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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p22.3
Chromosome location (bp)
497258 - 520296
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Growth factor, Mitogen
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P04085 [Direct mapping] Platelet-derived growth factor subunit A
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0001775[cell activation] GO:0001942[hair follicle development] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0005161[platelet-derived growth factor receptor binding] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005796[Golgi lumen] GO:0005902[microvillus] GO:0007267[cell-cell signaling] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0009986[cell surface] GO:0010512[negative regulation of phosphatidylinositol biosynthetic process] GO:0010544[negative regulation of platelet activation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014910[regulation of smooth muscle cell migration] GO:0016020[membrane] GO:0030031[cell projection assembly] GO:0030036[actin cytoskeleton organization] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0031954[positive regulation of protein autophosphorylation] GO:0032956[regulation of actin cytoskeleton organization] GO:0035790[platelet-derived growth factor receptor-alpha signaling pathway] GO:0035793[positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0042060[wound healing] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043588[skin development] GO:0046982[protein heterodimerization activity] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048286[lung alveolus development] GO:0048407[platelet-derived growth factor binding] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050919[negative chemotaxis] GO:0051781[positive regulation of cell division] GO:0051897[positive regulation of protein kinase B signaling] GO:0060683[regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070851[growth factor receptor binding] GO:1990265[platelet-derived growth factor complex] GO:1990401[embryonic lung development]
H7BYW6 [Direct mapping] Platelet-derived growth factor subunit A
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DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
P04085 [Direct mapping] Platelet-derived growth factor subunit A
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0001666[response to hypoxia] GO:0001775[cell activation] GO:0001942[hair follicle development] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0005161[platelet-derived growth factor receptor binding] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0005796[Golgi lumen] GO:0005902[microvillus] GO:0007267[cell-cell signaling] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008584[male gonad development] GO:0009410[response to xenobiotic stimulus] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0009986[cell surface] GO:0010033[response to organic substance] GO:0010035[response to inorganic substance] GO:0010512[negative regulation of phosphatidylinositol biosynthetic process] GO:0010544[negative regulation of platelet activation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014910[regulation of smooth muscle cell migration] GO:0016020[membrane] GO:0030031[cell projection assembly] GO:0030036[actin cytoskeleton organization] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0031954[positive regulation of protein autophosphorylation] GO:0032355[response to estradiol] GO:0032526[response to retinoic acid] GO:0032956[regulation of actin cytoskeleton organization] GO:0035790[platelet-derived growth factor receptor-alpha signaling pathway] GO:0035793[positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0042060[wound healing] GO:0042803[protein homodimerization activity] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043588[skin development] GO:0046982[protein heterodimerization activity] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048286[lung alveolus development] GO:0048407[platelet-derived growth factor binding] GO:0048839[inner ear development] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050919[negative chemotaxis] GO:0051781[positive regulation of cell division] GO:0051897[positive regulation of protein kinase B signaling] GO:0060683[regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070851[growth factor receptor binding] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:1990265[platelet-derived growth factor complex] GO:1990401[embryonic lung development]
A0A0A0MSC4 [Direct mapping] Platelet-derived growth factor subunit A
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins RAS pathway related proteins Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
