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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q21
Chromosome location (bp)
94973709 - 94999519
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Dioxygenase, Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K9 demethylation. Acts upstream of or within several processes, including cellular response to ionizing radiation; positive regulation of chromatin binding activity; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000724[double-strand break repair via homologous recombination] GO:0001932[regulation of protein phosphorylation] GO:0003684[damaged DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005721[pericentric heterochromatin] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006974[cellular response to DNA damage stimulus] GO:0016491[oxidoreductase activity] GO:0016570[histone modification] GO:0031490[chromatin DNA binding] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0035563[positive regulation of chromatin binding] GO:0035861[site of double-strand break] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0071479[cellular response to ionizing radiation] GO:0072562[blood microparticle] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000724[double-strand break repair via homologous recombination] GO:0001932[regulation of protein phosphorylation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0016491[oxidoreductase activity] GO:0016570[histone modification] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0035563[positive regulation of chromatin binding] GO:0035861[site of double-strand break] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0071479[cellular response to ionizing radiation] GO:0072562[blood microparticle] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0001932[regulation of protein phosphorylation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0016491[oxidoreductase activity] GO:0016570[histone modification] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0035563[positive regulation of chromatin binding] GO:0035861[site of double-strand break] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0071479[cellular response to ionizing radiation] GO:0072562[blood microparticle] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
The Human Protein Atlas project is funded
