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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q11.22
Chromosome location (bp)
22547701 - 22559361
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation 1,2. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding 3. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation 4. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0030154[cell differentiation] GO:0031462[Cul2-RING ubiquitin ligase complex] GO:0042974[nuclear retinoic acid receptor binding] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045596[negative regulation of cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:1990756[ubiquitin ligase-substrate adaptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0030154[cell differentiation] GO:0031462[Cul2-RING ubiquitin ligase complex] GO:0042974[nuclear retinoic acid receptor binding] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045596[negative regulation of cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:1990756[ubiquitin ligase-substrate adaptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0030154[cell differentiation] GO:0031462[Cul2-RING ubiquitin ligase complex] GO:0042974[nuclear retinoic acid receptor binding] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045596[negative regulation of cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:1990756[ubiquitin ligase-substrate adaptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0030154[cell differentiation] GO:0031462[Cul2-RING ubiquitin ligase complex] GO:0042974[nuclear retinoic acid receptor binding] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045596[negative regulation of cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:1990756[ubiquitin ligase-substrate adaptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0030154[cell differentiation] GO:0031462[Cul2-RING ubiquitin ligase complex] GO:0042974[nuclear retinoic acid receptor binding] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045596[negative regulation of cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:1990756[ubiquitin ligase-substrate adaptor activity]
The Human Protein Atlas project is funded
