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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.12
Chromosome location (bp)
49556544 - 49568145
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus 1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues 2. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity 3. Binds to G-quadruplex structures in mRNA 4. Binds to RNA homomer poly(G) and poly(U) 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA recombination, DNA repair, Host-virus interaction, Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables RNA binding activity and telomerase inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000123[histone acetyltransferase complex] GO:0000723[telomere maintenance] GO:0002151[G-quadruplex RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005844[polysome] GO:0006275[regulation of DNA replication] GO:0006281[DNA repair] GO:0006282[regulation of DNA repair] GO:0006310[DNA recombination] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006974[cellular response to DNA damage stimulus] GO:0008266[poly(U) RNA binding] GO:0010521[telomerase inhibitor activity] GO:0030425[dendrite] GO:0031011[Ino80 complex] GO:0033044[regulation of chromosome organization] GO:0034046[poly(G) binding] GO:0036211[protein modification process] GO:0043204[perikaryon] GO:0043981[histone H4-K5 acetylation] GO:0043982[histone H4-K8 acetylation] GO:0043984[histone H4-K16 acetylation] GO:0044545[NSL complex] GO:0045739[positive regulation of DNA repair] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0051571[positive regulation of histone H3-K4 methylation] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060382[regulation of DNA strand elongation] GO:0071339[MLL1 complex] GO:1900095[regulation of dosage compensation by inactivation of X chromosome] GO:1904357[negative regulation of telomere maintenance via telomere lengthening] GO:1904507[positive regulation of telomere maintenance in response to DNA damage] GO:1904751[positive regulation of protein localization to nucleolus]
A0A024R134 [Target identity:100%; Query identity:100%] Microspherule protein 1, isoform CRA_d
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
