CALHM6 INFORMATION
Proteini Calcium homeostasis modulator family member 6
Gene namei CALHM6 (C6orf187, dJ93H18.5, FAM26F, INAM, OTTHUMP00000017061, OTTHUMP00000017062, RP1-93H18.5)
Protein classi Transporters
Protein evidence Evidence at protein level (all genes)
Number of transcriptsi 3
Protein interactions Interacting with 2 proteins
PROTEIN EXPRESSION AND LOCALIZATION
Tissue profilei Not available
Subcellular locationi Not available
Predicted locationi Membrane, Intracellular (different isoforms)
TISSUE RNA EXPRESSION
Tissue specificityi Tissue enhanced (Lymphoid tissue)
Cerebral cortexCerebellumBasal gangliaHypothalamusMidbrainAmygdalaChoroid plexusHippocampal formationSpinal cordRetinaThyroid glandParathyroid glandAdrenal glandPituitary glandLungSalivary glandEsophagusTongueStomachDuodenumSmall intestineColonRectumLiverGallbladderPancreasKidneyUrinary bladderTestisEpididymisSeminal vesicleProstateVaginaOvaryFallopian tubeEndometriumCervixPlacentaBreastHeart muscleSmooth muscleSkeletal muscleAdipose tissueSkinAppendixSpleenLymph nodeTonsilBone marrowThymus020406080100120140
Cerebral cortexHippocampal formationAmygdalaBasal gangliaThalamusHypothalamusMidbrainCerebellumPonsMedulla oblongataSpinal cordWhite matterChoroid plexus0246810
Tissue expression clusteri Lymphoid tissue - Immune response (mainly)
Brain specificityi Low human brain regional specificity
Brain expression clusteri Non-specific - Mixed function (mainly)
CELL TYPE RNA EXPRESSION
Single cell type specificityi Cell type enhanced (Kupffer cells, monocytes, Macrophages, Hofbauer cells, B-cells)
Ciliated cellsBasal respiratory cellsClub cellsIonocytesMucus glandular cellsSerous glandular cellsGastric mucus-secreting cellsProximal enterocytesPaneth cellsDistal enterocytesIntestinal goblet cellsExocrine glandular cellsBasal prostatic cellsProstatic glandular cellsBreast glandular cellsBreast myoepithelial cellsGlandular and luminal cellsSecretory cellsBasal keratinocytesSuprabasal keratinocytesBasal squamous epithelial cellsSquamous epithelial cellsAlveolar cells type 1Alveolar cells type 2Salivary duct cellsDuctal cellsHepatocytesCholangiocytesProximal tubular cellsDistal tubular cellsCollecting duct cellsMesothelial cellsSertoli cellsGranulosa cellsEnteroendocrine cellsPancreatic endocrine cellsLeydig cellsExcitatory neuronsInhibitory neuronsCone photoreceptor cellsRod photoreceptor cellsBipolar cellsHorizontal cellsAstrocytesOligodendrocyte precursor cellsOligodendrocytesMicroglial cellsMuller glia cellsSchwann cellsSpermatogoniaSpermatocytesEarly spermatidsLate spermatidsOocytesCytotrophoblastsSyncytiotrophoblastsExtravillous trophoblastsEndothelial cellsLymphatic endothelial cellsCardiomyocytesSkeletal myocytesSmooth muscle cellsAdipocytesMelanocytesFibroblastsPeritubular cellsEndometrial stromal cellsOvarian stromal cellsUndifferentiated cellsT-cellsB-cellsPlasma cellsNk-cellsGranulocytesMonocytesMacrophagesHofbauer cellsKupffer cellsDendritic cellsLangerhans cellsErythroid cells050100150200
Single cell type
expression clusteri 		Monocytes - Innate immune response (mainly)
Tissue cell type classificationi Cell type enriched (Adrenal gland - Macrophages, Liver - Kupffer cells, Minor Salivary Gland - Macrophages, Spleen - Macrophages, Stomach - Macrophages)
Immune cell specificityi Immune cell enhanced (non-classical monocyte, intermediate monocyte)
Immune cell
expression clusteri 		Monocytes - Innate immune response (mainly)
CANCER & CELL LINES
Prognostic summary CALHM6 is a prognostic marker in Rectum adenocarcinoma 0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 9101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105106107108109110111112113114115116117118
Brain cancerNeuroblastomaAdrenocortical cancerThyroid cancerLung cancerEsophageal cancerHead and neck cancerColorectal cancerGastric cancerBile duct cancerGallbladder cancerLiver cancerPancreatic cancerBladder cancerKidney cancerProstate cancerTestis cancerBreast cancerCervical cancerOvarian cancerUterine cancerBone cancerRhabdoidSarcomaSkin cancerLeukemiaLymphomaMyelomaNon-cancerousUncategorized05101520
Cancer specificityi Low cancer specificity
Cell line
expression clusteri 		Myeloid leukemia - Innate immune response (mainly)
Cell line specificityi Cancer enhanced (Leukemia)
PROTEINS IN BLOOD
Detected in blood by
immunoassayi 		No (not applicable)
Detected in blood by
mass spectrometryi 		No
Detected in blood by
proximity extension assayi 		No
PROTEIN FUNCTION
Protein function (UniProt)i Pore-forming subunit of an ATP-permeable channel (By similarity). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels 1. show less
Molecular function (UniProt)i Ion channel
Biological process (UniProt)i Ion transport, Transport
Gene summary (Entrez)i Predicted to enable cation channel activity. Predicted to be involved in cation transmembrane transport. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] show less

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org