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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q34
Chromosome location (bp)
109752695 - 109786583
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May mediate the control of various cellular processes by insulin....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transducer
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002903[negative regulation of B cell apoptotic process] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006006[glucose metabolic process] GO:0007165[signal transduction] GO:0007420[brain development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0009749[response to glucose] GO:0010631[epithelial cell migration] GO:0010634[positive regulation of epithelial cell migration] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010907[positive regulation of glucose metabolic process] GO:0016477[cell migration] GO:0019216[regulation of lipid metabolic process] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019904[protein domain specific binding] GO:0030674[protein-macromolecule adaptor activity] GO:0030879[mammary gland development] GO:0030890[positive regulation of B cell proliferation] GO:0032000[positive regulation of fatty acid beta-oxidation] GO:0032024[positive regulation of insulin secretion] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033673[negative regulation of kinase activity] GO:0043539[protein serine/threonine kinase activator activity] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0044342[type B pancreatic cell proliferation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0046326[positive regulation of glucose import] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0055088[lipid homeostasis] GO:0071333[cellular response to glucose stimulus] GO:0071889[14-3-3 protein binding] GO:0140677[molecular function activator activity] GO:1901653[cellular response to peptide] GO:1904692[positive regulation of type B pancreatic cell proliferation]
The Human Protein Atlas project is funded
