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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.4
Chromosome location (bp)
72576141 - 72674591
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes 1,2,3. Has a higher efficiency with cGMP compared to cAMP 4. Plays a role in cell growth and migration 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0003170[heart valve development] GO:0003281[ventricular septum development] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0004118[cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0008081[phosphoric diester hydrolase activity] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010752[regulation of cGMP-mediated signaling] GO:0010754[negative regulation of cGMP-mediated signaling] GO:0010821[regulation of mitochondrion organization] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0019933[cAMP-mediated signaling] GO:0019934[cGMP-mediated signaling] GO:0030552[cAMP binding] GO:0030553[cGMP binding] GO:0030911[TPR domain binding] GO:0035904[aorta development] GO:0036006[cellular response to macrophage colony-stimulating factor stimulus] GO:0042301[phosphate ion binding] GO:0042734[presynaptic membrane] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043116[negative regulation of vascular permeability] GO:0043117[positive regulation of vascular permeability] GO:0043949[regulation of cAMP-mediated signaling] GO:0043951[negative regulation of cAMP-mediated signaling] GO:0046069[cGMP catabolic process] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0048471[perinuclear region of cytoplasm] GO:0050729[positive regulation of inflammatory response] GO:0061028[establishment of endothelial barrier] GO:0071260[cellular response to mechanical stimulus] GO:0071320[cellular response to cAMP] GO:0071321[cellular response to cGMP] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0097060[synaptic membrane] GO:1904613[cellular response to 2,3,7,8-tetrachlorodibenzodioxine]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Phobius predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0003170[heart valve development] GO:0003281[ventricular septum development] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0004118[cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0008081[phosphoric diester hydrolase activity] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010752[regulation of cGMP-mediated signaling] GO:0010754[negative regulation of cGMP-mediated signaling] GO:0010821[regulation of mitochondrion organization] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0019933[cAMP-mediated signaling] GO:0019934[cGMP-mediated signaling] GO:0030552[cAMP binding] GO:0030553[cGMP binding] GO:0030911[TPR domain binding] GO:0035904[aorta development] GO:0036006[cellular response to macrophage colony-stimulating factor stimulus] GO:0042301[phosphate ion binding] GO:0042734[presynaptic membrane] GO:0042803[protein homodimerization activity] GO:0043116[negative regulation of vascular permeability] GO:0043117[positive regulation of vascular permeability] GO:0043949[regulation of cAMP-mediated signaling] GO:0043951[negative regulation of cAMP-mediated signaling] GO:0046069[cGMP catabolic process] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0048471[perinuclear region of cytoplasm] GO:0050729[positive regulation of inflammatory response] GO:0061028[establishment of endothelial barrier] GO:0071260[cellular response to mechanical stimulus] GO:0071320[cellular response to cAMP] GO:0071321[cellular response to cGMP] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0097060[synaptic membrane] GO:1904613[cellular response to 2,3,7,8-tetrachlorodibenzodioxine]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0003170[heart valve development] GO:0003281[ventricular septum development] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0004118[cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0008081[phosphoric diester hydrolase activity] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010752[regulation of cGMP-mediated signaling] GO:0010754[negative regulation of cGMP-mediated signaling] GO:0010821[regulation of mitochondrion organization] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0019933[cAMP-mediated signaling] GO:0019934[cGMP-mediated signaling] GO:0030224[monocyte differentiation] GO:0030552[cAMP binding] GO:0030553[cGMP binding] GO:0030911[TPR domain binding] GO:0035904[aorta development] GO:0036006[cellular response to macrophage colony-stimulating factor stimulus] GO:0042301[phosphate ion binding] GO:0042734[presynaptic membrane] GO:0042803[protein homodimerization activity] GO:0043116[negative regulation of vascular permeability] GO:0043117[positive regulation of vascular permeability] GO:0043949[regulation of cAMP-mediated signaling] GO:0043951[negative regulation of cAMP-mediated signaling] GO:0046069[cGMP catabolic process] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0048471[perinuclear region of cytoplasm] GO:0050729[positive regulation of inflammatory response] GO:0061028[establishment of endothelial barrier] GO:0071260[cellular response to mechanical stimulus] GO:0071320[cellular response to cAMP] GO:0071321[cellular response to cGMP] GO:0071466[cellular response to xenobiotic stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0097011[cellular response to granulocyte macrophage colony-stimulating factor stimulus] GO:0097060[synaptic membrane] GO:1904613[cellular response to 2,3,7,8-tetrachlorodibenzodioxine]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0003170[heart valve development] GO:0003281[ventricular septum development] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0004118[cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0008081[phosphoric diester hydrolase activity] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010752[regulation of cGMP-mediated signaling] GO:0010754[negative regulation of cGMP-mediated signaling] GO:0010821[regulation of mitochondrion organization] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0019933[cAMP-mediated signaling] GO:0019934[cGMP-mediated signaling] GO:0030552[cAMP binding] GO:0030553[cGMP binding] GO:0030911[TPR domain binding] GO:0035904[aorta development] GO:0036006[cellular response to macrophage colony-stimulating factor stimulus] GO:0042301[phosphate ion binding] GO:0042734[presynaptic membrane] GO:0042803[protein homodimerization activity] GO:0043116[negative regulation of vascular permeability] GO:0043117[positive regulation of vascular permeability] GO:0043949[regulation of cAMP-mediated signaling] GO:0043951[negative regulation of cAMP-mediated signaling] GO:0046069[cGMP catabolic process] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0048471[perinuclear region of cytoplasm] GO:0050729[positive regulation of inflammatory response] GO:0061028[establishment of endothelial barrier] GO:0071260[cellular response to mechanical stimulus] GO:0071320[cellular response to cAMP] GO:0071321[cellular response to cGMP] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0097060[synaptic membrane] GO:1904613[cellular response to 2,3,7,8-tetrachlorodibenzodioxine]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0003170[heart valve development] GO:0003281[ventricular septum development] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0004118[cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0008081[phosphoric diester hydrolase activity] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010752[regulation of cGMP-mediated signaling] GO:0010754[negative regulation of cGMP-mediated signaling] GO:0010821[regulation of mitochondrion organization] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0019933[cAMP-mediated signaling] GO:0019934[cGMP-mediated signaling] GO:0030552[cAMP binding] GO:0030553[cGMP binding] GO:0030911[TPR domain binding] GO:0035904[aorta development] GO:0036006[cellular response to macrophage colony-stimulating factor stimulus] GO:0042301[phosphate ion binding] GO:0042734[presynaptic membrane] GO:0042803[protein homodimerization activity] GO:0043116[negative regulation of vascular permeability] GO:0043117[positive regulation of vascular permeability] GO:0043949[regulation of cAMP-mediated signaling] GO:0043951[negative regulation of cAMP-mediated signaling] GO:0046069[cGMP catabolic process] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0048471[perinuclear region of cytoplasm] GO:0050729[positive regulation of inflammatory response] GO:0061028[establishment of endothelial barrier] GO:0071260[cellular response to mechanical stimulus] GO:0071320[cellular response to cAMP] GO:0071321[cellular response to cGMP] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0097060[synaptic membrane] GO:1904613[cellular response to 2,3,7,8-tetrachlorodibenzodioxine]