544.0
TCGA-EB-A5SE-01A
0 years, male, white, stage:Stage IIB, dead, 401 days
480.7
TCGA-ER-A42H-01A
0 years, male, white, stage:'--, dead, 426 days
239.0
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MELANOMA - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
The Human Protein Atlas project is funded
