We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
p15.1
Chromosome location (bp)
4963253 - 4983283
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids 1. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH 2. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens 3. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate 4. Displays affinity for bile acids 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NADP
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q04828 [Direct mapping] Aldo-keto reductase family 1 member C1
Show all
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523[retinoid metabolic process] GO:0004032[alditol:NADP+ 1-oxidoreductase activity] GO:0004033[aldo-keto reductase (NADP) activity] GO:0004303[estradiol 17-beta-dehydrogenase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006693[prostaglandin metabolic process] GO:0006805[xenobiotic metabolic process] GO:0007586[digestion] GO:0008202[steroid metabolic process] GO:0008206[bile acid metabolic process] GO:0015721[bile acid and bile salt transport] GO:0016229[steroid dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016655[oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] GO:0018636[phenanthrene 9,10-monooxygenase activity] GO:0030283[testosterone dehydrogenase [NAD(P)] activity] GO:0030299[intestinal cholesterol absorption] GO:0030855[epithelial cell differentiation] GO:0031406[carboxylic acid binding] GO:0032052[bile acid binding] GO:0033703[3beta-hydroxy-5beta-steroid dehydrogenase activity] GO:0033764[steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0035410[dihydrotestosterone 17-beta-dehydrogenase activity] GO:0042448[progesterone metabolic process] GO:0042574[retinal metabolic process] GO:0042632[cholesterol homeostasis] GO:0044594[17-beta-hydroxysteroid dehydrogenase (NAD+) activity] GO:0044597[daunorubicin metabolic process] GO:0044598[doxorubicin metabolic process] GO:0046683[response to organophosphorus] GO:0047006[17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity] GO:0047023[androsterone dehydrogenase activity] GO:0047024[5alpha-androstane-3beta,17beta-diol dehydrogenase activity] GO:0047042[androsterone dehydrogenase (B-specific) activity] GO:0047044[androstan-3-alpha,17-beta-diol dehydrogenase activity] GO:0047045[testosterone 17-beta-dehydrogenase (NADP+) activity] GO:0047086[ketosteroid monooxygenase activity] GO:0047115[trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity] GO:0047718[indanol dehydrogenase activity] GO:0070062[extracellular exosome] GO:0071395[cellular response to jasmonic acid stimulus] GO:2000379[positive regulation of reactive oxygen species metabolic process]
The Human Protein Atlas project is funded
