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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.31
Chromosome location (bp)
45894527 - 46028334
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity 1. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both 2,3. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A7I2PJZ2 [Direct mapping] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
A0A7I2PLE3 [Direct mapping] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
A0A024RA17 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007416[synapse assembly] GO:0007611[learning or memory] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051260[protein homooligomerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
A0A024R9Y0 [Target identity:100%; Query identity:100%] Microtubule-associated protein
Show all
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
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A0A024RA19 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
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A0A024R9Y1 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
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A0A024RA17 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226[microtubule cytoskeleton organization] GO:0001774[microglial cell activation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0006475[internal protein amino acid acetylation] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007267[cell-cell signaling] GO:0007416[synapse assembly] GO:0007611[learning or memory] GO:0007613[memory] GO:0008017[microtubule binding] GO:0010288[response to lead ion] GO:0010506[regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0015630[microtubule cytoskeleton] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016072[rRNA metabolic process] GO:0016607[nuclear speck] GO:0017124[SH3 domain binding] GO:0019896[axonal transport of mitochondrion] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0021954[central nervous system neuron development] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0030673[axolemma] GO:0030674[protein-macromolecule adaptor activity] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031116[positive regulation of microtubule polymerization] GO:0031122[cytoplasmic microtubule organization] GO:0031175[neuron projection development] GO:0032930[positive regulation of superoxide anion generation] GO:0033044[regulation of chromosome organization] GO:0033673[negative regulation of kinase activity] GO:0034063[stress granule assembly] GO:0034185[apolipoprotein binding] GO:0034399[nuclear periphery] GO:0034452[dynactin binding] GO:0034605[cellular response to heat] GO:0034614[cellular response to reactive oxygen species] GO:0035091[phosphatidylinositol binding] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0036477[somatodendritic compartment] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043565[sequence-specific DNA binding] GO:0044297[cell body] GO:0044304[main axon] GO:0045121[membrane raft] GO:0045298[tubulin complex] GO:0045773[positive regulation of axon extension] GO:0046785[microtubule polymerization] GO:0048143[astrocyte activation] GO:0048167[regulation of synaptic plasticity] GO:0048312[intracellular distribution of mitochondria] GO:0048699[generation of neurons] GO:0050808[synapse organization] GO:0050848[regulation of calcium-mediated signaling] GO:0051087[chaperone binding] GO:0051258[protein polymerization] GO:0051260[protein homooligomerization] GO:0051721[protein phosphatase 2A binding] GO:0051879[Hsp90 protein binding] GO:0061564[axon development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071813[lipoprotein particle binding] GO:0072386[plus-end-directed organelle transport along microtubule] GO:0090140[regulation of mitochondrial fission] GO:0090258[negative regulation of mitochondrial fission] GO:0097386[glial cell projection] GO:0097418[neurofibrillary tangle] GO:0097435[supramolecular fiber organization] GO:0098930[axonal transport] GO:0099077[histone-dependent DNA binding] GO:0099609[microtubule lateral binding] GO:1900034[regulation of cellular response to heat] GO:1900452[regulation of long-term synaptic depression] GO:1901216[positive regulation of neuron death] GO:1902474[positive regulation of protein localization to synapse] GO:1902936[phosphatidylinositol bisphosphate binding] GO:1902988[neurofibrillary tangle assembly] GO:1903748[negative regulation of establishment of protein localization to mitochondrion] GO:1903829[positive regulation of protein localization] GO:1904115[axon cytoplasm] GO:1904428[negative regulation of tubulin deacetylation] GO:1905689[positive regulation of diacylglycerol kinase activity] GO:1990000[amyloid fibril formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2001020[regulation of response to DNA damage stimulus]
A0A7P0T936 [Direct mapping] Microtubule-associated protein
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Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)